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Image cytometric DNA analysis of mucosal biopsies in patients with primary achalasia

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World Journal of Gastroenterology 2006年第19期12卷 3020-3025页

作者： I Gockel P K(a|¨)mmerer J Brieger UR heinrich WJ Mann F Bittinger VF Eckardt T Junginger Department of General and Abdominal Surgery Johannes Gutenberg-University Mainz Laboratory of Tumor Biology Department of Otolaryngology Johannes Gutenberg-UniversityMainz Institute of Pathology Johannes Gutenberg-University Mainz Department of Gastroenterology German Diagnostic Clinic Wiesbaden

AIM： To determine DNA aneuploidy in mucosal biopsies of achalasia patients for subsequent rapid diagnosis. METHODS： Biopsies from the middle third of the esophagus were obtained in 15 patients with achalasia. Immunohistochemical staining was carried out with monoclonal antibodies MIB-1 for Ki67 and PAb 1801 for p53, in addition to the conventional histologic examination for dysplasia. Nuclei of fresh biopsy material were enzymatically and mechanically isolated, and the DNA content was determined with image cytometry after Feulgen staining. DNA grading of malignancy was assessed according to Boecking to determine the variability of DNA values noted around the normal diploid peak. Further indices measured included the aneuploid rate, and the 5c-, 7c- and 9c-exceeding rate. RESULTS： The histological examination did not demonstrate dysplasia; while MIB-1 （basal） showed a positive reaction in 8/15 achalasia specimens, p53 was negative in all specimens. Image cytometric DNA analysis detected aneuploidy in 4/15 （26.7%） specimens. Samples from 15 patients with squamous cell carcinoma as well as specimens obtained exclusively 2 cm proximal to the tumor served as reference tests. All carcinomas （15/15） as well as 9 of the peritumoral samples （9/15） were aneuploid. The comparison of biopsies from achalasia patients with peritumoral and carcinoma specimens revealed statistically significant differences regarding the aneuploid rate （diploid： P 〈 0.0001; tetraploid： P = 0.001）, grading of malignancy according to Boecking （P 〈 0.0001） and the 5c- （P 〈 0.0001）, 7c-（P 〈 0.0001）, and 9c- （P = 0.0001） exceeding rate with progredient DNA alterations in the respective order. CONCLUSION： The finding that DNA aneuploidy was identified by image cytometry in esophageal specimens of patients with achalasia, which may be due to specific chromosomal alterations presenting as precancerous lesions in 27% of patients, leads us to conclude that image cytometry represents a valuable screening

关键词： Achalasia Precancerous epithelial alterations Esophageal carcinoma Image cytometric DNA analysis Proliferation marker Ki67 Tumor suppressor gene p53

ENUMERATION OF (0,1)-MATRICES WITH CONSTANT ROW AND COLUMN SUMS

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Applied Mathematics:A Journal of Chinese Universities 2006年第4期21卷 479-486页

作者： heinrich Niederhausen Boca Raton Dept.of Math.Sci. Florida Atlantic Univ. FL 33431 USA

Let fs,t(m,n) be the number of (0,1) - matrices of size m x n such that each row has exactly s ones and each column has exactly t ones (sm = nt). How to determine fs,t(m,n)? As R. P. Stanley has observed (Enumerative CombinatoricsⅠ(1997), Example 1.1.3), the determination of fs,t(m, n) is an unsolved problem, except for very small s, t. In this paper the closed formulas for f2,2(n,n), f3,2(m,n), f4,2(m,n) are given. And recursion formulas and generating functions are discussed.

关键词： (0 1)-matrices labelled ball arrangement generating function.

In situ mass spectrometry of autoimmune liver diseases

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Cellular & Molecular Immunology 2011年第3期8卷 237-242页

作者： Christopher L Bowlus Erin H Seeley Joanna Roder Julia Grigorieva heinrich Roder Richard M Caprioli M Eric Gershwin Division of Gastroenterology and Hepatology University of CaliforniaDavisCAUSA Mass Spectrometry Research Center Vanderbilt University School of MedicineNashvilleTNUSA Biodesix Steamboat SpringsCOUSA Division of Clinical Immunology Allergy and RheumatologyUniversity of CaliforniaDavisCAUSA

Primary biliary cirrhosis(PBC),primary sclerosing cholangitis(PSC)and autoimmune hepatitis(AIH)are the major forms of autoimmune liver diseases each characterized by the destruction of a specific liver cell type and the presence of differing *** took a proteomic approach utilizing in situ matrix-assisted laser desorption/ionization mass spectrometry(MALDI MS)to obtain profiles directly from liver samples of patients with PBC,PSC,AIH and *** ability to precisely localize the region for acquisition of MALDI MS allowed us to obtain profiles from bile ducts,inflammatory infiltrates and hepatocytes from each biopsy *** tools developed to identify peaks and compare peaks across diseases and cell types were used to develop models to classify the *** an initial set of testing samples from PBC patients and controls,we identified unique peaks present in bile ducts,inflammatory infiltrates and hepatocytes that could classify samples in a validation cohort with 88–91%***,profiles of PSC and AIH did not differ significantly from *** of proteins in these peaks may represent novel autoantigens or effector *** findings illustrate the potential of a proteomic approach to autoimmune diseases with in situ MALDI MS.

关键词： autoimmune hepatitis mass spectrometry primary biliary cirrhosis primary sclerosing cholangitis

Erica Fox Brindley, Music, Cosmology, and the Politics of Harmony in Early China.

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Frontiers of Philosophy in China 2014年第3期9卷 491-494页

作者： heinrich Geiger Catholic Academic Service (KAAD)

Chinese music is a broad topic that includes a wide variety of methodological premises, which music historians, ethnomusicologists, music theorists, and systematic musicologists can use for fruitful exploration. In her book Music, Cosmology, and the Politics of Harmony in Early China （MCPH, hereafter）, Erica Fox Brindley, who is an intellectual and cultural historian of early China, undertakes an historical approach and works out the role of musical sound in the social, natural, and religious order. She explores ＂the role of music, and even sound itself, as both an agent and indicator of moral, orderly, and cosmically balanced rule＂（42）. Based on early imperial texts Brindley points out that already during the Warring States period （481-221BC） sound （sheng 声） is clearly a component of the cosmos and later, during the Han Dynasty （202BC-220AD）, possesses special cosmic efficacy （69）. The concept of sheng plays an important role in her explanations of the cosmological and political aspects of music,

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Dark Energy and Extreme CPA Laser Pulses for Non-thermal Igniting Laser Boron Fusion

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Journal of Energy and Power Engineering 2019年第10期13卷 369-372页

作者： heinrich Hora Department of Theoretical Physics University of New South WalesSydney 2052Australia

The difficulty with pressures at equilibrium temperatures in the range of dozens of hundred millions of°C for igniting nuclear fusion,can be overcome by the non-thermal pressures from interacting electric and magnetic laser fields with varying optical constants at laser interaction shown by nonlinear *** domination at the just reached picosecond CPA(chirped pulse acceleration)laser pulses at ultra-extreme powers led to measurements of laser fusion of hydrogen with boron-11 with orders of magnitudes higher energy gains than the earlier known classical low *** types of field densities without optical line radiation may be considered as an interstellar plasma state within galaxies representing the dark matter and dark energy.

关键词： Electromagnetic energy density CPA laser pulses laser boron fusion interstellar magnetic dark energy.

Sign, Image and Language in The Book of Changes CYijing 易经）

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Frontiers of Philosophy in China 2013年第4期8卷 607-623页

作者： heinrich Geiger Asia Department Catholic Academic Exchange Service (KAAD) 53129 Bonn Germany

It is challenging to estimate the degree to which the system of the Trigrams and Hexagrams in The Book of Changes （Yijing） had an impact on the whole history of Chinese thought. The universal paradigm from which it was derived formed the basis of a semiotic theory of evolution which, because of structural analogies, was applied to all fields and aspects of human life where decision making and action in correspondence with a cosmic principle was required. To achieve that goal, countless commentaries on and interpretations of the Yijing have been written. They can be divided into two schools. The first used the Yijing as a book for divination, in combination with manifestations of the universe and nature. The second interpreted it with a philosophical background, making it part of the tradition of Confucian thought. Modem scholars have also contributed some new approaches to the Yijing. My paper is based on the assumption that the Trigrams and Hexagrams of the Yijing cannot be understood in a purely representational way. They do not represent things apart from their relation to human needs or consciousness. Because of the co-determination of text and reader as a task without determinate end-points, it proves to be a unique case of effective-history. In the Yijing, there is no real line between culture and nature, sign/image/language and fact, the universe of semiosis and other universes. With its use of signs, images and language, the Yijing confirms that the universe of semiosis is the universe of heaven, earth and man. Against this background, my explanations will not only focus on the Trigrams and Hexagrams. My paper will also deal with the following topics：（1） interpenetration of linguistic meaning and objective reality and （2） the social nature of verbal or literary expression.

关键词： mind cosmology effective-history relation meaning sign image,language Yijing

Long-term follow-up after complete ablation of Barrett's esophagus with argon plasma coagulation

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World Journal of Gastroenterology 2005年第8期11卷 1182-1186页

作者： Ahmed Madisch Stephan Miehike Ekkehard Bayerdoerffer Birgit Wiedemann David Antos Anke Sievert Michael Vieth Manfred Stolte heinrich Schulz Medical Department Ⅰ Department of Hematology and Oncology Institute of Medical Statistics and Biometry Clinic for Pediatric Diseases Gastroenterologist in private practice Institute of Pathology

AIM: To report the long-term outcome of patients after complete ablation of non-neoplastic Barrett's esophagus (BE) with respect to BE relapse and development of intraepithelial neoplasia or esophageal adenocarcinoma. METHODS: In 70 patients with historically proven non neoplastic BE, complete BE ablation was achieved by argon plasma coagulation (APC) and high-dose proton pump inhibitor therapy (120 mg omeprazole daily). Sixty-six patients (94.4%) underwent further surveillance endoscopy. At each surveillance endoscopy four-quadrant biopsies were taken from the neo-squamous epithelium at 2 cm intervals depending on the pre-treatment length of BE mucosa beginning at the neo-Z-line, and from any endoscopically suspicious lesion. RESULTS: The median follow-up of 66 patients was 51 mo (range 9-85 mo) giving a total of 280.5 patient years. A mean of 6 biopsies were taken during surveillance endoscopies. In 13 patients (19.7%) tongues or islands suspicious for BE were found during endoscopy. In 8 of these patients (12.1%) non-neoplastic BE relapse was confirmed histologically giving a histological relapse rate of 3% per year. In none of the patients, intraepithelial neoplasia nor an esophageal adenocarcinoma was detected. Logistic regression analysis identified endoscopic detection of islands or tongues as the only positive predictor of BE relapse (P= 0.0004). CONCLUSION: The long-term relapse rate of non neoplastic BE following complete ablation with high-power APC is low (3% per year).

关键词： Barrett's esophagus Argon plasma coagulation Esophageal adenocarcinoma

Tetranuclear yttrium and gadolinium 2-acetylcyclopentanoate clusters：Synthesis and their use as spin-coating precursors for metal oxide film formation for field-effect transistor fabrication

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Journal of Rare Earths 2018年第10期36卷 1098-1105页

作者： Elaheh Pousaneh Andrea Preuβ Khaybar Assim Tobias Rüffer Marcus Korb Jana Tittmann-Otto Sascha Hermann Stefan E.Schulz heinrich Lang Technische Universitat Chemnitz Faculty of Natural Sciences Institute of Chemistry Inorganic Chemistry D-09107 Chemnitz Germany Technische Universitiat Chemnitz Center for Mierotechnologies D-09107 Chemnitz Germany Fraunhofer Institute for Electronic Nano Systems ENAS Technologie-Campus 3 D-09126 Chemnitz Germany

Lanthanide clusters [Ln4（μ3-OH）2（η2-accp）4（（μ-O）-η2-accp）6]（Ln = Y（4）,Gd（5）; accp = 2-acetylcyclopentanoate） are accessible by treatment of [M（NO33·6 H2 O]（M = Y（1）,Gd（2）） with 3 equiv. of Haccp（3） in presence of NaOH. The molecular structures of 4 and 5） in the solid-state are discussed. The thermal behavior of 4 and 5 was studied by TG under Ar and O2, showing multistep decomposition processes. Additionally, DSC studies were carried out under an atmosphere of O2. PXRD measurements of the TG residues confirm the formation of Ln2 ***-coating experiments were carried out with 4 and 5 for Ln2 O3 film deposition on silicon substrates. The layers are smooth, close and are of thicknesses of 18.87±1.13 nm and 25.59 ± 4.55 nm for Ln = Y and Gd, which was evidenced by SEM and EDX studies. Field-effect transistors were successfully fabricated by deposition of carbon nanotubes on top of the Y2 O3 films and formation of palladium contacts by a lift-off procedure. An on/off ratio of more than 4 orders of magnitude is achieved without considerable leakage currents. These results demonstrate the potential use of spin-coated Y2 O3 as a gate dielectric in electronic devices.

关键词： β-Diketonates Yttrium Gadolinium Thermal analysis Spin coating CNT transistor

Non-thermal laser driven plasma-blocks for proton boron avalanche fusion as direct drive option

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Matter and Radiation at Extremes 2017年第4期2卷 177-189页

作者： heinrich Hora Shalom Eliezer Noaz Nissim Paraskevas Lalousis Department of Theoretical Physics University of New South WalesSydneyAustralia Soreq Research Center YavneIsrael Institute of Electronic Structure and Laser FORTH HeraklionGreece

Fusion energy from protons reacting with ^(11) B,HB11,is extremely difficult or impossible when using thermal ignition by laser *** changes radically when using picosecond laser pulses with powers above petawatts dominated by nonlinear force driven ultrahigh ac-celeration of plasma blocks for a non-thermal initiation of igniting solid density HB11 *** a cylindrical trapping of the reaction,laser produced ultrahigh magnetic fields above kiloTesla,have to be *** experimentally confirmed highly increased HB11 fusion gains due to avalanche reaction may lead to a scheme of an environmentally clean and economic power reactor.

关键词： Boron laser fusion Plasma-block ignition ultrahigh acceleration Kilotesla field trapping Avalanche reaction Power reactor