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Six-year outcomes in neovascular age-related macular degeneration with ranibizumab

International Journal of Ophthalmology(English edition) 2017年第1期10卷 81-90页

作者： Julie Jacob heidi Brié Anita Leys Laurent Levecq Filip mevgaerts Kris Denhaerynck Stefaan Vancayzeele Eline Van Craeyveld Ivo Abraham Karen macDonald Leuven University Eye Hospital Kapucijnenvoer 33Leuven B-3000Belgium Novartis Pharma Medialaan 40Vilvoorde B-1800Belgium Catholic University of Louvain CHU UCL NamurYvoirB-5530Belgium medisch Centrum Aarschot Langdorpsesteenweg 129Aarschot B-3200Belgium matrix45 6159 W Sunset RdTucsonAZ 85743USA Center for Health Outcomes and Pharmacoeconomic Research University of ArizonaTucsonAZ 85721USA

AIm： To evaluate the outcomes of （6y ranibizumab therapy in neovascular age-related macular degeneration （AmD）.mETHODS： HELIX was a retrospective, observational effectiveness study using medical records of patients treated in three clinics in Belgium. Patients had neovascular AmD and were initially treated with intravitreal ranibizumab （0.5 mg） between November 1, 2007 and October 31, 2008, had （6y of data available, and were treated on an ongoing, as-needed basis. Outcomes included best-corrected visual acuity （BCVA） and central retinal thickness （CRT）.RESULTS： The sample consisted of 88 eyes from 69 patients. mean age was 76.4±6.5y, most patients were female （62.3%）. most eyes （62.5%） were treatment-naive, 33 previously treated eyes had received predominantly other anti-vascular endothelial growth factor agents and verteporfin. mean baseline BCVA was 57.4±12.7 ETDRS letters and CRT was 291.5±86.1 （m. On average, patients received 20.6±11.9 ranibizumab injections over the （6y. Intervals between injections were on average 12.7±16.1wk. mean change in BCVA from baseline to last observation for the sample was less than one letter （-0.9±17.3 letters）, with an average loss of -3.2±15.6 letters in previously treated eyes versus a gain of 0.6±18.4 letters in treatment-na？ve eyes. When considering a loss of 〈15 letters over 6y as stabilization of disease, 75.9% of all eyes showed a positive （improvement or stabilization） outcome. mean change in CRT from baseline to last observation for the sample was -26.9±148.4 （m with the greatest reduction observed in treatment-naive ***： This retrospective study of 69 neovascular AmD patients treated for （6y with ranibizumab demonstrates long-term visual stabilization. In light of the natural evolution of the disease, these data confirm that ranibizumab is effective long-term under real-world conditions of heterogeneity of patients, clinicians, and centers.

关键词： ranibizumab age-related macular degeneration visual acuity central retinal thickness optical coherence tomography visual function, long-term outcome

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Factors and expectations influencing concussion disclosure within NCAA DivisionⅠathletes:A mixed methodological approach

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Journal of Sport and Health Science 2023年第3期12卷 388-397页

作者： melissa C.Kay heidi Hennink-Kaminski Zachary Y.Kerr Paula Gildner Brittany m.Ingram Kenneth L.Cameron megan N.Houston Laura A.Linnan Stephen W.marshall Karen Y.Peck Johna K.Register-mihalik School of Health Professions College of Nursing and Health ProfessionsUniversity of Southern MississippiHattiesburgMS 39406USA School of media and Journalism University of North Carolina at Chapel HillChapel HillNC 27599USA Injury Prevention Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Exercise and Sport Science College of Arts and SciencesUniversity of North Carolina at Chapel HillChapel HillNC 27599USA matthew Gfeller Sport-Related Traumatic Brain Injury Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA Center for the Study of Retired Athletes University of North Carolina at Chapel HillChapel HillNC 27599USA Keller Army Hospital United States Military AcademyWest PointNY 10996USA Departments of Physical medicine and Rehabilitation and Surgery Uniformed Services University of the Health SciencesBethesdaMD 20814USA Department of Health Behavior School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Epidemiology School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

Background:Participation in sports is associated with many benefits to all aspects of health;however,it also comes with the risk of injury,particularly ***-disclosure and care seeking following a concussion are especially important because of the lack of outwardly visible signs and/or *** recent research has explored factors affecting concussion disclosure,use of isolated methodologies limits the ability to contextualize how disclosure or nondisclosure ***,the purpose of this study was to describe the factors and expectations of National Collegiate Athletic Association(NCAA)athletes that may influence concussion ***:This mixed-methods convergent parallel research study included 25 NCAA Division I athletes representing 13 sports,all of whom completed a concussion-education session with pre-/post-test surveys and a semistructured *** athletes were at least 18 years old and on an NCAA *** surveys focused on previous concussion-related disclosure behaviors,knowledge,attitudes,beliefs,norms,and intentions about disclosing *** focused on the athletes’experiences related to concussion *** data were analyzed using descriptive statistics and mann-Whitney U *** were analyzed using a Consensual Qualitative Research ***:Participants had good concussion knowledge(median=46.0),positive attitudes(median=38.0),strong beliefs(median=13.0),and strong intentions to disclose concussion symptoms(median=7.0).None of the constructs differed by participants’*** quantitative findings were mostly positive,interview data highlighted factors that may explain why some participants are successful in disclosing concussions and why others may find disclosure *** efforts,sport culture,and medical professional presence were the primary facilitators discussed by ***,pressure,and a lack of team support were perceived as di

关键词： Education medical professional presence mixed methodological research Reporting Sport culture

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Energetic Demands and Nutritional Strategies of Elite Cross-Country Skiers During Tour de Ski: A Narrative Review

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Journal of Science in Sport and Exercise 2021年第3期3卷 224-237页

作者： Ida A.Heikura Oona Kettunen Ina Garthe heidi Holmlund Silvana Bucher Sandbakk maarit Valtonen Johanna K.Ihalainen University of Jyvaskyla JyvaskylaFinland Research Institute for Olympic Sport JyvaskylaFinland Norwegian Olympic Sport Center OsloNorway Cardiac Exercise Research Group(CERG)at Department of Circulation and medical Imaging Norwegian University of Science and TechnologyTrondheimNorway Department of Teacher Education Norwegian University of Science and TechnologyTrondheimNorway

The Tour de Ski(TDS:6-9 sprint and distance races across 9-11 days)represents the most intense competition series of the cross-country(XC)ski season and is characterized by accumulated stress from consecutive days of high-intensity(~85%-160% VO_(2max))racing,travel,cold temperatures and low to moderate altitude(500-1500 m above sea level).Here,nutritional strategies play a key supportive role for optimized health,recovery and *** narrative review aims to provide an evidence-based discussion on the energetic demands of the TDS and recommendations for nutritional strate-gies to optimize health and performance of XC skiers during and following the *** highlight several challenges that may arise during the TDS,including the following:poor energy availability(EA)due to decreased appetite or a pressure to maintain a low body weight,suboptimal carbohydrate availability due to a failure to replenish muscle glycogen stores across consecutive-day racing and increased risk of illness due to a combination of factors,including high-intensity racing,poor nutrition,sleep,travel and *** encourage XC skiers to maintain optimal overall EA across the~1.5-week period,ensure high daily carbohydrate availability,as well as the use of strategies to maintain a healthy immune *** addition,we include practical guidelines on the management of nutrition support prior to and during the *** recognize that many nutritional questions remain unanswered both in the context of elite XC ski racing and specifically for extreme demands like the TDS that should be addressed in future investigations.

关键词： Nutrition Winter sports Cross-country skiing Ski tour Carbohydrates Recovery Performance

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Ion Coordination and Transport in magnesium Polymer Electrolytes Based on Polyester-co-Polycarbonate

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Energy material Advances 2021年第1期2021卷 48-61页

作者： Bumjun Park Rassmus Andersson Sarah G.Pate Jiacheng Liu Casey PO’Brien Guiomar Hernández Jonas mindemark Jennifer L.schaefer Department of Chemical and Biomolecular Engineering University of Notre DameNotre DameIN 46556USA Department of Chemistry-Ångström Laboratory Uppsala UniversityBox 538SE-75121 UppsalaSweden

magnesium-ion-conducting solid polymer electrolytes have been studied for rechargeable mg metal batteries,one of the beyond-Li-ion *** this paper,magnesium polymer electrolytes with magnesium bis(trifluoromethane)sulfonimide(mg(TFSI)2)salt in poly(ε-caprolactone-co-trimethylene carbonate)(PCL-PTmC)were investigated and compared with the poly(ethylene oxide)(PEO)*** thermal properties and vibrational spectroscopy indicated that the total ion conduction in the PEO electrolytes was dominated by the anion conduction due to strong polymer coordination with fully dissociated mg2+.On the other hand,in PCL-PTmC electrolytes,there is relatively weaker polymer–cation coordination and increased anion–cation *** mg-and F-rich particles were observed on the Cu electrodes after polarization tests in Cu|mg cells with PCL-PTmC electrolyte,suggesting that mg was conducted in the ion complex form(mgxTFSIy)to the copper working electrode to be reduced which resulted in anion ***,the mg metal deposition/stripping was not favorable with either mg(TFSI)2 in PCL-PTmC or mg(TFSI)2 in PEO,which inhibited quantitative analysis of magnesium conduction.A remaining challenge is thus to accurately assess transport numbers in these systems.

关键词： magnesium conduction anion

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ANGIOTENSIN Ⅱ-INDUCED CELLULAR HYPERTROPHY: POTENTIAL ROLE OF THE PROTEOLYTIC ACTIVITY IN CULTURED PROXImAL TUBULE CELLS (LLC-PK1)

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Chinese medical Journal 1995年第3期 77-77页

作者： Liliana schaefer Spiros Vamuakas Roland m schaefer markus Teschner August heidiand Division of Nephrology. University of Wuerzburg GermanyDivision of Nephrology. University of Wuerzburg GermanyDivision of Nephrology. University of Wuerzburg GermanyDivision of Nephrology. University of Wuerzburg GermanyDivision of Nephrology. University of Wuerzburg Germany

In a number of renal disease tubular epithelial cells often display hypertrophy rather than hyperplasia. This hypertrophy, characterized by an increase in protein conten and cell size, as well as an accumulation of extracellular matrix, is a key process which may lead subsequently to tubulointerstitial fibrosis and end-stage renal failure.

关键词： LLC-PK1 POTENTIAL ROLE OF THE PROTEOLYTIC ACTIVITY IN CULTURED PROXImAL TUBULE CELLS INDUCED CELLULAR HYPERTROPHY PK ANGIOTENSIN

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New tidal debris nearby the Sagittarius leading tail from the LAmOST DR2 m giant stars

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Research in Astronomy and Astrophysics 2016年第8期16卷 61-70页

作者： Jing Li Chao Liu Jeffrey L.Carlin Jing Zhong Jin-Liang Hou Li-Cai Deng heidi Jo Newberg Yong Zhang Yong-Hui Hou Yue-Fei Wang Key Laboratory of Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Dept. of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute Troy NY 12180 USA Nanjing Institute of Astronomical Optics & Technology National Astronomical Observatories Chinese Academy of Sciences Nanjing 210042 China

We report two new sets of tidal debris nearby the Sagittarius （Sgr） tidal stream in the north Galactic cap （NGC） identified from the m giant stars in LAmOST DR2. The m giant stars located in the sky area of 210° 〈 A 〈 290°, and having a distance of 10-20 kpc and We/HI 〈 -0.75 show clear bimodality in their velocity distribution. We denote the two peaks as Vel-3＋83 for the one within a mean velocity of -3 km s^-1 with respect to that of the well observed Sgr leading tail at the same A and Ve1＋162＋26 for the other one with a mean velocity of 162km s^-1 with respect to the Sgr leading tail. Although the projected A-Vgsr relation of Vel-3＋83 is very similar to the Sgr leading tail, the opposite trend in the A-distance relation as compared to the Sgr leading tail suggests Vel-3＋83 has a different 3D direction of motion with any branch of the simulated Sgr tidal stream from Law ＆ majewski. Therefore, we propose it is new tidal debris not related to the Sgr stream. Similarly, the other substructure Vel＋162＋26, which is the same one as the NGC group discovered by Chou et al., also moves toward a different direction with respect to the Sgr stream, implying that it may have a different origin than the Sgr tidal stream.

关键词： Galaxy: halo -- Galaxy structure -- Galaxy kinematics and dynamics

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Future development of Good Agricultural Practice in China under globalization of traditional herbal medicine trade

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Chinese Herbal medicines 2021年第4期13卷 472-479页

作者： Ru Zhang ming-xu Zhang Yuan Chen Cong-cong Wang Chun-hong Zhang heidi Heuberger Huan-ting Li min-hui Li Baotou medical College Baotou 014040China Institute of Crop Science and Plant Breeding Bavarian State Research Center for AgricultureFreisingGermany Inner mongolia Hospital of Traditional Chinese medicine Hohhot 010020China Inner mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization Baotou 014040China Key Laboratory of Resourceology of Chinese medicinal materials Baotou 014040China Inner mongolia medical University Hohhot 010110China

Traditional herbal medicine(THm)is an important part of the traditional Chinese medicine *** to its high medicinal potential,it should not only serve for the Chinese people’s medical use,but also contribute to the world medicine,THm for the international market must be standardized and large-scale,and produced according to the"Good Agriculture Practice"(GAP).The quality of THm directly affects the patient’s treatment status and safety of ***,the quality assurance of THm runs through the entire process of research and development,production and clinical *** standardized production and cultivation of THm is the starting point of the THm industry chain and plays a decisive role in the economic development of the THm *** article summarizes the development history,limitations and future development of GAP,and clarifies the opportunities for THm in the rapid development of the international and domestic Chinese medicine *** addition,analyzing the deficiencies that were existing in the former GAP implementation process and by suggesting science-based quality measures,it is hoped to stipulate improved GAP guidelines in the future and to lay the foundation for a modern THm international trade.

关键词： Belt and Road Initiatives Good Agricultural and Collection Practices Good Agricultural Practice quality assurance traditional herbal medicine

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Low-Cost Data Acquisition Systems for Photovoltaic System monitoring and Usage Statistics

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Journal of Energy and Power Engineering 2017年第11期11卷 719-728页

作者： Sofia Fanourakis Kevin Wang Patrick mcCarthy Lihong (heidi) Jiao School of Engineering Grand Valley State University Grand Rapids M149504 USA Forest Hills Central High School Grand Rapids MI 49546 USA

This paper presents the design of a low-cost DAS （data acquisition system） for monitoring a PV （photovoltaic） system＇s electrical quantities, battery temperatures, and state of charge of the battery. The electrical quantities are the voltages and currents of the solar panels, the battery, and the system loads. The system uses an Atmega328p microcontroller to acquire data from the PV system＇s charge controller. It also records individual load information using current sensing resistors along with a voltage amplification circuit and an analog to digital converter. The system is used in conjunction with a wall power DAS for the recording of regional power outages. Both DASs record data in microSD cards. The data have been successfully acquired from both systems and have been used to monitor the status of the PV system and the local power grid. As more data are gathered, it can be used for the maintenance and improvement of the PV system through analysis of the PV system＇s parameters and usage statistics.

关键词： Low-cost data acquisition PV system microcontroller.

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Impact of management Practices on Water Extractable Organic Carbon and Nitrogen from 12-Year Poultry Litter Amended Soils

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Open Journal of Soil Science 2017年第10期7卷 259-277页

作者： Zhongqi He mingchu Zhang Aiqing Zhao heidi m. Waldrip Paulo H. Pagliari R. Daren Harmel USDA-ARS Southern Regional Research Center New Orleans USA Department of Agriculture and Horticulture University of Alaska Fairbanks Fairbanks USA Editorial Department of the Transactions of the Chinese Society of Agricultural Engineering (TCSAE) Beijing China USDA-ARS Conservation and Production Research Laboratory Bushland USA Department of Soil Water and Climate University of Minnesota Southwest Research and Outreach Center Lamberton USA USDA-ARS Center for Agricultural Resources Research Fort Collins USA

Water extractable organic carbon (WEOC) and nitrogen (WEON) are two key parameters of soil water extractable organic matter (WEOm). Proper management of manure application rate in combination with tillage and cropping management could maintain appropriate WEOC and WEON concentrations in soils while decreasing the risk of their runoff from cropland and pastures. The objective of this research was to determine the effect of poultry litter (PL) application on WEOC and WEON in soils under different crops, tillage regimes, and grazing strategies. From 2001 to 2012, PL was applied at multiple rates to cultivated fields in a corn-oat/wheat-hay rotation or to pastures grazed by cattle or ungrazed. Soil samples (0 - 15 cm) were analyzed for KCl-extractable mineral N, and WEOC, and WEON contents. In addition, Ultraviolet-visible (UV-vis) and fluorescence spectroscopies were used to characterize WEOC stability. Organic N levels were higher at the high PL application rates. The soil C:N ratio narrowed as the PL application rate increased. However, the soil from pastures which received PL tended to have a wider range of C:N ratios than soil from the cultivated fields, despite identical PL application rates. The spectral analyses indicated that WEOC properties were responsive to management and PL application rate;therefore, this parameter may be used as a guide to provide best management strategy for manure application.

关键词： Biological Index Humification Index Poultry Litter Soil Organic matter Spe-cific Absorptivity UV-Vis Spectroscopy

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Small bowel carcinoid: Location isn’t everything!

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World Journal of Gastrointestinal Surgery 2013年第8期5卷 239-244页

作者： Danielle m Hari Stephanie L Goff heidi J Reich Anna m Leung myung-Shin Sim Ji Hey Lee Edward Wolin Farin Amersi Gastrointestinal Research Program John Wayne Cancer Institute at Saint John’s Health Center Dana-Farber Cancer Institute Division of Surgical Oncology Cedars-Sinai Medical Center Department of Biostatistics John Wayne Cancer Institute at Saint John’s Health Center

AIm: To investigate the prognostic significance of the primary site of disease for small bowel carcinoid(SBC) using a population-based ***: The Surveillance,Epidemiology and End Results(SEER) database was queried for histologically confirmed SBC between the years 1988 and *** survival(OS) and disease-specific survival(DSS) were analyzed using the Kaplan-meier method and compared using Log rank *** rank and multivariate Cox regression analyses were used to identify predictors of survival using age,year of diagnosis,race,gender,tumor histology/size/location,tumor-node-metastasis stage,number of lymph nodes(LNs) examined and percent of LNs with ***: Of the 3763 patients,51.2% were male with a mean age of 62.13 *** follow-up was 50 *** 10-year OS and DSS for duodenal primaries were significantly better when compared to jejunal and ileal primaries(P = 0.02 and multivariate Cox regression analysis,after adjusting for multiple factors,primary site location was not a significant predictor of survival(P = 0.752 for OS and P = 0.966 DSS) while age,number of primaries,number of LNs examined,T-stage and m-stage were independent predictors of ***: This 21-year,population-based study of SBC challenges the concept that location of the primary lesion alone is a significant predictor of survival.

关键词： Small bowel carcinoid Primary tumor location Survival Prognosis National Comprehensive Cancer network guidelines

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