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Double-blind randomized controlled study of the efficacy, safety and tolerability of eszopiclone vs placebo for the treatment of patients with post-traumatic stress disorder and insomnia

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World journal of Psychiatry 2020年第3期10卷 21-28页

作者： Sheila M Dowd Alyson K Zalta helen j burgess Elizabeth C Adkins Zerbrina Valdespino-Hayden Mark H Pollack Department of Psychiatry and Behavioral Sciences Rush University Medical CenterChicagoIL 60601United States Department of Psychological Science University of California IrvineIrvineCA 92697United States Sleep and Circadian Research Laboratory Department of PsychiatryUniversity of MichiganAnn ArborMI 48109United States Center for Behavioral Intervention Technologies|Department of Preventive Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Psychology Montclair State UniversityMontclairNJ 07043United States

BACKGROUND Sleep disturbance is a core feature of post-traumatic stress disorder(PTSD).Given the relationship between sleep disturbance and PTSD,there has been a relative paucity of studies examining the potential therapeutic impact of using pharmacotherapy to target sleep disturbance in patients with ***(ESZ)is a non-benzodiazepine y-aminobutyric acid-A receptor agonist indicated for the treatment of sleep and may affect sleep in patients with *** To evaluate the efficacy of ESZ vs placebo(PBO)for patients with PTSD and *** The study was a 12-wk,double blind,randomized controlled trial with 3 mg of ESZ(n=13)or PBO(n=12).RESULTS Patients in both arms experienced significant improvement in PTSD symptoms as assessed by the Clinician-Administered PTSD Scale for DSM-IV(CAPS):ESZ(t11=-3.12,P=0.005)and PBO(t11=-3.5,P=0.002)and by self-report with the Short PTSD Rating Interview(ESZ t11=-3.38,P=0.003 and PBO t11=-4.48,P=0.0005).There were no significant differences between treatments on the CAPS(t22=-0.13,P=0.70)or the Short PTSD Rating Interview(t22=-0.58,P=0.56).Similarly,both treated groups improved on sleep measures as assessed by the Pittsburgh Sleep Quality Index with PTSD Addendum(PSQI)and on total sleep time(TST)and sleep latency assessed by actigraphy with no significant differences between groups(PSQI t22=-0.24,P=0.81;total sleep time t10=0.13,P=0.90 and sleep latency t10=0.68,P=0.50).There was a significant correlation between improvement in sleep and overall improvement in PTSD as measured by change scores on the PSQI and CAPS,r(8)=0.79,P=0.01 for ESZ treated subjects,but not for those treated with PBO r(9)=0.16,P=*** events of ESZ were consistent with the known profile of the medication including dysgeusia(30%,mild),sedation(20%,mild)and headache(20%,moderate to severe).CONCLUSION Results do not support the hypothesis of a specific positive effect of ESZ compared to PBO for measures of PTSD and associated sleep disturban

关键词： Trauma Sleep disturbance Hypnotic Post-traumatic stress disorder

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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto helen Harvey Adriana H.Tremoulet jane C.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20j(Gamma).The third wave had Delta strains(clades 21A,21I,and 21j),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

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Continuity of care by a primary midwife(caseload midwifery):a cost analysis using results from the COSMOS randomised controlled trial

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Gynecology and Obstetrics Clinical Medicine 2024年第2期4卷 94-101页

作者： Emily j Callander Hannah jackson helen L McLachlan Mary-Ann Davey Della A Forster University of Technology Sydney SydneyNew South WalesAustralia The Royal Women's Hospital MelbourneVictoriaAustralia Faculty of Health University of Technology SydneyBroadwayNew South WalesAustralia judith Lumley Centre La Trobe UniversityMelbourneVictoriaAustralia School of Nursing and Midwifery a Trobe UniversityMelbourneVictoriaAustralia Department of Obstetrics and Gynaecology Monash UniversityClaytonVictoriaAustralia

Introduction Caseload midwifery(continuity of midwifery carer)offers benefits including lower caesarean section rates,lower risks of preterm birth and stilbirth,and improved maternal satisfaction of *** these advantages,concerns about additional costs hinder widespread *** study examinesthecost of caseload midwifery compared with standard maternity care from the perspective of both public hospitals and public *** A cost analysis was conducted using data from a randomised controlled trial of 2314 low-risk pregnant women in Melbourne,*** randomised to caseload care received antenatal,intrapartum and postpartum care from a primary midwife,with some care provided by a‘back-up'*** in standard care received midwifery-led care with varying levels of continuity,junior obstetric care or community-based medical *** cost analysis compared differences in mean costs of health resources to public hospitals and to public ***,a budget impact analysis estimated total costs to the health system between 2023 and *** For public hospitals,there was no significant difference in overall costs between women receiving caseload midwifery(n=1146)versus standard care(n=1151)($SA12363(SD:$A4967)vs$A12323(SD:$A7404);p=0.85).Conversely,public funders incurred lower expenditures for women receiving caseload midwifery($A20330(SD:$A8312))versus standard care($A21637(SD:$A11818);p<0.001).The budget impact analysis estimated savings of sA625million to the health system over the next 5 years with expanded access to caseloadmidwifery *** Caseloadmidwifery in low-risk women is cost-neutral to public hospitals and cost-saving to public *** abstract Continuity of midwifery for low-risk women reduces costs to public funders,with no additional costs to hospitals.

关键词： random continuity Continuity

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The role of crystallinity on differential attachment/ proliferation of osteoblasts and fibroblasts on poly （caprolactone-co-glycolide） polymeric surfaces

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Frontiers of Materials Science 2012年第1期6卷 47-59页

作者： helen CUI Patrick j.SINKO Advanced Technology and Regenerative Medicine(ATRM) LLCSomervilleNJ 08876USA Department of Pharmaceutics Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNJ 08854USA

The objective of the present study is to systematically evaluate the role of polymer crystallinity on fibroblast and osteoblast adhesion and proliferation using a series of poly（caprolactone-co-glycolide）（PCL/PGA） polymers. PCL/PGA polymers were selected since they reflect both highly crystalline and amorphous materials. PCL/PGA polymeric materials were fabricated by compression molding into thin films. Five compositions, from PCL or PGA to intermediate copolymeric compositions of PCL/PGA in ratios of 25：75, 35：65 and 45：55, were studied. Pure PCL and PGA represented the crystalline materials while the copolymers were amorphous. The polymers/copolymers were characterized using DSC to assess crystallinity, contact angle measurement for hydrophobicity, and AFM for nanotopography. The PCL/PGA films demonstrated similar hydrophobicity and nanotopography whereas they differed significantly in crystallinity. Cell adhesion to and proliferation on PCL/PGA films and proliferation studies were performed using osteoblasts and NIH-3T3 fibroblasts. It was observed that highly crystalline and rigid PCL and PGA surfaces were significantly more efficient in supporting fibroblast growth, whereas amorphous/flexible PCL/PGA 35：65 was significantly more efficient in supporting growth of osteoblasts. This study demonstrated that while chemical composition, hydrophobicity and surface roughness of PCL/PGA polymers were held constant, crystallinity and rigidity of PCL/PGA played major roles in determining cell responses.

关键词： crystallinity attachment proliferation osteoblast fibroblast PCL-PGA

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FURTHER EXTENSIONS OF SOME TRUNCATED HECKE TYPE IDENTITIES

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Acta Mathematica Scientia 2022年第1期42卷 73-90页

作者： helen W.j.ZHANG School of Mathematics Hunan UniversityChangsha 410082China

The main purpose of this paper is to generalize the study of the Hecke-Rogers type series,which are the extensions of truncated theorems obtained by Andrews,Merca,Wang and *** proofs rely heavily on the theory of Bail... 详细信息

关键词： theta functions truncated series Bailey pair Bailey transform

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Helicobacter pylori infection and endocrine disorders:Is there a link?

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World journal of Gastroenterology 2009年第22期15卷 2701-2707页

作者： Konstantinos X Papamichael Garyphallia Papaioannou helen Karga Anastasios Roussos Gerassimos j Mantzaris First Department of Gastroenterology Evaggelismos Hospital B'Department of Endocrinology Alexandra Hospital

Helicobacter pylori(H pylori) infection is a leading world-wide infectious disease as it affects more than half of the world population and causes chronic gastritis,peptic ulcer disease and gastric *** infection elicits a chronic cellular inflammatory response in the gastric ***,the effects of this local inflammation may not be confi ned solely to the digestive tract but may spread to involve extraintestinal tissues and/or ***,H pylori infection has been epidemiologically linked to extra-digestive conditions and *** this context,it has been speculated that H pylori infection may be responsible for various endocrine disorders,such as autoimmune thyroid diseases,diabetes mellitus,dyslipidemia,obesity,osteoporosis and primary *** is a review of the relationship between H pylori infection and these endocrine disorders.

关键词： Helicobacter pylori Hormones Thyroid Osteoporosis Diabetes Dyslipidemia

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Adult celiac disease with acetylcholine receptor antibody positive myasthenia gravis

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World journal of Gastroenterology 2009年第38期15卷 4741-4744页

作者： Hugh j Freeman helen R Gillett Peter M Gillett joel Oger Department of Medicine (Gastroenterology and Neurology) University of British Columbia

Celiac disease has been associated with some autoimmune disorders. A 40-year-old competitive strongman with celiac disease responded to a gluten-free diet, but developed profound and generalized motor weakness with acetylcholine receptor antibody positive myasthenia gravis, a disorder reported to occur in about 1 in 5000. This possible relationship between myasthenia gravis and celiac disease was further explored in serological studies. Frozen stored serum samples from 23 acetylcholine receptor antibody positive myasthenia gravis patients with no intestinal symptoms were used to screen for celiac disease. Both endomysial and tissue transglutaminase antibodies were examined. One of 23 (or, about 4.3%) was positive for both IgA-endomysial and IgA tissue transglutaminase antibodies. Endoscopic studies subsequently showed duodenal mucosal scalloping and biopsies confirmed the histopathological changes of celiac disease. Celiac disease and myasthenia gravis may occur together more often than is currently appreciated. The presence of motor weakness in celiac disease may be a clue to occult myasthenia gravis, even in the absence of intestinal symptoms.

关键词： Acetylcholine receptor antibodies Celiacdisease Myasthenia gravis Transglutaminase antibodies

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Adiponectin signalling in bone homeostasis,with age and in disease

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Bone Research 2021年第1期9卷 15-25页

作者： jonathan W.Lewis james R.Edwards Amy j.Naylor helen M.McGettrick Rheumatology Research Group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&Regeneration Research Group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and *** studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,human studies often demonstrate an inverse relationship between adiponectin concentration and bone ***,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional *** such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease.

关键词： homeostasis metabolism consequences

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Genomic regions underlying agronomic traits in linseed(Linum usitatissimum L.) as revealed by association mapping

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journal of Integrative Plant Biology 2014年第1期56卷 75-87页

作者： Braulio j.Soto-Cerda Scott Duguid helen Booker Gordon Rowland Axel Diederichsen Sylvie Cloutier Department of Plant Science University of Manitoba 66 Dafoe Road Cereal Research Center Agriculture and Agri-Food Canada 195 Dafoe Road Morden Research Station Agriculture and Agri-Food Canada 101 Route 100 Unit 100 Morden Department of Plant Sciences College of Agriculture and Bioresources University of Saskatchewan 51 Campus Drive Plant Gene Resources of Canada Agriculture and Agri-Food Canada 107 Science Place

The extreme climate of the Canadian Prairies poses a major chal enge to improve yield. Although it is possible to breed for yield per se, focusing on yield-related traits could be advantageous because of their simpler genetic architecture. The Canadian flax core col ection of 390 accessions was genotyped with 464 simple sequence repeat markers, and phenotypic data for nine agronomic traits including yield, bol s per area, 1,000 seed weight, seeds per bol , start of flowering, end of flowering, plant height, plant branching, and lodging col ected from up to eight environments was used for association mapping. Based on a mixed model （principal component analysis （PCA） t kinship matrix （K））, 12 significant marker-trait associations for six agronomic traits were identi-fied. Most of the associations were stable across environments as revealed by multivariate analyses. Statistical simulation for five markers associated with 1000 seed weight indicated that the favorable al eles have additive effects. None of the modern cultivars carried the five favorable al eles and the maximum number of four observed in any accessions was mostly in＆amp;nbsp;breeding lines. Our results confirmed the complex genetic architecture of yield-related traits and the inherent difficulties associated with their identification while il ustrating the potential for improvement through marker-assisted selection.

关键词： Linum usitatissimum marker-assisted selection

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Biodegradable stent or balloon dilatation for benign oesophageal stricture: Pilot randomised controlled trial

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World journal of Gastroenterology 2014年第48期20卷 18199-18206页

作者： Anjan Dhar helen Close Yirupaiahgari K Viswanath Colin j Rees helen C Hancock A Deepak Dwarakanath Rebecca H Maier Douglas Wilson james M Mason Department of Gastroenterology County Durhamand Darlington NHS Foundation Trust Co. Durham DL14 6ADUnited Kingdom Durham Clinical Trials Unit School of Medicine Pharmacy and Health Durham University Queen’s Campus Wolfson Research Institute University Boulevard Stockton-on-Tees TS17 6BH United Kingdom Department of Surgery James Cook University Hospital Marton Road Middlesbrough TS4 3BW United Kingdom Department of Gastroenterology South Tyneside Hospitals NHS Foundation Trust Harton Lane South Shields NE34 0PL United Kingdom Department of Gastroenterology University Hospitals of North Tees Hardwick Stockton on Tees TS19 8PE United Kingdom

AIM: To undertake a randomised pilot study comparing biodegradable stents and endoscopic dilatation in patients with strictures.

关键词： Benign oesophageal stricture Biodegradable stent Endoscopic balloon dilatation Pilot study Randomised controlled trial Dysphagia

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