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A New Species of Amsassia from the Ordovician of Korea and South China:Paleobiological and Paleogeographical Significance

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Acta Geologica Sinica(English Edition) 2016年第3期90卷 796-806页

作者： Mirinae LEE heeju park Nguyen Viet TIEN Suk-Joo CHOH Robert J.ELIAS Dong-Jin LEE Department of Earth and Environmental Sciences Andong National UniversityAndong36729Republic of Korea Institute of Geological Sciences-Vietnam Academy of Science and Technology(IGS-VAST) Hanoi100000Socialist Republic of Vietnam Department of Earth and Environmental Sciences Korea UniversitySeoul02841Republic of Korea Department of Geological Sciences The University of ManitobaWinnipegR3T 2N2Canada

A new species of the probable calcareous alga Amsassia, A. koreanensis, is recognized from the Duwibong Formation （Middle Ordovician, Darriwilian） of the Taebaeksan Basin in mid-eastern Korea. This is the first report of the genus from the Korean Peninsula, expanding its geographical range to the eastern Sino-Korean Block. The new species also occurs in the Xiazhen Formation （Upper Ordovician, Katian） at Zhuzhai in the South China Block. Amsassia koreanensis is the smallest species of this modular genus, having a maximum module diameter of 0.28 ram. Module increase is by bipartite, tripartite and quadripartite types of longitudinal axial fission, but unlike other species of the genus, quadripartite fission is common. The types of fission are comparable to those in some Tetradiida （now Prismostylales, florideophycean rhodophyte algae）, although the processes of fission are different. The distribution of A. koreanensis further strengthens the biogeographical connection between the Sino-Korean and South China blocks, suggesting that these two paleocontinents were located closer together during the Middle to Late Ordovician than previously speculated.

关键词： Amsassia koreanensis sp. nov. Ordovician Sino-Korean Block South China Block paleobiology paleogeography.

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Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease

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Translational Neurodegeneration 2023年第1期12卷 170-188页

作者： Hyunkyung Mo Juryun Kim Jennifer Yejean Kim Jang Woon Kim heeju Han Si Hwa Choi Yeri Alice Rim Ji Hyeon Ju Present Address:CiSTEM Laboratory Catholic iPSC Research CenterCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine and Health Science College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea YiPSCELL IncOmnibus ParkBanpo-daero 222Seocho-guSeoul 06591Republic of Korea Department of Biology Georgetown University3700 O St NWWashingtonDC 20057USA Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalInstitute of Medical ScienceCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Background Alzheimer’s disease(AD)is the most common neurodegenerative disorder in the elderly,resulting in gradual destruction of cognitive *** on the development of various AD treatments is underway;however,no definitive treatment has been developed ***,we present induced pluripotent stem cell(iPSC)-derived cortical neural stem cell secretome(CNSC-SE)as a new treatment candidate for AD and explore its *** We first assessed the effects of CNSC-SE treatment on neural maturation and electromagnetic signal during cortical nerve cell *** to confirm the efficacy in vivo,CNSC-SE was administered to the 5×FAD mouse model through the nasal cavity(5μg/g,once a week,4 weeks).The cell-mediated effects on nerve recovery,amyloid beta(Aβ)plaque aggregation,microglial and astrocyte detection in the brain,and neuroinflammatory responses were *** analysis of iPSC-derived CNSC-SE revealed that it contained components that could exert neuro-protective effects or amplify cognitive restorative *** Human iPSC-derived CNSC-SE increased neuronal proliferation and dendritic structure formation in ***,CNSC-SE-treated iPSC-derived cortical neurons acquired electrical network activity and action potential *** 5×FAD mice treated with CNSC-SE showed memory restoration and reduced Aβplaque *** Our findings suggest that the iPSC-derived CNSC-SE may serve as a potential,non-invasive therapeutic option for AD in reducing amyloid infiltration and restoring memory.

关键词： Induced pluripotent stem cells Alzheimer’s disease Cortical neural stem cells Secretome Intranasal administration Memory disorders Neuroprotective agents

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