检索结果-南通市图书馆

Pediatric Investigation 2021年第2期5卷 136-139页

作者： heidi c smith-vaughan Allen c cheng Sepehr N.Tabrizi Danielle F Wurzel Jemima Beissbarth Amanda J Leach Peter S Morris Michael J Binks Paul J Torzillo Anne B chang Robyn L Marsh Menzies School of Health Research Charles Darwin UniversityDarwinAustralia School of Medicine Griffith UniversityGold CoastAustralia Monash University MelbourneAustralia Murdoch children's Research Institute The Royal Children’s HospitalMelbourneAustralia Department of Obstetrics and Gynaecology University of MelbourneParkvilleVictoriaAustralia Royal Darwin Hospital DarwinAustralia Royal Prince Alfred Hospital SydneyAustralia Dept of Respiratory and Sleep Medicine I Queensland Children’s HospitalBrisbaneAustralia

Maternal urogenital human papillomavirus(HPV)infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of *** respiratory HPV prevalence is not known in remote-dwelling Aboriginal infants,who are at high risk of respiratory infection and where the population prevalence of urogenital HPV in women is *** data are necessary to inform HPV vaccination regimens.A retrospective analysis using PcR specific for HPV was performed on 64 stored nasopharyngeal swabs from remote-dwelling Aboriginal infantscted in any *** the negative result,we cannot exclude a role for HPV in respiratory infections affecting infants in this population;however,our data do not support HPV as an important contributor to acute respiratory infection in remote-dwelling Aboriginal children.

关键词： Human papillomavirus Nasopharyngeal swabs Infants

comparisons of oxbow lake fish assemblages in relation to bigheaded carp establishment in the lower White River, Arkansas

在线全文

学校读者我要写书评

暂无评论

Ecological Processes 2024年第1期13卷 188-205页

作者： Michael A.Eggleton cody J.Salzmann Joseph E.Kaiser Shannon c.F.smith Department of Aquaculture and Fisheries University of Arkansas at Pine Bluff Arkansas Game and Fish commission Virginia Institute of Marine Science

Background Since the late 1990s, bigheaded carps(largely silver carp [Hypophthalmichthys molitrix] but also bighead carp [H. nobilis]) have established throughout the lower Mississippi River basin. Using previously studied oxbow lakes in the lower White River basin, Arkansas, we compared current(2017, “post-carp” establishment) fish assemblages to historical(2002, “pre-carp” establishment) fish assemblages. Fish assemblages were comprehensively assessed using multiple gears, including boat electrofishing, mini-fyke nets, and experimental small-mesh gill *** T-tests suggested that fish assemblage indices of richness, diversity, evenness, and dominance were often greater(P carp period as reflected by boat electrofishing and experimental gill nets. However, all indices were generally similar(P > 0.05) between the pre-carp and post-carp period with fish assemblages depicted using mini-fyke nets. Nonmetric multidimensional scaling analyses indicated that fish assemblages differed structurally between pre-carp and post-carp periods. Assemblage differences were linked to both small and large abundance changes for more than 20 species. Abundances of gizzard shad(Dorosoma cepedianum), emerald shiner(Notropis atherinoides), pugnose minnow(Opsopoeodus emiliae), crappies(Pomoxis spp.), bluegill(Lepomis macrochirus), orangespotted sunfish(L. humilis), and yellow bass(Morone mississippiensis) declined between the pre-carp and postcarp periods. conversely, abundances of weed shiner(N. texanus), pallid shiner(Hybopsis amnis), longear sunfish(L. megalotis), buffalofishes(Ictiobus spp.), and gars(Lepisosteus spp.) generally increased during the same *** Although not possible to conclude assemblage shifts were entirely related to bigheaded carps due to the absence of an appropriate reference system where carps did not establish, the wide establishment of these carps is one of the most pervasive changes to have occurred in the lower White

关键词： Bigheaded carp Silver carp Aquatic nuisance species Fish assemblage Oxbow lake Large river

Multiple sclerosis is at a checkpoint: advancing the program

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Harnessing the power of complex light propagation in multimode fibers for spatially resolved sensing

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2024年第3期12卷 411-422页

作者： DARcY L.smith LINH V.NGUYEN MOHAMMAD I.REJA ERIK P.ScHARTNER HEIKE EBENDORFF-HEIDEPRIEM DAVID J.OTTAWAY STEPHEN c.WARREN-smith Institute for Photonics and Advanced Sensing and School of Physics Chemistry and Earth SciencesThe University of AdelaideAdelaideSA 5005Australia Australian Research council centre of Excellence for Gravitational Wave Discovery(OzGrav) AdelaideSAAustralia Future Industries Institute University of South AustraliaMawson LakesSA 5095Australia Laser Physics and Photonics Devices Laboratory University of South AustraliaMawson LakesSA 5095Australia

The propagation of coherent light in multimode optical fibers results in a speckled output that is both complex and sensitive to environmental *** properties can be a powerful tool for sensing,as small perturbations lead to significant changes in the output of the ***,the mechanism to encode spatially resolved sensing information into the speckle pattern and the ability to extract this information are thus far *** this paper,we demonstrate that spatially dependent mode coupling is crucial to achieving spatially resolved *** leverage machine learning to quantitatively extract the spatially resolved sensing information from three fiber types with dramatically different characteristics and demonstrate that the fiber with the highest degree of spatially dependent mode coupling provides the greatest accuracy.

关键词： fiber spatially resolved

cOVID-19 vaccination produces exercise-responsive SARS-coV-2 specific T-cells regardless of infection history

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha charles R.Pedlar Shane c.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona cancer center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(cOVID-19).We sought to determine if cOVID-19 vaccination would elicit exercise-responsive SARS-coV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a cOVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-coV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TcR)-βsequencing,and SARS-coV-2 nAb ***:cOVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of cD4+and cD8+naive T-cells,as well as cD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-coV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-coV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-coV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral cOVID-19 Exercise immunology SARS-coV-2 T-cells Vaccine

Thermodynamic analysis of metal segregation in dual phase high entropy ceramics

在线全文

学校读者我要写书评

暂无评论

Journal of Materiomics 2024年第4期10卷 889-895页

作者： Steven M.smith II William G.Fahrenholtz Gregory E.Hilmas Stefano curtarolo Missouri University of Science and Technology Materials Science and Engineering DepartmentRollaMO65409USA Duke University Department of Mechanical Engineering and Materials ScienceDurhamNC27708USA Duke University Center of Autonomous Materials DesignDurhamNC27708USA

Equilibrium Gibbs'free energy calculations were used to determine metal segregation trends between boride and carbide solid solutions containing two metals that are relevant to dual phase high entropy *** model predicted that Ti had the strongest tendency to segregate to the boride phase followed by Zr,Nb,Mo,V,Hf,and Ta,which matches experimental results of measured *** ratio of a metal in the carbide phase to the content of the same metal in the corresponding metal boride had a linear trend with the change in standard Gibbs'free energy of reaction for a metal carbide reacting with B_(4)c to produce its corresponding metal boride and *** proposed model was used to predict the changes in standard Gibbs'free energy for crc→crB_(2) to be−260 kJ and Wc→WB_(2) to be 148 kJ,which indicates that cr has the strongest segregation to the boride and W has the strongest segregation to the *** proposed model can be used to estimate the segregation of metals in dual phase high entropy boride-carbide ceramics of any boride/carbide ratio or metal content.

关键词： Dual phase High entropy ceramic Boride carbide Thermodynamics

Efficient Vision Transformers for Autonomous Off-Road Perception Systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of computer and communications 2024年第9期12卷 188-207页

作者： Max H. Faykus III Adam Pickeral Ethan Marquez Melissa c. smith Jon c. calhoun Holcombe Department of Electrical and computer Engineering Clemson University Clemson SC USA

The development of autonomous vehicles has become one of the greatest research endeavors in recent years. These vehicles rely on many complex systems working in tandem to make decisions. For practical use and safety reasons, these systems must not only be accurate, but also quickly detect changes in the surrounding environment. In autonomous vehicle research, the environment perception system is one of the key components of development. Environment perception systems allow the vehicle to understand its surroundings. This is done by using cameras, light detection and ranging (LiDAR), with other sensor systems and modalities. Deep learning computer vision algorithms have been shown to be the strongest tool for translating camera data into accurate and safe traversability decisions regarding the environment surrounding a vehicle. In order for a vehicle to safely traverse an area in real time, these computer vision algorithms must be accurate and have low latency. While much research has studied autonomous driving for traversing well-structured urban environments, limited research exists evaluating perception system improvements in off-road settings. This research aims to investigate the adaptability of several existing deep-learning architectures for semantic segmentation in off-road environments. Previous studies of two convolutional Neural Network (cNN) architectures are included for comparison with new evaluation of Vision Transformer (ViT) architectures for semantic segmentation. Our results demonstrate viability of ViT architectures for off-road perception systems, having a strong segmentation accuracy, lower inference speed and memory footprint compared to previous results with cNN architectures.

关键词： Semantic Segmentation Off-Road Vision Transformers cNNs Autonomous Driving

Predictors of survival in autoimmune liver disease overlap syndromes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph Wendy cheng Simon Hazeldine Briohny W smith Gerry c MacQuillan Michael c Wallace George Garas Leon A Adams Gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BAcKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBc)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSc)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBc,27%AIH-PSc).There was no significant difference in survival between AIH-PBc and *** was a significant predictor of liver-related mortality(Pc(n=14)but not AIH-PSc(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBc patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's c-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBc *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

Effect of Elevated Temperatures on Inflammatory cytokine Release:An In Vitro and Population-Based Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environment & Health 2024年第10期2卷 721-728页

作者： Xiaoxu Hu Hualing Fu Luou Zhang Qian Zhang Tong Xu Yangsheng chen Guomin chen Shuai Jiang Jiajia Ji heidi Qunhui Xie Li Xu Bin Zhao Key Laboratory of Environmental chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of chinese Academy of Sciences Beijing 100049China State Key Laboratory of Environmental chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Jinbo Bio-Pharmaceutical co LTDTaiyuan 300032 ShanxiChina Department of cardiology Beijing HospitalNational Center of GerontologyBeijing 100730China Environment and Health Department Shenzhen Center for Disease Control and PreventionShenzhen 518055 GuangdongChina School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Extreme high temperatures in the summer have become a global concern,and their risks to the inflammatory system have been largely *** we appraised the exposure risks of summer heatwaves by comparing the sera cytokine levels in healthy individuals under high and normal *** addition,we established a cell model with a 1.5°c temperature increase to investigate the regulatory mechanisms of temperature-related *** results suggest that elevated temperatures enhance the release of interleukin-6(IL-6)and interleukin-8(IL-8)via the aryl hydrocarbon receptor(AhR)pathway and augment the proinflammatory effects of other *** suggests that we may have underestimated the impact of high temperatures on the health of individuals beyond just mortality ***,seemingly minor temperature increases of just 1.5°c can still pose a challenge to cells.

关键词： global warming heatwaves inflammation aryl hydrocarbon receptor interleukin-6 interleukin-8

Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall Duncan Loader Santiago Gouveia Marta Burak James Halle-smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari Keith J Roberts Syed S Raza Michail Papamichail David c Bartlett Robert P Sutcliffe Nikolaos A chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom college of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

BAcKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dccA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dccA and present the experience of a highvolume tertiary-centre managing dccA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dccA who received *** patients from 2017 to 2022 who were referred for NAT for dccA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dccA was *** studies reported outcomes for 9 patients who received NAT for dccA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dccA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dccA is *** propose using the established National-comprehensive-cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review