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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 665-677页

作者： Levie Mweene Gilsang Hong hee-eun jeong hee-won Kang Hyunjung Kim Department of Earth Resources and Environmental Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea

Comparative experiments and theoretical analysis of the surface chemistry changes of goethite(GT)and goethite containing Ni(GTN)in the lattice in the presence of salicylhydroxamic acid(SA)were *** was revealed that in the presence of 100 g·t^(-1)of SA,the flotation recovery of GTN and GT increased with increasing pH,achieving a maximum recovery of 98.9%for both minerals at p H 8.3 and decreasing beyond that pH,with GTN having a slightly higher recovery than GT,except at pH *** was further confirmed by the higher complexation energies of GTN···SA(-883.87 kJ·mol^(-1))compared with GT···SA(-604.23 kJ·mol^(-1))resulting from covalent,closed-shell,and conventional hydrogen *** higher adsorption of SA onto GTN relative to GT was due to the formation of aπ-hole in GTN,thereby promoting a higher interaction of the collector with the ***,the presence of Ni in the GT lattice improves and decreases the adsorption and desorption of SA onto and from the mineral,respectively,compared with those onto and from GT.

关键词： nickel goethite adsorption salicylhydroxamic acid recovery

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid eun jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Antioxidant and anticancer activity of Artemisia princeps *** extract in HepG2 and Hep3B hepatocellular carcinoma cells

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Chinese Journal of Cancer Research 2013年第5期25卷 536-543页

作者： eun-jeong Choi Gun-hee Kim Plant Resources Research Institute Duksung Women's University

Objective：The aim of the present study was to investigate antioxidant and the anticancerigen activity of a methanol extract from Artemisia princeps *** （APME）,a well-known traditional herbal medicine in Asia,in hepatocellular cancer ***：To evaluate the antioxidant activity of APME,reactive oxygen species （ROS） and the antioxidant enzymes,superoxide dismutase （SOD） and catalase were investigated in HepG2 cells exposed to APME （5,100,and 200 μg/mL） for 72 ***,to evaluate the anticancer activity of APME,we investigated the proliferation and apoptosis induction of HepG2 and Hep3B cells exposed to APME （1-200 μg/mL） for 24,48,and 72 ***：APME dose-dependently reduced the generation of ROS in the presence of H2O2 compared with control ***,it increased catalase and SOD ***,APME inhibited cell proliferation in a dose-and time-dependcnt manner,but at concentrations lower than 100 μg/mL,the inhibition was less dose-dependent than ***2 and Hep3B cells exposed to 5,100,and 200 μg/mL APME for 72 h underwent cell cycle arrest and *** to APME resulted in a significant increase in the number of cells in G1 phase and a decrease in the G2/M phase cell *** addition,APME induced P53 expression of HepG2 cells in a dose-dependent manner,and played a role in the downregulation of Bcl-2 and upregulation of Bax in both HepG2 and Hep3B ***：These results indicate the potential role of APME as an antioxidant and anticancerigen agent in hepatocarcinoma cell lines.

关键词： Artemisia princeps var.orientalis antioxidant anticancer hepatocellular carcinoma

Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： Md Ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar Jae-Hun jeong Jihoon Lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Potassium hydroxide

Enhancing ammonia production rates from electrochemical nitrogen reduction by engineering three-phase boundary with phosphorus-activated Cu catalysts

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Journal of Energy Chemistry 2023年第9期84卷 394-401页

作者： Jeehye Kim Cho hee Lee Yong Hyun Moon Min hee Lee eun Hyup Kim Sun hee Choi Youn jeong Jang Jae Sung Lee School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Chemical Engineering Hanyang UniversitySeoul 04763Republic of Korea Pohang Accelerator Laboratory(PAL) Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Electrochemical N_(2) reduction reaction(eNRR) over Cu-based catalysts suffers from an intrinsically low activity of Cu for activation of stable N_(2) molecules and the limited supply of N_(2) to the catalyst due to its low solubility in aqueous ***,we propose phosphorus-activated Cu electrocatalysts to generate electron-deficient Cu sites on the catalyst surface to promote the adsorption of N_(2) *** eNRR system is further modified using a gas diffusion electrode(GDE) coated with polytetrafluoroethylene(PTFE) to form an effective three-phase boundary of liquid water-gas N_(2)-solid catalyst to facilitate easy access of N_(2) to the catalytic *** a result,the new catalyst in the flow-type cell records a Faradaic efficiency of 13.15% and an NH_(3) production rate of 7.69 μg h^(-1) cm^(-2) at-0.2 V_(RHE),which represent 3.56 and 59.2 times increases from those obtained with a pristine Cu electrode in a typical electrolytic *** work represents a successful demonstration of dual modification strategies;catalyst modification and N_(2) supplying system engineering,and the results would provide a useful platform for further developments of electrocatalysts and reaction systems.

关键词： Electrochemical nitrogen reduction reaction Ammonia production Phosphorous modified copper electrodes Gas diffusion electrodes Three-phase boundary PTFE coating

Breast adenoid cystic carcinoma arising in microglandular adenosis:A case report and review of literature

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World Journal of Clinical Cases 2021年第25期9卷 7579-7587页

作者： Jin Kyung An jeong Joo Woo eun Kyung Kim hee Yong Kwak Department of Radiology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Pathology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Surgery Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea

BACKGROUND Breast adenoid cystic carcinoma(AdCC)is a rare invasive carcinoma composed of epithelial and myoepithelial *** adenosis(MGA)is a rare benign proliferative lesion consisting of small,uniform,and round glands formed by a single layer of epithelial cells and basement membrane without a myoepithelial cell *** may progress to atypical MGA and carcinoma arising in *** various invasive carcinomas from MGA,AdCC has been rarely ***,we report a case of AdCC arising in *** SUMMARY A 59-year-old woman was diagnosed with a newly developed density on a routine *** density was similar to or slightly lower than that of the breast *** showed an irregular mass with a slightly higher echo than that of *** resonance imaging showed an irregular mass with a similar T1 signal intensity and a slightly higher T2 signal intensity compared to muscles or the breast *** lesion showed heterogeneous internal enhancement with an initially slow and delayed persistent enhancing ***,the tumor was composed of invasive AdCC,in situ AdCC,and *** is composed of basaloid and ductal epithelial cells forming cribriform or solid sheets,or haphazardly scattered small cribriform or tubular *** showed small glands with a single epithelial lining and retained lumen.S-100 staining was strongly positive in MGA *** patient underwent breast-conserving surgery with sentinel lymph node *** Breast AdCC arising in MGA showed unique imaging findings that was different from usual invasive cancer.

关键词： Breast neoplasms Fibrocystic breast disease Carcinoma Adenoid cystic Case report

Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

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Chinese Journal of Integrative Medicine 2022年第9期28卷 802-808页

作者： Bo-Ra Jeon Muhammad Irfan Seung eun Lee jeong Hoon Lee Man hee Rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal Science(NIHHS)Eumseong27709Republic of Korea

Objective:To examine the antiplatelet and antithrombotic activity of Rumex acetosella ***:Standard light aggregometry was used for platelet aggregation,intracellular calcium mobilization assessed using Fura-2/AM,granule secretion(ATP release)by luminometer,and fibrinogen binding to integrin α_(Ⅱb)β_(3) detected using flow *** blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase(MAPK)and phosphoinositide 3-kinase(PI3K)/Akt ***:Rumex acetosella displayed the ability to inhibit platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin α_(Ⅱb)β_(3).Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation(all P<0.01).Conclusion:Rumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling,and it may protect against the development of platelet-related cardiovascular diseases.

关键词： antiplatelet ethnomedicine integrinα_(Ⅱb)β_(3) mitogen-activated protein kinase Rumex acetosella L.

Rice tissue-specific promoters and conditiondependent promoters for effective translational application

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Journal of Integrative Plant Biology 2015年第11期57卷 913-924页

作者： hee-jeong jeong Ki-Hong Jung Department of Plant Molecular Systems Biotechnology and Crop Biotech Institute Kyung Hee University Graduate School of Biotechnology Kyung Hee University

Rice （Oryza sativa） is one of the most important staple food crops for more than half of the world＇s population. The demand is increasing for food security because of population growth and environmental challenges triggered by climate changes. This scenario has led to more interest in developing crops with greater productivity and sustainability. The process of genetic transformation, a major tool for crop improvement, utilizes promoters as one of its key elements. Those promoters are generally divided into three types： constitutive, spatiotemporal, and condition-dependent. Tran- scriptional control of a constitutive promoter often leads to reduced plant growth, due to a negative effect of accumu- lated molecules during cellular functions or energy consump- tion. To maximize the effect of a transgene on transgenic plants, it is better to use condition-dependent or tissue- specific promoters. However, until now, those types have not been as widely applied in crop biotechnology. In this review, we introduce and discuss four groups of tissue-specific promoters （5o promoters in total） and six groups of condition-dependent promoters （27 promoters）. These pro- moters can be utilized to fine-tune desirable agronomic traits and develop crops with tolerance to various stresses, enhanced nutritional value, and advanced productivity.

关键词： Condition-dependent promoters crop biotechnologyapplication genetic transformation rice tissue-specific promoters

Reliable high temperature, high humidity flexible thin film encapsulation using Al2O3/MgO nanolaminates for flexible OLEDs

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Nano Research 2020年第10期13卷 2716-2725页

作者： Ki Suk Kang So Yeong jeong eun Gyo jeong Kyung Cheol Choi School of Eetrical Enginerng Korea Advanced lstute of Sciencp and Tchcnoloy(KAIST) 291 Daehak roYuscong guDaejeon 34141Republic of Korea Department of Clothing and Textiles Chormam National University77 Yongbong.roBuk guGwangjiu 61186Republic of Korea

Since most organic materials are very sensitive to moisture and oxygen, organic light emitting diodes (OLEDs) require an encapsulation layer to protect the active layer from these gases. Since light, flexible and portable OLEDs are being employed in more diverse climates and environmental conditions, the OLED encapsulation layer must retain robust mechanical properties and stability in high temperature/high humidity conditions. Al2O3 films have demonstrated excellent barrier performance, but they readily hydrolyze when exposed to prolonged harsh environments. In this study, we fabricated a thin film encapsulation (TFE) film that was resistant to hydrolysis, using Al2O3/MgO (AM) nanolaminates. MgO has superior resistance to harsh environments, and the aluminate phase generated by the chemical reaction of Al2O3 and MgO provided excellent barrier performance, even after storage in harsh conditions. A multi-barrier fabricated using the AM nanolaminate showed excellent barrier performance, close to the level required by OLEDs. It did not significantly deteriorate even after a bending test of 1,000 iterations at 0.63% strain. After 1,000 cycle of bending, the electrical properties of the passivated OLEDs were not significantly degraded at shelf-lifetime test where the fabricated device was stored for 50 days in a harsh environment of 60℃, 90% relative humidity. The multi-barrier shows the best performance compared to previous studies on flexible encapsulation that can be used in harsh environments.

关键词： thin film encapsulation nanolaminate structure Al2O3 MgO flexible organic light emitting diode(OLED)

Electrochemical processing of spent nuclear fuels:An overview of oxide reduction in pyroprocessing technology

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Progress in Natural Science:Materials International 2015年第6期25卷 572-582页

作者： eun-Young Choi Sang Mun jeong Korea Atomic Energy Research Institute Department of Chemical Engineering Chungbuk National University

The electrochemical reduction process has been used to reduce spent oxide fuel to a metallic form using pyroprocessing technology for a closed fuel cycle in combination with a metal-fuel fast *** the electrochemical reduction process,oxides fuels are loaded at the cathode basket in molten LiO–LiCl salt and electrochemically reduced to the metal *** approaches based on thermodynamic calculations and experimental studies have been used to understand the electrode reaction and efficiently treat spent *** factors that affect the speed of the electrochemical reduction have been determined to optimize the process and scale-up the electrolysis *** addition,demonstrations of the integrated series of processes(electrorefining and salt distillation) with the electrochemical reduction have been conducted to realize the oxide fuel *** overview provides insight into the current status of and issues related to the electrochemical processing of spent nuclear fuels.

关键词： Pyroprocessing Electrochemical reduction Electrorefining Molten salt Spent oxide fuel