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Pharmacogenomics in colorectal cancer:current role in clinical practice and future perspectives

Journal of Cancer Metastasis and Treatment 2018年第1期4卷 146-170页

作者： Francesca Battaglin Alberto Puccini Madiha Naseem Marta Schirripa Martin DBerger Ryuma Tokunaga Michelle McSkane Taline Khoukaz Shivani Soni Wu Zhang Heinz-Josef Lenz Division of Medical Oncology Norris Comprehensive Cancer CenterKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Medical Oncology Unit 1 Clinical and Experimental Oncology DepartmentVeneto Institute of Oncology IOV-IRCCSPadua 35128Italy Department of Medical Oncology University Hospital of BernBern 3010Switzerland

The treatment scenario of colorectal cancer(CRC)has been evolving in recent years with the introduction of novel targeted agents and new therapeutic strategies for the metastatic disease.An extensive effort has been directed to the identification of predictive biomarkers to aid patients selection and guide therapeutic choices.Pharmacogenomics represents an irreplaceable tool to individualize patients treatment based on germline and tumor acquired somatic genetic variations able to predict drugs response and risk of toxicities.The growing knowledge of CRC molecular characteristics and complex genomic makeup has played a crucial role in identifying predictive pharmacogenomic biomarkers,while supporting the rationale for the development of new drugs and treatment combinations.Clinical validation of promising biomarkers,however,is often an issue.More recently,a deeper understanding of resistance mechanisms and tumor escape dynamics under treatment pressure and the availability of novel technologies are opening new perspectives in this field.This review aims to present an overview of current pharmacogenomic biomarkers and future perspectives of pharmacogenomics in CRC,in an evolving scenario moving from a single drug-gene interactions approach to a more comprehensive genome-wide approach,comprising genomics and epigenetics.

关键词： Colorectal cancer pharmacogenomics RAS BRAF microsatellite instability dihydropyrimidine dehydrogenase UDP-Glucuronosyltrasferase A1 epidermal growth factor receptor vascular endothelial growth factor DNA methylation

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确保工业数据网络中的通信

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现代制造 2014年第33期 30-31页

作者： heinz-josef HARTMANN

快速以太网Gigabit和Fast-Ethernet通信网络中的数据纵向整合，是创新型高性能全自动化生产支柱。由此形成的持续增长的数据和信息联网，使得用户对于安全的要求不断提高。

关键词：通信网络工业数据网络 Gigabit 快速以太网自动化生产信息联网持续增长创新型

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Intraductal ultrasound substantiates diagnostics of bile duct strictures of uncertain etiology

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World Journal of Gastroenterology 2013年第6期19卷 874-881页

作者： Tobias Meister Hauke S heinzow Carina Woestmeyer Philipp lenz josef Menzel Torsten Kucharzik Wolfram Domschke Dirk Domagk Department of Medicine B University of Münster Department of Medicine Ⅱ HELIOS AlbertSchweitzer University Teaching Hospital Department of MedicineⅡ Klinikum IngolstadtD-85049 IngolstadtGermany Department of Medicine University Teaching Hospital Lüneburg

AIM:To report the largest patient cohort study investigating the diagnostic yield of intraductal ultrasound (IDUS) in indeterminate strictures of the common bile duct.METHODS:A patient cohort with bile duct strictures of unknown etiology was examined by IDUS.Sensitivity,specificity and accuracy rates of IDUS were calculated relating to the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery.Analysis of the endosonographic report allowed drawing conclusions with respect to the T and N staging in 147 patients.IDUS staging was compared to the postoperative histopathological staging data allowing calculation of sensitivity,specificity and accuracy rates for T and N stages.The endoscopic retrograde cholangio-pancreatography and IDUS procedures were performed under fluoroscopic guidance using a side-viewing duodenoscope (Olympus TJF 160,Olympus,Ltd.,Tokyo,Japan).All procedures were performed under conscious sedation (propofol combined with pethidine) according to the German guidelines.For IDUS,a 6 F or 8 F ultrasound miniprobe was employed with a radial scanner of 15-20 MHz at the tip of the probe (Aloka Co.,Tokyo,Japan).RESULTS:A total of 397 patients (210 males,187 females,mean age 61.43 ± 13 years) with indeterminate bile duct strictures were included.Two hundred and sixty-four patients were referred to the department of surgery for operative exploration,thus surgical histopathological correlation was available for those patients.Out of 264 patients,174 had malignant disease proven by surgery,in 90 patients benign disease was found.In these patients decision for surgical exploration was made due to suspicion for malignant disease in multimodal diagnostics (computed tomography scan,endoscopic ultrasound or magnetic resonance imaging).Twenty benign bile duct strictures were misclassified by IDUS as malignant while 14 patients with malignant strictures were initially misdiagnosed by IDUS as benign resulting in sensitivity,specificity and accuracy ratesof 93.2

关键词： Intraductal ultrasound Bile duct strictures Accuracy

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The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

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Neural Regeneration Research 2019年第11期14卷 1950-1960页

作者： Petra Hundehege Manuela Cerina Susann Eichler Christian Thomas Alexander M. Herrmann Kerstin Goel Thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu Narayanan Thomas Budde Erwin-josef Speckmann heinz Wiendl Anna Schubart Tobias Ruck Sven G. Meuth Department of Neurology with Institute of Translational Neurology Westfalische Wilhelms-UniversitatMunsterGermany Institute of Physiology I Westfalische Wilhelms-UniversitatMunsterGermany Novartis Institutes of Biomedical Research BaselSwitzerland

Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas progressive MS(PMS) shows significant neuroaxonal damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial in patients with relapsing MS have limited success in PMS. BAF312(siponimod) is a novel sphingosine-1-phosphate receptor modulator shown to delay progression in PMS. Besides reducing inflammation by sequestering lymphocytes in lymphoid tissues, BAF312 crosses the blood-brain barrier and binds its receptors on neurons, astrocytes and oligodendrocytes. To evaluate potential direct neuroprotective effects, BAF312 was systemically or locally administered in the CNS of experimental autoimmune encephalomyelitis mice with distinct grey-and white-matter lesions(focal experimental autoimmune encephalomyelitis using an osmotic mini-pump). Ex-vivo flow cytometry revealed that systemic but not local BAF312 administration lowered immune cell infiltration in animals with both grey and white matter lesions. Ex-vivo voltage-sensitive dye imaging of acute brain slices revealed an altered spatio-temporal pattern of activation in the lesioned cortex compared to controls in response to electrical stimulation of incoming white-matter fiber tracts. Here, BAF312 administration showed partial restore of cortical neuronal circuit function. The data suggest that BAF312 exerts a neuroprotective effect after crossing the blood-brain barrier independently of peripheral effects on immune cells. Experiments were carried out in accordance with German and EU animal protection law and approved by local authorities(Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen;87-51.04.2010.A331) on December 28, 2010.

关键词： multiple sclerosis focal experimental autoimmune encephalomyelitis cortical grey matter white matter BAF312 neuroaxonal damage neuroprotection

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Applicability of a Variance Components Method for QTL Mapping in Comparison with Haley-Knott Regressions

Applicability of a Variance Components Method for QTL Mappin...

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2003北京国际养猪研讨会暨展览会

作者： heinz-josef Schreinemachers Ernst Tholen Klaus Wimmers Siriluck Ponsuksili Karl chellander Institute of Animal Breeding and Geneics Uiversity of BonnEndenicher Allee 15D-53115 BonnGermany Institute of Animal Breeding and Geneics Uiversity of BonnEndenicher Allee 15D-53115 BonnGermany Institute of Animal Breeding and Geneics Uiversity of BonnEndenicher Allee 15D-53115 BonnGermany Institute of Animal Breeding and Geneics Uiversity of BonnEndenicher Allee 15D-53115 BonnGermany Institute of Animal Breeding and Geneics Uiversity of BonnEndenicher Allee 15D-53115 BonnGermany

＜正＞ Introduction and objective In modern pig-breeding organizations, marker data from nucleus lines recorded in several generationsare available. Standard methods like Haly-Knott regression [3] are restricted to specific pedigree designsand therefore they are not fully applicable to thes kind of data. In general, vedance components methods（VC） are more flexible in handling of several traits with different underlying distributions and a complexpedigree structure. Applying these methods in QTL-mapping, the estimation of the proportion of variancecontributed by a QTL at a specific locus is feasible. In order to separate additive genetic and QTL-variance,

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100-112 Gbit/s complete ETDM systems based on monolithically integrated transmitter and receiver modules

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Journal of Beijing Institute of Technology 2011年第3期20卷 410-414页

作者：王轲李杰 Anders Djupsjbacka Marek Chaciński Urban Westergren Sergei Popov Gunnar Jacobsen Volker Hurm Robert Elvis Makon Rachid Driad Herbert Walcher josef Rosenzweig Andreas G.Steffan G.Giorgis Mekonnen heinz-Gunter Bach 李卓 Ari T.Friberg School of Optoelectronics Beijing Institute of Technology School of Information and Communication Technology Royal Institute of Technology Department of Networking and Transmission Laboratory Fraunhofer Institute for Applied Solid State Physics u2t Photonics AG 10553 BerlinGermany Departmen of Pthotonic Components-Integration Technology Fraunhofer Institute for Telecommunications

Traditional intensity modulated two-level electrical time-division multiplexing （ETDM） transmission systems working at 100 -112 Gbit/s were investigated. The complete ETDM systems based on monolithically integrated transmitter and receiver modules were demonstrated with biterror-rate （BER） performance of 10-s at 107 Gbit/s, and near error-free standard forward error correction （FEC） threshold （2 × 10 -3） at 112 Gbit/s. The experiment results showed that directly modulated high-speed ETDM transmission systems with the symbol rates at 100 Gbaud and beyond were promising candidate for cost-effective 100 GbE applications and might be a preform of the next generation of Terabit/s Ethernet.

关键词： 100 Gigabit Ethernet （GbE） bit-error-rate Eye-diagram electrical time-division multiplexing （ETDM） system modules

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A Phenomenological Extension of the Newtonian Gravity

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International Journal of Astronomy and Astrophysics 2019年第1期9卷 63-70页

作者： heinz Dehnen Fachbereich Physik Universit&auml t Konstanz Konstanz Germany

Following the idea of our previous paper we distinguish also in the case of Newtonian gravity as in the electrodynamics between extensive and intensive field quantities. Between both, a “material’’ quantity produced e.g. by vacuum polarisations induced by the gravitational field strength itself is mediated. It acts in such a way that it amplifies the field strength in weak gravitational fields and reduces the field strength in strong gravitational fields following lenz’s rule. Newton’s gravity is valid only in a very large intermediate range of middle field strength F?, F0? and F1?critical field strengths). In this way dark matter and black holes may be avoidable.

关键词： Flat Rotation Curves MOND Tully-Fisher Law Avoiding Singularities Vacuum-Polarisations lenz’s Rule

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一种预防噪声导致失聪的新方法(英文)

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解放军医学杂志 2009年第5期34卷 519-522页

作者： H.麦尔 T.列纳 M.缇雪 J.M.米勒 Bundeswehrkrankenhaus Ulm Ulm Germany Department of Otolaryngology Medical University of HannoverHannover Germany Kresge Hearing Research Institute University of Michigan Ann Arbor MI USA and Center for Hearing and Communication Kdrolinska Institute Stockholm Sweden

对一个国家来说,噪声导致的失聪是一种巨大的社会和经济损失,是以前未曾遇到过的医疗卫生问题,现在这个问题有了一种解决办法。美国农业部(FDA)近年来没有批准任何预防噪声导致失聪的新产品。在美国,这类产品(包括耳塞和耳罩)的市场价... 详细信息

对一个国家来说,噪声导致的失聪是一种巨大的社会和经济损失,是以前未曾遇到过的医疗卫生问题,现在这个问题有了一种解决办法。美国农业部(FDA)近年来没有批准任何预防噪声导致失聪的新产品。在美国,这类产品(包括耳塞和耳罩)的市场价值大约为2.43亿美元,其中约75%来自耳塞的销售。对听力的物理防护可以降低声压水平,但若噪声过强,这种物理防护并不能完全保证听力不受损害。而且,这类"屏蔽"方法也会损害需要通过听、说进行交流来保证的个人安全性。近十年来我们对应激、病理和年龄因素在决定细胞生存和死亡的分子和生化机制方面有了明显深入的了解和认识。我们可以确定导致细胞死亡的凋亡或坏死途径,以及对这些途径起调节作用的外部环境或内源性遗传启动因子、基因及转导因子。用这些新知识,我们开始设计新的干预方法来减轻或防止细胞死亡,使我们第一次能够预防或治疗以前不能预防或治疗的疾患,失聪即是其中一种。

关键词：噪声听力损伤抗氧化剂自由基血管扩张剂

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Measurements of the center-of-mass energies of e~+e~- collisions at BESⅢ

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Chinese Physics C 2021年第10期45卷 11-19页

作者： M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An X.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone J.F.Chang W.L.Chang G.Chelkov D.Y.Chen G.Chen H.S.Chen M.L.Chen S.J.Chen X.R.Chen Y.B.Chen Z.J.Chen W.S.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai X.C.Dai A.Dbeyssi R.E.de Boer D.Dedovich Z.Y.Deng A.Denig L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng M.Fritsch C.D.Fu Y.Gao X.Q.Hao F.A.Harris K.L.He F.H.Heinsius C.H.heinz T.Held Y.K.Heng C.Herold Y.Hu G.S.Huang L.Q.Huang X.T.Huang Y.P.Huang Z.Huang T.Hussain N Husken W.Ikegami Andersson W.Imoehl M.Irshad S.Jaeger S.Janchiv Q.Ji Q.P.Ji M.Q.Jing T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.G.Kurth W.Kuhn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff M.Lellmann T.lenz C.Li J.Q.Li J.S.Li Ke Li L.K.Li Lei Li P.R.Li S.Y.Li W.D.Li W.G.Li X.H.Li G.R.Liao 廖龙洲 J.Libby C.X.Lin B.J.Liu C.X.Liu D.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.L.Liu J.Y.Liu K.Liu K.Y.Liu L.Liu M.H.Liu P.L.Liu Q.Liu Q.Liu S.B.Liu M.M.Ma Q.M.Ma R.Q.Ma R.T.Ma X.X.Ma X.Y.Ma F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni Y.J.Mao Z.P.Mao S.Marcello Z.X.Meng J.G.Messchendorp G.Mezzadri T.J.Min R.E.Mitchell X.H.Mo N.Yu.Muchnoi H.Muramatsu S.Nakhoul Y.Nefedov F.Nerling I.B.Nikolaev Z.Ning P.Patteri M.Pelizaeus H.P.Peng K.Peters J.Pettersson J.L.Ping R.G.Ping S.Pogodin Z.Qian C.F.Qiao L.Q.Qin X.P.Qin X.S.Qin Z.H.Qin J.F.Qiu S.Q.Qu K.H.Rashid K.Ravindran C.F.Redmer A.Rivetti V.Rodin M.Rolo G.Rong Ch.Rosner M.Rump H.S.Sang A.Sarantsev Y.Schelhaas C.Schnier K.Schoenning M.Scodeggio D.C.Shan W.Shan X.Y.Shan J.F.Shangguan M.Shao C.P.Shen H.F.Shen P.X.Shen X.Y.Shen H.C.Shi R.S.Shi X.Shi X.D Shi J.J.Song W.M.Song Y.X.Song K.Wang L.L.Wang M.Wang M.Z.Wang Meng Wang W.Wang W.H.Wang W.P.Wang X.Wang X.F.Wang X.L.Wang Liaoning Normal University University of Science and Technology of China State Key Laboratory of Particle Detection and Electronics University of Jinan Southeast University Joint Institute for Nuclear Research INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di Frascati INFN Sezione di Ferrara INFN Sezione di Ferrara Peking University State Key Laboratory of Nuclear Physics and Technology Institute of High Energy Physics Institute of Physics and Technology University of Muenster University of Chinese Academy of Sciences the Moscow Institute of Physics and Technology Central China Normal University Nanjing University Institute of Modern Physics Hunan University School of Physics and Electronics Hunan University University of Turin and INFN IN-FNI-10125TurinItaly G.I.Budker Institute of Nuclear Physics SB RAS (BINP) Nankai University University of Turin and INFN University of Eastern Piedmont University of Turin and INFN IN-FN Sun Yat-Sen University University of South China Henan Normal University University of Hawaii Suranaree University of Technology Shandong University University of the Punjab the Novosibirsk State University Indiana University University of Groningen Liaoning University Shanxi Normal University GSI Helmholtzcentre for Heavy Ion Research GmbH Justus-Liebig-Universitaet Giessen Ⅱ. Physikalisches Institut Turkish Accelerator Center Particle Factory Group Istanbul Bilgi University HEP Res. Cent. Istinye University University of Manchester Indian Institute of Technology Madras Uppsala University Qufu Normal University Beijing Institute of Petrochemical Technology Lanzhou University Frontiers Science Center for Rare Isotopes Lanzhou University Lanzhou Center for Theoretical Physics Lanzhou University Tsinghua University Guangxi Normal University Shanxi University Guangxi University Henan University of Science and Technology Helmholtz Institute Mainz Fudan University Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) and Institute of Modern Physics Fudan Uni

During the 2016-17 and 2018-19 running periods, the BESⅢ experiment collected 7.5 fb-1of e~+e~- collision data at center-of-mass energies ranging from 4.13 to 4.44 GeV. These data samples are primarily used for the study of excited charmonium and charmoniumlike states. By analyzing the di-muon process e~+e~-→(γISR/FSR)μ~+μ~-, we measure the center-of-mass energies of the data samples with a precision of 0.6 MeV. Through a run-by-run study, we find that the center-of-mass energies were stable throughout most of the data-collection period.

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Observation of the Y(4230)and a new structure in e^(+)e^(-)→K^(+)K^(-)J/Ψ

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Chinese Physics C 2022年第11期46卷 7-21页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso 安美儒安琪白旭红白羽 O.Bakina R.Baldini Ferroli I.Balossino 班勇 V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲 G.Chelkov 陈琛陈刚陈和生陈玛丽陈申见 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.Dbeyssi R.Ede Boer D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇董静董燎原董明义董翔杜书先 P.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K.Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 顾旻皓关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩婷婷韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.heinz 衡月昆 C.Herold M.Himmelreich T.Holtmann 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄麟钦黄性涛黄燕萍 Z.Huang T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv Q.Ji 姬清平季晓斌季筱璐吉钰瑶贾泽坤姜侯兵姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson N.Kalantar-Nayestanaki 康晓珅 R.Kappert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann T.lenz 李聪李翠李春花李澄李德民李飞李刚李贺 H.Li 李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李紫源梁浩梁昊梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat C.X.Lin 林德旭 T.Lin 刘北江刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏卢泽辉罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 FEMaas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi H.Muramatsu Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥 Y.Pan A.Pathak A.Pathak M.Pelizaeus 彭海平 K.Peters J.Pettersson 平加伦平荣刚 S.Plura S.Pogodin R.Poling V.Prasad 齐法制齐航漆红荣祈鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 S.Q.Qu Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Jilin University Changchun 130012China Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16

The cross sections of e^(+)e^(-)→K^(+)K^(-)J/Ψat center-of-mass energies from 4.127 to 4.600 GeV are measured based on 15.6 fb-1data collected with the BESⅢ detector operating at the BEPCⅡ storage ring.Two resonant structures are observed in the line shape of the cross sections.The mass and width of the first structure are measured to be(4225.3±2.3±21.5)MeV and(72.9±6.1±30.8)MeV,respectively.They are consistent with those of the established Y(4230).The second structure is observed for the first time with a statistical significance greater than 8σ,denoted as Y(4500).Its mass and width are determined to be(4484.7±13.3±24.1)MeV and(111.1±30.1±15.2)MeV,respectively.The first presented uncertainties are statistical and the second ones are systematic.The product of the electronic partial width with the decay branching fractionΓ(Y(4230)→e^(+)e^(−))B(Y(4230)→K^(+)K^(−)J/Ψ)is reported.

关键词： Y states charmonium-like states BESⅢ

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