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Epigenetic modification associated with climate regulates betulin biosynthesis in birch

Journal of Forestry Research 2023年第1期34卷 21-35页

作者： Jiang wang Bowei Chen Shahid Ali Tianxu Zhang Yu wang He Zhang Lishan wang Yonglan Zhang Linan Xie Tingbo Jiang Jing Yin heike w.sederoff Gaurav Zinta Ronald R.sederoff Yuhua Li Qingzhu Zhang State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040People’s Republic of China College of Life Sciences Northeast Forestry UniversityHarbin 150040People’s Republic of China Forest Biotechnology Group Department of Forestry and Environmental ResourcesNorth Carolina State UniversityRaleighNC 27695USA Biotechnology Division CSIR-Institute of Himalayan Bioresource TechnologyPalampur 176061India

The Betula genus contains pentacyclic triterpenoid betulin known for its environmental adaptation and medicinal ***,the mechanisms underlying betulin biosynthesis responding to climate change remain *** this study,the role of epigenetic modification(DNA methylation) in betulin biosynthesis was examined and how climatic factors influence ***-genome bisulfite sequencing was performed for greenhouse-grown Chinese white birch(Betula platyphylla Sukaczev) treated with DNA methylation inhibitor zebularine(ZEB) and a natural birch population in Northeast *** treatment significantly affected the CHH methylation level of transposable elements and betulin content in a hormesis dose-dependent *** methylation and expression of bHLH9,a key transcriptional factor controlling betulin biosynthesis,were also consistently affected by ZEB treatment as a hormetic *** the natural population,there was a positive correlation between promoter methylation of bHLH9 and summer precipitation,while winter temperature was negatively *** climate-dependent methylation of bHLH9 regulates the expression of downstream genes involved in betulin *** study highlights the role of environmental signals to induce epigenetic changes that result in betulin production,possibly helping to develop resilient plants to combat ongoing climate change and enhance secondary metabolite production.

关键词： Epigenetics DNA methylation Betulin bHLH9 transcription factor Hormesis Climate change Secondary metabolite

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Exceptionally high genetic variance of the doubled haploid(DH)population of poplar

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林业研究:英文版 2023年第6期34卷 1941-1950页

作者： Caixia Liu Sui wang Yi Liu Meng wang Erqin Fan Chen Liu Shikai Zhang Chuanping Yang Junhui wang heike w.sederoff Xiangling You Vincent L.Chiang Su Chen Ronald R.sederoff Guanzheng Qu College of Life Science Northeast Forestry UniversityHarbin 150040People’s Republic of China State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040People’s Republic of China Key Laboratory of Soybean Biology in Chinese Ministry of Education Northeast Agricultural UniversityHarbin 150030People’s Republic of China State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of State Forestry AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091People’s Republic of China Department of Plant and Microbial Biology North Carolina State UniversityRaleighNC 27695USA Forest Biotechnology Group Department of Forestry and Environmental ResourcesNorth Carolina State UniversityRaleighNC 27695USA

Doubled haploid(DH)plants have been widely used for breeding and biological research in *** ulus *** been used as model woody plant species for biological ***,the induction of DH poplar plants is onerous,and limited biological or breeding work has been carried out on DH individuals or *** this study,we provide an effective protocol for poplar haploid induction based on an anther culture method.A total of 96 whole DH plant lines were obtained using an F1hybrid of Populus simonii×*** as a donor *** phenotypes of the DH population showed exceptionally high variance when compared to those of half-sib progeny of the donor *** DH line displayed distinct features compared to those of the other DH lines or the donor ***,some excellent homozygous lines have the potential to be model plants in genetic and breeding studies.

关键词： Populus Anther culture Doubled haploid Genetic variance Flow cytometry

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Qu-2,a robust poplar suspension cell line for molecular biology

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Journal of Forestry Research 2021年第2期32卷 733-740页

作者： Caixia Liu Kailong Li Meng wang Erqin Fan Chuanping Yang Junhui wang Pengyue Fu Xiaolan Ge heike w.sederoff Ronald Rsederoff Vincent LChiang Sui wang Guanzheng Qu State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040People’s Republic of China State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of State Forestry AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091People’s Republic of China Department of Plant and Microbial Biology North Carolina State UniversityRaleighNC 27695USA Forest Biotechnology Group Department of Forestry and Environmental ResourcesNorth Carolina State UniversityRaleighNC 27695USA Key Laboratory of Soybean Biology in Chinese Ministry of Education Northeast Agricultural UniversityHarbin 150030People’s Republic of China

Populus *** long been used as model woody plant species for molecular biology ***,tissues of poplar are often recalcitrant to experimental procedures for molecular *** generated a hormone autotrophic poplar suspension cell line from a hybrid of Populus alba×***‘Yinzhong’,named ***-2 cells are suitable as a model biological system for studying woody ***-2 cells have many advantages over suspension cell lines derived so far from any other woody ***-2 cells are very easy to cultivate and can grow on several common plant culture media without the addition of any plant *** show exceptionally high growth rates,reaching an approximately 150-fold increase in biomass after one week of *** important unique characteristic of Qu-2 cells is that they can be cryopreserved and readily ***-2 cells are suitable for molecular manipulations such as protoplast production,transient transformation,and RNA-seq ***,Qu-2 cells have the great potential to be an excellent model cell line in tree molecular biological research,ranging from physiology to gene *** Qu-2 cells will be made available to the plant community for research.

关键词： Qu-2 cell line Suspension cell Poplar Protoplast isolation Transient transformation

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Peri-implant gas accumulation in response to magnesium-based musculoskeletal biomaterials:Reframing current evidence for preclinical research and clinical evaluation

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Journal of Magnesium and Alloys 2024年第1期12卷 59-71页

作者： Yu Sun heike Helmholz Regine willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany

Historically,the rapid degradation and massive gas release from magnesium(Mg)implants resulted in severe emphysema and mechanical *** the advent of new alloys and surface treatment methods,optimized Mg implants have re-entered clinics since last decade with reliable ***,the optimization aims at slowing down the degradation process,rather than exemption of the gas *** study involved a systematic evaluation of current preclinical and clinical evidence,regarding the physical signs,symptoms,radiological features,pathological findings and complications potentially associated with peri±implant gas accumulation(PIGA)after musculoskeletal Mg *** literature search identified 196 potentially relevant publications,and 51 papers were enrolled for further analysis,including 22 preclinical tests and 29 clinical studies published from 2005 to *** Mg-based materials have been evaluated in animal research,and the application of pure Mg and Mg alloys have been reported in clinical follow-ups involving multiple anatomical sites and musculoskeletal *** tissue and intraosseous PIGA are common in both animal tests and clinical follow-ups,and potentially associated with certain adverse *** examinations especially micro-CT and clinical CT scans provide valuable information for quantitative and longitudinal *** according to simulation tests involving Mg implantation and chemical processing,tissue fixation could lead to an increase in the volume of gas cavity,thus the results obtained from ex vivo imaging or histopathological evaluations should be interpreted with *** still lacks standardized procedures or consensus for both preclinical and clinical evaluation of ***,by providing focused insights into the topic,this evidence-based study will facilitate future animal tests and clinical evaluations,and support developing biocompatible Mg implants for the treatment of musculoskeletal

关键词： Magnesium implant Degradation Hydrogen Gas release Postoperative follow-up

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Systemic modulation of skeletal mineralization by magnesium implant promoting fracture healing: Radiological exploration enhanced with PCA-based machine learning in a rat femoral model

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Journal of Magnesium and Alloys 2024年第3期12卷 1009-1020页

作者： Yu Sun heike Helmholz Regine willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonGermany

The clinical application of magnesium(Mg)and its alloys for bone fractures has been well supported by in vitro and in vivo ***,there were studies indicating negative effects of high dose Mg intake and sustained local release of Mg ions on bone metabolism or repair,which should not be ignored when developing Mg-based ***,it remains necessary to assess the biological effects of Mg implants in animal models relevant to clinical treatment *** primary purpose of this study was to validate the beneficial effects of intramedullary Mg implants on the healing outcome of femoral fractures in a modified rat *** addition,the mineralization parameters at multiple anatomical sites were evaluated,to investigate their association with healing outcome and potential clinical *** to the control group without Mg implantation,postoperative imaging at week 12 demonstrated better healing outcomes in the Mg group,with more stable unions in 3D analysis and high-mineralized bridging in 2D *** bone tissue mineral density(TMD)was higher in the Mg group at the non-operated femur and lumbar vertebra,while no differences between groups were identified regarding the bone tissue volume(TV),TMD and bone mineral content(BMC)in *** the surgical femur,the Mg group presented higher TMD,but lower TV and BMC in the distal metaphyseal region,as well as reduced BMC at the osteotomy *** component analysis(PCA)-based machine learning revealed that by selecting clinically relevant parameters,radiological markers could be constructed for differentiation of healing outcomes,with better performance than 2D *** study provides insights and preclinical evidence for the rational investigation of bioactive materials,the identification of potential adverse effects,and the promotion of diagnostic capabilities for fracture healing.

关键词： Magnesium Implants Bone fracture Mineralization Systemic modulation Principal component analysis.

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Harnessing the power of complex light propagation in multimode fibers for spatially resolved sensing

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Photonics Research 2024年第3期12卷 411-422页

作者： DARCY L.SMITH LINH V.NGUYEN MOHAMMAD I.REJA ERIK P.SCHARTNER heike EBENDORFF-HEIDEPRIEM DAVID J.OTTAwAY STEPHEN C.wARREN-SMITH Institute for Photonics and Advanced Sensing and School of Physics Chemistry and Earth SciencesThe University of AdelaideAdelaideSA 5005Australia Australian Research Council Centre of Excellence for Gravitational wave Discovery(OzGrav) AdelaideSAAustralia Future Industries Institute University of South AustraliaMawson LakesSA 5095Australia Laser Physics and Photonics Devices Laboratory University of South AustraliaMawson LakesSA 5095Australia

The propagation of coherent light in multimode optical fibers results in a speckled output that is both complex and sensitive to environmental *** properties can be a powerful tool for sensing,as small perturbations lead to significant changes in the output of the ***,the mechanism to encode spatially resolved sensing information into the speckle pattern and the ability to extract this information are thus far *** this paper,we demonstrate that spatially dependent mode coupling is crucial to achieving spatially resolved *** leverage machine learning to quantitatively extract the spatially resolved sensing information from three fiber types with dramatically different characteristics and demonstrate that the fiber with the highest degree of spatially dependent mode coupling provides the greatest accuracy.

关键词： fiber spatially resolved

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Epigenetic modification associated with climate regulates betulin biosynthesis in birch

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林业研究（英文版） 2023年第1期

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PET/MRI改善癌症患儿管理

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中华核医学与分子影像杂志 2024年第2期44卷 124-128页

作者： Lucia Baratto K.Elizabeth Hawk Lisa States Jing Qi Sergios Gatidis Louise Kiru heike E.Daldrup-Link 陈素芸(译) 王辉(审校) Department of Radiology Stanford UniversityStanfordCalifornia Department of Radiology Children′s Hospital of PhiladelphiaPhiladelphiaPennsylvania Department of Radiology Children′s WisconsinMilwaukeeWisconsin Department of Diagnostic and Interventional Radiology University Hospital TübingenTübingenGermany Department of Pediatrics Stanford UniversityStanfordCalifornia 上海交通大学医学院附属新华医院核医学科上海200092

一体化PET/MRI通过一站式成像提供肿瘤解剖学及功能评估,且与^(18)F-FDG PET/CT相比其辐射暴露量减少80%,因此对癌症患儿的分期与再分期具有显著临床价值。该文回顾了^(18)F-FDG PET/MRI在小儿肿瘤中的临床应用,尤其关注PET/MRI在患儿... 详细信息

一体化PET/MRI通过一站式成像提供肿瘤解剖学及功能评估,且与^(18)F-FDG PET/CT相比其辐射暴露量减少80%,因此对癌症患儿的分期与再分期具有显著临床价值。该文回顾了^(18)F-FDG PET/MRI在小儿肿瘤中的临床应用,尤其关注PET/MRI在患儿管理中的价值。来自4个不同机构的PET/MRI应用先行者分享了他们对PET/MRI技术在癌症患儿评估中特殊优势的见解。文章作者讨论了全身PET/MRI在评估某些解剖区域(如软组织和骨髓)中的价值以及儿童特殊的PET/MRI影像学特征,并强调了全身PET/MRI如何通过在不失去诊断准确性的同时减少所需放射学检查次数(因此减少辐射暴露),改善淋巴瘤、肉瘤和神经纤维瘤病患儿的临床管理。文章论述了PET/MRI如何帮助区分恶性肿瘤与感染性或炎性疾病;另外,简要探讨了PET/MRI用于接受免疫治疗的患儿疗效评估以及对不同诊疗一体化药物评估的未来研究方向。从儿童应用中所获得的经验也可拓展至成人患者的评估中。

关键词：肿瘤学儿科学 PET/MRI 癌症儿科肿瘤学

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A particle shape-based segmentation method to characterize spray dried materials by X-Ray microtomography

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Particuology 2023年第10期81卷 119-127页

作者： Nora Alina Ruprecht heike Teichmann Reinhard Kohlus University of Hohenheim Institute of Food Science and BiotechnologyDepartment of Process Engineering and Food PowdersGarbenstr.2570599StuttgartGermany

For accurate description of particle structure,single particle properties are required so that the properties of interest can be expressed as distributed parameters.X-Ray microtomography of the powder bed with subsequent particle separation can be used for this *** this paper,a new algorithm for X-Ray microtomography images of spray dried particles was introduced since standard methods tend to fail if the particle size distribution is *** algorithm is based on 2D shape classification and subsequent 3D reconstitution of the particle using only a shape classifier as free *** proposed algorithm was validated *** the algorithm,single particle porosities were obtained,which ranged from 0 to 70%.Prerequisites for the application of the algorithm are that a shape classifier can be set and that the 3D shape is regular.

关键词： Spray drying Particle structure X-Ray microtomography Segmentation algorithm Porosity distribution

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Effects of proteins on magnesium degradation-static *** conditions

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Journal of Magnesium and Alloys 2023年第4期11卷 1332-1342页

作者： Ruiqing Hou Frank Feyerabend heike Helmholz Vasil M.Garamus Regine willumeit-Römer School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloys Zhengzhou UniversityNo.100 Science AvenueZhengzhou 450001China Institute of Metallic Biomaterials Helmholtz-Zentrum Hereon(Hereon)Max-Planck-Str.1Geesthacht 21502Germany

The interaction between organic molecules and biomaterial surfaces determines the fate of biomaterials during their service life,which is also the research hotspots in the field of *** understand the mechanism of protein interaction with magnesium(Mg)degradation,alloying elements,immersion time,protein concentration and surface conditions have been previously considered for the effect of proteins on Mg ***,fluid flow,as one of the critical factors,drew little attention in this *** the present study,the effect of bovine serum albumin(BSA)and fetal bovine serum(FBS)on Mg degradation was compared under static and dynamic *** results revealed that both BSA and FBS slightly decreased the degradation rate of Mg in Hanks’balanced salt solution(HBSS)under static immersion due to the protein adsorption and the formation of a Ca/P-rich top layer on Mg surface,whereas under dynamic flow condition the degradation of Mg was significantly accelerated in the presence of BSA or *** reasons seemed to stem from the weakened protein adsorption on Mg surface in this case and the dynamically enhanced interaction between proteins and ions/products in solutions,which largely weaken the combination of the top Ca/P-rich layer with the inner corrosion product *** results highlight the importance of testing conditions for Mg characterization in vitro and the synergistic effect between different parameters on Mg degradation.

关键词： Flow Bovine serum albumin Fetal bovine serum Protein adsorption

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