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Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

Signal Transduction and Targeted Therapy 2023年第10期8卷 5085-5095页

作者： Ye Peng Lin Zhang Chris K.P.Mok Jessica Y.L.Ching Shilin Zhao Matthew K.L.Wong Jie Zhu Chunke Chen Shilan Wang Shuai Yan Biyan Qin Yingzhi Liu Xi Zhang Chun Pun Cheung Pui Kuan Cheong Ka Long Ip Adrian C.h.Fung Kenneth K.Y.Wong David S.C.hui Francis K.L.Chan Siew C.ng hein M.Tun Microbiota I-Center(MaglC) Hong KongChina Jockey Club School of Public health and Primary Care The Chinese University of Hong KongHong KongChina Li Ka Shing Institute of health Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina Stanley ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina Centre for Gut Microbiota Research The Chinese University of Hong KongHong KongChina

The role of gut microbiota in modulating the durability of cOVID-19 vaccine immunity is yet to be *** this cohort study,we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline,1 month,and 6 months post vaccination(p.v).Neutralisation antibody,plasma cytokine and chemokines were measured and associated with the gut microbiota and metabolome composition.

关键词： vaccine immunity vaccines

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A Simplified Analytical Procedure for Simultaneous Determination of Alkylphenol Ethoxylates and Brominated Flame Retardants in Fish Tissue Samples from Vaal River,South Africa

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American Journal of Analytical Chemistry 2015年第5期6卷 422-428页

作者： Tlou B.Chokwe Jonathan O.Okonkwo Linda L.Sibali Elmari Kruger hein du Preez Reveck hariram Esper J.Ncube Scientific Services Rand WaterVereenigingSouth Africa Department of Environmental Water and Earth SciencesTshwane University of TechnologyPretoriaSouth Africa Directorate of Research and Innovation Tshwane University of TechnologyPretoriaSouth Africa

In this study, the concentration of alkylphenol ethoxylates (APEs) and brominated flame retardants (BFRs) were determined in fish samples, Labeo umbratus and Carp, collected from the Vaal River in South Africa. Ultrasonic-assisted extraction technique was used to extract the organic contaminants from fish samples, and the resulting extract was purified by sulphuric acid lipid removal followed by Strata X-cartridge SPE clean-up. The APEs and BFRs were derivatized using heptafluorobutyric anhydride before analysis with GC-MS. In both types of fish samples, lower oligomers of APEs were more abundant than the higher oligomers, while hBCD, BDE99 and PBB101 were the dominant BFRs. The concentrations of these pollutants ranged from 1.061 ng/g lipids (t-BP) in Labeo umbratus to 11.860 ng/g lipids (hBCD) in Carp.

关键词： Alkylphenol Ethoxylates Brominated Flame Retardants Fish Sample heptafluorobutyric Anhydride Derivatization Vaal River South Africa

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