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Retinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke

Stroke & Vascular Neurology 2023年第5期8卷 379-386,I0001-I0007页

作者： Philipp Klyscz Thomas Ihl Inga Laumeier Maureen Steinicke Matthias Endres Georg Michelson heinrich J Audebert Neurology Charité-Universitätsmedizin BerlinBerlinGermany Center for Stroke Research Berlin Charité-Universitätsmedizin BerlinBerlinGermany Berlin Institute of Health BerlinGermany Excellence Cluster NeuroCure Charité-Universitätsmedizin BerlinBerlinGermany German Center for Neurodegenerative Diseases partner site BerlinGermany German Center for Cardiovascular Research partner site BerlinGermany Ophthalmology Friedrich-Alexander-Universität Erlangen-Nürnberg Medizinische FakultätErlangenGermany Talkingeyes&More GmbH ErlangenGermany

Background and purpose Retinal pathologies are an independent risk factor for ischaemic stroke,but research on the predictive value of retinal abnormalities for recurrent vascular events in patients with prior stroke is *** investigated the association of retinal pathologies with subsequent vascular *** In a substudy of the Intensified secondary prevention intending a reduction of recurrent events in TIA and minor stroke patients(INSPiRE-TMS)trial,we enrolled patients with recent transient ischaemic attack(TIA)or minor stroke with at least one modifiable risk *** outcome was the composite of subsequent vascular *** photographs were taken at baseline and categorised into three different fundus groups by a telemedically linked *** 722 patients participated in the current study and 109 major vascular events *** multivariable adjustments,we did not find a significant association between fundus categories and risk for subsequent vascular events(HRs for moderate vascular retinopathy and vascular retinopathy with vessel rarefaction in comparison to no vascular retinopathy 1.03(95%CI 0.64 to 1.67),p=0.905 and 1.17(95%CI 0.62 to 2.20),p=0.626).In a selective post hoc analysis in patients with diabetes mellitus and hypertension,patients with vascular retinopathy with vessel rarefaction had a higher risk for recurrent stroke(HR 24.14(95%CI 2.74 to 212.50),p=0.004).Conclusions Retinal changes did not predict major subsequent vascular events in patients with recent TIA or minor *** studies are needed to examine the utility of fundus photography in assessing the risk of stroke recurrence in patients with diabetes mellitus and hypertension.

关键词： patients Retinal prevention

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Photonic two-particle quantum walks in Su–Schrieffer–Heeger lattices

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Photonics Research 2021年第1期9卷 I0003-I0009页

作者： FRIEDERIKE KLAUCK MATTHIAS heinrich ALEXANDER SZAMEIT Institute for Physics University of Rostock18059 RostockGermany

We report on the experimental demonstration of two-photon quantum walks at the edge of a photonic Su–Schrieffer–Heeger lattice and compare them to those observed when launching photons at the edge of a homogeneous *** at the topological edge,one of the photons primarily remains close to the edge,both photons penetrate freely from the trivial edge into the *** behavior manifests also in the average interparticle distance,which is significantly larger at the topological ***,for a given propagation length,the entangled two-photon state launched at the topological edge extends over a wider domain of the lattice.

关键词： quantum topological particle

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Novel technique for measurement of coating layer thickness of fine and porous particles using focused ion beam

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Particuology 2019年第1期17卷 190-198页

作者： M. Goslinska I. Selmer C. Kleemann U.Kulozik I. Smirnova S. heinrich Hamburg University of Technology Institute of Solids Process Engineering and Particle TechnologyDenickestr1521073 HamburgGermany Hamburg University of Technology Institute of Thermal Separation ProcessesEiJ^endorfer Str. 3821073 HamburgGermany Technical University of Munich Chair of Food and Bioprocess EngineeringWeihenstephaner Berg 185354 FreisingGermany

A novel technique for the measurement of the coating layer thickness of fine particles was developed in this work based on cross-sectioning of micrometre-sized single coated particles using focused ion beam (FIB) milling. This technique was tested on two batches of aerogel particles coated with thin coatings in a spouted bed. The FIB milling procedure consisted of two steps. First, the desired part of the coated particle was removed using a high ion beam current. The resulting cross-sectioned area was then polished using a lower ion beam current to make the cross-section clearly visible. The FIB milling process was controlled with simultaneous scanning electron microscopy (SEM). Afterwards, the coating layer thickness was evaluated using the SEM images. The coating layer was successfully applied on the porous aerogel microparticles in the spouted bed. The coating uniformity of the highly porous particles increased with increasing sprayed coating solution amount, with up to 91% of the particle pores being covered. The FIB-cross-sectioning technique using an ion beam of 2.50 nA for the first milling and 0.43 nA for polishing of the surface resulted in successful generation of cross-sections of representative particles with a visible particle core and coating layer. A coating layer thickness of approximately 700 nm was achieved on particles with sizes of below 45 μm.

关键词： Coating layer thickness Focused ion beam Microparticle Aerogel Spouted bed Dilute spouting

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Modelling growing space of four valuable broadleaved tree species in southern China

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Forestry Studies in China 2013年第3期15卷 167-178页

作者： Johanna SCHULER Josephine CUENI heinrich SPIECKER Wen-Fu GUO Faculty of Environment and Natural Resources Albert-Ludwigs-Universitt Sci-Tech Division of the Experimental Centre for Tropical Forestry Chinese Academy of Forestry

We present management tools for growing four valuable broadleaved tree species, indigenous to *** southern China. Crown diameter （CD） of the species studied can be predicted very well by using a model that is so e y a near funct on of d ameter at breast he ght （DBH）. The add t on of tree age （AGE） and yield class （YC） to this-nodel did not significantly improve its predictive capacity. We used species-specific crown diameter models to calcu- ate the amount of growing space and subsequently stand density that each species needs to achieve desired stem ＂adial growth rates. Furthermore we used this information to calculate a ＂distance factor＂, a rule of thumb that roughly ~stimates the distance between two neighboring trees needed to achieve a desired future target diameter. These tools ＇acilitate the planning of thinning regimes by using crown diameter models combined with annual radial growth rates to ;alculate the number of crop trees per hectare required to reach a desired target stem diameter.

关键词： crown diameter diameter growth growth model valuable timber management tool

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A Prototype for Diagnosis of Psoriasis in Traditional Chinese Medicine

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Computers, Materials & Continua 2022年第12期73卷 5197-5217页

作者： Hai Long Zhe Wang Yidi Cui Junhui Wang Bo Gao Chao Chen Yan Zhu heinrich Herre Institute of Medical Informatics Statistics and EpidemiologyUniversity of LeipzigLeipzig04107Germany Zhejiang Academy of Traditional Chinese Medicine Hangzhou310007China Tongde Hospital of Zhejiang Province Hangzhou310007China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing100053China Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing100700China

Psoriasis is a chronic,non-communicable,painful,disfiguring and disabling disease for which there is no cure,with great negative impact on patients’quality of life(QoL).Diagnosis and treatment with traditional Chinese medical technique based on syndrome differentiation has been used in practice for a long time and proven effective,though,up to now,there are only a few available studies about the use of semantic technologies and the knowledge systems that use Traditional Chinese Medicine(TCM)-syndrome differentiation for information retrieval and automated *** this paper we use semantic techniques based on ontologies to develop a prototypical system for the diagnosis of *** this purpose,a domain ontology is developed for syndrome differentiation of psoriasis vulgaris(PV).This ontology is founded on an adapted version of the general formal ontology(GFO),with the evidence-based clinical practice guideline of TCM for psoriasis vulgaris(Guideline 2013)as the primary data *** implemented prototype,called ONTOPV,contains this domain ontology and is aimed at a decision support system for diagnosis and treatment of *** system uses a case-database for Case Based Reasoning(CBR),combined with fuzzy pattern *** results show that the ONTOPV realizes the basic functionalities of data collection,querying,browsing and navigation,and supports rule-based knowledge reasoning,and integrates fuzzy pattern *** can provide users with clinical decision support for TCM syndrome differentiation in diagnosis of psoriasis.

关键词： Clinical guideline knowledge base GFO ontology TCM CBR fuzzy pattern recognition psoriasis vulgaris

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Priority areas for watershed service conservation in the Guapi-Macacu region of Rio de Janeiro,Atlantic Forest,Brazil

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Ecological Processes 2014年第1期3卷 95-115页

作者： Vanesa Rodriguez Osuna Jan Borner Udo Nehren Rachel Bardy Prado Hartmut Gaese Jurgen heinrich Center for Development Research(ZEF) Department of Economic and Technological ChangeUniversity of BonnWalter-Flex-Str.353117 BonnGermany Institute for Technology and Resources Management in the Tropics and Subtropics(ITT) Cologne University of Applied SciencesBetzdorfer Str.250679 CologneGermany Empresa Brasileira de Pesquisa Agropecuária(EMBRAPA Soils) Brazilian Enterprise for Agricultural ResearchGeotechnologies and Environmental MonitoringRua Jardim BotanicoCEP 22460-000 Rio de JaneiroBrazil Institute for Geography Department of Physical GeographyUniversity of LeipzigJohannisallee 19a04103 LeipzigGermany

Introduction:Land use intensification and urbanisation processes are degrading hydrological ecosystem services in the Guapi-Macacu watershed of Rio de Janeiro.A proposal to pay farmers to restore natural watershed services might be an alternative to securing the water supply in the long-term for the around 2.5 million urban water users in the study *** study quantifies the costs of changing current land use patterns to enhance watershed services and compares these costs to the avoided costs associated with water treatment for public ***:We use farm-household data to estimate the opportunity costs of abandoning current land uses for the recovery of natural vegetation;a process that is very likely to improve water quality in terms of turbidity due to reduced inputs from *** cost estimates are extrapolated to the watershed scale based on remote sensing land use classifications and vulnerability analysis to identify priority zones for watershed management *** assess the potential demand for watershed services,we analyse water quality and treatment cost data from the main local water treatment ***:Changing agricultural land uses for watershed services provision generally comes at high opportunity costs in our study area near to the metropolis of Rio de *** low cost watershed conservation options do exist in the livestock production *** options have the potential to directly reduce the amount of sediments and nutrients reaching the water bodies,and in turn decrease the costs of treatment needed for drinking *** cover changes at the scale needed to improve water quality will,nonetheless,likely exceed the cost of additional investments in water ***:The state water utility company’s willingness to pay for watershed services alone will not be enough to induce provision of additional watershed *** conclude that monetary incentives conditioned on specific adjustme

关键词： Water services Drinking water treatment Water quality Incentive-based watershed management

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Hypercalcaemia after treatment with denosumab in children:bisphosphonates as an option for therapy and prevention?

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World Journal of Pediatrics 2020年第5期16卷 520-527页

作者： Carmen Sydlik Hans Roland Dürr Susanne Bechtold-Dalla Pozza Claudia Weiβenbacher Julia Roeb heinrich Schmidt Department of Pediatric Endocrinology Dr.v.Haunersches Children's HospitalLudwig-Maximilian-University of MunichLindwurmstr.480337 MunichGermany Department of Orthopaedics Physical Medicine and RehabilitationUniversity HospitalLudwig-Maximilian-University of MunichMunichGermany

Background Pharmacologic options for treatment of osteolytic diseases especially in children are *** not licensed for use,denosumab,a fully humanized antibody to RANKL,is used in children with good *** others,one possible indication are giant cell tumors and aneurysmatic bone ***,there are reports of severe hypercalcemia during weeks to months after termination of denosumab,that are rarely seen in *** We collected data of four patients,aged 6-17 years,who experienced severe hypercalcemia after completion of treatment with denosumab for unresectable giant cell tumors of bone or aneurysmal bone cysts and methods of their *** detailed case information were *** One patient was treated with long-term,high-dose steroid therapy,leading to typical Cushing's *** patient was restarted on denosumab repeatedly due to relapses of hypercalcemia after every ***,in two patients,hypercalcemia ceased definitely after treatment with ***,several applications were necessary to stabilize calcium *** There is a considerable risk of hypercalcemia as an adverse effect after denosumab treatment in *** and,preferably,preventive strategies are *** seem to be an option for both,but effective proceedings still remain to be established.

关键词： Aneurysmatic bone cyst Bisphosphonates Calcium homeostasis Denosumab Giant cell tumor of the bone

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Comparative eye-tracking evaluation of scatterplots and parallel coordinates

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Visual Informatics 2017年第2期1卷 118-131页

作者： Rudolf Netzel Jenny Vuong Ulrich Engelke Seán O’Donoghue Daniel Weiskopf Julian heinrich Visualization Research Center(VISUS) University of StuttgartStuttgartGermany Commonwealth Scientific and Industrial Research Organisation(CSIRO)(Sydney Hobart)Australia University of Tübingen TübingenGermany

We investigate task performance and reading characteristics for scatterplots(Cartesian coordinates)and parallel *** a controlled eye-tracking study,we asked 24 participants to assess the relative distance of points in multidimensional space,depending on the diagram type(parallel coordinates or a horizontal collection of scatterplots),the number of data dimensions(2,4,6,or 8),and the relative distance between points(15%,20%,or 25%).For a given reference point and two target points,we instructed participants to choose the target point that was closer to the reference point in multidimensional *** present a visual scanning model that describes different strategies to solve this retrieval task for both diagram types,and propose corresponding hypotheses that we test using task completion time,accuracy,and gaze positions as dependent *** results show that scatterplots outperform parallel coordinates significantly in 2 dimensions,however,the task was solved more quickly and more accurately with parallel coordinates in 8 *** eye-tracking data further shows significant differences between Cartesian and parallel coordinates,as well as between different numbers of *** parallel coordinates,there is a clear trend toward shorter fixations and longer saccades with increasing number of *** an area-of-interest(AOI)based approach,we identify different reading strategies for each diagram type:For parallel coordinates,the participants’gaze frequently jumped back and forth between pairs of axes,while axes were rarely focused on when viewing Cartesian *** further found that participants’attention is biased:toward the center of the whole plot for parallel coordinates and skewed to the center/left side for Cartesian *** anticipate that these results may support the design of more effective visualizations for multidimensional data.

关键词： Parallel coordinates Scatterplots Cartesian coordinates Eye tracking Controlled laboratory user study

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Model of the Pulsing Atom

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Advances in Materials Physics and Chemistry 2017年第5期7卷 188-197页

作者： heinrich Ehrlich Chemical Department Lomonosov Moscow State University Moscow Russia

In this work, we reanalyzed the movement of an electron in the electrostatic field of nucleus. The trajectory of the electron’s motion is an ellipse with a minor semiaxis, tending towards zero. From a mathematical point of view the movement of an electron in such an orbit will be equivalent to the oscillation of an electron. The action produced by electrons in movement between stationary points is discrete and proportional to a Planck constant. This condition sets the allowable values of the electron energy and the radius of their orbit. Electrons on the same shell perform symmetric synchronous oscillations. Their frequency is of the order of 1016 Hz. Most of the time the electrons are located on the periphery of the atom, periodically they simultaneously rush to the nucleus, the atom rapidly compresses and immediately decompresses, i.e. pulsates. The model gives Bohr formula for the energy of single-electron atom and suitable values of ionization potentials of the atoms of the second period of the Periodic Table.

关键词： Atom Structure Quantum Theory Oscillation Bohr-Sommerfeld Model Ionization Potentials

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Influence of zone formation on stability of continuous fluidized bed layering granulation with external product classification

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Particuology 2015年第6期13卷 1-7页

作者： C. Dreyschultze C. Neugebauer S. Palis A. Buck E. Tsotsas S. heinrich A. Kienle Otto yon Guericke University Universit~tsplatz 2 D-39106 Magdeburg Germany Max Planck Institute for Dynamics of Complex Technical Systems Sandtorstraabe 1 D-39106 Magdeburg Germanyc Hamburg University of Technology Denickestrae 15 D-21073 Hamburg Germany

Continuous fluidized bed layering granulation with external product classification and a sieve-mill cycle can show instability in the form of self-sustained nonlinear oscillations of the particle size distribution. In the present study, the stability and bifurcation analysis of this process is presented. The underlying process models explicitly account for compartmentalization of the fluidized bed into a granulation and a drying zone, which is an important feature of many technical processes. Implications for plant operations are discussed with the help of stability diagrams as a function of zone size, residence time within different zones, the addition of external seeds and particular properties of the sieve-mill cycle.

关键词： Fluidized bed Granulation Population balance Stability Bifurcation

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