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Developmental and Reproductive Biology 2001年第S1期10卷 93-93页

作者： c P IP,c m Briton-Jones,I　H　Lok,T T Y chiu,c J Haines 中国香港香港中文大学妇产科学系中国香港香港中文大学妇产科学系中国香港香港中文大学妇产科学系中国香港香港中文大学妇产科学系中国香港香港中文大学妇产科学系

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Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy

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chronic Diseases and Translational medicine 2019年第4期5卷 258-266页

作者： Amin Zargar Samantha chang Ankita Kothari Antoine m.Snijders Jian-Hua mao Jessica Wang Amanda c.Hernandez Jay D.Keasling Trever G.Bivona Joint BioEnergy Institute Lawrence Berkeley National LaboratoryEmeryvilleCA 94608USA QB3 Institute University of California-Berkeley174 Stanley HallBerkeleyCA 94720USA Biological Systems and Engineering Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of chem.c.l&Biomolecular Engineering Department of BioengineeringUniversity of CaliforniaBerkeleyCA 94720USA helen Diller Family comprehensive cancer center University of CaliforniaSan FranciscoCA 94143USA Department of cellular and molecular Pharm.c.logy University o f CaliforniaSan FranciscoCA 94143USA

Despite tremendous efforts to fight cancer,it remains a major public health problem and a leading cause of death *** increased knowledge of cancer pathways and improved technological platforms,precision therapeutics that specifically target aberrant cancer pathways have improved patient ***,a primary cause of unsuccessful cancer therapy remains cancer drug *** this review,we summarize the broad classes of resistance to cancer therapy,particularly pharm.c.kinetics,the tumor m.c.oenvironment,and drug resistance ***,we describe how bacterial-mediated cancer therapy,a bygone mode of treatment,has been revitalized by synthetic biology and is uniquely suited to address the primary resistance m.c.anisms that confound traditional *** genetic engineering,we discuss how bacteria can be potent anticancer agents given their tumor targeting potential,anti-tumor activity,safety,and coordinated delivery of anti-cancer drugs.

关键词： cancer therapy Synthetic biology Drug resistance Bacterial-mediated therapy

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Umbilical cord Blood mononuclear cell Treatment for Neonatal Rats with Hypoxic Ischemia

Umbilical Cord Blood Mononuclear Cell Treatment for Neonatal...

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第十六届中国医师协会神经外科医师年会

作者： Hao LYU Dong ming SUN chi Ping NG Wendy S cHENG Jun Fan cHEN Yu Zhong HE Sin Yu LAm Zhi Yuan ZHENG Guo Dong HUANG chi chiu WANG Wise Young Wai Sang POON Division of Neurosurgery Department of SurgeryFaculty of MedicineThe Chinese University of Hong Kong Department of Neurosurgery Shenzhen Key Laboratory of Neurosurgerythe Shenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen University W.m.Keck center for collaborative Neuroscience RutgersState University of New Jersey Department of Neurosurgery Hainan Hospital of People's Liberation Army General Hospital Department of Obstetrics and Gynecology The Chinese University of Hong Kong

Background:Hypoxic-Ischem.c.Encephalopathy(HIE) occurs when an infant’s brain has not received adequate oxygen and blood supply,resulting in ischem.c.and hypoxic ***,supportive care and hypothermia therapy have been the standard treatment for ***,there are still over 20% of treated infants died and 19-30% survived with significant *** animal model was first established by Vannucci et al,involving the ligation of one common carotid artery followed by *** this study,we investigated human umbilical cord blood(HUcB) and its two components mononuclear cell(m.c. and red cell fraction(RcF) in both short and long term study using a modified HIE rat ***:In this modified HIE model,both common carotid arteries were occluded,breathing 8% oxygen in a hypoxic chamber for 60-minute,followed by the release of the common carotid arteries ligature,mim.c.ing reperfusion *** cell therapeutic study,cells were intravenously injected to HIE rat pups,and both behavioral and histological changes were assessed at selected time ***:Statistically significant behavioral improvements were demonstrated on Day 7 and 1 month between saline treated HIE rats and UcB/m.c.treated ***,at 3 months,the therapeutic improvements were only showed between saline treated HIE animals and m.c.treated HIE *** histological analysis one month after cell injection,the number of functional neurons were statistically increased between saline treated HIE and UcB/m.c.RcF treated HIE *** 3 months,the significant increase in functional neurons was only present in m.c.treated HIE ***:We have used a bilateral temporary occlusion of 60 minutes,a moderately brain damaged model,for cell therapeutic *** umbilical cord blood(HUcB) mononuclear cell(m.c. therapy showed benefits in neonatal HIE rats in both short and long term behavioral and histological assessments.

关键词： Hypoxic Ischem.c.Encephalopathy animal model cell therapeutic

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宁夏回族自治区中部及陕西省北部地区蝗虫的调查

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昆虫学报 1965年第6期 576-590页

作者：郑哲民邱琼华陕西师范大学生物系

宁夏回族自治区及陕西省蝗虫的调查工作,过去进行的较少。Бей-Биенко及Мищенко等曾记录6种宁夏及贺兰山地区的蝗虫;夏凯龄记录陕西地区蝗虫25种。近几年来吴福桢等对宁夏地区农作物害虫进行了调查,记录宁夏地区蝗虫12种... 详细信息

宁夏回族自治区及陕西省蝗虫的调查工作,过去进行的较少。Бей-Биенко及Мищенко等曾记录6种宁夏及贺兰山地区的蝗虫;夏凯龄记录陕西地区蝗虫25种。近几年来吴福桢等对宁夏地区农作物害虫进行了调查,记录宁夏地区蝗虫12种;作者之一对陕西

关键词：后足胫节银川宁夏宁夏回族自治区闰脉腿节股节榆林地区中胸腹板郑哲民蝗虫黑腿星翅蝗陕西省

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先天性支气管狭窄手术治疗的预测因子:一项多中心文献分析

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世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 42-42页

作者： chiu P.P.L. Kim P.c.W. 刘凯 Division of General Surgery Hospital for Sick Children Toronto Ont. M5G 1X8 Canada

Background: congenital tracheal stenosis (cTS) often requires urgent surgical intervention. We evaluated prognostic factors to determine the risks of surgical interventions by conducting a retrospective review of recent case series. methods: cases of cTS between 2002 and 2004 from our institution and recently published series that provided primary data on the demographics, complications, and outcomes of patients with cTS were analyzed. Univariate, model fit, and multivariate logistic regression analyses were performed using the SAS Statistical Program. Results: There were 68 patients who were treated (cartilage patch tracheoplasty, n = 31; slide tracheoplasty, n = 37), with 19 deaths (overall mortality = 28%). A total of 10 patients who underwent cartilage patch tracheoplasty died (32%mortality), whereas only 9 patients died following slide tracheoplasty (24%mortality). A total of 8 of 11 patients who were repaired at the age of 1 month or younger died (73%mortality), whereas only 11 of 57 patients who were repaired at an age older than 1 month died (19%mortality) (P = .04). A total of 10 of 19 patients with cTS who had comorbid intracardiac anomalies died following cTS repair (53%mortality), whereas only 9 of 49 patients with cTS who did not have intracardiac anomalies died (18%mortality) (P = .02). conclusions: This is the first report on the prognostic factors determining surgical outcomes for cTS. The highest mortality rate was observed in cTS patients younger than 1 month and in those with intracardiac anomalies. congenital tracheal stenosis repairs in these patient subgroups should be considered with caution.

关键词：支气管狭窄手术治疗文献分析预测因子先天性 logistic回归分析多中心回顾性分析人口统计学治疗风险

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临床表现明显的血管环伴先天性气管狭窄患儿的长期预后

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 20-20页

作者： chiu P.P.L. Rusan m. Williams W.G. P.c.W. Kim 刘凯 Division of General Surgery Hospital for Sick ChildrenUniversity of TorontoTorontoOnt. M5G 1X8Canada

Aim: congenital tracheal stenosis (cTS) associated with vascular rings (VRs) is considered a secondary condition,but relative indications for selective VRs or combined VR and cTS repairs are unclear. Here,we report long-term outcomes after VR repair associated with tracheal narrowing (TN). method: Retrospective analysis of patients admitted to a single institution with VR from 1982 to 2004. Of 131 patients with VR (cardiac Registry Database),29 (19 males,10 females; age range,0 days-4 years) associated with symptomatic TN. Patients were followed until age 18 years. Results: One hundred thirty-one patients with VR were categorized into 3 treatment groups. There were 102 patients with VR with no symptomatic TN treated by VR repair (4 deaths,4% mortality). Of the 29 patients with VR + TN symptoms,16 were treated by selective VR repair (mean age,5.3 months; range,17-288 days) with 3 deaths (19% mortality) and 13 underwent combined VR and cTS repairs (mean age,11 months; range,1 day-4 years) with 6 deaths (46% mortality),for an overall mortality of 31% (P cardiac anomalies with 3 deaths (18% mortality). In contrast,7 of 29 patients with VR with TN and intracardiac anomalies died 4(57% mortality); 3 patients in combined cardiac and cTS repairs (2 deaths,67% mortality) and 4 in selective VR repairs (2 deaths,50% mortality). conclusions: Not all cases of TN associated with VR require combined repairs. The presence of TN and/or intracardiac anomalies in patients with VR,however,increases mortality risk to the repair of VR. Surgical decision requires individualized clinical pathway.

关键词：气管狭窄血管环心脏畸形修复术总体死亡率联合修复继发性疾病个体特点修复手术

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Fungal diversity notes 1036-1150:taxonom.c.and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.maharachchikumbura Walter Rossi marco Leonardi Hyang Burm Lee Hye Yeon mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot marcela E.S.caceres Samantha c.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun m.Thambugala Ruvishika S.Jayawardena Indunil c.Senanayake Saranyaphat Boonmee Jie chen Zong-Long Luo chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene mayrada Silva Soares Helio Longoni Plautz Jr helen maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira cristina mariade Souza-motta Oliane maria correia magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao milan c.Samarakoon Dhandevi Pem Anuruddha Karunarathna chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang monika c.Dayarathne Anusha H.Ekanayaka Subashini c.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-cheng Dai Xiao-Hong Ji Xue-mei Tian Armin mesic Sanjay K.Singh Kunthida Phutthacharoen Lei cai Touny Sorvongxay Vinodhini Thiyagaraja chada Norphanphoun Napalai chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage ming Zeng Thilini chethana Deping Wei martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa Jose Ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips chang-Hsin Kuo Erio camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones Putarak chomnunti Eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul m Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Plant medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly Department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil Departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of m.c.obial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideom.c.tes),five new genera(caatingom.c.s,cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellom.c.s lateris,Boubovia gelatinosa,Buellia viridula,caatingom.c.s brasiliensis,calophoma humuli,camarosporidiella mori,canalisporium dehongense,cantharellus brunneopallidus,***,castanediella meliponae,coprinopsis psammophila,cordyceps succavus,cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium.c.iangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatom.c.s bauhiniae,Jahnula queenslandica,Kamalom.c.s mangrovei,Lecidella yunnanensis,m.c.rea squamulosa,muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium.c.rculare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium.c.iangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatom.c.s chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandrom.c.s australi,***,***,***,P.

关键词： 71 new taxa Ascom.c.ta Basidiom.c.ta Dothideom.c.tes Eurotiom.c.tes Lecanorom.c.tes Leotiom.c.tes Pezizom.c.tes Phylogeny Taxonomy

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芳香化合物离子的电子自旋共振波谱

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物理学报 1963年第9期 583-598页

作者：裘祖文王文韵张守信

本文报导在ЭПР-2 975千周高频调制波谱仪中得到的近30个芳香离子的电子自旋共振波谱。多数离子具有分辨良好的超精细结构。部分离子可以用m.c.nnellσ-π构相互作用理论和Hckel L.c.A.O.-m.O.理论计算得理论图。比较理论图和实验结果... 详细信息

本文报导在ЭПР-2 975千周高频调制波谱仪中得到的近30个芳香离子的电子自旋共振波谱。多数离子具有分辨良好的超精细结构。部分离子可以用m.c.nnellσ-π构相互作用理论和Hckel L.c.A.O.-m.O.理论计算得理论图。比较理论图和实验结果,作者认为两者的符合程度是比较满意的。

关键词：离子波分辨力总宽度超精芳香化合物电子自旋共振波谱

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clinical practice guidelines in multisystem inflammatory syndrome(mIS-c)related to cOVID-19:a critical review and recommendations

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World Journal of Pediatrics 2022年第2期18卷 83-90页

作者： Alanood S.Algarni Njoud m.Alamri Noor Z.Khayat Raghad A.Alabdali Rawabi S.Alsubhi Shahad H.Alghamdi Department of Pharm.c.logy and Toxicology Faculty of PharmacyPharmacy CollageUmm Al-Qura UniversityMakkah 21955Saudi Arabia Pharm.c. collage.Umm Al-Qura University Makkah.Saudi Arabia

Background multisystem inflammatory syndrome in children(mIS-c)is a serious health condition that develops from and is linked to coronavirus disease ***-c is considered a multi-organ dysfunction involving cardiac,renal,respiratory,hematologic,gastrointestinal and neurological symptoms and groups of signs and symptoms such as rash or bilateral non-purulent conjunctivitis,hypotension or shock and acute gastrointestinal problems,which require immediate therapeutic intervention to prevent the aggravation of the patient’s health ***-c is relatively new in the field of evidence-based medicine;however,there are several clinical guidelines for good clinical *** every disorder,the guidelines have different ***,based on the current status of the evidence,recommendations have been combined to form a unified guideline for therapeutic *** This paper compares and evaluates the current mIS-c-specific clinical practice guidelines(namely,American Academy of Pediatrics,American college of Rheumatology,helen DeVos children’s Hospital Foundation,children’s Hospital of The King’s Daughters,and the Infectious Diseases Society of America).The compiled literature was then assessed by the authors separately,and an algorithm was proposed for each disorder,taking into consideration the various guidelines proposed for the management of the *** The features of mIS-c patients are unified;this is very helpful in managing its symptoms and decreasing mortality *** addition,recommendations for pharm.c.logical treatment for mIS-c symptoms are formulated after cross-comparison across five different *** This study provides a general interpretation of the results in the context of other evidence and implications for future *** proposes a unified guideline based on the current evidence,with the best potential to maintain suitable clinical standards in the Saudi Arabian ministry of Health.

关键词： coronavirus disease 2019 multisystem inflammatory syndrome Pediatric multisystem inflammatory syndrome

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Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, mary E. Flenniken, Ann m. Ji, Xiao Teboul, Lydia Wong, m.c.ael D. White, Jacqueline K. meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, candice N. Bower, Lynette Brown, James m. caddle, L. Brianna chiani, Francesco clary, Dave cleak, James Daly, mark J. Denegre, James m. Doe, Brendan Dolan, mary E. Edie, Sarah m. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance c. Lanoue, Louise Lawson, Thomas N. Lek, monkol mark, manuel Arschall, Susan m. mason, Jeremy mcElwee, melissa L. Newbigging, Susan Nutter, Lauryl m. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Sam.c.a, Kaitlin E. Seavitt, John R. Selloum, mohammed Szoke-Kovacs, Zsombor Tamura, masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi m.c.rthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William.c. Justice, monica J. Parkinson, helen E. moore, mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, martin Hrabe Herault, Yann mohun, Tim mallon, Ann-marie Henkelman, R. mark Brown, Steve D. m. Adams, David J. Lloyd, K. c. Kent mcKerlie, colin Beaudet, Arthur L. Bucan, maja murray, Stephen A. Dept mol Physiol & Biophys Houston TX 77030 USA Toronto ctr Phenogen Toronto ON M5T 3H7 Canada mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA med Res council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England mary Lyon ctr Harwell OX11 0RD Oxon England Hosp Sick children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res council cNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst mIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German mouse clin D-85764 Neuherberg Germany Baylor coll med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan childrens Hosp Oakland Res Inst Oakland CA 94609 USA ImPc San Anselmo CA 94960 USA Tech Univ munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German ctr Diabet Res DZD D-85764 Neuherberg Germany Francis crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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