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journal of magnesium and Alloys 2024年第1期12卷 332-344页

作者： Z.Y.Xue X.j.Li j.h.Chu m.m.Li D.N.Zou L.B.Tong School of metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced Design and manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of mg alloys seriously limit their potential applications in various *** conventional epoxy coating easily forms many intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a double-layer epoxy composite coating on mg alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assembly *** outer layer is functionalized graphene(FG)in waterborne epoxy resin(WEP)and the inner layer is Ce-based conversion(Ce)*** FG sheets can be homogeneously dispersed within the epoxy matrix to fill the intrinsic defects and improve the barrier *** Ce film connects the outer layer with the substrate,showing the transition *** corrosion rate of Ce/WEP/FG composite coating is 2131 times lower than that of bare mg alloy,and the wear rate is decreased by~90%.The improved corrosion resistance is attributed to the labyrinth effect(hindering the penetration of corrosive medium)and the obstruction of galvanic coupling *** synergistic effect derived from the FG sheet and blocking layer exhibits great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of mg alloys.

关键词： mg alloy Functionalized graphene Epoxy coating Corrosion/wear resistance Blocking layer

熊去氧胆酸与原发性胆汁性肝硬化患者的细胞色素P4503A的代谢无相关性

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 39-39页

作者： Dilger K. Denk A. heeg m.h.j. Beuers U. 杨瑗 Department of medicine II Klinikum Grosshadern Ludwig- Maximilians- Universitt Marchioninistraβe 15D- 81377 München Germany Dr.

Induction of cytochrome P450 3A (CYP3A) has been suggested as a mechanism of action of ursodeoxycholic acid (UDCA) in cholestasis. CYP3A is of key importance in human drug metabolism, being involved in presystemic extraction of more than 50% of all drugs currently available and of various endogenous compounds. The refore, we compared the induction potential of UDCA with that of the prototypica l inducer rifampicin in a human model study with the CYP3A substrates budesonide and cortisol. Twelve patients with early- stage primary biliary cirrhosis and eight healthy volunteers were treated with UDCA (15 mg/kg daily) for 3 weeks and subsequently with rifampicin (600 mg/d) for 1 week. Extensive pharmacokinetic p rofiling of oral budesonide (3 mg) was performed by determination of budesonide and phase I metabolites (6β - hydroxybudesonide, 16α - hydroxyprednisolone) in plasma and urine at baseline and at the end of each treatment. In parallel, u rinary 6β - hydroxycortisol, a validated marker of CYP3A induction, was determ ined. UDCA did not affect biotransformation of budesonide and urinary excretion of 6α - hydroxycortisol either in patients or in healthy volunteers. Ratios of areas under plasma concentration- time curves (AUC0- 12h during UDCA/AUC0- 1 2h before UDCA) of both metabolites were not higher than those of budesonide its elf. In contrast, administration of rifampicin markedly induced CYP3A metabolism , resulting in abolished budesonide plasma levels and high urinary excretion of 6β - hydroxycortisol. metabolite formation was enhanced by rifampicin, but not by UDCA (e.g., AUC16α - hydroxyprednisolone/ AUCbudesonide in patients: basel ine, 8.6 ± 3.9; UDCA, 10.7 ± 7.1; rifampicin, 527.0 ± 248.7). In conclusio n, UDCA is not a relevant inducer of CYP3A enzymes in humans.

关键词：熊去氧胆酸细胞色素泼尼松龙药物动力学参数 UDCA 药物代谢考的松诱导剂治疗阶段胆汁淤积

modelling dynamic pantograph loads with combined numerical analysis

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Railway Engineering Science 2024年第1期32卷 81-94页

作者： F.F.jackson R.mishra j.m.Rebelo j.Santos P.Antunes j.Pombo h.magalhaes L.Wills m.Askill School of Computing and Engineering University of HuddersfieldHuddersfieldUK School of Computing and Engineering Institute of Railway ResearchUniversity of HuddersfieldHuddersfieldUK IDmEC Instituto Superior TecnicoUniversidade de LisboaLisbonPortugal ISEL Instituto Politecnico de LisboaLisbonPortugal hitachi Rail Newton AycliffeUK Wabtec/Brecknell Willis ChardUK

Appropriate interaction between pantograph and catenary is imperative for smooth operation of electric *** heights of overhead lines to accommodate level crossings,overbridges,and tunnels pose significant challenges in maintaining consistent current collection performance as the pantograph aerodynamic profile,and thus aerodynamic load changes significantly with operational *** research aims to analyse the global flow characteristics and aerodynamic forces acting on individual components of an hSX pantograph operating in different configurations and orientations,such that the results can be combined with multibody simulations to obtain accurate dynamic insight into contact ***,computational fluid dynamics simulations are used to investigate the pantograph component loads in a representative setting,such as that of the recessed cavity on a Class 800 *** an aerodynamic perspective,this study indicates that the total drag force acting on non-fixed components of the pantograph is larger for the knuckle-leading orientation rather than the knuckle-trailing,although the difference between the two is found to reduce with increasing pantograph *** the aerodynamic loads acting on individual components with multibody tools allows for realistic dynamic insight into the pantograph *** results obtained show how considering aerodynamic forces enhance the realism of the models,leading to behaviour of the pantograph-catenary contact forces closely matching that seen in experimental tests.

关键词： Pantograph-catenary interaction Pantograph aerodynamics Computational fluid dynamics Pantograph loads Current collection performance

magnetic Topological Dirac Semimetal Transition Driven by SOC in Eumg_(2)Bi_(2)

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Chinese Physics Letters 2024年第1期41卷 63-67页

作者：王佳萌钱浩吉姜琦乔山叶茂 State Key Laboratory of Functional materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Research Center for Intelligent Chips and Devices Zhejiang LabHangzhou 311121China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

magnetic topological semimetals have been at the forefront of condensed matter physics due to their ability to exhibit exotic transport *** the interplay between magnetic and topological orders in systems with broken time-reversal symmetry is crucial for realizing non-trivial quantum *** delve into the electronic structure of the rare-earth-based antiferromagnetic Dirac semimetal Eumg_(2)Bi_(2) using first-principles calculations and angle-resolved photoemission *** calculations reveal that the spin-orbit coupling(SOC)in Eumg_(2)Bi_(2) prompts an insulator to topological semimetal transition,with the Dirac bands protected by crystal *** linearly dispersive states near the Fermi level,primarily originating from Bi 6p orbitals,are observed on both the(001)and(100)surfaces,confirming that Eumg_(2)Bi_(2) is a three-dimensional topological Dirac *** research offers pivotal insights into the interplay between magnetism,SOC and topological phase transitions in spintronics applications.

关键词： spectroscopy topological Dirac

On an isotropic porous solid cylinder:the analytical solution and sensitivity analysis of the pressure

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Applied mathematics and mechanics(English Edition) 2024年第9期45卷 1499-1522页

作者： h.ASGhARI L.mILLER R.PENTA j.mERODIO Departamento de matematica Aplicada a las TIC ETS de Ingenieria de Sistemas InformaticosUniversidad Politecnica de MadridMadrid 28031Spain School of mathematics and Statistics University of GlasgowGlasgow G128QQU.K.

Within this work,we perform a sensitivity analysis to determine the influence of the material input parameters on the pressure in an isotropic porous solid *** provide a step-by-step guide to obtain the analytical solution for a porous isotropic elastic cylinder in terms of the pressure,stresses,and elastic *** obtain the solution by performing a Laplace transform on the governing equations,which are those of Biot's poroelasticity in cylindrical polar *** enforce radial boundary conditions and obtain the solution in the Laplace transformed domain before reverting back to the time *** sensitivity analysis is then carried out,considering only the derived pressure *** analysis finds that the time t,Biot's modulus m,and Poisson's ratio ν have the highest influence on the pressure whereas the initial value of pressure P_(0) plays a very little role.

关键词： sensitivity analysis Laplace transform cylindrical polar coordinate Biot's modulus cylinder

Superplasticity of fine-grained mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mechanisms

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journal of magnesium and Alloys 2024年第1期12卷 316-331页

作者： h.T.jeong S.W.Lee W.j.Kim Department of materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The superplastic behavior and associated deformation mechanisms of a fine-grained mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm,primarily composed of the BCCβphase and a small amount of the hCPαphase,were examined in a temperature range of 473 K to 623 *** microstructural refinement of this alloy was achieved by employing high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations of 550±600%were *** the heating and holding stage of the tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider this effect when analyzing and understanding the superplastic deformation behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,while at high strain rates,lattice diffusion-controlled dislocation climb creep was the rate-controlling deformation *** was concluded that solute drag creep is unlikely to *** the late stages of deformation at 523 K,it was observed that grain boundary sliding led to the agglomeration of theαphase,resulting in significant strain *** mechanism maps were constructed forβ-mg-Li alloys in the form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using the constitutive equations for various deformation mechanisms derived based on the data of the current tests.

关键词： magnesium-lithium alloy Superplasticity Severe plastic deformation Grain size Grain growth

Quantitative Identification of Delamination Damage in Composite Structure Based on Distributed Optical Fiber Sensors and model Updating

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SDhm Structural Durability and health monitoring 2024年第6期18卷 785-803页

作者： Xu h. Wang j. Zhu R. Strauss A. Cao m. Wu Z. School of materials Science and Engineering Dalian University of Technology Dalian 116000 China School of mechanics and Aerospace Engineering Dalian University of Technology Dalian 116000 China Department of Civil Engineering and Natural hazards University of Natural Resources and Life Sciences Vienna 1180 Austria Department of Engineering mechanics Hohai University Nanjing China

Delamination is a prevalent type of damage in composite laminate structures. Its accumulation degrades structural performance and threatens the safety and integrity of aircraft. This study presents a method for the quantitative identification of delamination identification in composite materials, leveraging distributed optical fiber sensors and a model updating approach. Initially, a numerical analysis is performed to establish a parameterized finite element model of the composite plate. Then, this model subsequently generates a database of strain responses corresponding to damage of varying sizes and locations. The radial basis function neural network surrogate model is then constructed based on the numerical simulation results and strain responses captured from the distributed fiber optic sensors. Finally, a multi-island genetic algorithm is employed for global optimization to identify the size and location of the damage. The efficacy of the proposed method is validated through numerical examples and experiment studies, examining the correlations between damage location, damage size, and strain responses. The findings confirm that the model updating technique, in conjunction with distributed fiber optic sensors, can precisely identify delamination in composite structures. © 2024 The Authors. Published by Tech Science Press.

关键词： Composite structures damage identification fiber optic sensor model updating surrogate model

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.j.Dijkstra C.mota j.Bauer h.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa m.B.Baker L.moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYmAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

melt extrusion-based additive manufacturing(mE-Am)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of Am scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BmP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hmSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BmP receptor II(BmPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for mE-Am community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry human

Evidence for particle acceleration approaching PeV energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： Cao, Zhen Aharonian, F. Axikegu Bai, Y.X. Bao, Y.W. Bastieri, D. Bi, X.j. Bi, Y.j. Bian, W. Bukevich, A.V. Cao, Q. Cao, W.Y. Cao, Zhe Chang, j. Chang, j.F. Chen, A.m. Chen, E.S. Chen, h.X. Chen, Liang Chen, Lin Chen, Long Chen, m.j. Chen, m.L. Chen, Q.h. Chen, S. Chen, S.h. Chen, S.Z. Chen, T.L. Chen, Y. Cheng, N. Cheng, Y.D. Cui, m.Y. Cui, S.W. Cui, X.h. Cui, Y.D. Dai, B.Z. Dai, h.L. Dai, Z.G. Danzengluobu Dong, X.Q. Duan, K.K. Fan, j.h. Fan, Y.Z. Fang, j. Fang, j.h. Fang, K. Feng, C.F. Feng, h. Feng, L. Feng, S.h. Feng, X.T. Feng, Y. Feng, Y.L. Gabici, S. Gao, B. Gao, C.D. Gao, Q. Gao, W. Gao, W.K. Ge, m.m. Geng, L.S. Giacinti, G. Gong, G.h. Gou, Q.B. Gu, m.h. Guo, F.L. Guo, X.L. Guo, Y.Q. Guo, Y.Y. han, Y.A. hasan, m. he, h.h. he, h.N. he, j.Y. he, Y. hor, Y.K. hou, B.W. hou, C. hou, X. hu, h.B. hu, Q. hu, S.C. huang, D.h. huang, T.Q. huang, W.j. huang, X.T. huang, X.Y. huang, Y. ji, X.L. jia, h.Y. jia, K. jiang, K. jiang, X.W. jiang, Z.j. jin, m. Kang, m.m. Karpikov, I. Kuleshov, D. Kurinov, K. Li, B.B. Li, C.m. Li, Cheng Li, Cong Li, D. Li, F. Li, h.B. Li, h.C. Li, jian Li, jie Li, K. Li, S.D. Li, W.L. Li, X.R. Li, Xin Li, Y.Z. Li, Zhe Li, Zhuo Liang, E.W. Liang, Y.F. Lin, S.j. Liu, B. Liu, C. Liu, D. Liu, D.B. Liu, h. Liu, h.D. Liu, j. Liu, j.L. Liu, m.Y. Liu, R.Y. Liu, S.m. Liu, W. Liu, Y. Liu, Y.N. Luo, Q. Luo, Y. Lv, h.K. ma, B.Q. ma, L.L. ma, X.h. mao, j.R. min, Z. mitthumsiri, W. mu, h.j. Nan, Y.C. Neronov, A. Ou, L.j. Pattarakijwanich, P. Pei, Z.Y. Qi, j.C. Qi, m.Y. Qiao, B.Q. Qin, j.j. Raza, A. Ruffolo, D. Sáiz, A. Saeed, m. Semikoz, D. Shao, L. Shchegolev, O. Sheng, X.D. Shu, F.W. Song, h.C. Stenkin, Yu.V. Stepanov, V. Su, Y. Sun, D.X. Sun, Q.N. Sun, X.N. Sun, Z.B. Takata, j. Tam, P.h.T. Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China University of Chinese Academy of Sciences Beijing 100049 China TIANFU Cosmic Ray Research Center Chengdu China Dublin Institute for Advanced Studies 31 Fitzwilliam Place 2 Dublin Ireland max-Planck-Institut for Nuclear Physics P.O. Box 103980 Heidelberg 69029 Germany School of Physical Science and Technology & School of Information Science and Technology Southwest Jiaotong University Chengdu 610031 China School of Astronomy and Space Science Nanjing University Nanjing 210023 China Center for Astrophysics Guangzhou University Guangzhou 510006 China Tsung-Dao Lee Institute & School of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312 Russia hebei Normal University Shijiazhuang 050024 China University of Science and Technology of China Hefei 230026 China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark matter and Space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210023 China Research Center for Astronomical Computing Zhejiang Laboratory Hangzhou 311121 China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China School of Physics and Astronomy Yunnan University Kunming 650091 China Key Laboratory of Cosmic Rays (Tibet University) Ministry of Education Lhasa 850000 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100101 China School of Physics and Astronomy (Zhuhai) & School of Physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and Technology (Zhuhai) Sun Yat-sen University Zhuhai 519000 & Guangzhou 510275 Guangdong China Institute of Frontier and

The γ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays (CRs) accelerated by the shock of supernova remnant (SNR) W51C and the dense molecular clouds in the adjacent star-forming region, W51B. however, the maximum acceleration capability of W51C for CRs remains elusive. Based on observations conducted with the Large high Altitude Air Shower Observatory (LhAASO), we report a significant detection of γ rays emanating from the W51 complex, with energies from 2 to 200 TeV. The LhAASO measurements, for the first time, extend the γ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of TeV. By combining the "π0-decay bump" featured data from Fermi-LAT, the broadband γ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision model. The observed spectral bending feature suggests an exponential cutoff at ∼400 TeV or a power-law break at ∼200 TeV in the CR proton spectrum, most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV regime. Additionally, two young star clusters within W51B could also be theoretically viable to produce the most energetic γ rays observed by LhAASO. Our findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs. © 2024 Science China Press

关键词： Cosmic rays

Finding biomarkers of experience in animals

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journal of Animal Science and Biotechnology 2024年第3期15卷 925-944页

作者： Sarah Babington Alan j.Tilbrook Shane K.maloney jill N.Fernandes Tamsyn m.Crowley Luoyang Ding Archa h.Fox Song Zhang Elise A.Kho Daniel Cozzolino Timothy j.mahony Dominique Blache School of Agriculture and Environment The University of Western AustraliaCrawleyWA 6009Australia Centre for Animal Science The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of human Sciences The University of Western AustraliaCrawleyWA 6009Australia School of medicine Deakin UniversityGeelongVIC 3217Australia Poultry hub Australia University of New EnglandArmidaleNSW 2350Australia College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Centre for Nutrition and Food Sciences The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia

At a time when there is a growing public interest in animal welfare,it is critical to have objective means to assess the way that an animal experiences a *** is critical to ensure appropriate animal welfare *** behavioural,physiological,and neurobiological indicators that are used to assess animal welfare can verify the absence of extremely negative *** welfare is more than an absence of negative outcomes and an appropriate indicator should reflect the full spectrum of experience of an animal,from negative to *** this review,we draw from the knowledge of human biomedical science to propose a list of candidate biological markers(biomarkers)that should reflect the experiential state of non-human *** proposed biomarkers can be classified on their main function as endocrine,oxidative stress,non-coding molecular,and thermobiological *** also discuss practical challenges that must be addressed before any of these biomarkers can become useful to assess the experience of an animal in real-life.

关键词： Animal experience Animal welfare Biomarker Stress Welfare assessment