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Polysaccharide-based nanomedicines for cancer immunotherapy:A review

Bioactive Materials 2021年第10期6卷 3358-3382页

作者： Yujun Zeng Yufan Xiang Ruilong sheng helena tomás João Rodrigues Zhongwei Gu Hu Zhang Qiyong Gong Kui Luo Huaxi MR Research Center(HMRRC) Department of RadiologyDepartment of NeurosurgeryFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu610041China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengdu610041China CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9000-390FunchalMadeiraPortugal Amgen Bioprocessing Centre Keck Graduate InstituteClaremontCA91711USA

Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by ***,direct administration of“naked”immunotherapeutic agents(such as nucleic acids,cytokines,adjuvants or antigens without delivery vehicles)often results in:(1)an unsatisfactory efficacy due to suboptimal pharmacokinetics;(2)strong toxic and side effects due to low targeting(or off-target)*** overcome these shortcomings,a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side *** are a family of natural polymers that hold unique physicochemical and biological properties,as they could interact with immune system to stimulate an enhanced immune *** structures offer versatility in synthesizing multifunctional nanocomposites,which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor *** review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics.

关键词： Polysaccharides Drug delivery systems Nanomedicines Cancer immunotherapy Anticancer efficacy

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Development and challenges of cells-and materials-based tooth regeneration

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Engineered Regeneration 2022年第2期3卷 163-181页

作者： Zeyu Fu Yu Zhuang Jinjie Cui Ruilong sheng helena tomás João Rodrigues Bin Zhao Xudong Wang Kaili Lin Department of Oral and Cranio-Maxillofacial surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyResearch Unit of Oral and Maxillofacial Regenerative MedicineChinese Academy of Medical SciencesShanghai 200011China school of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9000-390 FunchalMadeiraPortugal school of Materials science and Engineering Center for Nano Energy MaterialsNorthwestern Polytechnical UniversityXi’an710072China

Tooth defect and loss are common clinical diseases in *** the extension of life expectancy,there is an increasing demand for tooth tissue and whole tooth *** with traditional oral prosthetic treatment,tooth regeneration has unique advantages and has become one of the hotspots towards oral biomedical *** this review,we discussed the development and challenges of tooth regeneration based on cells and materials,including tooth enamel,dentin,dental pulp,cementum,dentin-pulp complex,and the whole tooth regeneration,in order to provide a comprehensive,up-to-date,illustrative overview of tooth regeneration *** mechanisms of the regeneration were also summarized and ***,this review hints the future perspective and research direction of tooth regeneration in the challenging field of regenerative dentistry.

关键词： Tooth regeneration Cells Materials Regenerative dentistry

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Cytocompatible cellulose nanofibers from invasive plant species Agave americana *** Ricinus communis L.:a renewable green source of highly crystalline nanocellulose

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2021年第6期22卷 450-461页

作者： Olga L.EVDOKIMOVA Carla s.ALVEs Radenka M.KRsMANOVIC WHIFFEN Zaida O.RTEGA helena tomás Joao R.ODRIGUEs CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus Universitario da Penteada9020-105 FunchalPortugal Faculty of Polytechnics University of Donja GoricaOktoih 18 WOO PodgoricaMontenegro Departamento de Ingenieria de Procesos Universidad de Las Palmas de Gran Canaria35017 Las Palmas de Gran CanariaLas PalmasSpain school of Materials science and Engineering/Center for Nano Energy Materials Northwestern Polytechnical UniversityXi'an 710072China

In this study,the fibers of invasive species Agave americana *** Ricinus communis *** successfully used for the first time as new sources to produce cytocompatible and highly crystalline cellulose *** nanofibers were obtained by two methods,based on either alkaline or acid *** morphology,chemical composition,and crystallinity of the obtained materials were characterized by scanning electron microscopy(sEM)together with energy-dispersive X-ray spectroscopy(EDX),dynamic light scattering(DLs),X-ray diffraction(XRD),and Fourier transform infrared(FTIR)*** crystallinity indexes(CIs)of the cellulose nanofibers extracted from *** and *** were very high(94.1%and 92.7%,respectively).Biological studies evaluating the cytotoxic effects of the prepared cellulose nanofibers on human embryonic kidney 293 T(HEK293 T)cells were also *** nanofibers obtained using the two different extraction methods were all shown to be cytocompatible in the concentration range assayed(i.e.,0-500μg/mL).Our results showed that the nanocellulose extracted from *** and *** fibers has high potential as a new renewable green source of highly crystalline cellulose-based cytocompatible nanomaterials for biomedical applications.

关键词： Nanofiber Nanocellulose Agave americana L. Ricinus communis L. Crystallinity Invasive species Biomedical application

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Hormonal modulation of reproduction and fertility signaling in polistine wasps

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Current Zoology 2021年第5期67卷 519-530页

作者： Cintia Akemi OI Rafael Carvalho DA sILVA Ian sTEVENs helena Mendes FERREIRA Fabio santos NAsCIMENTO tom WENsELEERs Laboratory of socioecology and social Evolution KU LeuvenLeuven 3000Belgium Faculdade de Filosofia Ciencias e Letras de Ribeirao PretoDepartamento de BiologiaUniversidade de Sao Paulo—USPRibeirao PretoSP 14040-901Brazil

In social insects,it has been suggested that reproduction and the production of particular fertilitylinked cuticular hydrocarbons(CHC)may be under shared juvenile hormone(JH)control,and this could have been key in predisposing such cues to later evolve into full-fledged queen pheromone ***,to date,only few studies have experimentally tested this“hormonal pleiotropy”***,we formally test this hypothesis using data from four species of Polistine wasps,Polistes dominula,Polistes satan,Mischocyttarus metathoracicus,and Mischocyttarus cassununga,and experimental treatments with JH using the JH analogue methoprene and the anti-JH *** line with reproduction being under JH control,our results show that across these four species,precocene significantly decreased ovary development when compared with both the acetone solvent-only control and the methoprene *** with the hormonal pleiotropy hypothesis,these effects on reproduction were further matched by subtle shifts in the CHC profiles,with univariate analyses showing that in *** and *** the abundance of particular linear alkanes and mono-methylated alkanes were affected by ovary development and our hormonal *** results indicate that in primitively eusocial wasps,and particularly in Polistes,reproduction and the production of some CHC cues are under joint JH *** suggest that pleiotropic links between reproduction and the production of such hydrocarbon cues have been key enablers for the origin of true fertility and queen signals in more derived,advanced eusocial insects.

关键词： Polistinae wasps fertility cues queen pheromones cuticular hydrocarbons juvenile hormone

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Quantification of uric acid in vasculature of patients with gout using dual-energy computed tomography

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World Journal of Radiology 2020年第8期12卷 184-194页

作者： sharon Hannah Barazani Wei-Wei Chi Renata Pyzik helena Chang Adam Jacobi tom O’Donnell Zahi A Fayad Yousaf Ali Venkatesh Mani Department of Radiology Translational and Molecular Imaging InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Rheumatology Department of MedicineIcahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Population Health science and Policy Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Radiology Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States siemens Healthineers Erlangen 91052Germany

BACKGROUNDGout, caused by hyperuricemia and subsequent deposition of aggregatedmonosodium urate crystals (MsU) in the joints or extra-articular regions, is themost common inflammatory arthritis. There is increasing evidence that gout is anindependent risk factor for hypertension, cardiovascular disease progression *** evaluate if dual energy computed tomography (DECT) could identify MsUwithin vessel walls of gout patients, and if MsU deposits within the vasculaturediffered between patients with gout and controls. This study may help elucidatewhy individuals with gout have increased risk for cardiovascular ***31 gout patients and 18 controls underwent DECT scans of the chest andabdomen. A material decomposition algorithm was used to distinguish regions ofMsU (coded green), and calcifications (coded purple) from soft tissue (uncoded). Volume of green regions was calculated using a semi-automated volumeassessment program. Between-group differences were analyzed using Mann-Whitney U exact test and nonparametric rank *** patients had significantly higher volume of MsU within the aorta comparedto controls [Median (Min-Max) of 43.9 (0-1113.5) vs 2.9 (0-219.4), P = 0.01].Number of deposits was higher in gout patients compared to controls [Median(Min-Max) of 20 (0-739) vs 1.5 (0-104), P = 0.008]. However, the difference wasinsignificant after adjustment for age, gender, history of cardiovascular diseaseand diabetes. Increased age was positively associated with total urate volume (rs =0.64;95% confidence interval: 0.43-0.78).CONCLUsIONThis pilot study showed that DECT can quantify vascular urate deposits withvariation across groups, with gout patients possibly having higher *** relationship disappeared when adjusted for age, and there was a positiverelationship between age and MsU deposition. While this study does not provethat green coded regions are truly MsU deposition, it corroborates recent studiesthat show the pr

关键词： Gout Tophaceous Dual-energy computed tomography Hyperuricemia Monosodium urate Cardiovascular disease

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Resolving the taxonomy of emerging zoonotic pathogens in the Trichophyton benhamiae complex

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Fungal Diversity 2020年第5期104卷 I0001-I0055页

作者： AdélaČmoková Miroslav Kolařík Radim Dobiáš Lois L.Hoyer helena Janouškovcová Rui Kano Ivana Kuklová Pavlína Lysková Lenka Machová Thomas Maier Naďa Mallátová Matěj Man Karel Mencl Pietro Nenoff Andrea Peano Hana Prausová Dirk stubbe silke Uhrlaß tomášVětrovský Cornelia Wiegand Vit Hubka Department of Botany Faculty of ScienceCharles UniversityPragueCzech Republic Laboratory of Fungal Genetics and Metabolism Institute of MicrobiologyCzech Academy of SciencesPragueCzech Republic Public Health Institute in Ostrava OstravaCzech Republic Department of Biomedical sciences Institute of Microbiology and ImmunologyFaculty of MedicineUniversity of OstravaOstravaCzech Republic Department of Pathobiology University of Illinois at Urbana-ChampaignUrbanaILUSA Faculty of Medicine in Pilsen Biomedical CenterCharles UniversityPilsenCzech Republic Department of Veterinary Dermatology Nihon University College of Bioresource SciencesFujisawaJapan Department of Dermatology and Venereology First Faculty of MedicineGeneral University Hospital in PragueCharles University and General University Hospital in PraguePragueCzech Republic Public Health Institute inÚstíNad Labem PragueCzech Republic Microbiological Laboratory/R&D Bioanalytics Bruker Daltonik GmbHBremenGermany Laboratory of Medical Parasitology and Mycology HospitalČeskéBudějoviceČeskéBudějoviceCzech Republic Institute of Botany Czech Academy of SciencesPrůhoniceCzech Republic Pardubice Regional Hospital PardubiceCzech Republic Laboratory of Medical Microbiology MölbisGermany Department of Veterinary sciences University of TurinTurinItaly Clinical Veterinary Laboratory Labvet PragueCzech Republic Mycology and Aerobiology service SciensanoBrusselsBelgium Laboratory of Environmental Microbiology Institute of MicrobiologyCzech Academy of SciencesPragueCzech Republic Department of Dermatology University Hospital JenaJenaGermany

species of the Trichophyton benhamiae complex are predominantly zoophilic pathogens with a worldwide *** pathogens have recently become important due to their epidemic spread in pets and pet *** genetic and phenotypic variability has been revealed in these emerging pathogens,but the species limits and host spectra have not been clearly *** this study,we used an approach combining phylogenetic analysis based on four loci,population-genetic data,phenotypic and physiological analysis,mating type gene characterization and ecological data to resolve the taxonomy of these *** approach supported the inclusion of nine taxa in the complex,including three new species and one new *** benhamiae *** ***.(“yellow phenotype”strains)is currently a major cause of zoonotic tinea corporis and capitis in Europe(mostly transmitted from guinea pigs).The isolates of the“white phenotype”do not form a monophyletic group and are segregated into three taxa,*** ***(mostly North America;dogs),*** ***.(mostly Europe;guinea pigs),and *** ***.(predominant in East Asia but also found in Europe;rabbits and guinea pigs).The new species *** *** proposed for the“African”race of *** introduction to new geographic areas and host jump followed by extinction of one mating type gene have played important roles in the evolution of these *** to considerable phenotypic similarity of many dermatophytes and phenomena such as incomplete lineage sorting or occasional hybridization and introgression,we demonstrate the need to follow polyphasic approach in species *** evolving and noncoding DNA regions showed significantly higher discriminatory power compared to conventional protein-coding *** options for species identification in practice based on molecular markers,phenotype and MALDI-TOF spectra are presented.A microsatellite typi

关键词： Epizootic fungal infections Microsatellite typing scheme Multigene phylogeny Population genetic structure superficial skin infections Zoophilic dermatophytes

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PNAs：科学焉已在蝙蝠机体中发现白血病病毒的史前祖先

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现代生物医学进展 2017年第11期17卷 I0002-I0002页

作者： helena Farkašová[a], tomáš Hron[a], Jan Pačes[b] Pavel Hulva[c],[d] Petr Benda[c],[e] Robert James Gifford[f], Daniel Elleder[a], [a]Laboratory of Viral and Cellular Genetics Institute of Molecular Genetics The Czech Academy of Sciences Prague 14220 Czech Republic [b]Laboratory of Genomics and Bioinformatics Institute of Molecular Genetics The Czech Academy of Sciences Prague 14220 Czech Republic [c]Department of Zoology Charles University Prague 12844 Czech Republic [d]Department of Biology and Ecology University of Ostrava Ostrava 71000 Czech Republic [e]Department of Zoology National Museum (Natural History) Prague 11579 Czech Republic [f]MRC-University of Glasgow Centre for Virus Research Glasgow G12 8TA United Kingdom

近日,一项刊登在国际杂志PNAs上的研究报告中,来自格拉斯哥大学和捷克科学院的研究人员通过研究在蝙蝠的基因组中发现了引发罕见类型白血病的病毒家族的古老DNA痕迹。

关键词：白血病病毒科学院蝙蝠祖先机体研究人员 DNA 基因组

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