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2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor

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Journal of Environmental Sciences 2019年第2期31卷 368-376页

作者： Yangsheng Chen Rui Sha Li Xu Yingjie Xia Yiyun Liu Xuejun Li heidi Qunhui Xie Naijun Tang Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Occupational and Environmental Health sTianjin Medical University

Emerging evidence showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) could induce expression of certain reactivation-associated genes in astrocytes, however, the consequent cellular effects and molecular mechanisms are still unclear. During the process of astrocyte reactivation, migration is a critical cellular event. In the present study, we employed woundhealing assay and Transwell? motility assay to explore the effects of TCDD on cell migration in primary cultured rat cortical astrocytes. We found that upon TCDD treatments at relative low concentrations(10^(-10) and/or 10^(-9) mol/L), the ability of primary astrocytes to migrate horizontally and vertically was promoted. In line with this cellular effect, the mR NA expression of two promigratory genes, including cell division cycle 42(CDC42) and matrix metalloproteinase 2(MMP2)was induced by TCDD treatment. Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor(AhR) pathway. So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191. We found that application of CH223191 significantly reversed the pro-migratory effects of TCDD. Interestingly, the basal ability of horizontal migration as well as basal levels of CDC42 and MMP2 expression were dramatically reduced suggesting a possible physiological role of AhR in maintaining the endogenous migration ability of the primary astrocytes. These findings support the notion that dioxin promotes astrocyte reactivation at molecular and cellular levels.

关键词： 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Astrocyte Migration Gene expression Aryl hydrocarbon receptor (AhR) pathway

Theory of a Mach Effect Thruster II

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Journal of Modern Physics 2015年第13期6卷 1868-1880页

作者： heidi f.arn Nolan van Rossum Keith Wanser James f. Woodward Department of Physics California State University Fullerton Fullerton CA USA Department of Aerospace Engineering Iowa State University Ames IA USA

According to Einstein, General Relativity contains the essence of Mach’s ideas. Mach’s principle can be summarized by stating that the inertia of a body is determined by the rest of the mass-energy content of the universe. Inertia here arises from mass-energy there. The latter, was a statement made by John Wheeler in his 1995 book, Gravitation and Inertia, coauthored by Ciufolini. Einstein believed that to be fully Machian, gravity would need a radiative component, an action-at-a-distance character, so that gravitational influences on a body from far away could be felt immediately. In 1960’s, Hoyle and Narlikar (HN) developed such a theory which was a gravitational version of the Absorber theory derived by Wheeler-feynman for classical electrodynamics and later expanded upon by Davies and Narlikar for quantum electrodynamics. The HN-field equation has the same type of mass fluctuation terms as in the Woodward Mach effect thruster theory. The force equation, used to predict the thrust in our device, can be derived from the mass fluctuation. We outline a new method for deriving the force equation. We present new experimental tests of the thruster to show that the thrust seen in our device is not due to either heating or Dean Drive effects. Successful replications have been performed by groups in Austria and Canada, but their work is still pending in the peer review literature.

关键词： Mach Effect Drive Transient Mass fluctuations Mach’s Principle Action at a Distance Advanced Waves Event Horizon

The role of seaweed as a potential dietary supplementation for enteric methane mitigation in ruminants: Challenges and opportunities

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Animal Nutrition 2021年第4期7卷 1371-1387页

作者： Byeng R.Min David Parker David Brauer heidi Waldrip Catherine Lockard Kristin Hales Alexia Akbay Simona Augyte College of Agriculture Environment and Nutrition SciencesTuskegee UniversityTuskegeeAL 36088USA United States Department of Agriculture(USDA) Agriculture Research Service(ARS)2300 Experiment Station Dr.BushlandTX 79012USA Department of Animal and food Sciences Texas Tech UniversityLubbockTX 79409USA Symbrosia Inc Kailua-KonaHI 96740USA

Seaweeds are macroalgae,which can be of many different morphologies,sizes,colors,and chemical *** include brown,red,and green *** seaweeds have been more investigated and exploited in comparison to other seaweed types for their use in animal feeding studies due to their large sizes and ease of *** in vitro and in vivo studies suggest that plant secondary compound-containing seaweeds(e.g.,halogenated compounds,phlorotannins,etc.)have the potential to mitigate enteric methane(CH_(4))emissions from ruminants when added to the diets of beef and dairy *** seaweeds including Asparagopsis *** rich in crude protein and halogenated compounds compared to brown and green *** halogenated-containing red seaweeds are used as the active ingredient in ruminant diets,bromoform concentration can be used as an indicator of antimethanogenic ***-containing brown seaweed has also the potential to decrease CH_(4) ***,numerous studies examined the possible anti-methanogenic effects of marine seaweeds with inconsistent *** work reviews existing data associated with seaweeds and in vitro and in vivo rumen fermentation,animal performance,and enteric CH4 emissions in *** understanding of the seaweed supplementation related to rumen fermentation and its effect on animal performance and CH_(4) emissions in ruminants may lead to novel strategies aimed at reducing greenhouse gas emissions while improving animal productivity.

关键词： Seaweed Bromoform Methane Phlorotannins Ruminant Cattle

Dioxin induces expression of hsa-mi R-146b-5p in human neuroblastoma cells

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Journal of Environmental Sciences 2018年第1期30卷 260-267页

作者： Tuan Xu heidi Q.Xie Yunping Li Yingjie Xia Rui Sha Lingyun Wang Yangsheng Chen Li Xu Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Dioxin can cause a series of neural toxicological effects. Micro RNAs（mi Rs） play important roles in regulating nervous system function and mediating cellular responses to environmental pollutants, such as dioxin. Hsa-mi R-146 b-5 p appears to be involved in neurodegenerative diseases and brain tumors. However, little is known about effects of dioxin on the expression of hsa-mi R-146 b-5 p. We found that the hsa-mi R-146 b-5 p expression and its promoter activity were significantly increased in dioxin treated SK-N-SH cells, a human-derived neuroblastoma cell line. Potential roles of hsa-mi R-146 b-5 p in mediating neural toxicological effects of dioxin may be due to the regulation of certain target genes. We further confirmed that hsa-mi R-146 b-5 p significantly suppressed acetylcholinesterase（ACh E） activity and targeted the3′-untranslated region of the ACh E T subunit, which has been down-regulated in dioxin treated SK-N-SH cells. functional bioinformatic analysis showed that the known and predicted target genes of hsa-mi R-146 b-5 p were involved in some brain functions or cyto-toxicities related to known dioxin effects, including synapse transmission, in which ACh E may serve as a responsive gene for mediating the effect.

关键词： 2 3 7 8-Tetrachlorodibenzo-p-dioxin(TCDD) MicroRNA Acetylcholinesterase(AChE) Neuron Transcription regulation Post-transcriptional regulation

fhree tips every parent needs to know

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空中英语教室（高级版．彭蒙惠英语） 2016年第3期 12-14,40,41页

作者： heidi Stevens

ZUR ?KONOMIE ?GYPTENS BIS ZUM ENDE DES NEUEN REICHES

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Journal of Ancient Civilizations 2017年第2期32卷 211-228页

作者： heidi Kopp-Junk Agyptologie Universitat Trier

Der Nil bildete mit seinen Nebenflüssen und Kan?len sowie einem weitverzweigten System von Landwegen ein zusammenh?ngendes Transportund Verkehrsnetz,das eine florierende Wirtschaft erm?*** dem Binnenhandel ist zudem seit frühester Zeit ein weitreichender fernhandel ***?gyptische Gesellschaft warüberwiegend agrarisch gepr?gt,und seit der frühzeit ist ein anwachsender Beamtenstand *** Durchführung von staatlichen Bauvorhaben wie Pyramiden oder Tempeln *** Arbeitseins?tzen wurde die Bev?lkerung seit dem Alten Reich zum Corvée-Dienst verpflichtet.

关键词： Der Nil bildete Beamtenstand Corvée-Dienst verpflichtet

Treatment Based on Narcolepsy Promote Sleep in Insomniacs

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科技英语学习 2007年第3期 8-9页

作者： heidi Ledford 陈静

瑞士Actelion制药公司的研究人员在新一期《自然医学》杂志上报告说,他们新发现一种可以阻止大脑激素神经肤活动的化学物质,可以帮助白天昏昏欲睡但夜间无法入睡的人摆脱痛苦。神经肽与睡眠有关,这种激素在有嗜睡症的人体内含量较低,使... 详细信息

瑞士Actelion制药公司的研究人员在新一期《自然医学》杂志上报告说,他们新发现一种可以阻止大脑激素神经肤活动的化学物质,可以帮助白天昏昏欲睡但夜间无法入睡的人摆脱痛苦。神经肽与睡眠有关,这种激素在有嗜睡症的人体内含量较低,使他们习惯性地昏昏欲睡,甚至会在工作时或驾车时入睡。研究人员称,现有的大多数治疗失眠药物都有一些副作用,会导致服用者第二天出现记忆损失和头昏等症状,但新发现的化学物质基本没有这类副作用。

关键词：化学物质 Treatment Based on Narcolepsy Promote Sleep in Insomniacs

Do people with low back pain walk differently? A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第4期11卷 450-465页

作者： Jo Armour Smith heidi Stabbert Jennifer J.Bagwell Hsiang-Ling Teng Vernie Wade Szu-Ping Lee Department of Physical Therapy Chapman UniversityIrvineCA 92618USA Department of Physical Therapy California State UniversityLong BeachCA 90840USA Department of Physical Therapy University of NevadaLas VegasNV 89154USA

Background:The biomechanics of the trunk and lower limbs during walking and running gait are frequently assessed in individuals with low back pain(LBP).Despite substantial research,it is still unclear whether consistent and generalizable changes in walking or running gait occur in association with *** purpose of this systematic review was to identify whether there are differences in biomechanics during walking and running gait in individuals with acute and persistent LBP compared with back-healthy ***:A search was conducted in PubMed,CINAHL,SPORTDiscus,and PsycINfO in June 2019 and was repeated in December *** were included if they reported biomechanical characteristics of individuals with and without LBP during steady-state or perturbed walking and *** data included spatiotemporal,kinematic,kinetic,and electromyography *** reporting quality and potential for bias of each study was *** were pooled where possible to compare the standardized mean differences(SMD)between back pain and back-healthy control ***:Ninety-seven studies were included and *** studies investigated acute pain and the rest investigated persistent *** studies investigated running *** the studies,20%had high reporting quality/low risk of *** comparison with back-healthy controls,individuals with persistent LBP walked slower(SMD=-0.59,95%confidence interval(95%CI):-0.77 to-0.42)and with shorter stride length(SMD=-0.38,95%CI:-0.60 to-0.16).There were no differences in the amplitude of motion in the thoracic or lumbar spine,pelvis,or hips in individuals with *** walking,coordination of motion between the thorax and the lumbar spine/pelvis was significantly more in-phase in the persistent LBP groups(SMD=-0.60,95%CI:-0.90 to-0.30),and individuals with persistent LBP exhibited greater amplitude of activation in the paraspinal muscles(SMD=0.52,95%CI:0.23-0.80).There were no consistent differences in ru

关键词： Biomechanics Low back pain Running Walking

Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure

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Journal of Environmental Sciences 2017年第12期29卷 92-99页

作者： Yangsheng Chen Li Xu heidi Q.H.Xie Tuan Xu Hualing fu Songyan Zhang Rui Sha Yingjie Xia Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Several cohort studies have reported that dioxin and dioxin-like polychlorinated biphenyls might impair the nervous system and lead to neurological or neurodegenerative diseases in the elder people, but there is limited research on the involved mechanism. By using microarray analysis, we figured out the differentially expressed genes between brain samples from SD rats after low-dose（0.1 μg/（kg？bw）） dioxin exposure for six months and controls. To investigate the function changes in the course of dioxin exposure, Gene Ontology（GO） annotation and Kyoto Encyclopedia of Genes and Genomes（KEGG） pathway analysis were performed on the differentially expressed genes. And the changes of several picked genes have been verified by real-time PCR. A total of 145 up-regulated and 64 down-regulated genes were identified. The metabolic processes, interleukin-1 secretion and production were significantly associated with the differentially expressed genes. And the genes regulated by dioxin also clustered to cholinergic synapse and long-term potentiation. Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin. furthermore, synaptic plasticity and neuro-immune system may be two principal affected areas by dioxin.

关键词： TCDD Long-term exposure Neurotoxicity Microarray Neuroinflammation