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Establishment of a prediction tool for ocular trauma patients with machine learning algorithm

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1941-1949页

作者： Seungkwon choi Jungyul Park Sungwho Park Iksoo Byon hee-young choi Department of Ophthalmology Pusan National University HospitalBusan 49241Republic of Korea Biomedical Research Institute of Pusan National University Hospital Busan 49241Republic of Korea Department of Ophthalmology School of MedicinePusan National UniversityBusan 49241Republic of Korea

AIM:To predict final visual acuity and analyze significant factors influencing open globe injury ***:Prediction models were built using a supervised classification algorithm from Microsoft Azure Machine Learning *** best algorithm was selected to analyze the predicted final visual *** retrospectively reviewed the data of 171 patients with open globe injury who visited the Pusan National University Hospital between January 2010 and July *** then applied cross-validation,the permutation feature importance method,and the synthetic minority over-sampling technique to enhance tool ***:The two-class boosted decision tree model showed the best predictive *** accuracy,precision,recall,F1 score,and area under the receiver operating characteristic curve were 0.925,0.962,0.833,0.893,and 0.971,*** increase the efficiency and efficacy of the prognostic tool,the top 14 features were finally selected using the permutation feature importance method:(listed in the order of importance)retinal detachment,location of laceration,initial visual acuity,iris damage,surgeon,past history,size of the scleral laceration,vitreous hemorrhage,trauma characteristics,age,corneal injury,primary diagnosis,wound location,and lid ***:Here we devise a highly accurate model to predict the final visual acuity of patients with open globe *** tool is useful and easily accessible to doctors and patients,reducing the socioeconomic *** further multicenter verification using larger datasets and external validation,we expect this model to become useful worldwide.

关键词： machine learning ocular trauma open globe injury predictive model vision preservation

Myeloid sarcoma of the eyelid mimicking pre-septal cellulitis in acute myeloid leukemia

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1359-1361页

作者： Jungyul Park Hyeshin Jeon hee-young choi Department of Ophthalmology Pusan National UniversityHospitalBusan602-739Korea Biomedical Research Institute of Pusan National UniversityHospital Busan602-739Korea

Dear Editor,I am Dr. Jungyul Park from the Division of oculoplasty, Department of Ophthalmology, Pusan National University Hospital, Busan, Korea. I write to discuss a case of myeloid sarcoma of the eyelid mimicking p... 详细信息

关键词： AML Myeloid sarcoma

Direct approach to thrombosed superior ophthalmic vein of recalcitrant indirect carotid cavernous fistula in thrombocythemia failed with multiple conventional embolization treatment

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 687-692页

作者： Jungyul Park Jae-Il Lee Hyeshin Jeon hee-young choi Department of Ophthalmology Pusan National University HospitalBusan 49241Korea Biomedical Research Institute of Pusan National University Hospital Busan 49241Korea Department of Neurosurgery Pusan National University HospitalBusan 49241Korea Department of Ophthalmology School of MedicinePusan National UniversityBusan 49241Korea

Dear Editor,I am Dr. Jungyul Park from the Division of Oculoplasty, Department of Ophthalmology, Pusan National University Hospital, Busan, Korea. I am writing to present a case of direct approach to thrombosed superior ophthalmic vein of recalcitrant indirect carotid cavernous fistula which was failed to treat with multiple conventional embolization treatment. To our knowledge this is very challenging procedure to the ophthalmologist, and not well described in literatures, especially in thrombocythemia patient with thrombosed superior ophthalmic vein.

关键词： thrombo fistula carotid

Central retinal artery occlusion in eosinophilic granulomatosis with polyangiitis(Churg-Strauss Syndrome):the first case report in South Korea

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 948-951页

作者： Jungyul Park Up Huh hee-young choi Seunggeun Lee Miyeun Han Sungwoon Chung Hyerim Kim Department of Ophthalmology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Department of Rheumatology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Department of Nephrology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Department of Laboratory Medicine Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea

Dear Editor,I am *** Park from the Department of Ophthalmology,Pusan National University Hospital,Busan,Korea.I am writing to present a case of eosinophilic granulomatosis with polyangiitis(EGPA)with central retinal artery occlusion(CRAO).It provides important information about the relationship between ANCA and CRAO in a patient who was diagnosed with EGPA who had ophthalmic *** believe that our study makes a significant contribution to the literature because to our knowledge,the literature of EGPA with CRAO are rare worldwide and this is even the first case of EGPA with CRAO in Republic of Korea.

关键词： granuloma occlusion eosinophilic

Higher plasma bilirubin predicts veno-occlusive disease in early childhood undergoing hematopoietic stem cell transplantation with cyclosporine

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World Journal of Transplantation 2016年第2期6卷 403-410页

作者： Kwi Suk Kim Aree Moon Hyoung Jin Kang hee young Shin young hee choi Hyang Sook Kim Sang Geon Kim Department of Pharmacy Seoul National University Hospital College of Pharmacy Duksung Women’s University Department of Pediatrics Cancer Research InstituteSeoul National University College of Medicine College of Pharmacy Dongguk University College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University

AIM: To analyze the association between plasma bilirubin levels and veno-occlusive disease(VOD) in non-adult patients undergoing hematopoietic stem cell transplantation(HSCT) during cyclosporine ***: A total of 123 patients taking cyclosporinewere evaluated using an electronic medical system at the Seoul National University Children's Hospital from the years 2004 through 2011. Patients were grouped by age and analyzed for incidence and type of adverse drug reactions(ADRs) including VOD. RESULTS: The HSCT patients were divided into three age groups: G#1 ≥ 18; 9 ≤ G#2 ≤ 17; and G#3 ≤ 8 years of age). The majority of transplant donor types were cord blood transplantations. Most prevalent ADRs represented acute graft-vs-host disease(a GVHD) and VOD. Although the incidences of a GVHD did not vary among the groups, the higher frequency ratios of VOD in G#3 suggested that an age of 8 or younger is a risk factor for developing VOD in HSCT patients. After cyclosporine therapy, the trough plasma concentrations of cyclosporine were lower in G#3 than in G#1, indicative of its increased clearance. Moreover, in G#3 only, a maximal total bilirubin level(BILmax) of ≥ 1.4 mg/d L correlated with VOD incidence after cyclosporine therapy. CONCLUSION: HSCT patients 8 years of age or younger are more at risk for developing VOD, diagnosed as hyperbilirubinemia, tender hepatomegaly, and ascites/weight gain after cyclosporine therapy, which may be represented by a criterion of plasma BILmax being ≥ 1.4 mg/d L, suggestive of more sensitive VOD indication in this age group.

关键词： Hematopoietic stem cell transplantation Veno-occlusive disease Cyclosporine Adverse drug reaction Total bilirubin

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

Projections of ocean climate for northwestern Pacific Ocean

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Acta Oceanologica Sinica 2005年第1期24卷 134-145页

作者： choi Byung Ho KIM Dong Hoon choi young Jin YUK Jin hee Department of Civil and Environmental Engineering Sungkyunkwan University Suwon KoreaAbiko Research Laboratory Central Research Institute of Electric Power Industry JapanResearch Institute of Applied Mechanics Kyushu University JapanDepartment of Civil and Environmental Engineering Sungkyunkwan University Suwon Korea

The long-term adjustment processes of atmosphere and ocean in response to gradually increased atmospheric CO2 concentration have been analyzed in 70 and 140 a integrations with NCAR fully-coupled climate system model (CSM). In these experiments the CO2 concentration has been increased to double and quadruples the initial concentration, respectively. After 70 a, at the time of CO2 doubling, the model predicts surface air temperature rises by 1.2 and 1.5 K for the globe and the northwestern Pacific Ocean, respectively. The behavior of the quadrupling run is similar: each global and regional mean surface air temperatures increase by 2.8 and 3.0 K at the time of CO2 quadrupling. From the experiments, surface air temperature changes in the northwestern Pacific Ocean will be more distinctive compared with the global average, mainly due to exceptionally large wanning and sea level change near the entrance of the Kuroshio extension.

关键词： Climate model simulation global warming northwestern Pacific Ocean

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