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Granisetron Transdermal Patch for Treatment of Nausea in Patients Undergoing Cisplatin Based Chemotherapy for Cervical Cancer

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Journal of Cancer Therapy 2012年第6期3卷 1159-1163页

作者： helen Dunnington Rodney Hunter michael Frumovitz Judith Smith College of Pharmacy Texas Southern University Houston USA University of Texas m. D. Anderson Cancer Center Houston USA. University of Texas medical School at Houston Houston USA University of Texas medical School at Houston Houston USA&College of Pharmacy Texas Southern University Houston USA&University of Texas M. D. Anderson Cancer Center Houston USA

Objective: The purpose of this study was to define the incidence of chemotherapy-induced nausea and vomiting (CINV) in newly diagnosed cervical cancer patients receiving cisplatin and radiation treatment;and to determine if the granisetron transdermal patch (Sancuso?) would be appropriate to recommend as part of standard antiemetic regimen for the cisplatin radiation chemotherapy order set. methods: This is a retrospective case-controlled study of cervical cancer patients receiving cisplatin chemotherapy with radiation (cisXRT);comparing patients receiving the granisetron transdermal patch to matched patients receiving oral 5HT3 blockers. All patients prescribed cisXRT between September 15th 2008 and November 30, 2011 were identified using pharmacy dispensing records. Patients were included if they received at least a partial dose of cisXRT and Sancuso? patch as standard antiemetic prophylaxis prior to cisXRT for cervical cancer treatment. Exclusion criteria included concomitant investigational agents, biotherapy and/or chemotherapy agents;prior chemotherapy;or incomplete or restricted medical records. Patients will be matched based on age. Patients were matched 3:1 (oral:patch). A total of 404 patients that received and completed cisXRT were identified utilizing an existing de-identified database from previous study were reviewed to evaluate parameters of interest. Results: A total of 285 patients’ medication records were reviewed for Sancuso? use, and 47 were identified. Of these 47 charts only five patient cases met eligibility criteria to be included in the study. All five patients that received the granisetron patch had at least three known risk factors for nausea. The nausea/vomiting in these patients did not worsen after receiving the Sancuso? patch, and four out of five had subjective improvement. CINV was unrelated to changes in laboratory values or incidence of other toxicity and was not dose-related. Conclusions: While no definitive conclusions could be d

关键词： Granisetron Nausea Vomiting Cisplatin Radiation

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Unique biogenesis and kinetics of hornwort Rubiscos revealed by synthetic biology systems

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molecular Plant 2024年第12期17卷 1833-1849页

作者： Zhen Guo Oh Tanner Ashton Robison Dan Hong Loh Warren Shou Leong Ang Jediael Zheng Ying Ng Fay-Wei Li Laura helen Gunn School of Integrative Plant Science Cornell UniversityIthacaNY 14853USA Boyce Thompson Institute IthacaNY 14853USA max Planck Institute for Terrestrial microbiology 35043 MarburgGermany Department of Cell and molecular Biology Uppsala University75124 UppsalaSweden

Hornworts are the only land plants that employ a pyrenoid to optimize Rubisco’s CO_(2) fixation,yet hornwort Rubisco remains poorly *** we assembled the hornwort Anthoceros agrestis Rubisco(AaRubisco)using the Arabidopsis thaliana SynBio expression system and observed the formation of stalled intermediates,prompting us to develop a new SynBio system with *** cognate *** successfully assembled AaRubisco and Rubisco from three other hornwort *** *** Rubisco,AaRubisco assembly is not dependent on RbcX or *** characterization reveals that hornwort Rubiscos exhibit a range of catalytic rates(3–10 s−1),but with similar affinity(∼30μm)and specificity(∼70)for CO_(2).These results suggest that hornwort Rubiscos do not comply with the long-held canonical catalytic trade-off observed in other land plants,providing experimental support that Rubisco kinetics may be phylogenetically ***,we observed a 50%increase in AaRubisco catalytic rates when RbcX was removed from our SynBio system,without any reduction in *** biology,biochemistry,and proteomic analysis suggest that subtle differences in Rubisco large-subunit interactions,when RbcX is absent during biogenesis,increases the accessibility of active sites and catalytic turnover ***,this study uncovered a previously unknown Rubisco kinetic parameter space and provides a SynBio chassis to expand the survey of other Rubisco *** discoveries will contribute to developing new approaches for engineering Rubisco with superior kinetics.

关键词： hornworts CO_(2)fixation Rubisco synthetic biology structural biology assembly factors

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Designing for Softness in Semiconducting Conjugated Polymers

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Accounts of materials Research 2023年第3期4卷 205-208页

作者： Nathan Sung Yuan Hsu Angela Lin helen Tran Department of Chemistry University of TorontoTorontoON M5S 3H6Canada

BEYOND STRETCHABLE:SOFT CONJUGATED POLYmERS Our interactions with electronics are rapidly being reimagined:contact lenses can be functionalized to report blood glucose levels via tear analytes,drug therapeutics can be released slowly from skin-like wearable films,and implantable bioelectronics can monitor the dynamics of neurotransmitters in vivo.1,2 To ensure seamless integration with our dynamic and curvilinear bodies,electronic materials that are soft and stretchable must be ***,inherently rigid inorganic materials can be rendered stretchable through strain engineering,whereas organic materials can be designed on a molecular level to be intrinsically *** for softness,notable approaches include preparing composites of conductive fillers with inert soft matrixes,in situ polymerization of conductive polymers on soft materials,and formulating conductive hydrogels.A ubiquitous polymer used for soft and stretchable conductive materials is poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)(PEDOT:PSS).There are comparatively fewer examples of soft semiconducting materials,even though there are numerous reports of stretchable semiconducting ***,the terms stretchable and softness are conflated,especially as they are typically synonymous in the development of conductive materials based on PEDOT:***,we aim to provide key distinguishing characterization metrics on softness and discuss molecular design strategies for soft semiconducting polymers.

关键词： conducting preparing render

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治疗糖尿病合并癌症患者面临的临床挑战

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糖尿病天地(临床) 2008年第2期2卷 68-72页

作者： helen m.Psarakis 王佳邹大进 Yale New Haven Hospital in New Haven Conn.

糖尿病与癌症是两种独立的困扰病人与临床医生的疾病,大约有8%～18%%的癌症病人同时患有糖尿病,对这两种疾病共存的特殊人群进行治疗,是医生面临的巨大挑战。然而,临床医生对于这个问题的知识仅仅局限在有限的证据,

关键词：糖尿病临床医生代谢病胰岛素抵抗血糖高血糖症高血糖病癌症患者昂丹司琼格列

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Treatment of severe lithium poisoning and dialysis-induced hypophosphatemia with phosphorus-enriched hemodialysis: a case report

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Chinese medical Journal 2005年第16期118卷 1405-1408页

作者： Srivasa B. Chebrolu helen K. C. Yang Aileen Hariman Antonios H. Tzamaloukas Carl m. Kjellstrand Todd S. Ing Departments of medicine Veterans Affairs Hospital Hines Stritch School of medicine Loyola University Chicago Maywood IllinoisUSA Department of medicine Veterans Affairs Medical Center Albuquerque New Mexico USA

Severe lithium intoxication requires intensive and prolonged hemodialysis as a definitive therapeutic measure. Such an aggressive stand is often needed to prevent the post-dialytic rebound in plasma lithium levels as a result of the drug＇s relatively slow equilibration across cellular membranes. Use of a conventional, phosphorus-free, bicarbonate-based dialysis solution in the course of a dialytic treatment may engender hypophosphatemia in these individuals.

关键词： lithium intoxication · hemodialysis · hypophosphatemia · phosphorus-enriched dialysis solution

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最深情的家庭聚会

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疯狂英语（阅读版） 2005年第6期 32-33页

作者： helen m.Trimble 庄荣金

去年夏天,在嫂子利厄的临终要求之下,我们一年一度的家庭聚会提前了举行。在与乳腺癌的搏斗快要结束之时,她最后希望能够躺在我父母在马里兰州的家里,由亲爱的家人围拢着离开人间。我们一整天都围在利厄的床边,又哭又笑,一起重温这些年... 详细信息

去年夏天,在嫂子利厄的临终要求之下,我们一年一度的家庭聚会提前了举行。在与乳腺癌的搏斗快要结束之时,她最后希望能够躺在我父母在马里兰州的家里,由亲爱的家人围拢着离开人间。我们一整天都围在利厄的床边,又哭又笑,一起重温这些年来我们共同度过的美好时光。但利厄只哭了一次, 她哽咽着说她今生最大的遗憾就是没机会和家人一起到爱尔兰旅行,因为那里是她崇拜的作家的故土。母亲总有办法, 她随即兴奋地宣布:“有办法了!我们一起去爱尔兰吧,现在就启程!闭上你们的眼睛,我将带你们去那里!”

关键词：爱尔兰家庭 and 乳腺癌家人马里兰州母亲临终围拢眼睛

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Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population

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World Journal of Gastroenterology 2011年第42期17卷 4682-4688页

作者： Dana L Bruden michael G Bruce Karen m miernyk Julie morris Debby Hurlburt Thomas W Hennessy helen Peters Frank Sacco Alan J Parkinson Brian J mcmahon Arctic Investigations Program Division of Preparedness and Emerging InfectionsNational Center for Emerging Zoonoses and Infectious DiseasesCenters for Disease Control and Prevention Alaska Native Tribal Health Consortium Anchorage

AIm： TO evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori （H. pylon] infection, H. pyIori treatment failure, and gastric cancer in this population necessitate documentation of infection status at multiple time points over a patient＇s *** test, 13C urea breath test （UBT）, and immunoglobulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori test by culture or, in case of a negative culture result, by positive histology and a positive rapid urease test.RESULTS： The sensitivity and specificity of the 13C- UBT were 93% and 88%, respectively, relative to the gold standard. The antibody test had an equivalent sensitivity of 93% with a reduced specificity of 68%. The false positive results for the antibody test were associated with previous treatment for an H. pylorlinfection [relative risk （RR） = 2.8]. High levels of antibodies to H. py/or/were associated with chronic gastritis and male gender, while high scores in the 13C-UBT test were associated with older age and with theH. pylori bacteria load on histological examination （RR = 4.4）. CONCLUSION： The 13C-UBT outperformed the antibody test for H. pylori and could be used when a noninvasive test is clinically necessary to document treatment outcome or when monitoring for reinfection.

关键词： Urea breath test Antibody test Sensitivity Specificity

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Shanghai and Hong Kong Frail Older Persons’ Quality-of-Life Concerns and Healthcare Expectations in the End of Life

Shanghai and Hong Kong Frail Older Persons’ Quality-of-Life...

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The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics

作者： Samantha m.C.Pang helen Y.L.Chan Enid W.Y.Kwong The Hong Kong Polytechnic University Hung Hom KowloonHong Kong SAR The Hong Kong Polytechnic University Hung Hom KowloonHong Kong SAR The Hong Kong Polytechnic University Hung Hom KowloonHong Kong SAR

＜正＞Purpose:To explore quality of life and end-of-life treatment preferences among frail older adults in Shanghai and Hong Kong.

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医生中的利益冲突 "网片丑闻"表明:实施利益冲突注册至关重要

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英国医学杂志中文版 2020年第12期23卷 689-690页

作者： helen macdonald margaret mcCartney Carl Heneghan Fiona Godlee 季媛媛(译) The BmJ LondonUK Centre for Evidence Based medicine University of OxfordOxfordUK 中华医学杂志英文版

一项由Julia Cumberledge教授主持开展的独立药品和医疗设备安全性审查研究,调查了英国卫生系统如何回应对激素妊娠试验Primodos、妊娠期间服用抗癫痫药物丙戊酸钠,以及盆腔网片负面结果的报道。该研究提出的9项建议中包含:英国医学总会... 详细信息

一项由Julia Cumberledge教授主持开展的独立药品和医疗设备安全性审查研究,调查了英国卫生系统如何回应对激素妊娠试验Primodos、妊娠期间服用抗癫痫药物丙戊酸钠,以及盆腔网片负面结果的报道。该研究提出的9项建议中包含:英国医学总会(GmC)注册制度"应扩大至包含所有医生存在的经济性及非经济性利益清单,公众有权了解这些内容"。研究组广泛听取了患者意见,其中一位患者表示:"我们应知晓临床医生是否存在与药品或医疗设备厂商之间的经济性或非经济性利益,这样我们才能对选择接受哪位医生的诊疗及何种治疗做出明智选择。"

关键词：非经济性利益冲突卫生系统妊娠试验抗癫痫药物丙戊酸钠明智选择注册制度

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Challenges and opportunities for third-generation ethanol production:A critical review

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Engineering microbiology 2023年第1期3卷 22-36页

作者： Caroline müller Thamarys Scapini Alan Rempel Ederson Rossi Abaide Aline Frumi Camargo mateus Torres Nazari Viviani Tadioto Charline Bonatto marcus Vinícius Tres Giovani Leone Zabot Luciane maria Colla helen Treichel Sérgio Luiz Alves Jr Laboratory of Yeast Biochemistry Federal University of Fronteira SulCampus ChapecóSC 484Km 2ChapecóSCBrazil Laboratory of microbiology and Bioprocess Environmental Science and TechnologyFederal University of Fronteira SulCampus ErechimRS 135200ErechimRSBrazil Graduate Program in Civil and Environmental Engineering University of Passo FundoBR 285Passo FundoRSBrazil Department of Chemical Engineering Federal University of Santa Maria1000Roraima AvenueSanta MariaRS 97105-900Brazil Laboratory of Agroindustrial Processes Engineering Federal University of Santa Maria1040Sete de Setembro st.Cachoeira do SulRSBrazil

In recent decades,third-generation(3G)biofuels have become a more attractive method of fuel production,as algae cultivation does not infringe on resources needed for food ***,algae can adapt to different environments,has high photosynthetic efficiency(CO_(2)fixation),and has a high potential for carbohydrate *** prevalence of algae worldwide demonstrates its ability to adapt to different environments and climates,proving its biodiversity and *** can be grown in wastewater,seawater,and even sewage,thus ensuring a lower water footprint and greater energy efficiency during algal biomass *** of this,the optimization of 3G ethanol production appears to be an excellent alternative to mitigate environmental impacts and increase energy and food *** critical review presents(i)the stages of cultivation and processing of micro and macroalgae;(ii)the selection of yeasts(through engineering and/or bioprospecting)to produce ethanol from these biomasses;(iii)the potential of seawater-based facilities to reduce water footprint;and(iv)the mass and energy balances of 3G ethanol production in the world energy *** article is,above all,a brainstorm on the environmental viability of algae bioethanol.

关键词： Algae ethanol Biomass Energy balance Seawater Water footprint Yeasts

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