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Genetic diversity of food-medicinal Lycium *** China:Insights from chloroplast genome

Chinese Herbal Medicines 2024年第3期16卷 401-411页

作者： Ruyu Yao Bin Wang Michael heinrich Qiuling Wang Peigen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikou 570311China Research Group‘Pharmacognosy and Phytotherapy’ UCL School of PharmacyUniversity of LondonLondon WC1N1AXUnited Kingdom Kunming Institute of Botany Chinese Academy of SciencesKunming 650201China

Objective:Goji(fruits of Lycium spp.)is commonly consumed as food and *** increasing market demand for goji has led to its wide cultivation and broad breeding,which might cause loss of genetic *** study aims to uncover the genetic diversity of the cultivated and wild ***:The chloroplast genome(CPG)of 34 accessions of Chinese food-medicinal Lycium spp.,including the popular cultivars and their wild relatives,was re-sequenced and assembled,based on which the genetic diversity was ***:Sequence structural comparison shows that CPG is comparatively conserved within *** analysis indicates that CPG is sufficient for the discrimination of Lycium species;combined with nuclear ribosomal internal transcribed spacer(Nr ITS)sequences,materials with mixed genetic backgrounds can be *** diversity analysis reveals that the modern cultivars are probably with a common maternal parent,while the wild accessions are with higher level of genetic ***:For the first time this study reveals the intraspecies genetic diversity of Lycium *** CPG,highlighting the urgent conservation demand of wild genetic resources of *** study also demonstrates that CPG provides crucial evidence for identification of Lycium species with mixed genetic backgrounds and highlights the importance of the wild relatives in genetic diversity *** CPG-based technology will contribute to the sustainable development of medicinal plants broadly.

关键词： chloroplast genome cultivar food-medicine genetic diversity goji wild relative

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根据智能手机数据预测个性

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数据分析与知识发现 2020年第7期4卷 75-75页

作者：本刊讯 Clemens Stachl Quay Au Ramona Schoedel Samuel D.Gosling Gabriella M.Harari Daniel Buschek Sarah Theres Volkel Tobias Schuwerk Michelle Oldemeier Theresa Ullmann heinrich hussmann Bernd Bischl Markus Bühner 不详

智能手机用户都不可避免地产生大量可供他人访问的数据,这些数据为识别用户的性格提供线索。心理学家正在研究如何揭示这些线索。对于世界各地的大多数人来说,智能手机已经成为他们日常生活中不可或缺的组成部分。这些设备不断收集的数... 详细信息

智能手机用户都不可避免地产生大量可供他人访问的数据,这些数据为识别用户的性格提供线索。心理学家正在研究如何揭示这些线索。对于世界各地的大多数人来说,智能手机已经成为他们日常生活中不可或缺的组成部分。这些设备不断收集的数据是名副其实的"金矿",不仅是IT公司,科学界对这些数据也产生了极大的兴趣。

关键词：数据预测智能手机 IT公司名副其实日常生活心理学家

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MP-PIC simulation of circulating fluidized beds using an EMMS based drag model for Geldart B particles

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Particuology 2021年第6期19卷 76-90页

作者： Timo Dymala Tom Wytrwat Stefan heinrich Hamburg University of Technology Institute of Solids Process Engineering and Particle TechnologyDenickestr.1521073 HamburgGermany

In this study the multiphase particle-in-cell(MP-PIC)method is used for the simulation of two pilot-scale circulating fluidized beds(CFBs)with quartz sand belonging to Geldart’s group B as bed *** simulations were performed using a homogeneous drag model as well as a structure dependent drag model based on the energy minimization multi-scale method(EMMS).The results are compared with experimental data from literature as well as *** simulations with the EMMS based drag model show a good agreement of the time-averaged axial solids concentration,circulation rate and riser pressure ***,a lower grid sensitivity is observed compared to the homogeneous drag *** contrast to the conventional drag model a dense bottom zone is predicted by the EMMS based drag *** overprediction of the solid concentration in the dense bottom zone is presumably due to an overprediction of the cluster diameter that is calculated using an empirical cluster diameter *** shows the necessity for a new meso-scale cluster correlation for the simulation of Geldart B ***,the results of the time-averaged radial solids concentration differ from the expectations of a core-annulus flow indicating that a mesh refinement at the walls is ***,the importance of using a realistic particle size distribution is identified.

关键词： 3D-CFD simulation Circulating fluidized bed(CFB) Multiphase particle-in-cell method(MP-PIC) Energy minimizing multi-scale theory(EMMS) Validation study

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Pathological tumor response to neoadjuvant therapy in borderline resectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 305-306页

作者： Stefan heinrich General Visceral and Transplantation Surgery University Hospital of Mainz

Surgery is the standard therapy for pancreatic ductal adenocarcinoma(PDAC).After the dramatic decline of operative mortality over the past decades,the indications for pancreas resections have been continuously extended:currently resections of the portal/superior mesenteric vein are considered standard by many centers,and even arterial resections are under *** these changes,different expert groups have defined resectability criteria containing a grey zone(“borderline resectable disease”)of tumors,which may be technically resectable with appropriate surgical expertise,but resection inherits an increased risk of an R1-resection[1].

关键词： Surgery mortality operative

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Why surgeons care about systemic chemotherapy for pancreatic cancer?

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 860-863页

作者： Stefan heinrich Department of General Visceral and Transplantation SurgeryUniversity Hospital of MainzMainzGermany

Pancreatic adenocarcinoma(PDAC)has become the seventh most frequent cause of cancer death in the world with increasing incidence independent of patient sex and age with smoking and alcohol consumption being the most important risk factors(1).The high mortality rate is mainly attributed to the biological characteristics of this disease:even small tumors reveal perineural invasion or local spread into lymph and blood vessels resulting in systemic *** estimated risk of occult distant metastasis at the time of surgery is 28%and 94%for tumors with a diameter of 1 and 3 cm,respectively(2).Consequently,many patients present with disseminated or locally advanced disease and are at high risk for early tumor recurrence(3).

关键词： cancer invasion mortality

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The current role of liver surgery in the treatment of colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 552-554页

作者： Stefan heinrich General Visceral and Transplantation SurgeryUniversity Hospital of MainzMainzGermany

Since the establishment of a survival benefit for patientswith colorectal cancer liver metastases(CRLM)undergoingliver resection,perioperative outcome has continuouslyimproved,and surgery for CRLM is currently offered... 详细信息

关键词： colorectal surgery metastases

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Variability of European beech wood density as influenced by interactions between treering growth and aspect

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Forest Ecosystems 2016年第3期3卷 165-173页

作者： Daniela Diaconu Marc Wassenberg heinrich Spiecker Chair of Forest Growth and Dendroecology Albert-Ludwigs-University

Background： Wood density is considered to be the most important predictor of wood quality but despite its importance, diffuse-porous tree species have been the subject of only a limited number of studies. The importance of European beech forests for Central Europe calls for profound research to examine the potential impact of a warmer climate on the quality of beech timber. Methods： In this study we analysed the influence of tree-ring width and tree-ring age on the wood density of beech, and whether the wood density response to these two parameters is modified by aspect. A linear mixed-effects model for wood density was constructed for mean density data measured with high frequency densitometry on stem discs from 72 beech trees sampled from two different aspects （northeast -NE and southwest -SW） of a valley in southwestern Germany. Results： Part of the variability of mean annual wood density was explained by cambial age： an increase in cambial age resulted in an increase in mean wood density. Tree-ring width and aspect had only a small influence on wood density, Wood density on the SW aspect was lower than on the NE with a difference of approximately 0.006 g/cm3. The between-tree variability was very high. Conclusions： The significant interaction between cambial age and aspect reflects the importance of site conditions at older tree ages： with increasing cambial age the difference between aspects becomes stronger. Our results give a better understanding of the importance of site conditions on the wood quality of beech.

关键词： Fagus sylvatica HF densitometry Wood quality Wood density Aspect

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Neoadjuvant therapy for pancreatic ductal adenocarcinoma—real effects or patient selection?

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 289-291页

作者： Stefan heinrich Department of General Visceral and Transplantation Surgery University Hospital of Mainz Mainz Germany

Surgery is the only treatment with curative potential for patients with pancreatic ductal adenocarcinoma (PDAC).Unfortunately, the majority of patients do not qualify for curative resection due to locally advanced or ... 详细信息

关键词： adenocarcinoma Surgery curative

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法律解释的修辞学基础

法律方法

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法律方法 2024年第2期 224-246页

作者： [德]海因里希·洪塞尔韦达(译) 苏黎世大学萨尔茨堡大学华东政法大学

法律解释的论证属性植根于其修辞学渊源。古代修辞学的争点论在法律上的最大影响是语义与目的之区分。在修辞学的视野中,法律解释的发展即是由文义解释优先演变至目的解释主导的过程。法律解释中的修辞因素使整个解释过程更注重形成正... 详细信息

法律解释的论证属性植根于其修辞学渊源。古代修辞学的争点论在法律上的最大影响是语义与目的之区分。在修辞学的视野中,法律解释的发展即是由文义解释优先演变至目的解释主导的过程。法律解释中的修辞因素使整个解释过程更注重形成正确的论证,而非产生适当的理解。法律解释是一种论证理论,而非认识论。通过认识要素与决断要素的区分,司法判决的正义性便在于如何进行自圆其说且令人信服的论证。

关键词：法律解释修辞学文义解释目的解释法律论证

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Influence of liquid layers on energy absorption during particle impact

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Particuology 2009年第4期7卷 245-259页

作者： Sergiy Antonyuk Stefan heinrich Niels Deen Hans Kuipers Hamburg University of Technology Institute of Solids Process Engineering and Particle Technology Denickestr. 15 21071 Hamburg Germany University of Twente Fundamentals of Chemical Reaction Engineering Faculty of Science and Technology PO Box 217 Enschede 7500 AE The Netherlands

The influence of the thickness of a covering liquid layer and its viscosity as well as the impact velocity on energy loss during the normal impact on a flat steel wall of spherical granules with a liquid layer was studied. Free-fall experiments were performed to obtain the restitution coefficient of elastic-plastic γ- Al2O3 granules by impact on the liquid layer, using aqueous solutions of hydroxypropyl methylcellulose with different concentrations for variation of viscosity （1-300 mPa s）, In the presence of a liquid layer, increase of liquid viscosity decreases the restitution coefficient and the minimum thickness of the liquid layer at which the granule sticks to the wall. The measured restitution coefficients were compared with experiments performed without liquid layer. In contrast to the dry restitution coefficient, due to viscous losses at lower impact velocity, higher energy dissipation was obtained, A rational explanation for the effects obtained was given by results of numerically solved force and energy balances for a granule impact on a liquid layer on the wall. The model takes into account forces acting on the granule including viscous, surface tension, capillary, contact, drag, buoyancy and gravitational forces. Good agreement between simulations and experiments has been achieved.

关键词： Granule impact Restitution coefficient Energy dissipation Liquid layer Liquid bridge

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