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Osteogenic differentiation of encapsulated cells in dexamethasone-loaded phospholipid-induced silk fibroin hydrogels

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Biomaterials Translational 2022年第3期3卷 213-220页

作者： Chavee Laomeephol helena Ferreira Sorada Kanokpanont Jittima Amie Luckanagul Nuno M Neves Siriporn Damrongsakkul Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkokThailand Biomaterial Engineering for Medical and Health Research Unit Chulalongkorn UniversityBangkokThailand B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Department of Chemical Engineering Faculty of EngineeringChulalongkorn UniversityBangkokThailand Biomedical Engineering Research Center Faculty of EngineeringChulalongkorn UniversityBangkokThailand Center of Excellence in Plant-produced Pharmaceuticals Chulalongkorn UniversityBangkokThailand

The tissue engineering triad comprises the combination of cells,scaffolds and biological ***,we prepared cell-and drug-loaded hydrogels using in situ silk fibroin(SF)hydrogels induced by dimyristoyl glycerophosphoglycerol(DMPG).DMPG is reported to induce rapid hydrogel formation by SF,facilitating cell encapsulation in the hydrogel matrix while maintaining high cell viability and proliferative *** addition,DMPG can be used for liposome formulations in entrapping drug ***(Dex)was loaded into the DMPG-induced SF hydrogels together with human osteoblast-like SaOS-2 cells,then the osteogenic differentiation of the entrapped cells was evaluated in vitro and compared to cells cultured under standard *** production by cells cultured in DMPG/Dex-SF hydrogels with Dex-depleted osteogenic medium was equivalent to that of cells cultured in conventional osteogenic medium containing *** extended-release of the entrapped Dex by the hydrogels was able to provide a sufficient drug amount for osteogenic *** controlled release of Dex was also advantageous for cell viability even though its dose in the hydrogels was far higher than that in osteogenic *** results confirmed the possibility of using DMPG-induced SF hydrogels to enable dual cell and drug encapsulation to fulfil the practical applications of tissue-engineered constructs.

关键词： DMPG osteogenic differentiation silk fibroin three-dimensional cell culture tissue engineering

电子支付形式下取消现金返还的功能对印度尼西亚消费者持续使用该平台的影响

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电子支付形式下取消现金返还的功能对印度尼西亚消费者持续使用该...

作者： helena 华东师范大学

学位级别：硕士

本文旨在分析和总结电子支付关于取消现金返还功能在印度尼西亚持续使用的客户群体中,使用该应用程序的反馈及影响。为了解如果撤回现金返还功能后,消费者是否还会继续使用该应用程序,作者进行了大量的文献综述,并提出了理论框架以及采... 详细信息

本文旨在分析和总结电子支付关于取消现金返还功能在印度尼西亚持续使用的客户群体中,使用该应用程序的反馈及影响。为了解如果撤回现金返还功能后,消费者是否还会继续使用该应用程序,作者进行了大量的文献综述,并提出了理论框架以及采用实验法验证所提出的框架。之后作者对数据进行了分析,在此基础上,作者进行了总结,并针对未来的发展和印度尼西亚电子支付行业提供了建议。分析员的方法将通过问卷调查。作者将向50(五十)名受访者分发2(两)套调查问卷,每套问卷将有100(一百)名受访者,这将有助于本文收到有助于公司洞察其进一步计划或决策的结果.通过这份问卷,笔者想知道公司继续提供现金返还和公司何时决定停止提供现金返还之间的反应是否存在差异。现金返还是导致最终结果的人们行为的唯一和首要原因,还是自变量和中介变量等其他因素也可能在人类对因变量的行为中发挥作用。换句话说,除了现金返还作为独立变量之外,作者想确定诸如便利性、享乐动机和感知损失等中介变量是否也是影响印度尼西亚电子钱包作为因变量的持续使用的因素多变。之所以进行这项研究,也是因为在过去的一年中出现了电子钱包服务数量突然急剧增加的现象,以及提供最大回报的现金返还冷战,确保参与租户的战争以及建立合作伙伴关系的战争与其他购物供应商,例如,在商店A购买商品,将需要有电子钱包X才能在商店A付款,并在其商家合作伙伴中获得更大的现金返还。这导致许多人在没有太多选择的情况下,必须下载并注册所有电子钱包提供商,以确保返现可以自由用于扣除他们即将到来的先前付款,并且他们收集的返现价值/积分没有到期日。

关键词：电子支付印度尼西亚消费者行为现金返还取消现金返还

A NEW APPROACH TO RECOVERY OF DISCONTINUOUS GALERKIN

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Journal of Computational Mathematics 2009年第6期27卷 697-712页

作者： Sebastian Franz Lutz Tobiska helena Zarin Institut für Numerische MathematikTechnische Universitt Dresden Institut für Analysis und NumerikOtto-von-Guericke Universitt Magdeburg Department of Mathematics and Informatics University of Novi SadTrg Dositeja Obradovica 421 000 Novi Sad

A new recovery operator P ：Qn^disc（T）→Qn＋1^disc（M） for discontinuous Galerkin is derived. It is based on the idea of projecting a discontinuous, piecewise polynomial solution on a given mesh T into a higher order polynomial space on a macro mesh M. In order to do so, we define local degrees of freedom using polynomial moments and provide global degrees of freedom on the macro mesh. We prove consistency with respect to the local L2-projection, stability results in several norms and optimal anisotropic error estimates. As an example, we apply this new recovery technique to a stabilized solution of a singularly perturbed convection-diffusion problem using bilinear elements.

关键词： Discontinuous Galerkin Postprocessing Recovery.

Development and challenges of cells-and materials-based tooth regeneration

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Engineered Regeneration 2022年第2期3卷 163-181页

作者： Zeyu Fu Yu Zhuang Jinjie Cui Ruilong Sheng helena Tomás João Rodrigues Bin Zhao Xudong Wang Kaili Lin Department of Oral and Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyResearch Unit of Oral and Maxillofacial Regenerative MedicineChinese Academy of Medical SciencesShanghai 200011China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9000-390 FunchalMadeiraPortugal School of Materials Science and Engineering Center for Nano Energy MaterialsNorthwestern Polytechnical UniversityXi’an710072China

Tooth defect and loss are common clinical diseases in *** the extension of life expectancy,there is an increasing demand for tooth tissue and whole tooth *** with traditional oral prosthetic treatment,tooth regeneration has unique advantages and has become one of the hotspots towards oral biomedical *** this review,we discussed the development and challenges of tooth regeneration based on cells and materials,including tooth enamel,dentin,dental pulp,cementum,dentin-pulp complex,and the whole tooth regeneration,in order to provide a comprehensive,up-to-date,illustrative overview of tooth regeneration *** mechanisms of the regeneration were also summarized and ***,this review hints the future perspective and research direction of tooth regeneration in the challenging field of regenerative dentistry.

关键词： Tooth regeneration Cells Materials Regenerative dentistry

Optimal plot design in a multipurpose forest inventory

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Forest Ecosystems 2016年第1期3卷 37-50页

作者： helena M.Henttonen Annika Kangas Natural Resources Institute Finland(Luke) Economics and Society unit

Background： We explore the factors affecting the optimal plot design （size and type as well as the subsample tree selection strategies within a plot） and their relative importance in defining the optimal plot design in amultipurpose forest inventory. The factors include time used to lay out the plot and to make the tree measurements within the plot, the between-plot variation of each of the variables of interest in the area, and the measurement and model errors for the different variables. Methods： We simulate different plot types and sizes and subsample tree selection strategies on measuredtest areas from North Lapland. The plot types used are fixed-radius, concentric and relascope plots. Weselect the optimal type and size first at plot level using a cost-plus-loss approach and then at cluster level byminimizing the weighted standard error with fixed budget. Results： As relascope plots are ve~/efficient at the plot level for volume and basal area, and fixed-radius plots for stems per ha, the optimal plot type strongly depends on the relative importance of these variables. The concentric plot seems to be a good compromise between these two in many cases. The subsample tree selection strategy was more important in selecting optimal plot than many other factors. In cluster level, the most important factor is the transfer time between plots. Conclusions： While the optimal radius of plots and other parameters were sensitive to the measurement times and other cost factors, the concentric plot type was optimal in almost all studied cases. Subsample tree measurement strategies need further studies, as they were an important cost factor. However, their importance to the precision was not as clear.

关键词： Sample Plot Forest inventory Measurement Cost Loss

Implications of receptor for advanced glycation end products for progression from obesity to diabetes and from diabetes to cancer

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World Journal of Diabetes 2023年第7期14卷 977-994页

作者： Andrea Garza-Campos José Roberto Prieto-Correa José Alfredo Domínguez-Rosales Zamira helena Hernández-Nazará Programa de Doctorado en Ciencias en Biología Molecular en Medicina Universidad de GuadalajaraGuadalajara 44340JaliscoMexico Departamento de Biología Molecular y Genómica Instituto de Investigación en Enfermedades Crónico-DegenerativasUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Obesity and type 2 diabetes mellitus(T2DM)are chronic pathologies with a high incidence *** share some pathological mechanisms,including hyperinsulinemia,the production and release of hormones,and *** above,over time,affects other systems of the human body by causing tissue hypoxia,low-grade inflammation,and oxidative stress,which lay the pathophysiological groundwork for *** leading causes of death globally are T2DM and *** main alterations of this pathological triad include the accumulation of advanced glycation end products and the release of endogenous alarmins due to cell death(i.e.,damage-associated molecular patterns)such as the intracellular proteins high-mobility group box protein 1 and protein S100 that bind to the receptor for advanced glycation products(RAGE)-a multiligand receptor involved in inflammatory and metabolic and neoplastic *** review analyzes the latest advanced reports on the role of RAGE in the development of obesity,T2DM,and cancer,with an aim to understand the intracellular signaling mechanisms linked with cancer *** review also explores inflammation,oxidative stress,hypoxia,cellular senescence,RAGE ligands,tumor microenvironment changes,and the“cancer hallmarks”of the leading tumors associated with *** assimilation of this information could aid in the development of diagnostic and therapeutic approaches to lower the morbidity and mortality associated with these diseases.

关键词： Type 2 diabetes Cancer Obesity Advanced glycation end product receptor Receptor for advanced glycation end products Glycation end products,advanced

Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

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Cellular & Molecular Immunology 2020年第4期17卷 313-322页

作者： Gianni Cutillo Anna-helena Saariaho Seppo Meri Translational Immunology Research Program and the Department of Bacteriology and Immunology University of HelsinkiHelsinkiFinland Humanitas University MilanRozzanoItaly Helsinki University Hospital Laboratory(HUSLAB) HelsinkiFinland

Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human *** play important roles in protecting us against immune attacks,yet they can become targets for autoimmunity and act as receptors for microbes,like the influenza viruses,and toxins,such as the cholera *** expression patterns of gangliosides vary in different tissues,during different life periods,as well as in different *** against gangliosides(AGA)can target immune attack e.g.,against neuronal cells and neutralize their complement inhibitory *** are important especially in acquired demyelinating immune-mediated neuropathies,like Guillain–Barrésyndrome(GBS)and its variant,the Miller–Fisher syndrome(MFS).They can emerge in response to different microbial agents and immunological ***,they can be involved in a variety of *** addition,antibodies against GM3 were found in the sera of patients vaccinated with Pandemrix®,who developed secondary narcolepsy,strongly supporting the autoimmune etiology of the disease.

关键词： ganglioside Guillain-Barre syndrome complement narcolepsy sialic acid

Fabulous Glamping Destinations in Georgia

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空中英语教室（高级版．彭蒙惠英语） 2022年第5期 11-13,40,41页

作者： helena Oliviero 徐佩仪(译) 不详

现在正是享受户外的美好季节一外出踏青、烤棉花糖,也许睡在星空下也很宜人:对于想要摆脱电子产品而重新投入大自然怀抱,却又(丝毫)不想吃苦头的人而言,“豪华露营”也许正投其所好:佐治亚州有若干个目的地可以让你依偎在大自然的怀抱,... 详细信息

现在正是享受户外的美好季节一外出踏青、烤棉花糖,也许睡在星空下也很宜人:对于想要摆脱电子产品而重新投入大自然怀抱,却又(丝毫)不想吃苦头的人而言,“豪华露营”也许正投其所好:佐治亚州有若干个目的地可以让你依偎在大自然的怀抱,又不必牺牲家的舒适。下面就来看看其中四个景点:奇克莫加的烛光森林树屋。

关键词：佐治亚州棉花糖投其所好电子产品

Comparison of Classical Models for Evaluating the Heat Requirements of Olive(Olea europeae L.) in Portugal

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Journal of Integrative Plant Biology 2006年第6期48卷 664-671页

作者： helena Ribeiro Mário Cunha Ilda Abreu Autonomous Section of Agricultural Sciences Faculty of Sciences University of Porto4485-661 VairaoPortugal Department of Botany Faculty of SciencesUniversity of Porto1191-4150 PortoPortugal Institute of Agricultural Sciences and Technology 4485-661 VairaoPortugal Department of Botany Faculty of Sciences University of Porto1191-4150 PortoPortugal Institute for Molecular and Cell Biology 823-4150 PortoPortugal

The aim of the present study was to compare the accuracy and reproducibility of six statistical models for the calculation of olive （Olea europeae L.） heat requirements to trigger the onset of flowering in three Portuguese regions： Reguengos de Monsaraz, Valenga do Douro, and Braga. Other alms were to ascertain the date on which the heat-accumulation period started and the threshold temperatures above which the development of reproductive structures starts in olives. The starting and peak dates for the regional O. europeae flowering season were estimated by monitoring airborne pollen from 1998 to 2004 using ＂Cour＂- type samplers. The threshold temperature values calculated for the three regions were very similar （9.0 ℃ for Valenca do Douro, 9.2 ℃ for Reguengos de Monsaraz, and 9.7 ℃ for Braga）. The accumulated daily mean temperature model had less interannual and inter-regional variation, showing best predictive results for 2004, with absolute differences between the observed and predicted dates of 4 d in Reguengos de Monsaraz and 2 d In Valenca do Douro and Braga for the onset of flowering date and of 2 d In Reguengos de Monsaraz, 7 d in Valenca do Douro, and 4 d in Braga for peak flowering dates. This model was the most accurate, reproducible, and operational to calculate heat requirements for olives to flower, with an average mean temperature accumulation of 1 446 ℃ In Reguengos, 1 642 ℃ in Valenga do Douro, and 1 703℃ In Braga to reach the onset of flowering. The best initial date for this accumulation was 1 January.

关键词： flowering season heat requirements olives pollen Portugal