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Uterine cervical carcinoma treated with chemoradiotherapy: impact of three-month mRI follow-up on clinical management and outcome

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Journal of Cancer metastasis and Treatment 2021年第1期7卷 889-900页

作者： helena sundström Lennart Blomqvist Kristina Hellman Department of molecular medicine and Surgery Karolinska InstitutetStockholm 17176Sweden Department of Imaging and Physiology Karolinska University HospitalStockholm 17176Sweden Department of Women’s and Children’s Health Karolinska InstitutetStockholm 17176Sweden Department of Gynaecologic Cancer Theme CancerKarolinska University HospitalStockholm 17176Sweden.

Aim:The aim of this study was to evaluate the impact of mRI performed three months after treatment on further follow-up interventions and outcome in patients with uterine cervical carcinoma treated with definitive ***:Sixty consecutive women diagnosed with uterine cervical cancer FIGO 2009 stage IB1-IVA during 2011-2012 treated with definitive chemoradiotherapy/radiotherapy with curative intent at the Department of Gynaecological Oncology at Karolinska University Hospital were retrospectively included.A review of mRI reports and medical records with focus on follow-up interventions associated to imaging was ***:On follow-up mRI three months post treatment,29/60 women had complete remission(mrCR),24/60 women had partial remission(mrPR)and 7/60 had progressive disease(mrPD).In patients with mrCR,no additional procedures were *** group with mrPR had 27 additional mRIs,3 PET/CT examinations and 9 biopsy procedures,none leading to diagnosis of residual *** control rate was 96%after 6.5 months(median).No patient had cervical relapse only;2/53 had cervical relapse in combination with non-regional lymph nodes and distant *** was no statistically significant difference in overall survival between patients with mrCR and mrPR(HR=2.2,P=0.21).Conclusion:Patients with residual changes on mRI at three months post treatment have a low risk for locoregional *** this is not recognised,follow-up mRI results in unnecessary additional procedures with low impact on treatment *** studies are needed regarding the most appropriate imaging modality and timing of post-treatment evaluation.

关键词： Uterine cervical carcinoma chemoradiotherapy locoregional control mRI post-radiation changes relapse residual tumour natural course

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Optimal plot design in a multipurpose forest inventory

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Forest Ecosystems 2016年第1期3卷 37-50页

作者： helena m.Henttonen Annika Kangas Natural Resources Institute Finland(Luke) Economics and Society unit

Background： We explore the factors affecting the optimal plot design （size and type as well as the subsample tree selection strategies within a plot） and their relative importance in defining the optimal plot design in amultipurpose forest inventory. The factors include time used to lay out the plot and to make the tree measurements within the plot, the between-plot variation of each of the variables of interest in the area, and the measurement and model errors for the different variables. methods： We simulate different plot types and sizes and subsample tree selection strategies on measuredtest areas from North Lapland. The plot types used are fixed-radius, concentric and relascope plots. Weselect the optimal type and size first at plot level using a cost-plus-loss approach and then at cluster level byminimizing the weighted standard error with fixed budget. Results： As relascope plots are ve~/efficient at the plot level for volume and basal area, and fixed-radius plots for stems per ha, the optimal plot type strongly depends on the relative importance of these variables. The concentric plot seems to be a good compromise between these two in many cases. The subsample tree selection strategy was more important in selecting optimal plot than many other factors. In cluster level, the most important factor is the transfer time between plots. Conclusions： While the optimal radius of plots and other parameters were sensitive to the measurement times and other cost factors, the concentric plot type was optimal in almost all studied cases. Subsample tree measurement strategies need further studies, as they were an important cost factor. However, their importance to the precision was not as clear.

关键词： Sample Plot Forest inventory measurement Cost Loss

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Comparison of Classical models for Evaluating the Heat Requirements of Olive(Olea europeae L.) in Portugal

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Journal of Integrative Plant Biology 2006年第6期48卷 664-671页

作者： helena Ribeiro mário Cunha Ilda Abreu Autonomous Section of Agricultural Sciences Faculty of Sciences University of Porto4485-661 VairaoPortugal Department of Botany Faculty of SciencesUniversity of Porto1191-4150 PortoPortugal Institute of Agricultural Sciences and Technology 4485-661 VairaoPortugal Department of Botany Faculty of Sciences University of Porto1191-4150 PortoPortugal Institute for molecular and Cell Biology 823-4150 PortoPortugal

The aim of the present study was to compare the accuracy and reproducibility of six statistical models for the calculation of olive （Olea europeae L.） heat requirements to trigger the onset of flowering in three Portuguese regions： Reguengos de monsaraz, Valenga do Douro, and Braga. Other alms were to ascertain the date on which the heat-accumulation period started and the threshold temperatures above which the development of reproductive structures starts in olives. The starting and peak dates for the regional O. europeae flowering season were estimated by monitoring airborne pollen from 1998 to 2004 using ＂Cour＂- type samplers. The threshold temperature values calculated for the three regions were very similar （9.0 ℃ for Valenca do Douro, 9.2 ℃ for Reguengos de monsaraz, and 9.7 ℃ for Braga）. The accumulated daily mean temperature model had less interannual and inter-regional variation, showing best predictive results for 2004, with absolute differences between the observed and predicted dates of 4 d in Reguengos de monsaraz and 2 d In Valenca do Douro and Braga for the onset of flowering date and of 2 d In Reguengos de monsaraz, 7 d in Valenca do Douro, and 4 d in Braga for peak flowering dates. This model was the most accurate, reproducible, and operational to calculate heat requirements for olives to flower, with an average mean temperature accumulation of 1 446 ℃ In Reguengos, 1 642 ℃ in Valenga do Douro, and 1 703℃ In Braga to reach the onset of flowering. The best initial date for this accumulation was 1 January.

关键词： flowering season heat requirements olives pollen Portugal

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The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein

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International Journal of Oral Science 2018年第4期10卷 197-202页

作者： helena Ritchie Department of Cariology Restorative Sciences and EndodonticsUniversity of Michigan School of Dentistry

Phosphophoryn (PP) and dentin sialoprotein (DSP) are the most dominant non-collagenous proteins in dentin. PP is an extremely acidic protein that can function as a mineral nucleator for dentin mineralization. DSP was first identified in 1981, yet its functional significance is still controversial. Historically, these two proteins were considered to be independently synthesized and secreted by dental pulp cells into the developing dentin matrix. However, with the identification of the DSP coding sequence in 1994, followed2 years later by the finding that the PP coding sequence was located immediately downstream from the DSP sequence, it became immediately clear that DSP and PP proteins were derived from a single DSP-PP (i.e., dentin sialophosphoprotein, DSPP) *** DSPP cDNA became available, tremendous progress has been made in studying DSP-PP mRNA distribution and DSP generation from the DSP-PP precursor protein at specific cleavage sites by protease tolloid-related-1 (TLR1) or bone morphogenetic protein 1 (BmP1). The functions of DSP-PP and DSP were investigated via DSP-PP knockout (KO) and DSP knockin in DSP-PP KO mice. In addition, a number of in vitro studies aimed to elucidate DSPP and DSP function in dental pulp cells.

关键词： DSP The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein

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Polarization effect in tip-enhanced infrared nanospect- roscopy studies of the selective Y5 receptor antagonist Lu AA33810

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Nano Research 2018年第8期11卷 4401-4411页

作者： Natalia Piergies Ewa Pinta Czestawa Paluszkiewicz helena Domin Wojciech m.Kwiatek Institute of Nuclear Physics Polish Academy of Sciences PL-31342 Krakow Poland Institute of Pharmacology Polish Academy of Sciences Department of Neurobiology 31-343 Krakow Smetna Street 12 Poland Natalia Piergies and Ewa Pieta contributed equally to this work.

A novel approach of combining conventional infrared spectroscopy （IR） and atomic force microscopy （AFm） is presented to better understand the behavior of a drug adsorbed on a metal substrate at the nanoscale level. Tip-enhanced infrared nanospectroscopy （TEIRA） was used for the first time to investigate Lu AA33810, a selective brain-penetrating Y5 receptor antagonist, after immobilization on gold nanopartides （GNPs）. Here, a gold coated AFm tip and gold substrate were used to obtain the near-field electromagnetic field trapping effect. Because of the huge signal enhancement, it was possible to obtain the spectral information regarding the self-assembled monolayer of the investigated molecule. The effect of two orthogonal polarizations （p- and s-polarization modulations） of the excitation laser beam on the spectral patterns is also discussed. The results show that there is a strong relationship between the state of polarization of the incident radiation and the relative infrared band intensities. Another factor affecting the observed spectral differences is the topology of the metal substrate, which may result in the induction of a cross-polarization effect. The performed analysis indicates that the C--C bond from the cyclohexyl group is oriented almost parallel to the metal surface. Conversely, the p- and s-polarized spectral variations suggest that the O=S---O angle is high enough to enable the simultaneous interaction of both oxygen atoms with the GNPs.

关键词： tip-enhanced infrared nanospectroscopy polarization modulation Y5 receptor antagonist gold nanoparticles adsorption

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mycorrhizal synthesis between Pisolithus arhizus and adult clones of Arbutus unedo in vitro and in nursery

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Journal of Forestry Research 2013年第4期24卷 659-670页

作者： Filomena Gomes helena machado Esteban San martin A.Portugal Jorge m.Canhoto Filomena Gomes.CERNAS Dep.Recursos FlorestaisEscola Superior Agrária Coimbra INIAV Instituto Nacional de Investigao Agráriae VeterináriaIP.Av.República Centre of Functional Ecology Department of Life SciencesUniversity of Coimbra

Arbutoid mycorrhizae were synthesized between adult se- lected clones of Arbutus unedo L. and Pisolithus arhizus. Two micro- propagated clones were tested： ALl, in vitro and C1 （acclimatized plants） in nursery and later in a field trial. In vitro, rooted shoots were trans- ferred to test tubes containing the substrate previously inoculated with mycelium cultured on agar. In the nursery, two inoculation treatments were tested （vegetative inocula or dry sporocarps） and compared to con- trol plants. In the field trial, plants from nursery inoculation treatments were compared and an additional control treatment using seedlings was implemented. Plant height was evaluated 4 months later in the nursery and 20 months later in the field trial.

关键词： arbutoid mycorrhizae Ericaceae field plants Arbutus unedoor strawberry tree

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A NEW APPROACH TO RECOVERY OF DISCONTINUOUS GALERKIN

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Journal of Computational mathematics 2009年第6期27卷 697-712页

作者： Sebastian Franz Lutz Tobiska helena Zarin Institut für Numerische MathematikTechnische Universitt Dresden Institut für Analysis und NumerikOtto-von-Guericke Universitt Magdeburg Department of mathematics and Informatics University of Novi SadTrg Dositeja Obradovica 421 000 Novi Sad

A new recovery operator P ：Qn^disc（T）→Qn＋1^disc（m） for discontinuous Galerkin is derived. It is based on the idea of projecting a discontinuous, piecewise polynomial solution on a given mesh T into a higher order polynomial space on a macro mesh m. In order to do so, we define local degrees of freedom using polynomial moments and provide global degrees of freedom on the macro mesh. We prove consistency with respect to the local L2-projection, stability results in several norms and optimal anisotropic error estimates. As an example, we apply this new recovery technique to a stabilized solution of a singularly perturbed convection-diffusion problem using bilinear elements.

关键词： Discontinuous Galerkin Postprocessing Recovery.

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Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

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Cellular & molecular Immunology 2020年第4期17卷 313-322页

作者： Gianni Cutillo Anna-helena Saariaho Seppo meri Translational Immunology Research Program and the Department of Bacteriology and Immunology University of HelsinkiHelsinkiFinland Humanitas University MilanRozzanoItaly Helsinki University Hospital Laboratory(HUSLAB) HelsinkiFinland

Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human *** play important roles in protecting us against immune attacks,yet they can become targets for autoimmunity and act as receptors for microbes,like the influenza viruses,and toxins,such as the cholera *** expression patterns of gangliosides vary in different tissues,during different life periods,as well as in different *** against gangliosides(AGA)can target immune attack e.g.,against neuronal cells and neutralize their complement inhibitory *** are important especially in acquired demyelinating immune-mediated neuropathies,like Guillain–Barrésyndrome(GBS)and its variant,the miller–Fisher syndrome(mFS).They can emerge in response to different microbial agents and immunological ***,they can be involved in a variety of *** addition,antibodies against Gm3 were found in the sera of patients vaccinated with Pandemrix®,who developed secondary narcolepsy,strongly supporting the autoimmune etiology of the disease.

关键词： ganglioside Guillain-Barre syndrome complement narcolepsy sialic acid

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Energy efficiency in a water supply system:Energy consumption and CO_2 emission

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Water Science and Engineering 2010年第3期3卷 331-340页

作者： helena m.RAmOS Filipe VIEIRA Dídia I.C.COVAS Department of Civil Engineering ISTTechnical University of Lisbon CEHIDRO IST-DECivilLisbon 1049-001Portugal

This paper presents important fundamentals associated with water and energy efficiency and highlights the importance of using renewable energy sources. A model of multi-criteria optimization for energy efficiency based on water and environmental management policies, including the preservation of water resources and the control of water pressure and energy consumption through a hybrid energy solution, was developed and applied to a water supply system. The methodology developed includes three solutions：（1） the use of a water turbine in pipe systems where pressures are higher than necessary and pressure-reducing valves are installed, （2） the optimization of pumping operation according to the electricity tariff and water demand, and （3） the use of other renewable energy sources, including a wind turbine, to supply energy to the pumping station, with the remaining energy being sold to the national electric grid. The use of an integrated solution （water and energy-） proves to be a valuable input for creating benefits from available hydro energy in the water supply system in order to produce clean power, and the use of a wind source allows for the reduction of energy consumption in pumping stations, as well as of the CO2 emission to the atmosphere.

关键词： multi-criteria optimization energy efficiency water supply renewable energy sources CO2 emission

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A comparative study on emergent pollutants photo-assisted degradation using ruthenium modified titanate nanotubes and nanowires as catalysts

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Journal of Environmental Sciences 2020年第6期32卷 38-51页

作者： Beatriz Barrocas m.Conceicao Oliveira helena I.S.Nogueira Sara Fateixa Olinda C.monteiro Centro de Química Estrutural Faculdade de CienciasUniversidade de LisboaLisboa 1749-016Portugal Centro Química Estrutural Instituto Superior TécnicoUniversidade de LisboaLisboa 1049-001Portugal Department of Chemistry CICECO-Aveiro Institute of MaterialsUniversity of AveiroAveiro 3810-193Portugal

Several methods have been used to tailor nanomaterials structure and ***,slight changes in the structure outcomes expressive improvements in the optical and photocatalytic properties of semiconductor *** this context,the influence of the metal doping and the morphology on a catalyst performance was studied in this ***,ruthenium doped titanate nanotubes(RuTNT)were synthesised for the first time using an amorphous Ru-containing ***,the photocatalytic performance of this sample was compared to the one obtained for ruthenium titanate nanowires(RuTNW),recently *** samples,RuTNW and RuTNT,were produced using the same Ru-containing precursor but distinct hydrothermal *** powders were structural,morphological and optical characterized by X-ray diffraction and fluorescence,transmission electron microscopy,Raman,X-ray photoelectron and photoluminescence *** variations on the structural and optical properties of the RuTNT and RuTNW nanoparticles,due to ruthenium incorporation were *** potential use as photocatalysts was evaluated on the hydroxyl radical photo-assisted *** samples were catalytic for this reaction,presenting better performances than the pristine counterparts,being RuTNT the best ***,the degradation of two emergent pollutants,caffeine and sulfamethazine,was *** demonstrated to be better photocatalyst than RuTNW for caffeine but identical performances were obtained for *** both catalysts,the degradation mechanism of the pollutants was explored through the identification and quantification of the intermediate compounds produced and several differences were *** indicates the importance of the structural and morphological aspects of a material on its catalytic performance.

关键词： Titanate nanotubes and nanowires Ruthenium doping Ru-Ti replacement Emergent pollutants Photocatalytic degradation

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