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Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1521-1533页

作者： Chao Teng Chenshi Lin Feifei huang Xuyang Xing Shenyu Chen Ling Ye helena S.Azevedo Chenjie Xu Zhengfeng Wu Zhongjian Chen Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 210009China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China School of Engineering and Materials Science Institute of BioengineeringUniversity of LondonLondon E14NSUK Department of Biomedical Engineering City University of Hong KongKowloonHong KongChina Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Atherosclerosis(AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein,targeted codelivery of anti-miR 155 and anti-inflammatory baicalein is exploited to polarize macrophages toward M2 phenotype, inhibit inflammation and treat AS. The codelivery system consists of a carrier-free strategy(drug-delivering-drug, DDD), fabricated by loading anti-miR155 on baicalein nanocrystals,named as baicalein nanorods(BNRs), followed by sialic acid coating to target macrophages. The codelivery system, with a diameter of 150 nm, enables efficient intracellular delivery of anti-miR155 and polarizes M1 to M2, while markedly lowers the level of inflammatory factors in vitro and in vivo. In particular, intracellular fate assay reveals that the codelivery system allows for sustained drug release over time after internalization. Moreover, due to prolonged blood circulation and improved accumulation at the AS plaque, the codelivery system significantly alleviates AS in animal model by increasing the artery lumen diameter, reducing blood pressure, promoting M2 polarization, inhibiting secretion of inflammatory factors and decreasing blood lipids. Taken together, the codelivery could potentially be used to treat vascular inflammation.

关键词： miR155 inflammatory sustained

Measuring academic contributions via keyword analytics

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Journal of Library Science in China 2019年 186-187页

作者： Charles C.huang Star X.ZHAO BIAN Yangyi Ronda J.ZHANG helena H.ZHANG Fred Y.YE 不详

As a tool of logical thinking and derivation,the basic element of language is the *** words reflect concepts,and core concepts construct knowledge,while knowledge evolution contributes to academic *** on the theoretical foundation that keywords in the academic literature characterize concepts,this work attempts to get beyond traditional citation analysis and introduce a framework of academic contribution analysis based on keywords.

关键词： Measuring academic contributions

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测量学术贡献的关键词分析法探析

中国图书馆学报 2019年第6期45卷 84-99页

作者：黄晨赵星卞杨奕张家榕张慧叶鹰浙江大学图书馆华东师范大学信息管理系南京大学信息管理学院

语言作为逻辑思维和推理工具,其基本要素是语词。重要语词映射成概念,核心概念建构知识,而知识演进促成学术发展。本文以学术文献中的关键词作为概念演化基础,尝试超越传统引文分析法探讨测量学术贡献的关键词分析法。研究发现以一个学... 详细信息

语言作为逻辑思维和推理工具,其基本要素是语词。重要语词映射成概念,核心概念建构知识,而知识演进促成学术发展。本文以学术文献中的关键词作为概念演化基础,尝试超越传统引文分析法探讨测量学术贡献的关键词分析法。研究发现以一个学科内的关键词向量和关键词流量为基准,可分别定义关键词向量通量谱和累积通量谱的h截断和g截断,构成h核和g核内主流关键词,进而可定义主流率和主流指数,用作测量对主流学术研究之学术贡献的新型学术测评参数。合并CNKI、万方、维普三大中文数据库元数据和WoS、Ei里的中文记录元数据建立了2008—2017年数据支持平台,具体探讨了针对学术团体和学术期刊的中观层面实证案例。本文给出的关键词分析法基础框架重点是挖掘学术主体或客体对主流研究的学术贡献,建议在试用和应用中进一步改良和完善。图5。表5。参考文献23。

关键词：分析法关键词向量关键词流量关键词通量主流率主流指数学术评价

An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 386-403,I0014-I0016页

作者： Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng Department of Nephrology Jiangnan University Medical CenterWuxiChina Affiliated Wuxi Clinical College of Nantong University WuxiChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineAzienda Ospedaliera Universitaria Integrata VeronaVeronaItaly Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southamptonand Southampton General HospitalUniversity of SouthamptonSouthamptonUK Department of Renal Medicine University College LondonLondonUK Department of Medicine and Therapeutics Chinese University of Hong KongHong KongChina Center for Fatty Liver Department of GastroenterologyXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Internal Medicine I GastroenterologyEndocrinology&MetabolismMedical University InnsbruckInnsbruckAustria Department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Division of Nephrology Department of MedicineWürzburg University ClinicWürzburgGermany Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghaiChina Section of Gastroenterology Boston Medical CenterBoston University School of MedicineBostonMAUSA Division of Nephrology Department of Medicine(M.K.)Koc University School of MedicineIstanbulTurkey Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCAUSA Section of Nephrology and Institute of Clinical and Translational Research Baylor College of Medicineand Michael E.DeBakey VA Medical CenterHoustonTXUSA Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRizeTurkey Department of Cardiology Shunde HospitalSouthern Medical UniversityFoshanChina Division of Hepat

Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly *** 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without ***,to date,there is no appropriate guidance on CKD in individuals with ***,there has been little attention paid to the link between MAFLD and CKD in the Nephrology *** and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and ***:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases.

关键词： Metabolic dysfunction-associated fatty liver disease(MAFLD) non-alcoholic fatty liver disease(NAFLD) chronic kidney disease(CKD) consensus

应用国产全自动电泳系统筛查、监测新生儿α-地中海贫血

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现代科学仪器 2010年第4期27卷 76-78页

作者：韦喜娟黄寿星黄春葵邹贺明广西恭城瑶族自治县人民医院 542500

目的:探讨应用国产SH-2040型全自动琼脂糖凝胶电泳系统筛查、监测新生儿α-地中海贫血的实用性。方法:采用国产SH—2040型全自动琼脂糖凝胶电泳系统对2826例新生儿脐血进行血红蛋白电泳、Bart含量测定,筛查α-地中海贫血;其中,34例标本... 详细信息

目的:探讨应用国产SH-2040型全自动琼脂糖凝胶电泳系统筛查、监测新生儿α-地中海贫血的实用性。方法:采用国产SH—2040型全自动琼脂糖凝胶电泳系统对2826例新生儿脐血进行血红蛋白电泳、Bart含量测定,筛查α-地中海贫血;其中,34例标本与美国helena公司SPIFE快速自动电泳分析系统作对照检测。结果:检出α-地中海贫血221例,其中:Bart胎儿水肿综合征3例,血红蛋白H病7例,静止型(α地贫2)82例,标准型(α地贫1)129例;34例标本与美国Heiena公司SPIFE快速自动电泳系统对照分析结果都符合。结论:应用国产SH-2040型全自动琼脂糖凝胶电泳系统筛查、监测新生儿α地中海贫血是可行的。

关键词： SH-2040型全自动琼脂糖凝胶电泳系统,新生儿血红蛋白电泳 α-地中海贫血筛查监测

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金扇凤蝶和红纹凤蝶生物学特性观察

武夷科学 2002年第1期18卷 134-137页

作者：应霞玲曾玲黄寿山华南农业大学昆虫生态研究室广州510642

金扇凤蝶 Troides H elena (Linnaeus)在广州一年发生 5至 6代 ,越冬蛹期为 12 2 - 15 6天。 1996年 6- 7月 ,平均每雌产卵量为 4 7.7粒 ,卵期为 5 .2 5± 0 .5 3天 ,幼虫期为 15 .4 5± 0 .5 1天 ,蛹期为 18.73± 1.16天 ,成虫寿命为 1... 详细信息

金扇凤蝶 Troides H elena (Linnaeus)在广州一年发生 5至 6代 ,越冬蛹期为 12 2 - 15 6天。 1996年 6- 7月 ,平均每雌产卵量为 4 7.7粒 ,卵期为 5 .2 5± 0 .5 3天 ,幼虫期为 15 .4 5± 0 .5 1天 ,蛹期为 18.73± 1.16天 ,成虫寿命为 11- 18天。红纹凤蝶 Pachlioptera aristolochiae(Fabricius)在广州一年发生 9至 10代 ,越冬蛹期为 83- 114天 ,平均每雌产卵量为 5 0 .8粒 ,卵期为 3.6 3± 0 .78天 ,幼虫期为 12 .77± 1.0 2天 ,蛹期为11.75± 0 .5

关键词：金扇凤蝶,红纹凤蝶,生物学

罕见的血红蛋白H病同时合并异常血红蛋白Q和E家系分析

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中华检验医学杂志 2007年第4期30卷 427-432页

作者：陈和平郑卫东陈冬葛艳芬陈澍英黄志新叶瑞兴荣卡彬广东省人民医院病理医学部检验科广州510080

目的对广州市一个罕见的血红蛋白 H 病同时合并异常血红蛋白 Q 和 E 家系进行分析。方法采用美国 helena 公司全自动快速电泳分析系统测定血红蛋白(Hb)各种区带定量;同时进行异常 Hb 各项测定,包括吸收光谱试验、C 结晶试验、溶解度试... 详细信息

目的对广州市一个罕见的血红蛋白 H 病同时合并异常血红蛋白 Q 和 E 家系进行分析。方法采用美国 helena 公司全自动快速电泳分析系统测定血红蛋白(Hb)各种区带定量;同时进行异常 Hb 各项测定,包括吸收光谱试验、C 结晶试验、溶解度试验、异丙醇试验、连二硫酸钠过筛试验、血红蛋白肽链裂解试验。首证者做了骨髓检查;4例均做外周血红细胞形态检查、常规血液检查、红细胞温育脆性试验、高铁血红蛋白还原试验、G6PD/6PGD 酶比值法(紫外法)测定;α-THAL基因检测:多重 PCR 检测α-THAL 基因缺失;β-THAL 基因检测:DNA 芯片反向点杂交(RDB)检测中国人较常见的18种β—THAL 基因,鉴定β—THAL 基因突变类型。结果父亲的α-THAL 基因型:α~Qα^(4.2)/αα;β—THAL 基因型:β~E/N;表现型:轻型β-THAL 携带者合并异常 HbQ 和异常 Hb E 多重杂合子;母亲的α-THAL 基因型:α/--^(SEA/);β-THAL 基因型:βN/βN。根据综合分析,母亲的表现型:轻型α-THAL 复合轻型β-THAL 携带者同时合并异常 Hb F 持续增高症(HPFH)。首证者的α-THAL基因型:α~Qα^(4.2)/--^(SEA);表现型:缺失型 Hb H-Q 病;β-THAL 基因型:βEM/βEM;表现型:βE纯合子。根据综合分析,为缺失型异常 Hb H 合并异常 Hb Q 和异常 Hb E 多重杂合子。其弟的α-THAL基因型:α~Qα^(4.2)/--^(SEA);β-THAL基因:BN/BN;表现型:缺失型异常 Hb H 病。母亲及其小儿子均同时合并 G6PD 缺陷。结论广东省是α-THAL 和β-THAL、异常 Hb E 和异常 Hb Q 以及 G6PD 缺乏症的发高区,从地域异常 Hb 的高发率上,Hb E 和 Hb Q 是可能存在某种关联性,但是在非同源染色体上两种类型的异常 Hb 同时合并 Hb H 病在一个个体上,实为罕见。本研究提示对其配偶的婚前检查尤为必要。

关键词：血红蛋白类异常血红蛋白H α-地中海贫血