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The speed of kill of fluralaner(BravectoTM) against Ixodes ricinus ticks on dogs

The speed of kill of fluralaner(BravectoTM) against Ixodes r...

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中国畜牧兽医学会兽医药理毒理学分会第十五次学术讨论会

作者： Christina Wengenmayer heike williams Eva Zschiesche Andreas Moritz Judith Langenstein Rainer KA Roepke Anja R Heckeroth MSD Animal Health Innovation GmbH Zur Propstei Department of Veterinary Clinical Sciences Clinical PathophysiologyJustus-Liebig-University

Background:Pathogens that are transmitted by ticks to dogs,such as Anaplasma phagocytophilum,Babesia spp.,Borrelia burgdorferi sensu latu,and Ehrlichia canis,are an increasing problem in the *** method to prevent pathogen transmission to dogs is to kill the ticks before transmission ***(Bravecto) is a novel isoxazoline insecticide and acaricide that provides long persistent antiparasitic activity following systemic *** study investigated the speed of kill of fluralaner against Ixodes ricinus ticks on ***:A total of 48 dogs were randomized to 8 groups of 6 dogs and each dog was infested with 50 female and 10 male *** *** days later(day 0),4 groups received a single treatment of 25 mg fluralaner/kg body weight as Bravecto chewable tablets;the dogs in the other 4 groups were left *** control and treatment groups were paired at each time point(4,8,12,or 24 hours after treatment) for assessment of tick-killing *** 4,8,and 12 weeks after treatment,all dogs were re-infested with 50 female *** ticks and subsequently assessed for live or dead ticks at either 4,8,12,or 24 hours after *** was calculated for each assessment time point by comparison of the treatment group with the respective control ***:Tick-killing efficacy was 89.6% at 4 hours,97.9% at 8 hours,and 100% at12 and 24 hours after treatmentEight hours after re-infestation,efficacy was 96.8%,83.5%,and 45.8% at 4,8,and 12 weeks after treatment,*** least 98.1% tick-killing efficacy was demonstrated 12 and 24 hours after re-infestation over the entire 12 week study ***:Fluralaner kills ticks rapidly after treatment at 4 hours,and over its entire 12-week period of efficacy,it achieves an almost complete killing effect within 12 hours after tick *** rapid tick-killing effect together with the long duration of efficacy enables fluralaner to aid in the prevention of tick

关键词： BravectoTM chewable tablets Fluralaner Speed of kill Dog Tick Ixodes ricinus Tick-borne diseases Efficacy

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