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2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor

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Journal of Environmental Sciences 2019年第2期31卷 368-376页

作者： Yangsheng Chen Rui Sha Li Xu Yingjie Xia Yiyun Liu Xuejun Li heidi Qunhui Xie Naijun Tang Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Occupational and Environmental Health sTianjin Medical University

Emerging evidence showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) could induce expression of certain reactivation-associated genes in astrocytes, however, the consequent cellular effects and molecular mechanisms are still unclear. During the process of astrocyte reactivation, migration is a critical cellular event. In the present study, we employed woundhealing assay and Transwell? motility assay to explore the effects of TCDD on cell migration in primary cultured rat cortical astrocytes. We found that upon TCDD treatments at relative low concentrations(10^(-10) and/or 10^(-9) mol/L), the ability of primary astrocytes to migrate horizontally and vertically was promoted. In line with this cellular effect, the mR NA expression of two promigratory genes, including cell division cycle 42(CDC42) and matrix metalloproteinase 2(MMP2)was induced by TCDD treatment. Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor(AhR) pathway. So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191. We found that application of CH223191 significantly reversed the pro-migratory effects of TCDD. Interestingly, the basal ability of horizontal migration as well as basal levels of CDC42 and MMP2 expression were dramatically reduced suggesting a possible physiological role of AhR in maintaining the endogenous migration ability of the primary astrocytes. These findings support the notion that dioxin promotes astrocyte reactivation at molecular and cellular levels.

关键词： 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Astrocyte Migration Gene expression Aryl hydrocarbon receptor (AhR) pathway

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The role of seaweed as a potential dietary supplementation for enteric methane mitigation in ruminants: Challenges and opportunities

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Animal Nutrition 2021年第4期7卷 1371-1387页

作者： Byeng R.Min David Parker David Brauer heidi Waldrip Catherine Lockard Kristin Hales Alexia Akbay Simona Augyte College of Agriculture Environment and Nutrition SciencesTuskegee UniversityTuskegeeAL 36088USA United States Department of Agriculture(USDA) Agriculture Research Service(ARS)2300 Experiment Station Dr.BushlandTX 79012USA Department of Animal and Food Sciences Texas Tech UniversityLubbockTX 79409USA Symbrosia Inc Kailua-KonaHI 96740USA

Seaweeds are macroalgae,which can be of many different morphologies,sizes,colors,and chemical *** include brown,red,and green *** seaweeds have been more investigated and exploited in comparison to other seaweed types for their use in animal feeding studies due to their large sizes and ease of *** in vitro and in vivo studies suggest that plant secondary compound-containing seaweeds(e.g.,halogenated compounds,phlorotannins,etc.)have the potential to mitigate enteric methane(CH_(4))emissions from ruminants when added to the diets of beef and dairy *** seaweeds including Asparagopsis *** rich in crude protein and halogenated compounds compared to brown and green *** halogenated-containing red seaweeds are used as the active ingredient in ruminant diets,bromoform concentration can be used as an indicator of antimethanogenic ***-containing brown seaweed has also the potential to decrease CH_(4) ***,numerous studies examined the possible anti-methanogenic effects of marine seaweeds with inconsistent *** work reviews existing data associated with seaweeds and in vitro and in vivo rumen fermentation,animal performance,and enteric CH4 emissions in *** understanding of the seaweed supplementation related to rumen fermentation and its effect on animal performance and CH_(4) emissions in ruminants may lead to novel strategies aimed at reducing greenhouse gas emissions while improving animal productivity.

关键词： Seaweed Bromoform Methane Phlorotannins Ruminant Cattle

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Mental Illness Education through Stories of Lived Experience: Validation Review of the DoNOHarm Framework

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International Journal of Mental Health Promotion 2021年第4期23卷 455-469页

作者： Debra Rickwood Kerry Thomas Patricia M.Brown heidi Prowse Faculty of Health University of CanberraCanberra2600Australia Mental Illness Education ACT Canberra2601Australia

The lived experience of people with mental illness is a powerful way to promote mental health literacy and reduce the stigma associated with mental ***,there is little guidance on how to do this *** Illness Education ACT is an Australian organisation that since 1993 has supported volunteer educators to share their individual stories of lived experience to school and community *** 2011,they developed the DoNOHarm Framework to assist volunteers to be able to talk about their experiences in a way that is safe for them and for their audience,a gap that they recognised in *** study reports a review of the Framework,considering the extent to which it is supported by the current literature and how it is being implemented and experienced by the volunteer *** research questions were addressed by a literature review and interviews with 14 volunteer educators and the staff that support *** review of published literature over the past 10 years showed strong evidence for three of the six principles of the Framework:Context and Purpose,Recovery Emphasis,and Safe *** the principle of Respectful and Inclusive Language is widely promoted in the mental healthfield,no recent studies investigated the benefits of this ***,there was no recent research into the two principles of Limits to Helping and Self *** interviews revealed strong support for the Frame-work among *** was seen to be effective to protect the safety of both presenter and audience,ensure the relevance of the presentation,give educators confidence in their message and delivery,convey a hopeful message,and make certain that presentations were engaging for the ***,this review shows that the DoNO-Harm Frameworkfills an important gap for mental health education,with a sound evidence base where there is published evidence available.

关键词： Mental illness education lived experience storytelling harm safety framework

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Dioxin induces expression of hsa-mi R-146b-5p in human neuroblastoma cells

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Journal of Environmental Sciences 2018年第1期30卷 260-267页

作者： Tuan Xu heidi Q.Xie Yunping Li Yingjie Xia Rui Sha Lingyun Wang Yangsheng Chen Li Xu Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Dioxin can cause a series of neural toxicological effects. Micro RNAs（mi Rs） play important roles in regulating nervous system function and mediating cellular responses to environmental pollutants, such as dioxin. Hsa-mi R-146 b-5 p appears to be involved in neurodegenerative diseases and brain tumors. However, little is known about effects of dioxin on the expression of hsa-mi R-146 b-5 p. We found that the hsa-mi R-146 b-5 p expression and its promoter activity were significantly increased in dioxin treated SK-N-SH cells, a human-derived neuroblastoma cell line. Potential roles of hsa-mi R-146 b-5 p in mediating neural toxicological effects of dioxin may be due to the regulation of certain target genes. We further confirmed that hsa-mi R-146 b-5 p significantly suppressed acetylcholinesterase（ACh E） activity and targeted the3′-untranslated region of the ACh E T subunit, which has been down-regulated in dioxin treated SK-N-SH cells. Functional bioinformatic analysis showed that the known and predicted target genes of hsa-mi R-146 b-5 p were involved in some brain functions or cyto-toxicities related to known dioxin effects, including synapse transmission, in which ACh E may serve as a responsive gene for mediating the effect.

关键词： 2 3 7 8-Tetrachlorodibenzo-p-dioxin(TCDD) MicroRNA Acetylcholinesterase(AChE) Neuron Transcription regulation Post-transcriptional regulation

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Accuracy of abdominal ultrasound for the diagnosis of small bowel obstruction in the emergency department

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World Journal of Emergency Medicine 2018年第4期9卷 267-271页

作者： Sarah E. Frasure Amy F. Hildrcth Raghu Seethala heidi H. Kimberly George Washington University Hospital Washington DC 20037 USA NavalMedical Center San Diego San Diego CA 92134 USA Department of Emergency Medicine Brigham and Women 's Hospital Boston MA 02115 USA

BACKGROUND: Emergency physicians frequently encounter patients with acute small bowel obstructions(SBO). Although computed tomography(CT) imaging is the current gold standard in the assessment of patients with suspected SBO in the emergency department, a few studies have examined the use of ultrasound as an alternative imaging technique. METHODS: We evaluated the accuracy of ultrasound performed in the ED by a variety of providers(physicians with various levels of training, physician assistants) compared to CT imaging in 47 patients with suspected SBOs. RESULTS: Our data demonstrated a sensitivity of 93.8% and a specificity of 93.3% when compared to abdominal CT, and a sensitivity of 94.3% and specificity of 95.2% using a composite endpoint of abdominal CT and discharge diagnosis. CONCLUSION: Ultrasound can play an important role in the identification of small bowel obstructions in ED patients.

关键词：小学英语课外阅读阅读材料

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Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure

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Journal of Environmental Sciences 2017年第12期29卷 92-99页

作者： Yangsheng Chen Li Xu heidi Q.H.Xie Tuan Xu Hualing Fu Songyan Zhang Rui Sha Yingjie Xia Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Several cohort studies have reported that dioxin and dioxin-like polychlorinated biphenyls might impair the nervous system and lead to neurological or neurodegenerative diseases in the elder people, but there is limited research on the involved mechanism. By using microarray analysis, we figured out the differentially expressed genes between brain samples from SD rats after low-dose（0.1 μg/（kg？bw）） dioxin exposure for six months and controls. To investigate the function changes in the course of dioxin exposure, Gene Ontology（GO） annotation and Kyoto Encyclopedia of Genes and Genomes（KEGG） pathway analysis were performed on the differentially expressed genes. And the changes of several picked genes have been verified by real-time PCR. A total of 145 up-regulated and 64 down-regulated genes were identified. The metabolic processes, interleukin-1 secretion and production were significantly associated with the differentially expressed genes. And the genes regulated by dioxin also clustered to cholinergic synapse and long-term potentiation. Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin. Furthermore, synaptic plasticity and neuro-immune system may be two principal affected areas by dioxin.

关键词： TCDD Long-term exposure Neurotoxicity Microarray Neuroinflammation

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Phenolics,tannins,flavonoids and anthocyanins contents influenced antioxidant and anticancer activities of Rubus fruits from Western Ghats,India

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Food Science and Human Wellness 2019年第1期8卷 73-81页

作者： Kasipandi Muniyandi Elizabeth George Saikumar Sathyanarayanan Blassan P.George heidi Abrahamse Suman Thamburaj Parimelazhagan Thangaraj Bioprospecting Laboratory Department of BotanyBharathiar UniversityCoimbatoreTamil Nadu 641046India Department of Botany Mar Thoma CollegeChungatharaKerala 679334India Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgP.O.Box 17011Doornfontein 2028South Africa

Rubus fruits are rich in nutrition with a wide range of phytochemical and consumed by humans,but many of its wild varieties are not commercially *** exploration of these wild fruits could improve the commercial usage of these Rubus *** study focuses to analyze the phytochemical,antioxidant and cytotoxicity of three wild Rubus ellipticus,*** and *** fruits comparatively,which has not *** in vitro antioxidant studies indicated the ethyl acetate and methanol extracts of studied Rubus species competent in scavenging different stable and generated *** correlation and regression analysis also statistically supported the contents in the extracts could act against various *** between phytochemical constituent and radical scavenging activity found to be highly *** results acquired from this investigation revealed that they are equally competent and could be recommended as dietary supplements or as nutraceuticals.

关键词： Anticancer Antioxidant Flavonoids Nutraceuticals Phenolics

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Echocardiography in centenarians： characteristics, utility and follow-up

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Journal of Geriatric Cardiology 2018年第5期15卷 328-333页

作者： Jorge A Brenes-Salazar Jaime de la Fuente Punnaiah Marella Hari Chaliki Christopher Scott heidi M Connolly Roger L Click Department of Cardiovascular Diseases Mayo Clinic Rochester USA Department of Internal Medicine Mayo Clinic Rochester USA Department of Cardiovascular Diseases Mayo Clinic Arizona USA Division of Biostatistics Mayo Clinic Rochester USA

BackgroundEchocardiography 被显示了是在许多心脏的条件的诊断的一个珍贵资源，并且能在所有年龄组被使用到，从胎儿最旧旧。在一张逐渐地变老的人口的上下文，在百岁老人的 echocardiography 的影响和用途大部分是未知的。这研究是... 详细信息

BackgroundEchocardiography 被显示了是在许多心脏的条件的诊断的一个珍贵资源，并且能在所有年龄组被使用到，从胎儿最旧旧。在一张逐渐地变老的人口的上下文，在百岁老人的 echocardiography 的影响和用途大部分是未知的。这研究是决定在百岁老人的 echocardiography 是否帮助从 1986 ～ 2014 使临床的耐心的管理 *** 成为 echocardiograms 的回顾的评论，在二个隶属于的第三级的中心，在是在考试的时候的 100 岁以上的个人。病人和 echocardiogram 特征，管理决定基于 echocardiography，和死亡是 ***114 百岁老人有的 echocardiograms，与从 100 ～ 107

关键词：老人用途特征诊断信息调查结果年龄组管理上下文

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Fhree tips every parent needs to know

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空中英语教室（高级版．彭蒙惠英语） 2016年第3期 12-14,40,41页

作者： heidi Stevens

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Treatment Based on Narcolepsy Promote Sleep in Insomniacs

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科技英语学习 2007年第3期 8-9页

作者： heidi Ledford 陈静

瑞士Actelion制药公司的研究人员在新一期《自然医学》杂志上报告说,他们新发现一种可以阻止大脑激素神经肤活动的化学物质,可以帮助白天昏昏欲睡但夜间无法入睡的人摆脱痛苦。神经肽与睡眠有关,这种激素在有嗜睡症的人体内含量较低,使... 详细信息

瑞士Actelion制药公司的研究人员在新一期《自然医学》杂志上报告说,他们新发现一种可以阻止大脑激素神经肤活动的化学物质,可以帮助白天昏昏欲睡但夜间无法入睡的人摆脱痛苦。神经肽与睡眠有关,这种激素在有嗜睡症的人体内含量较低,使他们习惯性地昏昏欲睡,甚至会在工作时或驾车时入睡。研究人员称,现有的大多数治疗失眠药物都有一些副作用,会导致服用者第二天出现记忆损失和头昏等症状,但新发现的化学物质基本没有这类副作用。

关键词：化学物质 Treatment Based on Narcolepsy Promote Sleep in Insomniacs

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