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Tyrosine-mediated analog resistive switching for artificial neural networks

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Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song Seok Daniel Namgung Hojung Lee Jeong Hyun yoon young-Woong Song Kang hee Cho yoon-Sik Lee Jong-Seok Lee Ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network

Cobalt phosphide nanoarrays with crystalline-amorphous hybrid phase for hydrogen production in universal-pH

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Nano Research 2020年第9期13卷 2469-2477页

作者： Hyunseok yoon hee Jo Song Bobae Ju Dong-Wan Kim School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea

To accomplish mass hydrogen production by electrochemical water-splitting,it is a necessary to develop robust,highly active,stable,and cost-effective hydrogen evolution reaction(HER)electrocatalysts that perform comparably to Pt in the universal pH *** this work,cobalt phosphide hybrid nanosheets supported on carbon felt(CoP HNS/CF)are presented,which exhibit the superior electrocatalytic hydrogen production under a *** these nanosheets,a single CoP HNS is composed of polycrystalline CoP and oxygen-enriched amorphous Co-O-P *** from its unique nanoarchitecture,as-fabricated CoP HNS/CF exhibits a tremendous electrocatalytic HER activity and outperforms Pt/C as well as state-of-the-art CoP electrocatalysts in *** acidic and neutral media,the CoP HNS/CF shows superior electrocatalytic activity while maintaining its original hybrid crystalline-amorphous phase and *** alkaline medium,the unexpected phase and morphological reorganization of CoP HNS/CF results in outstanding electrocatalytic *** HNS/CF not only achieves high electrocatalytic activity and kinetics,but also a stable and long operating lifetime even under a high current density of 500 mA cm'***,the fabrication of CoP HNS/CF can be scaled up easily,and the large CoP HNS/CF electrode also exhibits similar electrocatalytic activity and stability.

关键词： cobalt phosphide self-supporting electrocatalyst hydrogen evolution reaction universal-ph large-scale

Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults

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World Journal of Gastroenterology 2009年第44期15卷 5620-5623页

作者： Sook hee Chung young Sook Park Yun Ju Jo Seong Hwan Kim Dae Won Jun Byoung Kwan Son Jun young Jung Dae Hyun Baek Dong hee Kim yoon young Jung Won Mi Lee Department of Internal Medicine Eulji General Hospital Eulji University School of MedicineSeoul 139-711South Korea Department of General Surgery Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Radiology Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Pathology Eulji General Hospital Eulji University School of MedicineSeoul 139-711 South Korea

Lymphangioma, a benign neoplasm of the lymphatic system, is common in children but rare in adults. Its clinical manifestations include abdominal pain, nausea, vomiting and a palpable mass. However, abdominal sonography or abdominal computed tomography （CT） scan can also incidentally reveal lymphangioma. A larger or symptomatic lymphangioma is treated with total resection to prevent recurrence, infection, torsion and enlargement. Although lymphangioma rarely becomes malignant, its prognosis is generally good. We report a cystic lymphangioma of the spleen and retroperitoneum, which was incidentally found in a 56-year-old man who was hospitalized due to a colon mass. Physical examination showed no specific findings. Abdominal CT revealed a 5.7 cm, non-enhanced multilobulated cystic mass with multiple sepia in the spleen and a 10 cm lobulated cystic mass in the paraaortic area. Splenectomy and retroperitoneal resection of the cystic mass were conducted. The endothelium of splenic and retroperitoneal cyst was immunohistochemically stained with D2-40 antibody. The patient was finally diagnosed with splenic cystic and retroperitoneal cavernous lymphangioma.

关键词： Lymphangioma Retroperitoneum Spleen

A study on the interference effects for tidal current power rotors

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Science China(Technological Sciences) 2010年第11期53卷 3094-3101页

作者： Chul-hee JO Kang-hee LEE Jin-young YIM Department of Naval Architecture & Ocean Engineering Inha University

Due to global warming, the need to secure an alternative resource has become more important nationally. With the high tidal range of up to 9.7 m on the west coast of Korea, numerous tidal current projects are being planned and constructed. To extract a significant quantity of power, a tidal current farm with a multi-arrangement is necessary in the ocean. The rotor, which initially converts the energy, is a very important component because it affects the efficiency of the entire system, and its performance is determined by various design variables. The power generation is strongly dependent on the size of the rotor and the incoming flow velocity. However, the interactions between devices also contribute significantly to the total power capacity. Therefore, rotor performance considering the interaction problems needs to be investigated for generating maximum power in a specific field. This paper documents a performance study of devices considering the interference between rotating rotors with axial, transverse and diagonal arrangements.

关键词： TCP (tidal current power) renewable energy interference effect rotor CWC (circulation water channel) CFD (computational fluid dynamics)

Spectrum and Singular Integrals on a New Weighted Function Space

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Acta Mathematica Sinica,English Series 2018年第11期34卷 1692-1702页

作者： hee Chul PAK young Ja PARK Department of Mathematics Dankook University Dandae-ro 119 Dongnam-gu Cheonan-si Chungnam 31116 Republic of Korea Department of Mathematics Hoseo University Hoeo-ro 79 Asan-si Chungnam 31499 Republic of Korea

We introduce a new function space that is much finer than the classical Lebesgue spaces, and investigate the continuity and the discontinuity of the Calderon-Zygmund operators on the new weighted spaces. In order to identify the continuity of singular integrals, we prove an interpolation theorem on the new spaces and propose a concept of the spectrum of base functions.

关键词： Function spaces singular integrals interpolation Calderdn Zygmund operators Holder's inequality L log L

Thermal deformation of aluminum alloy casting materials for tire mold by numerical analysis

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中国有色金属学会会刊：英文版 2012年第S3期22卷 859-863页

作者： hee-Sung yoon Je-Se CHOI Yool-Kwon OH Department of Advanced Parts and Materials Engineering Chosun University Department of Mechatronics Engineering Chosun University

Thermal deformation of aluminum alloy casting materials for manufacturing the tire mold was numerically *** AC7A and AC4C casting material was selected as casting material and the metal casting device was used in order to manufacture the mold product of automobile tire in the actual industrial *** temperature distribution and the cooling time of casting materials were numerically calculated by finite element analysis (FEA).Also,the thermal deformation such as displacement and stress distribution was calculated from the temperature *** thermal deformation was closely related to the temperature difference between the surface and inside of the *** numerical analysis results reveal that the thermal deformation of AC7A casting material is higher than that of AC4C casting ***,the thermal deformation results at the central part are larger than that on the side of casting because of the shrinkage caused by the cooling speed difference.

关键词： thermal deformation finite element analysis AC7A casting material AC4C casting material

Epidemic obesity in children and adolescents:risk factors and prevention

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Frontiers of Medicine 2018年第6期12卷 658-666页

作者： Eun young Lee Kun-Ho yoon Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Korea Institute of Catholic Ubiquitous Health Care The Catholic University of KoreaSeoul 06591Korea

The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, with more than 100 million affected in 2015. Moreover, the epidemic of obesity in this population has been an important public health problem in developed and developing countries for the following reasons. Childhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseases, including type 2 diabetes, hypertension, and cardiovascular disease. Furthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death. Although an imbalance between caloric intake and physical activity is a principal cause of childhood and adolescent obesity, environmental factors are exclusively important for development of obesity among children and adolescents. In addition to genetic and biological factors, socioenvironmental factors, including family, school, community, and national policies, can play a crucial role. The complexity of risk factors for developing obesity among children and adolescents leads to difficulty in treatment for this population. Many interventional trials for childhood and adolescent obesity have been proven ineffective. Therefore, early identification and prevention is the key to control the global epidemic of obesity. Given that the proportion of overweight children and adolescents is far greater than that of obesity, an effective prevention strategy is to focus on overweight youth, who are at high risk for developing obesity. Multifaceted, comprehensive strategies involving behavioral, psychological, and environmental risk factors must also be developed to prevent obesity among children and adolescents.

关键词： obesity children adolescents epidemiology risk factor prevention

Toward genetic transformation of mitochondria in mammalian cells using a recoded drug-resistant selection marker

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Journal of Genetics and Genomics 2011年第4期38卷 173-179页

作者： young Geol yoon Michael Duane Koob Mitochondria Hub Regulation Center and Department of Anatomy and Cell Biology Dong-A University College of Medicine 3-1 Dongdaesin-dongSeo-gu Busan 602-714 Republic of Korea Department of Laboratory Medicine and Pathology and Institute of Human Genetics University of Minnesota Medical School 420 Delaware St. S.E.Minneapolis MN 55455 USA

Due to technical difficulties,the genetic transformation of mitochondria in mammalian cells is still a *** this report,we described our attempts to transform mammalian mitochondria with an engineered mitochondrial genome based on selection using a drug resistance *** the standard drug-resistant neomycin phosphotransferase confers resistance to high concentrations of G418 when targeted to the mitochondria,we generated a recoded neomycin resistance gene that uses the mammalian mitochondrial genetic code to direct the synthesis of this protein in the mitochondria,but not in the nucleus（mitochondrial version）.We also generated a universal version of the recoded neomycin resistance gene that allows synthesis of the drug-resistant proteins both in the mitochondria and *** we transfected these recoded neomycin resistance genes that were incorporated into the mouse mitochondrial genome clones into mouse tissue culture cells by electroporation,no DNA constructs were delivered into the *** found that the universal version of the recoded neomycin resistance gene was expressed in the nucleus and thus conferred drug resistance to G418 selection,while the synthetic mitochondrial version of the gene produced no background drug-resistant cells from nuclear *** recoded synthetic drug-resistant genes could be a useful tool for selecting mitochondrial genetic transformants as a precise technology for mitochondrial transformation is developed.

关键词： Mitochondrial codon Recode Mitochondrial transformation Selection marker G418 Neo^R

Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors——8 cases: A case report

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World Journal of Gastroenterology 2019年第16期25卷 2010-2018页

作者： Jwa Hoon Kim Min-hee Ryu young Soo Park Hyun Jin Kim Hyojung Park yoon-Koo Kang Department of Oncology Asan Medical CenterUniversity of Ulsan College of Medicine Department of Pathology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

BACKGROUND Intra-abdominal desmoid tumors(DTs) can mimic recurrence or progression of gastrointestinal stromal tumors(GISTs). Differential diagnosis is important to avoid unnecessary or inappropriate *** SUMMARY All 8 patients experienced surgical resection of GIST, and median time to diagnosis of DT was 1.8 years after surgical resection. All sites of DT were in the peritoneum around the surgical sites of GIST. The following clinical suspicion coupled with radiological findings contributed to the suspicion of intraabdominal DTs:(1) Occurrence of a new single lesion in the peritoneum around the surgical sites of GIST;(2) uncontrolled lesion with imatinib while other lesions being controlled with imatinib;(3) well-defined ovoid shaped lesion with delayed or mild enhancement and absence of necrosis, hemorrhage, and cystic change on computed tomography; and(4) a lesion showing mild or no hypermetabolic activity on 18 fluorodeoxyglucose-positron emission tomography,contrary to initially hyperactive lesion of GIST. All DTs were surgically removed except for one unresectable DT and only one DT recurred at another site of peritoneum, which was also surgically *** Intra-abdominal DT should be a differential diagnosis for a new single lesion in patients with GIST.

关键词： Desmoid tumor Gastrointestinal stromal tumor Radiology Surgicalresection Imatinib mesylate Case report