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Changes in urinary excretion of water and sodium transporters during amiloride and bendroflumethiazide treatment

World Journal of Nephrology 2015年第3期4卷 423-437页

作者： Janni m Jensen Frank H mose Anna-Ewa O Kulik Jesper N Bech Robert A Fenton Erling B Pedersen University Clinic in Nephrology and Hypertension Department of Medical ResearchHolstebro HospitalRegional Hospital Jutland West and Aarhus University Department of Biomedicine Aarhus University

AIm:To quantify changes in urinary excretion of aquaporin2 water channels(u-AQP2),the sodiumpotassium-chloride co-transporter(u-NKCC2) and the epithelial sodium channels(u-ENa C) during treatment with bendroflumethiazide(BFTZ),amiloride and ***:In a randomized,double-blinded,placebocontrolled,3-way crossover study we examined 23 healthy subjects on a standardized diet and fluid *** subjects were treated with amiloride 5 mg,BFTZ 1.25 mg or placebo twice a day for 4.5 d before each examination *** the examination day,glomerular filtration rate was measured by the constant infusion clearance technique with 51Cr-EDTA as reference *** estimate the changes in water transport via AQP2 and sodium transport via NKCC2 and ENa C,u-NKCC2,the gamma fraction of ENa C(u-ENa Cγ),andu-AQP2 were measured at baseline and after infusion with 3% hypertonic saline.U-NKCC2,u-ENa Cγ,u-AQP2 and plasma concentrations of vasopressin(p-AVP),renin(PRC),angiotensin Ⅱ(p-ANG Ⅱ) and aldosterone(p-Aldo) were measured,by *** blood pressure was estimated by applanation tonometry and body fluid volumes were estimated by bio-impedance *** linear model with repeated measures or related samples Friedman's two-way analysis was used to compare *** hoc Bonferroni correction was used for multiple comparisons of post infusion periods to baseline within each treatment ***:At baseline there were no differences in u-NKCC2,u-ENa Cγ and ***,p-Ang Ⅱ and p-Aldo were increased during active treatments(P miloride(6% ± 34%;P = 0.081) and increased significantly during placebo(17% ± 24%;P = 0.010).U-AQP2 increased significantly during amiloride(31% ± 22%;P < 0.001) and placebo(34% ± 27%;P < 0.001),while u-NKCC2 and u-AQP2 did not change significantly during BFTZ(-7% ± 28%;P = 0.257 and 5% ± 16%;P = 0.261).U-ENa Cγ increased in all three groups(P < 0.050).PRC,AngⅡ an

关键词：苯氟甲酰肼尿道治疗方法临床分析

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