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A Validation Study of the Deep-Learning-Based Prostate Imaging Reporting and Data System Scoring Algorithm

Open Journal of Radiology 2022年第3期12卷 59-67页

作者： Ryusuke Irie Maki Amano Kazusa Sugeno Shingo Okada Ali Kamen Bin Lou heinrich von busch Robert Grimm Dorin Comaniciu Toshiaki Akashi Ryohei Kuwatsuru Shigeo Horie Kanako K. Kumamaru Shigeki Aoki Department of Radiology Juntendo University School of Medicine Tokyo Japan Department of Radiology Juntendo University Shizuoka Hospital Shizuoka Japan Digital Technology and Innovation Division Siemens Healthineers Princeton USA Digital Health Siemens Healthcare GmbH Erlangen Germany MR Application Predevelopment Siemens Healthcare GmbH Erlangen Germany Department of Urology Juntendo University School of Medicine Tokyo Japan

Purpose: The Prostate Imaging Reporting and Data System (PI-RADS) was introduced to standardize prostate cancer diagnosis by MRI. However, the inter-reader agreement by PI-RADS scoring is not always high. The purpose of this study was to validate a deep-learning-based diagnostic algorithm of PI-RADS. Methods: We applied a Siemens Healthineers Prostate Artificial Intelligence (AI) prototype (work in progress) for fully automated prostate lesion detection, classification and reporting. More than 2000 bi-parametric MRI studies along with the PI-RADS reports were included as training, validation, and test data. This prospective validation study includes 101 consecutive patients suspected of prostate cancer, and 100 patients were included in the analysis. All subjects underwent a noncontrast-enhanced bi-parametric MRI including T2-weighted and diffusion-weighted imaging. Two board-certified radiologists independently scored the PI-RADS, and if there were disagreements;another radiologist confirmed the diagnosis. We compared the AI results with the interpretation results by the radiologists. Results: The sensitivity of our AI model for PI-RADS ≥ 4 was 0.76, and the specificity was 0.76. For the cases with PI-RADS ≥ 3, the sensitivity was 0.69, and the specificity was 0.76. In the lesion-based analysis, AI detection rates of PI-RADS 3, 4, 5 lesions in the peripheral zone were 43%, 63%, and 100%, respectively. In the transition zone, AI detection rates of PI-RADS 3, 4, 5 were 30%, 54%, and 100%, respectively. Conclusion: Our deep-learning-based algorithm has been validated and shown to help score PI-RADS.

关键词： Deep Learning Artificial Intelligence Prostate Cancer PI-RADS

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欧洲第一个高油酸低亚麻酸冬油菜品种——“SPLENDOR”

欧洲第一个高油酸低亚麻酸冬油菜品种——“SPLENDOR”

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第十二届国际油菜大会

作者： Jean Pierre,Despeghel heinrich,busch Claude Sciaccaluga Nelly Guguin Lili Lehmann MONSANTO SAS Centre de Recherche de Boissay 28310 Toury France

我们主要工作是选育具有高油酸低亚麻酸(HOLL)的冬油菜品种(纯系)。我们一直在收集具有稳定油酸和亚麻酸的材料,它们经过多年多点鉴定,具有较好的农艺性状和正常的油菜形态。值得一提的是,我们所获得的HOLL品系无带化现象,并且根系发育...

我们主要工作是选育具有高油酸低亚麻酸(HOLL)的冬油菜品种(纯系)。我们一直在收集具有稳定油酸和亚麻酸的材料,它们经过多年多点鉴定,具有较好的农艺性状和正常的油菜形态。值得一提的是,我们所获得的HOLL品系无带化现象,并且根系发育正常,不像文献中所报道的大多数突变体那样。对具有常规脂肪酸含量(但油酸含量不同:低油酸75%,或亚麻酸<3.5%)的冬油菜品种间进行了杂交。这些材料通过自交系统选至F7代甚至更高世代。对所有世代脂肪酸都进行分析,而且对主要的育种性状(如熟期、抗倒、抗病)进行选择,以消除带化,保证根系等发育正常。F1代以后的所有世代都进行脂肪酸成份分析,只保留那些油酸超过75%且亚麻酸低于3.5%的育种材料。通过这种方法获得了一系列HOLL品种,并且“SPLENDOR”成为欧洲第一个获得注册的HOLL品种。“SPLENDOR”于2004年在法国注册,它的油酸含量为76.48%,亚麻酸含量为2.73%,这是两年14个点的测试结果。

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Genetic diversity of food-medicinal Lycium *** China:Insights from chloroplast genome

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Chinese Herbal Medicines 2024年第3期16卷 401-411页

作者： Ruyu Yao Bin Wang Michael heinrich Qiuling Wang Peigen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikou 570311China Research Group‘Pharmacognosy and Phytotherapy’ UCL School of PharmacyUniversity of LondonLondon WC1N1AXUnited Kingdom Kunming Institute of Botany Chinese Academy of SciencesKunming 650201China

Objective:Goji(fruits of Lycium spp.)is commonly consumed as food and *** increasing market demand for goji has led to its wide cultivation and broad breeding,which might cause loss of genetic *** study aims to uncover the genetic diversity of the cultivated and wild ***:The chloroplast genome(CPG)of 34 accessions of Chinese food-medicinal Lycium spp.,including the popular cultivars and their wild relatives,was re-sequenced and assembled,based on which the genetic diversity was ***:Sequence structural comparison shows that CPG is comparatively conserved within *** analysis indicates that CPG is sufficient for the discrimination of Lycium species;combined with nuclear ribosomal internal transcribed spacer(Nr ITS)sequences,materials with mixed genetic backgrounds can be *** diversity analysis reveals that the modern cultivars are probably with a common maternal parent,while the wild accessions are with higher level of genetic ***:For the first time this study reveals the intraspecies genetic diversity of Lycium *** CPG,highlighting the urgent conservation demand of wild genetic resources of *** study also demonstrates that CPG provides crucial evidence for identification of Lycium species with mixed genetic backgrounds and highlights the importance of the wild relatives in genetic diversity *** CPG-based technology will contribute to the sustainable development of medicinal plants broadly.

关键词： chloroplast genome cultivar food-medicine genetic diversity goji wild relative

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MP-PIC simulation of circulating fluidized beds using an EMMS based drag model for Geldart B particles

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Particuology 2021年第6期19卷 76-90页

作者： Timo Dymala Tom Wytrwat Stefan heinrich Hamburg University of Technology Institute of Solids Process Engineering and Particle TechnologyDenickestr.1521073 HamburgGermany

In this study the multiphase particle-in-cell(MP-PIC)method is used for the simulation of two pilot-scale circulating fluidized beds(CFBs)with quartz sand belonging to Geldart’s group B as bed *** simulations were performed using a homogeneous drag model as well as a structure dependent drag model based on the energy minimization multi-scale method(EMMS).The results are compared with experimental data from literature as well as *** simulations with the EMMS based drag model show a good agreement of the time-averaged axial solids concentration,circulation rate and riser pressure ***,a lower grid sensitivity is observed compared to the homogeneous drag *** contrast to the conventional drag model a dense bottom zone is predicted by the EMMS based drag *** overprediction of the solid concentration in the dense bottom zone is presumably due to an overprediction of the cluster diameter that is calculated using an empirical cluster diameter *** shows the necessity for a new meso-scale cluster correlation for the simulation of Geldart B ***,the results of the time-averaged radial solids concentration differ from the expectations of a core-annulus flow indicating that a mesh refinement at the walls is ***,the importance of using a realistic particle size distribution is identified.

关键词： 3D-CFD simulation Circulating fluidized bed(CFB) Multiphase particle-in-cell method(MP-PIC) Energy minimizing multi-scale theory(EMMS) Validation study

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Pathological tumor response to neoadjuvant therapy in borderline resectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 305-306页

作者： Stefan heinrich General Visceral and Transplantation Surgery University Hospital of Mainz

Surgery is the standard therapy for pancreatic ductal adenocarcinoma(PDAC).After the dramatic decline of operative mortality over the past decades,the indications for pancreas resections have been continuously extended:currently resections of the portal/superior mesenteric vein are considered standard by many centers,and even arterial resections are under *** these changes,different expert groups have defined resectability criteria containing a grey zone(“borderline resectable disease”)of tumors,which may be technically resectable with appropriate surgical expertise,but resection inherits an increased risk of an R1-resection[1].

关键词： Surgery mortality operative

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Why surgeons care about systemic chemotherapy for pancreatic cancer?

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 860-863页

作者： Stefan heinrich Department of General Visceral and Transplantation SurgeryUniversity Hospital of MainzMainzGermany

Pancreatic adenocarcinoma(PDAC)has become the seventh most frequent cause of cancer death in the world with increasing incidence independent of patient sex and age with smoking and alcohol consumption being the most important risk factors(1).The high mortality rate is mainly attributed to the biological characteristics of this disease:even small tumors reveal perineural invasion or local spread into lymph and blood vessels resulting in systemic *** estimated risk of occult distant metastasis at the time of surgery is 28%and 94%for tumors with a diameter of 1 and 3 cm,respectively(2).Consequently,many patients present with disseminated or locally advanced disease and are at high risk for early tumor recurrence(3).

关键词： cancer invasion mortality

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The current role of liver surgery in the treatment of colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 552-554页

作者： Stefan heinrich General Visceral and Transplantation SurgeryUniversity Hospital of MainzMainzGermany

Since the establishment of a survival benefit for patientswith colorectal cancer liver metastases(CRLM)undergoingliver resection,perioperative outcome has continuouslyimproved,and surgery for CRLM is currently offered... 详细信息

关键词： colorectal surgery metastases

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Variability of European beech wood density as influenced by interactions between treering growth and aspect

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Forest Ecosystems 2016年第3期3卷 165-173页

作者： Daniela Diaconu Marc Wassenberg heinrich Spiecker Chair of Forest Growth and Dendroecology Albert-Ludwigs-University

Background： Wood density is considered to be the most important predictor of wood quality but despite its importance, diffuse-porous tree species have been the subject of only a limited number of studies. The importance of European beech forests for Central Europe calls for profound research to examine the potential impact of a warmer climate on the quality of beech timber. Methods： In this study we analysed the influence of tree-ring width and tree-ring age on the wood density of beech, and whether the wood density response to these two parameters is modified by aspect. A linear mixed-effects model for wood density was constructed for mean density data measured with high frequency densitometry on stem discs from 72 beech trees sampled from two different aspects （northeast -NE and southwest -SW） of a valley in southwestern Germany. Results： Part of the variability of mean annual wood density was explained by cambial age： an increase in cambial age resulted in an increase in mean wood density. Tree-ring width and aspect had only a small influence on wood density, Wood density on the SW aspect was lower than on the NE with a difference of approximately 0.006 g/cm3. The between-tree variability was very high. Conclusions： The significant interaction between cambial age and aspect reflects the importance of site conditions at older tree ages： with increasing cambial age the difference between aspects becomes stronger. Our results give a better understanding of the importance of site conditions on the wood quality of beech.

关键词： Fagus sylvatica HF densitometry Wood quality Wood density Aspect

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Neoadjuvant therapy for pancreatic ductal adenocarcinoma—real effects or patient selection?

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 289-291页

作者： Stefan heinrich Department of General Visceral and Transplantation Surgery University Hospital of Mainz Mainz Germany

Surgery is the only treatment with curative potential for patients with pancreatic ductal adenocarcinoma (PDAC).Unfortunately, the majority of patients do not qualify for curative resection due to locally advanced or ... 详细信息

关键词： adenocarcinoma Surgery curative

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法律解释的修辞学基础

法律方法

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法律方法 2024年第2期 224-246页

作者： [德]海因里希·洪塞尔韦达(译) 苏黎世大学萨尔茨堡大学华东政法大学

法律解释的论证属性植根于其修辞学渊源。古代修辞学的争点论在法律上的最大影响是语义与目的之区分。在修辞学的视野中,法律解释的发展即是由文义解释优先演变至目的解释主导的过程。法律解释中的修辞因素使整个解释过程更注重形成正... 详细信息

法律解释的论证属性植根于其修辞学渊源。古代修辞学的争点论在法律上的最大影响是语义与目的之区分。在修辞学的视野中,法律解释的发展即是由文义解释优先演变至目的解释主导的过程。法律解释中的修辞因素使整个解释过程更注重形成正确的论证,而非产生适当的理解。法律解释是一种论证理论,而非认识论。通过认识要素与决断要素的区分,司法判决的正义性便在于如何进行自圆其说且令人信服的论证。

关键词：法律解释修辞学文义解释目的解释法律论证

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