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Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

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Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu heleen van beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-Macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of Molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

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钝化技术:断喙的替代方法

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中国家禽 2006年第23期28卷 35-36页

作者： heleen A.van de Weerd 刘向萍

英国的最新研究发现表明让蛋鸡自己钝化喙是一种成功的断喙的替代方法。对蛋鸡进行断喙已经在欧盟引起广泛争议，一些国家已经禁止进行断喙，这将对家禽业产生很大影响，尤其是对于非笼养的鸡群，当不进行断喙时，很难预防大群损伤性啄... 详细信息

英国的最新研究发现表明让蛋鸡自己钝化喙是一种成功的断喙的替代方法。对蛋鸡进行断喙已经在欧盟引起广泛争议，一些国家已经禁止进行断喙，这将对家禽业产生很大影响，尤其是对于非笼养的鸡群，当不进行断喙时，很难预防大群损伤性啄癖的发生，而由于动物福利的原因，非笼养鸡群的比例将增加，因为英国政府计划2001年禁止断喙，因此资助对断喙的替代方法进行研究。

关键词：钝化技术断喙动物福利政府计划家禽业蛋鸡英国鸡群

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Capacity Building and Transfer of Know-how in Radiation Protection. Dissemination of Enetrap Projects Results

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Journal of Health Science 2017年第1期5卷 25-32页

作者： Cristina Llorente Herranz Marisa Marco Arboli Michele Coeck Marcel Schouwenburg heleen van Elsacker-Degenaar Paul Livolsi Education and Training department CIEMAT Madrid 28040 Spain Academy for Nuclear Science and Technology SCK'CEN Brussels 2400 Belgium Training Center Delft TUDelft Delft 2600 The Netherlands Radiation and Environment department NRG Consultancy & Services Petten 1755 The Netherlands Institute for Nuclear Science and Technology CEA-INSTN 38054 Grenoble France

The ENETRAP （European Network on Education and Training in RAdiological Protection） project series, since the first edition in 2005 till the current ENETRAP III, always have been the objective to maintain a high level of competence in radiation protection （RP）, assuring the continued development of suitable well-trained personnel and adequate knowledge management. This objective is crucial to ensure future safe use of ionizing radiations （IR） and the development of new technologies in a safe way. A big effort and lot of work has been done in these 11 years including the new definitions in the BSS for RP Expert （RPE）, RP Officer （RPO） and Medical Physics Expert （MPE） which are the basis for future national development and implementation and adequate the high-level education and training （E＆T） in the countries. In order to manage all the valuable results of the projects and to distribute them to the society, is required a tool, developed with this specific propose, that will be the object of this paper.

关键词： Capacity building radiation protection education & training Radiation Protection Expert Radiation Protection Officer knowledge management ECVET Train-the-trainers.

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Growth and development of term infants fed with milk with long-chain polyunsaturated fatty acid supplementation

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Chinese Medical Journal 2004年第8期117卷 1268-1270页

作者：贲晓明周晓玉赵卫华喻文亮潘伟张伟利吴圣楣 Christien M.van beusekom Anne Schaafsma Department of Paediatrics Jiangbei Hospital South East UniversityNanjing210048China Nanjing Children’s Hospital Nanjing Medical University Nanjing210008China Paediatric Nutrition Xinhua Hospital ShanghaiSecond Medical University Shanghai200092China Friesl and Nurtition POBox226 8901 MALeeuwardenNetherlands

Presently, there is growing interest in long-chain polyunsaturated fatty acids (LCPUFAs), which are considered a major determinant of growth, visual and neural development, and long-term health.1 Two groups of LCPUFAs have received special interest: homologues of linoleic acid (LA) of the n-6 series, which are precursors of arachidonic acid (AA), and homologues of α-linolenic acid (ALA) of the n-3 series, which are precursors of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

关键词： long-chain polyunsaturated fatty acids ·arachidonic acid · docosahexaenoic acid ·infant ·growth · development

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Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora and fermentation in term infants

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Chinese Medical Journal 2004年第6期117卷 927-931页

作者：贲晓明周晓玉赵卫华喻文亮潘伟张伟利吴圣楣 Christien M. van beusekom Anne Schaafsma Department of Newborn Infants Nanjing Children's HospitalNanjing University Department of Pediatrics Affiliated Hospital of South East University Paediatric Research Institute Xinhua HospitalShanghai Second Medical University Friesland Research Institute

Background Oligosaccharides in human milk may protect infants by improving the intestinal micro-flora and fermentation. This study was to investigate effects of infant formula milk consisting of galacto-oligosaccharide (GOS) on intestinal microbial populations and the fermentation characteristics in term infants in comparison with that of human milk. Methods The test formula (Frisolac H,Friesland,Netherland) was supplemented with GOS at a concentration of 0.24 g/dl. Human milk and another formula without oligosaccharides (Frisolac H,Friesland,Netherland) were used as positive and negative control respectively. Growth,stool characteristics,and side effects of the recruited infants were recorded after 3 and 6 months’ follow-up,and the fecal species were collected for the analysis of intestinal micro-flora,short chain fatty acid (SCFA) and *** At the end of 3- and 6-month feeding period,intestinal Bifidobacteria and Lactobacilli were significantly increased in infants fed with GOS supplemented formula and human milk when compared with infants fed with negative control formula; however,there was no statistically significant difference between GOS supplemented formula and human milk groups. Stool characteristics were influenced by the supplement and main fecal SCFA (acetic),and stool frequency were significantly increased in infants fed with GOS supplemented formula and human milk,while the fecal pH was significantly decreased as compared with that of negative control ( P <0.05). Supplementation had no influence on incidence of side effects (including crying,regurgitation and vomiting). Conclusions Supplementing infant formula with GOS at a concentration of 0.24 g/dl stimulates the growth of Bifidobacteria and Lactobacilli in the intestine and stool characteristics are similar to in term infants fed with human milk.

关键词： galacto-oligosaccharides·intestinal micro-flora·fermentation·infant

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Join us on an amazing journey towards next-generation treatments for CNS disorders:Launch of Neuroprotection,a new high-quality journal in translational neuroscience

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Neuroprotection 2023年第1期1卷 5-8页

作者： Xunming Ji Piotr Walczak heleen M.M.van beusekom Ana I.Casas Andrew Clarkson Tracy Farr Jukka Jolkkonen Yajie Liang Michel M.Modo Paulo H.Rosado-de-Castro Karsten Ruscher Yan-Jiang Wang Haitao Wu Marietta Zille Shen Li Johannes Boltze Beijing Institute of Brain Disorders Capital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine Center for Advanced Imaging ResearchUniversity of MarylandBaltimoreMarylandUSA Department of Cardiology Erasmus MC RotterdamUniversity Medical Center RotterdamRotterdamThe Netherlands Department of Neurology Center for Translational Neuro‐and Behavioral Sciences(C‐TNBS)University Clinics EssenEssenGermany Department of Anatomy Brain Health Research Center and Brain Research New ZealandDunedinNew Zealand Medical School Queen's Medical CentreUniversity of NottinghamNottinghamUK A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland McGowan Institute for Regenerative Medicine University of PittsburghPittsburghPennsylvaniaUSA Department of Radiology University of PittsburghPittsburghPennsylvaniaUSA Department of Bioengineering University of PittsburghPittsburghPennsylvaniaUSA Department of Anatomy and Department of Radiology School of MedicineInstitute of Biomedical SciencesFederal University of Rio de JaneiroRio de JaneiroBrazil Laboratory for Experimental Brain Research University of LundLundSweden Department of Neurology Daping HospitalCenter for Clinical NeuroscienceChongqingChina Department of Neurobiology Beijing Institute of Basic Medical SciencesBeijingChina Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaViennaAustria Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina School of Life Sciences University of WarwickCoventryUK

Translational medicine in neurodegenerative and neurovascular diseases is approaching a breakthrough *** years have led to dramatic progress in both experimental and clinical *** on a much better and continuously increasing understanding of disease mechanisms,progression and pathophysiology,new therapies with an improved translational potential to protect tissue either against acute or chronic degeneration and even approaches potentially capable of repairing damaged brain tissue are emerging.

关键词： cytoprotection nervous system repair neurodegeneration neuroprotection neurovasculardiseases translational research

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异乎寻常的新消费观

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商业周刊（中文版） 2010年第9期 54-59页

作者：德温·伦纳德（Devin Leonard）迈克尔·巴松（Michaei Bathon）玛丽·范博塞克姆（Mary van beusekom）艾拉·布德威（Ira Boudway）克里斯·伯里特（Chris Burritt）瑞安·弗袜（Ryan Flinn）罗切尔·加纳（Rochelle Garner）珍妮弗·约翰逊（Jennifer Johnson）西奥·基思（Theo Keith）瑞安·麦卡菲（Ryan McAFee）朱莉娅·莫尔普戈（Julia Morpurgo） Pham-Duy Nguyen 萨默·萨阿迪（Sommer Saadi）罗伯特·施特劳斯（Robert Strauss）迈克尔·怀特（Michael Wuce）卡罗琳·温特（Caroline Winter）赵斌（译）

美国人现在一文不名、一蹶不振；与此同时，他们又在痛饮3美元一杯的拿铁咖啡、排长队等待购买新的iPhone。

关键词：消费观美国人经济

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