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Organotypic Models for Functional Drug Testing of Human Cancers

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Biomedical Engineering Frontiers 2023年第1期4卷 103-112页

作者： Yu Ling Huang Lindsay K.Dickerson heidi Kenerson Xiuyun Jiang Venu Pillarisetty Qiang Tian Leroy Hood Taranjit S.Gujral Raymond S.Yeung Division of Human Biology Fred Hutchinson Cancer CenterSeattleWAUSA Department of Surgery University of WashingtonSeattleWAUSA National Research Center for Translational Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Institute for Systems Biology Phenome Health InstituteSeattleWAUSA

In the era of personalized oncology,there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual *** ideal assay will serve as a diagnostic companion to inform the oncologist of the various treatments that are sensitive and insensitive,thus improving outcome while minimizing unnecessary toxicities and *** date,no such platform exists for clinical use,but promising approaches are on the horizon that take advantage of improved techniques in creating human cancer models that encompass the entire tumor microenvironment,alongside technologies for assessing and analyzing tumor *** review summarizes a number of current strategies that make use of intact human cancer tissues as organotypic cultures in drug sensitivity testing.

关键词： Cancer horizon Human

Older candidates for kidney transplantation:Who to refer and what to expect?

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World Journal of Transplantation 2016年第4期6卷 650-657页

作者： Beatrice P Concepcion Rachel C Forbes heidi M Schaefer Department of Medicine Division of Nephrology and Hypertension Vanderbilt University Medical Center Division of Kidney and Pancreas Transplantation Vanderbilt University Medical Center

The number of older end-stage renal disease patients being referred for kidney transplantation continues to increase. This rise is occurring alongside the continually increasing prevalence of older end-stage renal disease patients. Although older kidney transplant recipients have decreased patient and graft survival compared to younger patients, transplantation in this patient population is pursued due to the survival advantage that it confers over remaining on the deceased donor waiting list. The upper limit of age and the extent of comorbidity and frailty at which transplantation ceases to be advantageous is not known. Transplant physicians are therefore faced with the challenge of determining who among older patients are appropriate candidates for kidney transplantation. This is usually achieved by means of an organ systemsbased medical evaluation with particular focus given to cardiovascular health. More recently, global measures of health such as functional status and frailty are increasingly being recognized as potential tools in risk stratifying kidney transplant candidates. For those candidates who are deemed eligible, living donor transplantation should be pursued. This may mean accepting a kidney from an older living donor. In the absence of any living donor, the choice to accept lesser quality kidneys should be made while taking into account the organ shortage and expected waiting times on the deceased donor list. Appropriate counseling of patients should be a cornerstone in the evaluation process and includes a discussion regarding expected outcomes, expected waiting times in the setting of the new Kidney Allocation System, benefits of living donor transplantation and the acceptance of lesser quality kidneys.

关键词： Kidney transplant outcomes Frailty Elderly Expanded criteria donor Quality of life

Future development of Good Agricultural Practice in China under globalization of traditional herbal medicine trade

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Chinese Herbal Medicines 2021年第4期13卷 472-479页

作者： Ru Zhang Ming-xu Zhang Yuan Chen Cong-cong Wang Chun-hong Zhang heidi Heuberger Huan-ting Li Min-hui Li Baotou Medical College Baotou 014040China Institute of Crop Science and Plant Breeding Bavarian State Research Center for AgricultureFreisingGermany Inner Mongolia Hospital of Traditional Chinese Medicine Hohhot 010020China Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization Baotou 014040China Key Laboratory of Resourceology of Chinese Medicinal Materials Baotou 014040China Inner Mongolia Medical University Hohhot 010110China

Traditional herbal medicine(THM)is an important part of the traditional Chinese medicine *** to its high medicinal potential,it should not only serve for the Chinese people’s medical use,but also contribute to the world medicine,THM for the international market must be standardized and large-scale,and produced according to the"Good Agriculture Practice"(GAP).The quality of THM directly affects the patient’s treatment status and safety of ***,the quality assurance of THM runs through the entire process of research and development,production and clinical *** standardized production and cultivation of THM is the starting point of the THM industry chain and plays a decisive role in the economic development of the THM *** article summarizes the development history,limitations and future development of GAP,and clarifies the opportunities for THM in the rapid development of the international and domestic Chinese medicine *** addition,analyzing the deficiencies that were existing in the former GAP implementation process and by suggesting science-based quality measures,it is hoped to stipulate improved GAP guidelines in the future and to lay the foundation for a modern THM international trade.

关键词： Belt and Road Initiatives Good Agricultural and Collection Practices Good Agricultural Practice quality assurance traditional herbal medicine

Relationships between Emotional Well-Being, Patient Activation and Social Support among Adults with Severe Obesity Who Have Undergone Gastric Bypass Surgery

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Open Journal of Nursing 2015年第7期5卷 596-604页

作者： Hege Solberg Morten Aarflot Liv heidi Skotnes Marit Graue Department of Medicine North-Tr&oslashndelag Health Trust Namsos Hospital Namsos Norway Faculty of Health and Social Sciences Centre for Evidence-Based Practice Bergen University College Bergen Norway Department of Pediatrics Haukeland University Hospital Bergen Norway

Objective: To examine the relationship between emotional well-being, patient activation and social support in a cohort of adults with severe obesity who underwent gastric bypass surgery from January to December 2012. Design: Cross-sectional survey. Subjects: Of a total population of 129 people, aged 18 - 68 years, at a local hospital in central Norway, 64 (50%) responding to the questionnaire, 52 (81%) being women. Main Outcome Measures: The World Health Organization—Five Well-Being Index (WHO-5), the 13-item Patient Activation Measure (PAM-13), a 16-item instrument on the frequency and content of social support, and demographic and clinical data. Results: A significant positive association was found between higher level of patient activation and better emotional well-being (P = 0.02) in linear regression analysis. A higher level of family support was significantly associated with better emotional well-being (practical social support from the family (P = 0.04), emotional social support from family (P = 0.01) and from friends (P = 0.005)). Conclusion: Screening tools for emotional well-being should be used systematically in postoperative consultations to recognize those who need a more individually tailored post-surgery follow-up care after gastric bypass surgery. In addition, health care providers in both specialist and primary health care settings should consider assessing the level of social support as part of regular follow-up routines.

关键词： Emotional Well-Being Social Support Obesity Diabetes Bariatric Surgery

Corrigendum to “Development and characterization of monoclonal antibodies against human aryl hydrocarbon receptor”[J. ***.39(2016) 165–174]

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Journal of Environmental Sciences 2016年第8期46卷 259-260页

作者： Wenjing Tian Xinhui Pei heidi Qunhui Xie Sherry Li Xu Jijing Tian Qin Hu Haiming Xu Yangsheng Chen Hualing Fu Zhengyu Cao Bin Zhao Research Center for Eco-Environmental Sciences Chinese Academy of Sciences China Pharmaceutical University

Low-Cost Data Acquisition Systems for Photovoltaic System Monitoring and Usage Statistics

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Journal of Energy and Power Engineering 2017年第11期11卷 719-728页

作者： Sofia Fanourakis Kevin Wang Patrick McCarthy Lihong (heidi) Jiao School of Engineering Grand Valley State University Grand Rapids M149504 USA Forest Hills Central High School Grand Rapids MI 49546 USA

This paper presents the design of a low-cost DAS （data acquisition system） for monitoring a PV （photovoltaic） system＇s electrical quantities, battery temperatures, and state of charge of the battery. The electrical quantities are the voltages and currents of the solar panels, the battery, and the system loads. The system uses an Atmega328p microcontroller to acquire data from the PV system＇s charge controller. It also records individual load information using current sensing resistors along with a voltage amplification circuit and an analog to digital converter. The system is used in conjunction with a wall power DAS for the recording of regional power outages. Both DASs record data in microSD cards. The data have been successfully acquired from both systems and have been used to monitor the status of the PV system and the local power grid. As more data are gathered, it can be used for the maintenance and improvement of the PV system through analysis of the PV system＇s parameters and usage statistics.

关键词： Low-cost data acquisition PV system microcontroller.

How discrimination and participation are associated with psychosomatic problems among boys and girls in northern Sweden

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Health 2012年第10期4卷 866-872页

作者： heidi Carlerby Eija Viitasara Anders Knutsson Katja Gillander Gadin Department of Health Sciences Mid Sweden University Sundsvall Sweden

Background: Negative impact on health from school disturbance due to asymmetric power relations such as discrimination and offensive treatment are frequent problems among students. This study sought to analyze associations between occurrence of discrimination at schools, participation and psychosomatic problems. Methods: Pupils in grades 6 - 9 in ten schools in a northern Swedish municipality participated in the study. The frequency of discrimination at school was measured by six items: sex;culture or ethnicity;disability;religion beliefs;sexual preferences;and any other form of discrimination. The Social and Civic Objectives Scale (SCOS) was used for an estimation of the level of participation. The pupils’ health was measured by the PsychoSomatic Problem (PSP) scale. Multivariate logistic regression models were used for estimation of increased risk of PSP. The formula Z = d/s(d) was used to test mediation. Results: Two thirds of the boys and three fourths of the girls reported occurrences of discrimination at schools (p = 0.001). Discrimination was a mediating factor between participation and PSP among boys and girls as the mediating formula Z = d/s (d) was > ± 2 SD, -2.59 for boys and -39.27 for girls. Independent of each other, low participation and discrimination were associated with increased risk of PSP. Conclusion: Discrimination was a mediating factor between participation and PSP. The mediating effect was stronger in girls than in boys. There is a need for school health promotion programs focusing on participation in terms of democratic processes, communication and cooperation in the classroom.

关键词： Discrimination Participation Psychosocial School Environment PsychoSomatic Problems Scale Social and Civic Objective Scale

Resection of orthotopic murine brain glioma

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Neuroimmunology and Neuroinflammation 2021年第1期8卷 64-69页

作者： Bingtao Tang Kari Foss Terence Lichtor heidi Phillips Edward Roy Department of Molecular and Integrative Physiology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Veterinary Clinical Medicine University of Illinois at Urbana-ChampaignUrbanaIL 61802USA Carle Illinois College of Medicine University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Glioma is a malignant brain tumor with a poor *** resection is usually the first line of ***,animal models of glioma do not include surgical resection and tumors are typically treated before they become *** report demonstrates the feasibility of surgical resection of advanced gliomas in *** described technique establishes a murine model which could be used for the development of immunotherapy for advanced glioma after surgical *** of surgical resection in murine models could increase the probability that therapies developed in mice will translate to human patients.

关键词： Glioma surgical resection immunotherapy overcoming immunosuppression surgical stress prolonged survival

Thinking of,Teaching With,And Learning About The Internet

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Thinking of,Teaching With,And Learning About The Internet