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Extracellular matrix-derived materials for tissue engineering and regenerative medicine:A journey from isolation to characterization and application

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Bioactive Materials 2024年第4期34卷 494-519页

作者： helena Vilaça-Faria Jennifer Noro Rui L.reis Rogério P.Pirraco 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciência e TecnologiaZona Industrial da Gandra4805-017BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory BragaGuimarãesPortugal

Biomaterial choice is an essential step during the development tissue engineering and regenerative medicine(TERM)*** selected biomaterial must present properties allowing the physiological-like recapitulation of several processes that lead to the reestablishment of homeostatic tissue or organ *** derived from the extracellular matrix(ECM)present many such properties and their use in the field has been steadily *** this growing importance,it becomes imperative to provide a comprehensive overview of ECM biomaterials,encompassing their sourcing,processing,and integration into TERM *** review compiles the main strategies used to isolate and process ECM-derived biomaterials as well as different techniques used for its characterization,namely biochemical and chemical,physical,morphological,and ***,some of their applications in the TERM field are explored and discussed.

关键词： Extracted ECM Extraction methods Characterization ECM-derived applications

Low-grade mucinous appendiceal neoplasm mimicking an ovarian lesion: A case report and review of literature

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World Journal of Clinical Cases 2021年第10期9卷 2334-2343页

作者： André Luís Borges Catarina reis-de-Carvalho Martinha Chorão helena Pereira Dusan Djokovic Department of Obstetrics and Gynecology Hospital de São Francisco Xavier-Centro Hospitalar Lisboa OcidentalLisbon 1449-005Portugal Faculdade de Ciências da Saúde Universidade da Beira InteriorCovilhã6201-001Portugal Department of Obstetrics Gynecology and Reproductive MedicineHospital de Santa Maria-Centro Hospitalar Universitário Lisboa NorteLisbon 1649-028Portugal Department of Pathology Hospital Egas MonizCentro Hospitalar Lisboa OcidentalLisbon 1349-019Portugal Department of Obstetrics and Gynecology Maternidade Dr.Alfredo da Costa-Centro Hospitalar Universitário de Lisboa CentralLisbon 2890-495Portugal Faculdade de Ciências Médicas Nova Medical SchoolLisbon 1169-056Portugal

BACKGROUND Appendiceal tumors are rare lesions that may not be easily differentiated from primary ovarian lesions preoperatively,despite the use of advanced diagnostic methods by experienced *** SUMMARY A 59-year-old G2P2 woman,with chronic pelvic pain,underwent a pelvic ultrasound that revealed an adnexal mass measuring 58 mm×34 mm×36 mm,with irregular borders,heterogeneous echogenicity,no color Doppler vascularization and without acoustic *** ovarian tissue was visualized in contact with the lesion,and it was impossible to separate the lesion from the ovary by applying pressure with the ultrasound ***,peritoneal metastases or other alterations were not *** the international ovarian tumor analysis ADNEX model,the lesion was classified as a malignant tumor(the risk of malignancy was 27.1%,corresponding to Ovarian-Adnexal Reporting Data System category 4).Magnetic resonance imaging confirmed the presence of a right adnexal mass,apparently an ovarian tumor measuring 65 mm×35 mm,without signs of invasive or metastatic *** explorative laparotomy,normal morphology of the internal reproductive organs was noted.A solid mobile lesion involved the entire *** was *** of the abdominal cavity revealed no signs of malignant ***,the appendiceal lesion corresponded to a completely resected low-grade mucinous appendiceal neoplasm(LAMN).CONCLUSION The appropriate treatment and team of specialists who should provide health care to patients with seemingly adnexal lesions depend on the nature(benign vs malignant)and origin(gynecological vs nongynecological)of the ***,gynecologists and other pelvic surgeons should be familiar with the imaging signs of LAMN whose clinical presentation is silent or *** assistance of a consultant specializing in intestinal tumors is important support that gynecological surgeons can receive during the operation

关键词： Adnexal mass Appendiceal neoplasm Diagnostic imaging Pelvic neoplasm Adnexal diseases Pelvic neoplasm Case report

The Development of Mathematical Modelling Activities from Thematic Projects in the Social-Critical Perspective

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Journal of Mathematics and System Science 2012年第6期2卷 341-347页

作者： Regina helena de Oliveira Lino Franchi Frederico da Silva reis Department of Mathematics Federal University of Ouro Preto Ouro Preto 35400-000 Brazil

In this paper, the authors present a modelling activity developed from a thematic project in the models and mathematical modelling class of the professional master＇s degree program in mathematics education at the Federal University of Ouro Preto. The students enrolled in the class chose to study the theme Brazilian Public Politics. After several debates regarding the theme, the students were separated into three groups and each group chose a subtheme to study. The themes were IDH （index of human development）, minimum wage and social security. As an example, a description of the thematic project about the minimum wage in Brazil is presented. The principal results obtained in the study of this theme include a discussion about the potentialities of the theme as a classroom activity in different levels of schooling. As an educational activity, the thematic project demonstrated itself to be greatly relevant, since not only did it provide the learning possibility of mathematics related to the issues studied, but also promoted various discussions regarding the theme, which, in our conception, contributes to the social-critical development of the students. Finally, from the point of view of applied mathematics and mathematics education, the development of a modelling activity from thematic projects showed itself to be a good source of researches.

关键词： Mathematical modelling thematic projects social-critical perspective.

Prevascularized spongy-like hydrogels maintain their angiogenic potential after prolonged hypothermic storage

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Bioactive Materials 2024年第7期37卷 253-268页

作者： Sara Freitas-Ribeiro helena Moreira Lucília P.da Silva Jennifer Noro Belem Sampaio-Marques Paula Ludovico Mariana Jarnalo Ricardo Horta Alexandra P.Marques Rui L.reis Rogerio P.Pirraco B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciencia e TecnologiaZona Industrial da Gandra4805-017BarcoGuimaraesPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimaraesPortugal Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal Department of Plastic and Reconstructive Surgery and Burn UnityCentro Hospitalar de Sao JoaoPortoPortugal Faculty of Medicine-University of Porto Portugal

The chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems *** engineering offers a potential solution to address these shortages,but several challenges remain,with prevascularization being a critical factor for in vivo survival and integration of tissue engineering ***,a different challenge hindering the clinical implementation of such products,regards their efficient preservation from the fabrication site to the *** has emerged as a potential solution for this issue due to its milder effects on biologic systems in comparison with other cold preservation *** impact on prevascularization,however,has not been well *** this work,3D prevascularized constructs were fabricated using adipose-derived stromal vascular fraction cells and preserved at 4◦C using Hypothermosol or basal culture media(α-MEM).Hypothermosol efficiently preserved the structural and cellular integrity of prevascular networks as compared to constructs before *** contrast,the use ofα-MEM led to a clear reduction in prevascular structures,with concurrent induction of high levels of apoptosis and autophagy at the cellular *** vivo evaluation using a chorioallantoic membrane model demonstrated that,in opposition toα-MEM,Hypothermosol preservation retained the angiogenic potential of constructs before preservation by recruiting a similar number of blood vessels from the host and presenting similar integration with host *** results emphasize the need of studying the impact of preservation techniques on key properties of tissue engineering constructs such as prevascularization,in order to validate and streamline their clinical application.

关键词： Tissue engineering Prevascularization Hypothermic preservation Clinical translation

Bond Strength of Brackets Bonded with Chemically and Light Activated Materials after Thermal Cycling

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Advances in Materials Physics and Chemistry 2015年第9期5卷 351-360页

作者： Rafael Menezes-Silva Leonardo Amaral dos reis Bhenya Otonni Tostes Dhelfeson Willyan Douglas de Oliveira Maria helena Santos Department of Dentistry Endodontics and Dental Materials Bauru Dental School University of Sao Paulo—USP Bauru Brazil Department of Pathology Piracicaba Dental School University of Campinas—UNICAMP Piracicaba Brazil Department of Dentistry Federal University of Minas Gerais—UFMG Belo Horizonte Brazil Department of Dentistry Federal University of the “Vales do Jequitinhonha e Mucuri”—UFVJM Diamantina Brazil

The aim of this study was to evaluate the bond strength of orthodontic brackets bonded to tooth enamel with different polymer composites after simulated clinical aging, and analyze the enamel/ bond system fracture interface. 80 human premolars, were randomly divided into five groups (n = 16). G1: CO (Concise Ortodontica—3M ESPE), G2: SB (SuperBond—Ortho Source), G3: FMO (Fill Magic Ortodontico—Vigodent), G4: TXT (Transbond XT—3M ESPE) and G5: TP (Transbond Plus Self Etching Primer + Transbond Plus Color Change—3M ESPE). In all groups, the metal orthodontic bracket was bonded to the tooth enamel surface. The specimens were submitted to 3000 thermal cycling baths for 30 s, at temperatures of 5°C, 37°C and 55°C (±1°C). Afterwards they were subjected to shear testing and the results were analyzed by the Student’s-t test (p G5 > G2 > G3. In all groups the majority of the fractures at the interface of the specimens were cohesive, except in G3, which presented the largest number of adhesive fractures. After clinical aging, the chemically activated material (CO) showed higher bond strength than the light activated types (FMO, TXT and TP). The self-etching adhesive system (TP) showed similar bond strength to that of conventional systems (FMO and TXT).

关键词： Dental Bonding Orthodontic Brackets Orthodontics

Cytokines and T Helper Cells in Diabetic Nephropathy Pathogenesis

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Journal of Diabetes Mellitus 2016年第4期6卷 230-246页

作者： Liliane Silvano Araújo Marcos Vinícius da Silva Crislaine Aparecida da Silva Maria Luiza reis Monteiro Lívia helena de Morais Pereira Laura Penna Rocha Rosana Rosa Miranda Corrêa Marlene Antônia reis Juliana reis Machado General Pathology and Nephropathology Service Institute of Biological and Natural Sciences of Federal University of Triangulo Mineiro Uberaba Brazil Immunology Institute of Biological and Natural Sciences of Federal University of Triangulo Mineiro Uberaba Brazil General Pathology Institute of Tropical Pathology and Public Health of Federal University of Goiás Goiania Brazil

Diabetic Nephropathy (DN) is considered the main cause of end stage kidney disease around the world. However, its pathogenesis is not completely established. More than just a direct consequence of chronic glycemic changes, recent studies had suggested Diabetic Nephropathy could be considered an inflammatory disease. It has been shown that concentrations of pro-inflammatory cytokines, as IL-1, IL-6, IL-18, IL-33, IFN-γ and TNF-α actively participate in development and progression of DN, and thus, are involved in pathogenesis. Besides, changes in acquired immune response, especially the presence of cellular immune response profiles of pro-inflammatory and effector nature, mainly Th1 and Th17, as the imbalance between interaction of cytokines and T regulatory cells, foment the onset and progression of DN. Here we summarize the main evidences that support the critical role of the immune system in this condition. These new conceptual advances in DN understanding are essential for development of new the rapeutical strategies and prognostic factors, which could be protagonists or adjuvants to the current ones, leading ultimately to a better clinical management of DN patients.

关键词： Diabetic Nephropathy Cytokines Cellular Immunity

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可充压复合树脂修复Ⅱ类洞微渗漏的体外研究

中国口腔医学继续教育杂志 2005年第4期8卷 7-11页

作者： Alessandro Dourado Loguercio Jose Roberto de Oliveira Bauer Alessandra reis Rosa helena Miranda Grande 田福聪（译）姬爱平（校）不详北京大学口腔医学院北京海淀区中关村南大街22号100081

目的评价龈壁位于不同位置时Ⅱ类洞树脂修复体的边缘微渗漏及不同树脂的聚合收缩性。材料与方法在32颗离体磨牙上制备4种标准Ⅱ类洞洞型（3mm×5mm×2mm），龈壁边缘分别位于釉质牙骨质界（CEJ）上1mm或下1mm，然后将离体牙分组并分别... 详细信息

目的评价龈壁位于不同位置时Ⅱ类洞树脂修复体的边缘微渗漏及不同树脂的聚合收缩性。材料与方法在32颗离体磨牙上制备4种标准Ⅱ类洞洞型（3mm×5mm×2mm），龈壁边缘分别位于釉质牙骨质界（CEJ）上1mm或下1mm，然后将离体牙分组并分别用以下4种树脂与粘接剂的组合修复：（1组）Single Bond＋P60；（2组）Prime＆Bond NT＋Surefil；（3组）Bond-1＋Alert：（4组）Prime＆Bond2．1＋TPH。7天之后，将样本循环加热（5℃～55℃，500次。每次15秒），然后浸于0．5％亚甲蓝溶液中24小时，切开，由2位检查者采用0～3记分系统评估龈缘微渗漏的水平（双面）。树脂的聚合收缩（n=6）则采用偏转片法评估。微渗漏的数据采用非参数重复性测量的方差分析进行统计学分析，聚合收缩的百分比采用方差分析与tukey检验评估。结果只有第3组的釉质边缘与牙骨质边缘微渗漏存在显著差异：各组之间的釉质边缘微渗漏没有显著差异；仅第1组在牙骨质边缘提供了良好的边缘封闭。所有可充压复合树脂的聚合收缩都比混和填料树脂低。结论所有组合在釉质边缘都能有效防止微渗漏，但只有第1组可以更好地减少牙骨质边缘的微渗漏：可充压复合树脂比混合填料树脂有较低的聚合收缩。

关键词：复合树脂修复边缘微渗漏 Ⅱ类洞体外研究釉质边缘方差分析收缩性龈缘微渗漏统计学分析重复性测量

Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease(GCKD)cohort

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Bone Research 2023年第4期11卷 764-771页

作者： Katharina Charlotte Reimer Jennifer Nadal Heike Meiselbach Matthias Schmid Ulla T.Schultheiss Fruzsina Kotsis helena Stockmann Nele Friedrich Matthias Nauck Vera Krane Kai-Uwe Eckardt Markus P.Schneider Rafael Kramann Jürgen Floege Turgay Saritas Department of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experimental Medicine and Systems Biology RWTH Aachen UniversityAachenGermany Institute for Cell and Tumor Biology RWTH Aachen UniversityAachenGermany Institute of Medical Biometry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Department of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidemiology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Medicine IV-Nephrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Nephrology and Medical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Department of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chemistry and Laboratory Medicine University Medicine GreifswaldGreifswaldGermany DZHK(German Centre for Cardiovascular Research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Department of Medicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

Mineral and bone disorder(MBD)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aimed to compare the prognostic value of nine MBD biomarkers to determine those associated best with adverse cardiovascular(CV)outcomes and *** 5217 participants of the German CKD(GCKD)study enrolled with an estimated glomerular filtration rate(eG FR)between 30–60 mL·min-1 per 1.73 m2 or overt proteinuria,serum osteoprotegerin(OPG),C-terminal fibroblast growth factor-23(FGF23),intact parathyroid hormone(iP TH),bone alkaline phosphatase(BAP),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-terminal propeptide(P1NP),phosphate,calcium,and 25-OH vitamin D were measured at *** with missing values among these parameters(n=971)were excluded,leaving a total of 4246 participants for *** a median follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal major adverse CV events(MACEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcomes,with the highest hazard ratios(HRs)for *** the final Cox regression model,adjusted for CV risk factors,including kidney function and all other investigated biomarkers,each standard deviation increase in OPG was associated with non-CV death(HR 1.76,95%CI:1.35–2.30),CV death(HR 2.18,95%CI:1.50–3.16),MACE(HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the nine biomarkers examined,stratification based on serum OPG best identified the CKD patients who were at the highest risk for any adverse CV outcome and mortality.

关键词： Kidney cardiovascular vitamin