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Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel,flavopiridol,and 5-fluorouracil

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Acta Pharmacologica Sinica 2006年第10期27卷 1375-1381页

作者： Jun GUo~2 an-wu ZHoU~2 Yu-cai FU~3 Udit n VERMA~2 Debu TRIPATHY~2 Eugene P FREnKEL~(2,5) Carlos R BECERRA~4 ~2Harold C.Simmons Cancer Center,Division of Hematology-oncology,Department of Medicine,University of Texas Southwestern Medical Centel.Dallas,Texas 75390,USA ~3Laboratory of Cell Senescence,Shantou University Medical College,Shantou 515041,China ~4Sammons Cancer Center,Baylor University Medical Center,ToPA-US oncology,Dallas,Texas 75246,USA Division of Hematology-oncology Department of Medicine Harold C. Simmons Cancer Center University of Texas Southwestern Medical Center Dallas USA Laboratory of Cell Senescence Shantou University Medical College Shantou China Sammons Cancer Center Baylor University Medical Center TOPA-US Oncology Dallas USA

Aim:Clinical treatment of solid tumors with docetaxel,flavopiridol,or 5-fluorou-racil(5-FU)often encounters undesirable side effects and drug *** aims to evaluate the potential role of combination therapy with docetaxel,flavopiridol,or 5-FU in modulating chemosensitivity and better understand howthey might be used ***:HCT116 colon cancer cells were treatedwith docetaxel,flavopiridol,and 5-FU in several different administrative sche-dules in vitro,either sequentially or *** survival was measuredby MTT *** activity of caspase-3 was determined by caspase-3 assaysand the soft agar colony assay was used to test the colony formation of HCT116cells in soft *** also established xenograft models to extend in vitro obser-vations to an in vivo ***:The maximum cytotoxicity was found whenhuman colon cancer HCT116 cells were treated with docetaxel for 1 h followed byflavopiridol for 24 h and 5-FU for another 24 *** sequential combinationtherapy not only inhibits tumor cell growth more strongly compared to othercombination therapies but also significantly reduces colony formation in soft agarand augments apoptosis of HCT116 *** of docetaxel followed 1 hlater by flavopiridol,followed 24 h later by 5-FU in xenograft models,also resultedin delayed tumor growth and higher survival ***:These resultshighlight the importance of an administrative schedule when combining docetaxelwith flavopiridol and 5-FU,providing a rationale explanation for its developmentin clinical trials.

关键词： combination drug therapy docetaxel flavopiridol fluorouracil colonic neoplasms

活性RAG转座子的发现揭示V(D)J重排的起源

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科学新闻 2017年第4期 37-37页

作者： Shengfeng Huang Xin Tao Shaochun Yuan Yuhang Zhang Peiyi Li helen.A.Beilinson Ya Zhang Wenjuan Yu Pierre Pontarotti Hector Escriva Yann Le Petillon Xiaolong Liu Shangwu Chen David G.Schatz 徐安龙北京中医药大学

文章简介有颌类脊椎动物适应性免疫起源的关键事件之一是介导抗体基因V(D)J重排机制的RAG1和RAG2蛋白的出现。有科学家认为RAG1/2源自一个古老的转座元件,但在此之前一直没有确切的证据证明这一点。本研究从现存最古老的脊索动物文昌鱼... 详细信息

文章简介有颌类脊椎动物适应性免疫起源的关键事件之一是介导抗体基因V(D)J重排机制的RAG1和RAG2蛋白的出现。有科学家认为RAG1/2源自一个古老的转座元件,但在此之前一直没有确切的证据证明这一点。本研究从现存最古老的脊索动物文昌鱼中,发现了一个名为Proto RAG的全新DnA转座子。该转座子可在插入位点形成5bp的靶位点重复(TSD),拥有一对

关键词：转座子重排文昌鱼双尖鱼头索动物 RAG D)J

nat Genet:单基因突变导致过敏性皮炎的发生

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现代生物医学进展 2017年第27期17卷 I0004-I0004页

作者： Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie niemela, Sergio D Rosenzweig Yu Zhang, helen.F Matthews Joshua J McElwee nina Jones Alejandro Palma, Matías oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper neil Romberg Laboratory of Allergic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda Maryland USA Immunodeficiency Diagnosis and Treatment Program Department of Pediatrics National Jewish Health Denver Colorado USA Department of Translational Medicine University of Piemonte Orientale Novara Italy Department of Immunobiology Yale University School of Medicine New Haven Connecticut USA Immunology Service Department of Laboratory Medicine NIH Clinical Center National Institutes of Health Bethesda Maryland USA Human Immunological Disease Section National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Merck Research Laboratories Merck and Co. Inc. Boston Massachusetts USA Clinical Research Directorate/Clinical Monitoring Research Program Leidos Biomedical Research Inc. NCI Campus at Frederick Frederick Maryland USA Servicio de Immunología y Reumatología Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan Buenos Aires Argentina Division of Dermatology Department of Medicine Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Division of Rheumatology and Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA.

最近，研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变：CARDll。来自美国nIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析，发现了这一导致疾病产生的基因、

关键词：过敏性皮炎基因突变 nat 神经性皮炎血缘关系研究所传染病 nIH

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兆伏级锥形束CT在自适应性放疗中的应用

中国癌症杂志 2006年第9期16卷 763-764页

作者： o.Morin M. Aubin J. Chen H. Chen J - F. Aubry A. Gillis K. Bucci M. Geffen K. Kelly H.Chen L.Simpson J.Pouliot 王艳阳（译）陆嘉德（校） UCSF Comprehensive Cancer Center San Francsico California CA-94143. Savannah oncology Center Savannah GA-31406 Christiana Care Health Services Helen F Graham Cancer Center Newark DE 19713 复旦大学附属肿瘤医院放疗科新加坡国立肿瘤中心

随着兆伏级锥形束CT(MegavoltageCone-BeamCT,MVCBCT)技术的诞生,目前利用电子验证影像设备(electronicportalimagingdevices,EPID)与治疗用X线束在治疗体位状态下对患者进行三维成像,并根据所获影像进行电子密度校准,已逐渐在临床上获... 详细信息

随着兆伏级锥形束CT(MegavoltageCone-BeamCT,MVCBCT)技术的诞生,目前利用电子验证影像设备(electronicportalimagingdevices,EPID)与治疗用X线束在治疗体位状态下对患者进行三维成像,并根据所获影像进行电子密度校准,已逐渐在临床上获得应用。本文首先介绍MVCBCT的一般特性,并对其在适应性放疗(AdaptiveRadiationTherapy,ART)中的临床应用及发展方向进行探讨。

关键词：计算机断层摄影术 X线放射治疗体位体重放射治疗剂量

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