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Measurement system that improves the accuracy of polyp size determined at colonoscopy

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World Journal of Gastroenterology 2015年第7期21卷 2178-2182页

作者： Qiang Leng hei-ying jin National Center of Colorectal Surgery Jiangsu Integrated Colorectal Oncology Center the Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine

AIM:To assess the accuracy of polyp size using an endoscopic lesion measurement system(ELMS).METHODS:The accuracy of polyp size assessment was compared among measurements acquired by visual estimation,disposable graduated biopsy forceps(DGBF;used as a"scale-plate")and the ***:There were 192 polyps from 166 cases included in this *** mean diameter of the post polypectomy measurement was 0.85±0.53 cm(range:0.2-3.0 cm).The mean diameter by visual estimation was 1.10±0.53 cm,which was significantly different compared to the actual size of the polyp(P<0.001).The mean diameters obtained using DGBF(0.87±0.54cm)and ELMS(0.85±0.53 cm)did not significantly differ from the actual size of the *** difference between the measurements from the ELMS and DGBF was not ***:Unlike visual estimations at colonoscopy,endoscopic graduated biopsy forceps and the endoscopic lesion measurement system are accurate methods to estimate polyp size.

关键词： Accuracy Colonoscopy Endoscopic lesion measurement

Treatment of adult congenital anal atresia with rectovestibular fistula:A rare case report

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World Journal of Clinical Cases 2023年第33期11卷 8065-8070页

作者： Jun Wang Xin-Yi Zhang Ji-Han Chen hei-ying jin Department of Anorectal Surgery The Second Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210017Jiangsu ProvinceChina

BACKGROUND Female anorectal malformation is a correctable congenital *** manifestations in patients with anal deformities are uncommon,especially after *** SUMMARY The clinical data of a 19-year-old adult female patient with congenital anal atresia accompanied by rectovestibular fistula as the main manifestation was retrospectively *** was made based on the patient's clinical symptoms,signs,imaging showing the fistula,X-ray and magnetic resonance imaging *** preoperative examination was *** was *** patient exhibited an improvement in quality of life and presented no evidence of fecal incontinence during the 6-mo *** Transfistula anorectoplasty is a reasonable and reliable surgical method for the treatment of adult congenital anal atresia and rectovestibular fistula.

关键词： Anorectal malformations Congenital anorectal atresia Rectovestibular fistula Transfistula anorectoplasty Case report

Anal fistula plugvs mucosa advancement flap in complex fistula-in-ano:A meta-analysis

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World Journal of Gastrointestinal Surgery 2012年第11期4卷 256-261页

作者： Qiang Leng hei-ying jin National Center of Colorectal Surgery the Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine

AIM:To investigate the efficacy of the anal fistula plug(AFP) compared to the mucosa advancement flap(MAF),considered the best procedure for patients with a complex anal ***:The literature search included PubMed,EMBASE,Cochrane Library and OVID original studies on the topic of AFP compared to MAF for complex fistula-in-ano that had a deadline for publication by April *** controlled trials,controlled clinical trials and prospective cohort studies were included in the *** information collection,a meta-analysis was performed using data on overall success rates as well as incidence of incontinence and *** quality of postoperative life was also included with the clinical ***:Six studies involving 408 patients(AFP = 167,MAF = 241) were included in the *** differences in the overall success rates and incidence of fistula recurrence were not statistically significant between the AFP and MAF [risk difference(RD) =-0.12,95%CI:-0.39-0.14;RD = 0.13;95%CI:-0.18-0.43,respectively].However,for the AFP,the risk of postoperative impaired continence was lower(RD =-0.08,95%CI:-0.15--0.02) as was the incidence of other complications(RD =-0.06,95%CI:-0.11-0.00).The postoperative quality of life,for patients treated using the AFP was superior to that of the MAF *** treated with the AFP had less persistent pain of a shorter duration and the healing time of the fistula and hospital stay were also ***:The AFP is an effective procedure for patients with a complex anal fistula;it has the same success rate but a lower risk of complications than the MAF and may also be associated with an improved postoperative quality of *** evidence is needed to confirm these findings.

关键词： Complex anal fistula Anal fistula plug Mucosa advancement flap Meta-analysis

Epigallocatechin gallate inhibits dimethylhydrazine-induced colorectal cancer in rats

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World Journal of Gastroenterology 2020年第17期26卷 2064-2081页

作者： Yu Wang hei-ying jin Ming-Zhi Fang Xiao-Feng Wang Hao Chen Shu-Liang Huang De-Song Kong Min Li Xiu Zhang Yu Sun Shui-Ming Wang Department of Oncology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210001Jiangsu ProvinceChina Department of Colorectal Surgery The Second Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina National Center of Colorectal Disease Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210001Jiangsu ProvinceChina Department of Pathology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Scientific Research Administration Department Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese MedicineNanjing 210001Jiangsu ProvinceChina Endoscopy Center Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210001Jiangsu ProvinceChina Origin Bioscience Inc Nanjing 210000Jiangsu ProvinceChina

BACKGROUND Epigallocatechin gallate(EGCG)is a polyhydroxy phenolic compound extracted from tea and its antitumor effect has received widespread *** explored the inhibitory effect of EGCG on dimethylhydrazine(DMH)-induced colorectal cancer(CRC)using a rat model,predicted the interaction between EGCG and CRC target genes using a database,and explained the EGCG associated target pathways and mechanisms in *** To understand the inhibitory mechanisms of EGCG on CRC cell proliferation and identify its pharmacological targets by network pharmacology *** DMH(40 mg/kg,s.c.,twice weekly for eight weeks)was used to induce CRC in *** model establishment,the rats were administered with EGCG(50,100,or 200 mg/kg,p.o.,once daily for eight weeks)and killed 12 and 20 wk after the start of the *** of aberrant crypt foci and tumor was studied by histological *** network pharmacology analysis,candidate and collective targets of EGCG and CRC were identified,and Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes analyses were used to predict the pathways altered by *** At week 12,high-dose EGCG treatment significantly reduced the tumor formation rate,total number of tumors,cancerous and non-cancerous tumors,tumor volume,ascites formation,and aberrant crypt foci *** week 20,all three doses of EGCG were ***-eight collective targets of EGCG and CRC were identified,of which 28 genes were dysregulated in *** Encyclopedia of Genes and Genomes and GO analyses showed that the dysregulated genes were enriched in hsa05210(CRC),hsa04115(p53 signaling pathway),and hsa04151(PI3K-Akt signaling pathway),GO:0043124(negative regulation of I-kappaB kinase/NF-kappaB signaling pathway),GO:0043409(negative regulation of mitogen-activated protein kinase cascade),and GO:2001244(positive regulation of intrinsic apoptotic signaling pathway)*** EGCG inhibits the formation of DMH-induced CRC

关键词： Epigallocatechin gallate Dimethylhydrazine Colorectal cancer Aberrant crypt foci Mitogen-activated protein kinase The Cancer Genome Atlas

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低位直肠癌术后肛门生理的改变及其对策

世界华人消化杂志 2018年第16期26卷 1005-1009页

作者：金黑鹰江苏省第二中医院(南京中医药大学第二附属医院)肛肠中心江苏省南京市210017

低位直肠癌保肛手术明显提高了患者的生活质量,但是低位直肠癌手术后常常由于肛门内外括约肌的损伤、神经损伤、直肠储存粪便的能力下降等因素导致肛门控便能力下降,影响患者术后生活质量;因此应该重视低位直肠癌术前的肛门生理的评估... 详细信息

低位直肠癌保肛手术明显提高了患者的生活质量,但是低位直肠癌手术后常常由于肛门内外括约肌的损伤、神经损伤、直肠储存粪便的能力下降等因素导致肛门控便能力下降,影响患者术后生活质量;因此应该重视低位直肠癌术前的肛门生理的评估、术中尽量减少肌肉和神经损伤,术后给予生物反馈等康复治疗,以提高患者生活质量.

关键词：低位直肠癌保肛手术肛门失禁生活质量

Retrorectal tumors in adults:Magnetic resonance imaging findings

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World Journal of Gastroenterology 2010年第46期16卷 5822-5829页

作者： Bo-Lin Yang,Yun-Fei Gu,Wan-jin Shao,Hong-jin Chen,Gui-Dong Sun,Department of Coloproctology,The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China hei-ying jin,Department of Coloproctology,The 3rd Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China Xin Zhu,Department of Radiology,The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China Department of Radiology The Affiliated Hospital of Nanjing University of Chinese Medicine No.155 Hanzhong Road Nanjing 210029 China.

AIM:To retrospectively evaluate the magnetic resonance imaging (MRI) features of adult retrorectal tumors and compare with histopathologic ***:MRI features of 21 patients with preoperative suspicion of retrorectal tumors were analyzed based on the histopathological and clinical ***:Fourteen benign cystic lesions appeared hypointense on T1-weighted images,and hyperintense on T2-weighted images with regular peripheral *** or dermoid cysts were unilocular,and tailgut cysts were *** of intracystic intermediate signal intensity was observed in one case of tailgut cyst with a component of *** solid tumors were malignant lesions and showed heterogeneous intensity on *** adenocarcinomas showed high signal intensity on T2-weighted and mesh-like enhancing areas on fat-suppressed T2-weighted *** was a fistula between the mass and anus with an internal opening in mucinous adenocarcinomas arising from anal *** stromal tumors displayed low signal intensity on T1-weighted images,and intermediate to high signal intensity on T2-weighted *** necrosis could be seen as a high signal on T2-weighted ***:MRI is a helpful technique to define the extent of the retrorectal tumor and its relationship to the surrounding structures,and also to demonstrate possible complications so as to choose the best surgical approach.

关键词： Retrorectal tumor Presacral lesions Magnetic resonance imaging Congenital cyst Malignant tumor Diagnosis

表皮生长因子受体靶向治疗结直肠癌的临床进展

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世界华人消化杂志 2010年第17期18卷 1804-1809页

作者：王玉方明治金黑鹰南京中医药大学江苏省南京市210029 南京中医药大学第三附属医院肿瘤康复科江苏省南京市210029 南京中医药大学第三附属医院全国肛肠医疗中心江苏省南京市210029

当今,靶向治疗成为肿瘤治疗模式里越来越重要的因子,而靶向治疗中研究最多的是关于表皮生长因子受体(epidermal growth factor receptor,EGFR)靶向治疗药物.随着临床的深入研究,EGFR分子靶向药物的临床应用利弊也成为关注的焦点.此文就E... 详细信息

当今,靶向治疗成为肿瘤治疗模式里越来越重要的因子,而靶向治疗中研究最多的是关于表皮生长因子受体(epidermal growth factor receptor,EGFR)靶向治疗药物.随着临床的深入研究,EGFR分子靶向药物的临床应用利弊也成为关注的焦点.此文就EGFR在结直肠癌靶向治疗中的研究进展作一综述.

关键词：表皮生长因子受体靶向治疗结直肠癌

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国内外肛瘘诊疗现状的对比与启示

世界华人消化杂志 2016年第6期24卷 978-982页

作者：陈豪冷强金黑鹰章蓓南京中医药大学第一临床医学院江苏省南京市210029 南京市中医院肛肠科江苏省南京市210001

目的:调查目前国内外肛瘘诊治的具体情况,了解目前国内外肛瘘诊治的现状及发展方向.方法:检索2009-01/2015-12国内外发表的关于肛瘘治疗的相关文献,对肛瘘诊疗过程中的方法和效果进行分析.结果:共获得中文文献612篇,英文文献83篇.对肛... 详细信息

目的:调查目前国内外肛瘘诊治的具体情况,了解目前国内外肛瘘诊治的现状及发展方向.方法:检索2009-01/2015-12国内外发表的关于肛瘘治疗的相关文献,对肛瘘诊疗过程中的方法和效果进行分析.结果:共获得中文文献612篇,英文文献83篇.对肛瘘的诊断大多数文献仍依靠临床症状和临床物理检查为主,仅少部分文献描述采用腔内超声或MRI进行诊断.在肛瘘的治疗中,中文文献主要采用传统的肛瘘切开切除或切割挂线治疗,英文文献在使用传统治疗方法的同时,保留括约肌的肛瘘手术比例明显增大.术后随访过程中,仍主要依靠临床症状和物理检查对复发肛瘘进行诊断,仅少部分采用腔内超声或MRI进行诊断.结论:国内外对于肛瘘的诊断多以医生经验诊断为主,对于肛瘘的客观诊断均重视不够;国外文献肛瘘以Parks分类方法为主,但是国内文献分类方法不统一;关于治疗方法,国外以括约肌保留手术为主而国内仍以对括约肌损伤较大的传统手术为主;国内外对治疗结果随访更关注复发而忽略了对失禁率的关注.

关键词：肛瘘治疗现状调查

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直肠前突影像学诊断的研究进展

世界华人消化杂志 2016年第14期24卷 2198-2203页

作者：杜永红薛雅红金黑鹰南京中医药大学第三附属医院肛肠科南京市中医院全国肛肠医疗中心江苏省南京市210001

直肠前突是出口梗阻型便秘的常见表现之一,目前临床上评估直肠前突的常用影像学方法包括传统排粪造影、动态磁共振排粪造影、盆底超声检查,用以明确直肠前突的分度,以指导临床治疗.目前认为传统排粪造影仍然是诊断的金标准,直肠前突的... 详细信息

直肠前突是出口梗阻型便秘的常见表现之一,目前临床上评估直肠前突的常用影像学方法包括传统排粪造影、动态磁共振排粪造影、盆底超声检查,用以明确直肠前突的分度,以指导临床治疗.目前认为传统排粪造影仍然是诊断的金标准,直肠前突的手术指证仍以其测量的深度为标准,但是存在辐射等缺点;磁共振排粪造影具有多方位成像、优良的软组织对比度、无电离辐射等优点,有广阔的应用前景,但存在检查费用高、非生理姿势排便状态下检查等缺点;盆底超声成像技术作为一项新近开展的诊断技术,能够对后盆底内所有功能异常状态进行有效评估,同时避免辐射损害,但还需要进一步的研究.

关键词：直肠前突便秘 X射线计算机磁共振成像超声