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16～20年前暴露于硫芥子气的伊朗退伍军人发生延迟性皮肤和免疫系统并发症

世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 21-22页

作者： hefazi m maleki m mahmoudi m m. Balali-mood 董平 medical Toxicology Center Imam Reza Hospital Mashhad University of Medical Sciences Mashhad 91735-348 Iran Prof.

Background: Extensive cutaneous burns caused by alkylating chemical warfare agent sulfur mustard (Sm) have been associated with the severe suppression of the immune system in humans. We aimed to study the association between late cutaneous and immunological complications of Sm poisoning. methods: Skin examination was performed on all Sm-poisoned Iranian veterans in the province of Khorasan, Iran, who had significant clinical complications, and their Sm intoxication was confirmed by toxicological analysis. Light microscopy was performed on eight skin biopsies. Blood cell counts, serum immunoglobulin and complement factor, as well as flow cytometric, analyses were performed on all the patients. The severity of cutaneous complications were classified into four grades and compared with hematological and immunological parameters, using Spearman’s rank correlation test. Results: Forty male subjects, confirmed with Sm poisoning *** earlier, were studied. The main objective findings were hyperpigmentation (55%), dry skin (40%), multiple cherry angiomas (37.5%), atrophy (27.5%), and hypopigmentation (25%). Histopathologic findings were nonspecific and compatible with hyperpigmented old atrophic scars. Except for the hematocrit and C4 levels, hematological and immunological parameters revealed no significant correlation with the severity grades of cutaneous complications. Conclusion: Sulfur mustard is an alkylating agent with prolonged adverse effects on both the skin and the immune system. Allthough skin is a major transporting system for Sm’s systemic absorption, there is probably no correlation between the severity of late cutaneous and immunological complications of Sm poisoning.

关键词：硫芥子气并发症并发病疾病免疫系统退伍军人皮肤解剖部位伊朗

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Reliability of a patient survey assessing ＂Short Form Injury Questionnaire 7＂ in Iran

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Chinese Journal of Traumatology 2012年第3期15卷 145-147页

作者： mahdi Sharif-Alhoseini Soheil Saadat Afarin Rahimi-movaghar Abbas motevalian masoumeh Amin-Esmaeili mitra hefazi Vafa Rahimi-movaghar Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran 11365-3876 Iran Iranian Research Center for HIV/AIDS(IRCHA) Tehran University of Medical Sciences Tehran 11365-3876 Iran School of Public Health Tehran University of Medical Sciences Tehran 11365-3876 Iran

Objective： Injury is a major cause of morbidity and mortality in the world. The assessment of patterns and severity of injury in high-risk groups is crucial for planning and service development. On a large scale na- tional household survey, we estimated the annual incidence and the patterns of injury, the demographics of the injured people, as well as the service use for all injuries in Iran. The current study aims at assessing the reliability of the ques- tionnaire before carrying out a national survey. methods： In a pilot study using cluster random sam- pling approach, 73 people were interviewed. The interview- ers asked the participants to report all injuries occurred in them and the care provided during the previous 12 months, based on ＂Short Form Injury Questionnaire 7＂. About two weeks later, the interview was repeated by another interviewer. Results： In our test-retest reliability, Kappa score was good for three and moderate for four questions. The ques- tion on the injured organ had the highest test-retest reliabil- ity with a Kappa score of 0.84. Conclusions： The reliability of the questionnaire and the procedure of questioning are confirmed. The ques- tionnire is proper for utilization in large national surveies.

关键词： Injury severity score Reproducibility of results Iran

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