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The role of crystallinity on differential attachment/ proliferation of osteoblasts and fibroblasts on poly （caprolactone-co-glycolide） polymeric surfaces

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Frontiers of Materials Science 2012年第1期6卷 47-59页

作者： helen cui Patrick J.SINKO Advanced Technology and Regenerative Medicine(ATRM) LLCSomervilleNJ 08876USA Department of Pharmaceutics Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNJ 08854USA

The objective of the present study is to systematically evaluate the role of polymer crystallinity on fibroblast and osteoblast adhesion and proliferation using a series of poly（caprolactone-co-glycolide）（PCL/PGA） polymers. PCL/PGA polymers were selected since they reflect both highly crystalline and amorphous materials. PCL/PGA polymeric materials were fabricated by compression molding into thin films. Five compositions, from PCL or PGA to intermediate copolymeric compositions of PCL/PGA in ratios of 25：75, 35：65 and 45：55, were studied. Pure PCL and PGA represented the crystalline materials while the copolymers were amorphous. The polymers/copolymers were characterized using DSC to assess crystallinity, contact angle measurement for hydrophobicity, and AFM for nanotopography. The PCL/PGA films demonstrated similar hydrophobicity and nanotopography whereas they differed significantly in crystallinity. Cell adhesion to and proliferation on PCL/PGA films and proliferation studies were performed using osteoblasts and NIH-3T3 fibroblasts. It was observed that highly crystalline and rigid PCL and PGA surfaces were significantly more efficient in supporting fibroblast growth, whereas amorphous/flexible PCL/PGA 35：65 was significantly more efficient in supporting growth of osteoblasts. This study demonstrated that while chemical composition, hydrophobicity and surface roughness of PCL/PGA polymers were held constant, crystallinity and rigidity of PCL/PGA played major roles in determining cell responses.

关键词： crystallinity attachment proliferation osteoblast fibroblast PCL-PGA

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Mineralized collagen artificial bone repair material products used for fusing the podarthral joints with internal fixation—a case report

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Regenerative Biomaterials 2017年第5期4卷 295-298页

作者： Nihar S.Ghate helen cui Division of Foot and Ankle Surgery Indiana Regional Medical CenterIndianaPA 15701USA Beijing Allgens Medical Science and Technology Co. Ltd.Beijing 100176China

In this study,we reported a case with collapse and subluxation of metatarsal-cuneiform joint,navicular-cuneiform joint with subluxed the right first metatarsophalangeal *** injured medial column was internally fixed with compression *** fusion site was firmed up with BonGoldVR Bone Sponge and Bone *** prognosis of fused navicular-cuneiform joint and metatarsal-cuneiform joint were examined by X-ray shortly after surgical operation and followed up 2,4,6,9 and 13 weeks after the surgical *** column was perfectly fused by compression *** results justified and favored the application of mineralized collagen as an excellent alternative to autograft in fusing the podarthral joints with internal fixation.

关键词： medial column metatarsophalangeal joint navicular-cuneiform fusion mineralized collagen

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High-strength mineralized collagen artificial bone

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Frontiers of Materials Science 2014年第1期8卷 53-62页

作者： Zhi-Ye QIU Chun-Sheng TAO helen cui Chang-Ming WANG Fu-Zhai cui School of Materials Science and Engineering Tsinghua University Beijing 100084 China Beijing AIIgens Medical Science & Technology Co. Ltd. Beijing 100176 China

Mineralized collagen （MC） is a biomimetic material that mimics natural bone matrix in terms of both chemical composition and microstructure. The biomimetic MC possesses good biocompatibility and osteogenic activity, and is capable of guiding bone regeneration as being used for bone defect repair. However, mechanical strength of existing MC artificial bone is too low to provide effective support at human load-bearing sites, so it can only be used for the repair at non-load-bearing sites, such as bone defect filling, bone graft augmentation, and so on. In the present study, a high strength MC artificial bone material was developed by using collagen as the template for the biomimetic mineralization of the calcium phosphate, and then followed by a cold compression molding process with a certain pressure. The appearance and density of the dense MC were similar to those of natural cortical bone, and the phase composition was in conformity with that of animal＇s cortical bone demonstrated by XRD. Mechanical properties were tested and results showed that the compressive strength was comparable to human cortical bone, while the compressive modulus was as low as human cancellous bone. Such high strength was able to provide effective mechanical support for bone defect repair at human load-bearing sites, and the low compressive modulus can help avoid stress shielding in the application of bone regeneration. Both in vitro cell experiments and in v/vo implantation assay demonstrated good biocompatibility of the material, and in v/vo stability evaluation indicated that this high-strength MC artificial bone could provide long-term effective mechanical support at human load- bearing sites.

关键词： mineralized collagen (MC) high strength biomimeUc mineralization coldcompression molding

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A Bi-population Cooperative Optimization Algorithm Assisted by an Autoencoder for Medium-scale Expensive Problems

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IEEE/CAA Journal of Automatica Sinica 2022年第11期9卷 1952-1966页

作者： Meiji cui Li Li MengChu Zhou Jiankai Li Abdullah Abusorrah Khaled Sedraoui IEEE the School of Intelligent Manufacturing Nanjing University of Science and TechnologyNanjing 210094China the Department of Electronics and Information Engineering Tongji UniversityShanghai 201804China the helen and John C.Hartmann Department of Electrical and Computer Engineering New Jersey Institute of TechnologyNewarkNJ 07102 USA Center of Research Excellence in Renewable Energy and Power Systems Department of Electrical and Computer EngineeringFaculty of Engineeringand K.A.CARE Energy Research and Innovation CenterKing Abdulaziz UniversityJeddah 21589Saudi Arabia

This study presents an autoencoder-embedded optimization(AEO)algorithm which involves a bi-population cooperative strategy for medium-scale expensive problems(MEPs).A huge search space can be compressed to an informative lowdimensional space by using an autoencoder as a dimension reduction *** search operation conducted in this low space facilitates the population with fast convergence towards the *** strike the balance between exploration and exploitation during optimization,two phases of a tailored teaching-learning-based optimization(TTLBO)are adopted to coevolve solutions in a distributed fashion,wherein one is assisted by an autoencoder and the other undergoes a regular evolutionary ***,a dynamic size adjustment scheme according to problem dimension and evolutionary progress is proposed to promote information exchange between these two phases and accelerate evolutionary convergence *** proposed algorithm is validated by testing benchmark functions with dimensions varying from 50 to *** indicated in our experiments,TTLBO is suitable for dealing with medium-scale problems and thus incorporated into the AEO framework as a base *** with the state-of-the-art algorithms for MEPs,AEO shows extraordinarily high efficiency for these challenging problems,t hus opening new directions for various evolutionary algorithms under AEO to tackle MEPs and greatly advancing the field of medium-scale computationally expensive optimization.

关键词： Autoencoder dimension reduction evolutionary algorithm medium-scale expensive problems teaching-learning-based optimization

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State of the art review on the production and bond behaviour of reinforced geopolymer concrete

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Low-carbon Materials and Green Construction 2023年第1期1卷 322-346页

作者： Yifei cui Weixia Ai Biruk Hailu Tekle Menghua Liu Shihao Qu Peng Zhang Center for Durability&Sustainability Studies of Shandong Province Qingdao University of TechnologyFushun Road 11Qingdao 266033P.R.China School of Civil Engineering Federation University AustraliaUniversity DriveMt HelenBallaratVIC 3350Australia

Geopolymer is produced through the polymerization of active aluminosilicate material with an alkaline activator,leading to the formation of a green,inorganic polymer *** concrete(GPC)has become a promising low-carbon alternative to traditional Portland cement-based concrete(OPC).GPC-bonded reinforcing bars offer a promising alternative for concrete structures,boasting excellent geopolymer binder/reinforcement bonding and superior corrosion and high-temperature resistance compared to Portland ***,due to differences in the production process of GPC,there are distinct engineering property variations,including bonding *** literature review provides an examination of the manufacturing procedures of GPC,encompassing source materials,mix design,curing regimes,and other factors directly influencing concrete ***,it delves into the bond mechanism,bond tests,and corresponding results that represent the bond *** main conclusions are that GPC generally has superior mechanical properties and bond performance compared to ordinary Portland cement concrete(OPC).However,proper standardization is needed for its production and performance tests to limit the contradictory results in the lab and on site.

关键词： Geopolymer concrete Geopolymerisation and production Bond study FRP bar reinforced concrete

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A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson’s disease: a brain radiomics study

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Neural Regeneration Research 2022年第12期17卷 2743-2749页

作者： Xiao-Jun Guan Tao Guo Cheng Zhou Ting Gao Jing-Jing Wu Victor Han Steven Cao Hong-Jiang Wei Yu-Yao Zhang Min Xuan Quan-Quan Gu Pei-Yu Huang Chun-Lei Liu Jia-Li Pu Bao-Rong Zhang Feng cui Xiao-Jun Xu Min-Ming Zhang Department of Radiology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Neurology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCAUSA Institute for Medical Imaging Technology School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina School of Information Science and Technology ShanghaiTech UniversityShanghaiChina helen Wills Neuroscience Institute University of CaliforniaBerkeleyCAUSA Department of Radiology Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiang ProvinceChina

Brain radiomics can reflect the characteristics of brain ***,the value of T1-weighted images,quantitative susceptibility mapping,and R2*mapping in the diagnosis of Parkinson’s disease(PD)was underestimated in previous *** this prospective study to establish a model for PD diagnosis based on brain imaging information,we collected high-resolution T1-weighted images,R2*mapping,and quantitative susceptibility imaging data from 171 patients with PD and 179 healthy controls recruited from August 2014 to August *** to the inclusion time,123 PD patients and 121 healthy controls were assigned to train the diagnostic model,while the remaining 106 subjects were assigned to the external validation *** extracted 1408 radiomics features,and then used data-driven feature selection to identify informative features that were significant for discriminating patients with PD from normal controls on the training *** informative features so identified were then used to construct a diagnostic model for *** constructed model contained 36 informative radiomics features,mainly representing abnormal subcortical iron distribution(especially in the substantia nigra),structural disorganization(e.g.,in the inferior temporal,paracentral,precuneus,insula,and precentral gyri),and texture misalignment in the subcortical nuclei(e.g.,caudate,globus pallidus,and thalamus).The predictive accuracy of the established model was 81.1±8.0%in the training *** the external validation dataset,the established model showed predictive accuracy of 78.5±2.1%.In the tests of identifying early and drug-naïve PD patients from healthy controls,the accuracies of the model constructed on the same 36 informative features were 80.3±7.1%and 79.1±6.5%,respectively,while the accuracies were 80.4±6.3%and 82.9±5.8%for diagnosing middle-to-late PD and those receiving drug management,*** accuracies for predicting tremor-dominant and non-tremor-dominant PD w

关键词： diagnosis imaging biomarker iron magnetic resonance imaging neuroimaging Parkinson’s disease quantitative susceptibility mapping R2*mapping radiomics T1-weighted imaging

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基于SURF特征的栈式自编码网络人脸对齐算法

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液晶与显示 2018年第3期33卷 254-260页

作者：崔凯才华刘广文刘智长春理工大学电子信息工程学院吉林长春130022

人脸对齐是人脸识别系统中的一个核心部分,定位的准确性和定位速度直接影响到人脸识别的效果。人脸图像存在不同姿态、不同表情、不同光照条件等因素的影响,真实场景下的人脸对齐成为一个难题。本文提出了一种基于SURF特征的栈式自编码... 详细信息

人脸对齐是人脸识别系统中的一个核心部分,定位的准确性和定位速度直接影响到人脸识别的效果。人脸图像存在不同姿态、不同表情、不同光照条件等因素的影响,真实场景下的人脸对齐成为一个难题。本文提出了一种基于SURF特征的栈式自编码网络人脸对齐方法,首先通过粗糙定位网络找到近似人脸特征点,并提取局部的SURF特征,输入到局部细化网络,通过级联结构,进一步精确化人脸特征点的具体位置。最后,在人脸数据集AFLW和helen上与近几年的对齐方法进行对比实验,平均错误率8.80%,i5四核CPU,2.3Hz主频硬件平台下计算时间7.6ms。我们的人脸对齐方法在真实场景下(包括单人和多人)具有较好的鲁棒性,可以实现准确定位。

关键词： SURF特征人脸对齐自编码器网络

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关于HCl、CoCl2、MnCl2和HgCl2在丙酮及丙酮—水混合溶剂中存在形态的研究

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太原机械学院学报 1987年第1期 113-120页

作者：崔秀生

本文用电导法研究了 HCl、CoCl2、MnCl2以及 HgCl2在丙酮和丙酮——水混合溶剂中的存在形态,得出了 HCl、CoCl2和 MnCl2在丙酮和丙酮——水混合溶剂中（含水20%以下）都是弱电解质的结论。通过对 HgCl2丙酮溶液的电导和红外光谱的研究,... 详细信息

本文用电导法研究了 HCl、CoCl2、MnCl2以及 HgCl2在丙酮和丙酮——水混合溶剂中的存在形态,得出了 HCl、CoCl2和 MnCl2在丙酮和丙酮——水混合溶剂中（含水20%以下）都是弱电解质的结论。通过对 HgCl2丙酮溶液的电导和红外光谱的研究,本文还发现了 HgCl2能与丙酮发生化学反应的现象。

关键词：丙酮摩尔电导极限红外谱脂肪族酮 MnCl2 HgCl2 混合溶剂 HCl

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《战争与和平》中两位女性形象的塑造

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教育教学论坛 2017年第30期 59-60页

作者：关翠琼长江大学外国语学院湖北荆州434023

本文以翻译家刘辽逸《战争与和平》译本为依据,概括了小说中两位重要的女性娜塔莎和玛丽亚公爵小姐的性格形象特征:娜塔莎活泼烂漫、纯朴善良、热爱生活,富有民族情怀和爱国心;玛丽亚公爵小姐虔诚、理性、隐忍、博爱,淡泊名利,热爱国家... 详细信息

本文以翻译家刘辽逸《战争与和平》译本为依据,概括了小说中两位重要的女性娜塔莎和玛丽亚公爵小姐的性格形象特征:娜塔莎活泼烂漫、纯朴善良、热爱生活,富有民族情怀和爱国心;玛丽亚公爵小姐虔诚、理性、隐忍、博爱,淡泊名利,热爱国家,富于自我牺牲精神。文章将两个人物进行对比,并与小说中另一女性海伦进行对比,以凸显两位女性的精神美。

关键词：娜塔莎玛丽亚公爵小姐海伦精神美

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会话合作原则在《典型的美国佬》的人物性格分析中的应用

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菏泽学院学报 2014年第1期36卷 105-107,120页

作者：苏翠英菏泽学院外国语系山东菏泽274015

运用会话合作原则对小说《典型的美国佬》中的经典人物对话进行分析可知:美国多元文化语境中的两位女主人公海伦和特蕾萨隐忍、知性、富有创造力,同时具备充满矛盾的内心世界和丰富强烈的女性自主意识;而男主人公拉尔夫则任性、盲目,总... 详细信息

运用会话合作原则对小说《典型的美国佬》中的经典人物对话进行分析可知:美国多元文化语境中的两位女主人公海伦和特蕾萨隐忍、知性、富有创造力,同时具备充满矛盾的内心世界和丰富强烈的女性自主意识;而男主人公拉尔夫则任性、盲目,总是试图彰显其男性话语霸权。而女性意识也是《典型的美国佬》的重要主题之一。

关键词：会话合作原则人物性格《典型的美国佬》

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