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East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan

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Research in Astronomy and Astrophysics 2021年第8期21卷 220-234页

作者： Yu-Zhu Cui Kazuhiro Hada Motoki Kino Bong-Won Sohn Jongho Park Hyun-Wook Ro Satoko Sawada-Satoh Wu Jiang Lang Cui Mareki Honma Zhi-Qiang Shen Fumie Tazaki Tao An Ilje Cho Guang-Yao Zhao Xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-Kang Zhang Noriyuki Kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo Xia Yong-Bin Jiang Lin-Feng Yu Wei Gou Ju-Yeon Hwang Yong-Chen Jiang Yun-Xia Sun Dong-Kyu jung Hyo-Ryoung Kim Jeong-sook Kim Hideyuki Kobayashi Jee-Won Lee Jeong-Ae Lee Hua Zhang Guang-Hui Li Zhi-Qiang Xu Peng Li jung-Hwan Oh Se-Jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh Katsunori-M.Shibata Wen Guo Rong-Bing Zhao Wei-Ye Zhong Jin-Qing Wang Wen-jun Yang Hao Yan Jae-Hwan Yeom Bin Li Xiao-Fei Li Jian-Ping Yuan Jian Dong Zhong Chen Kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki Hagiwara Jeffrey Hodgson Tae-Hyun jung Kee-Tae Kim Sang-Sung Lee Kunwoo Yi Qing-Hui Liu Xiang Liu Ru-Sen Lu Masanori Nakamura Sascha Trippe Na Wang Xue-Zheng Wang Bo Zhang Department of Astronomical Science The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan Mizusawa VLBI Observatory National Astronomical Observatory of Japan2-12 HoshigaokaMizusawaOshuIwate 023-0861Japan Kogakuin University of Technology and Engineering Academic Support Center2665-1 NakanoHachiojiTokyo 192-0015Japan Korea Astronomy and Space Science Institute Yuseong-guDaejeon 34055Korea Department of Astronomy Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Korea Department of Astronomy and Space Science University of Science and Technology217 Gajeong-roDaejeonKorea Institute of Astronomy and Astrophysics Academia Sinica645 N Aohoku PIHiloHI 96720USA Graduate School of Sciences and Technology for Innovation Yamaguchi UniversityYoshida 1677-1YamaguchiYamaguchi 753-8512Japan Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Institute of Astronomy The University of Tokyo2-21-1 OsawaMitakaTokyo 181-0015Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomia s/nGranada E-18008Spain Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Center for Astronomy Ibaraki University2-1-1 BunkyoMitoIbaraki 310-8512Japan Space Light Laboratory 77Yangjaedae-ro 86 roadGangdong-guSeoulKorea Massachusetts Institute of Technology Haystack Observatory 99 Millstone RoadWestfordMA 01886USA National Radio Astronomy Observatory 520 Edgemont RdCharlottesvilleVA 22903USA Toyo University 5-28-20 HakusanBunkyo-kuTokyo 112-8606Japan Department of Physics and Astronomy Seoul National UniversityGwanak-guSeoul 08826Korea Max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany SNU Astronomy Research Center Seoul National UniversityGwanak-guSeoul 08826Korea

The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and *** aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian *** the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively *** we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in *** test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and *** a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA *** addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular *** the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully *** demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in *** expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network.

关键词： galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies

Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

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npj Flexible Electronics 2022年第1期6卷 840-853页

作者： Ju Young Lee Sang Hoon Park Yujin Kim Young Uk Cho Jaejin Park jung-Hoon Hong Kyubeen Kim Jongwoon Shin Jeong Eun Ju In Sik Min Mingyu Sang Hyogeun Shin Ui-Jin Jeong Yuyan Gao Bowen Li Aizhan Zhumbayeva Kyung Yeun Kim Eun-Bin Hong Min-Ho Nam Hojeong Jeon Youngmee jung Huanyu Cheng Il-Joo Cho Ki jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-KIST Convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous

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基于辣椒基因组测序探究辣味在种群中的进化

辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo hee-Bum Yang hee-Jin Jeong Won-hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun Lim june Hyun Park Jin Hoe Huh june-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-sook Pai hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation Korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental Sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological Sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

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RLWT与APA车辙试验加载模式比较分析

公路 2006年第7B期51卷 331-336页

作者：张俊标徐科张肖宁广东省高速公路有限公司广州市510010 华南理工大学道路工程研究所广州市510640

旋转车辙仪(RLW T-R otary Loaded W hee l T ester or R u tm eter)于20世纪90年代末开始在美国出现,因其轻便、易用,迅速受到关注。研究表明,RLW T与沥青路面分析仪(APA)、国际车辙仪的相关性都不理想。本文利用数字图像处理技术对RL... 详细信息

旋转车辙仪(RLW T-R otary Loaded W hee l T ester or R u tm eter)于20世纪90年代末开始在美国出现,因其轻便、易用,迅速受到关注。研究表明,RLW T与沥青路面分析仪(APA)、国际车辙仪的相关性都不理想。本文利用数字图像处理技术对RLW T与APA车辙试验的加载模式进行了分析,通过量测RLW T试件、APA试件与原样试件中粗集料颗粒长轴与X轴夹角的差异,得出结论:RLW T与APA车辙试验的加载模式存在较大差异。

关键词：旋转车辙仪(RLWT) 沥青路面分析仪(APA) 车辙试验数字图像处埋

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采用OFDM信号作为标记的光分组交换方案

光子学报 2010年第1期39卷 84-88页

作者：张超俐陈林邵宇丰曹子峥李登科余建军湖南大学计算机与通信学院微纳光电器件及应用教育部重点实验室长沙410082

以光正交频分复用信号作为光标记,利用两个不同波长的光载波分别经过强度调制,产生了10 Gb/sook光载荷和2.5 Gb/sOFDM光标记。测得了光分组信号经光纤传输前后接收载荷的眼图和标记的星座图以及误码率曲线,结果表明:经过40 km光纤传输后... 详细信息

以光正交频分复用信号作为光标记,利用两个不同波长的光载波分别经过强度调制,产生了10 Gb/sook光载荷和2.5 Gb/sOFDM光标记。测得了光分组信号经光纤传输前后接收载荷的眼图和标记的星座图以及误码率曲线,结果表明:经过40 km光纤传输后,载荷与标记的功率代价分别为1dB和0.5dB。

关键词：光纤通信光标记交换强度调制正交频分复用

Y_(1.95-x)Gd_xSiO_5:Eu_(0.05)的真空紫外光谱

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发光学报 2000年第2期21卷 145-149页

作者：宋桂兰尤洪鹏洪广言曾小青甘树才金昌弘卞钟洪庾炳容裴贤淑权一亿朴哲熙长春科学技术大学中国科学院长春应用化学研究所中国科学院长春应用化学研究所吉林长春130022 Division of Applied Scienxe

利用高温固相法合成了Ｙ１．９５－ｘＧｄｘＳｉＯ５：Ｅｕ０．０５（ｘ＝０．６ｍｏｌ％）荧光体。结构测定表明所合成的荧光体为单斜晶系的Ｘ２型Ｙ２ＳｉＯ５相，空间群为Ｂ２／ｂ。真空紫外光谱表明：随着Ｇｄ３＋含量的增加，在... 详细信息

利用高温固相法合成了Ｙ１．９５－ｘＧｄｘＳｉＯ５：Ｅｕ０．０５（ｘ＝０．６ｍｏｌ％）荧光体。结构测定表明所合成的荧光体为单斜晶系的Ｘ２型Ｙ２ＳｉＯ５相，空间群为Ｂ２／ｂ。真空紫外光谱表明：随着Ｇｄ３＋含量的增加，在１９２ｕｍ附近，出现了Ｇｄ＋的激发峰，且此峰的强度随着Ｇｄ３＋含量的增加而增大；同时位于１５０～１８５ｎｍ之间的基质吸收带的强度也增大；而位于２００～３００ｎｍ之间的Ｅｕ的电行迁移带的强度却随着Ｇｄ３＋含量的增加而降低。

关键词：真空紫外光谱基质吸收带荧光粉

Efficacy of Pegylated Interferon Monotherapy versus Sequential Therapy of Entecavir and Pegylated Interferon in Hepatitis B e Antigen-Positive Hepatitis B Patients： A Randomized, Multicenter, Phase IIIb Open-Label Study （POTENT Study）

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Chinese Medical Journal 2018年第14期131卷 1645-1651页

作者： Dae Won jun Sang Bong Ahn Tae Yeob Kim Joo Hyun Sohn Sang Gyune Kim Se Whan Lee Byung Ho Kim Dong Joon Kim Ja Kyung Kim Hyoung Su Kim Seong Gyu Hwang Won Choong Choi Won Young Tak Heon Ju Lee Ki Tae Yoon Byung Cheol Yun Sung Wook Lee Soon Koo Baik Seung Ha Park Ji Won Park Sol Ji Park Ji Sung Lee Department of Internal Medicine Hanyang University Seoul Hospital Hanyang University Seou104763 Korea Department of Internal Medicine Nowon Eulji Hospital Eulji University Seou101830 Korea Department of Internal Medicine Hanyang University Guri Hospital Hanyang University Guri 11923 Korea Department of Internal Medicine SoonChunHyang University Bucheon Hospital SoonChunHyang University Bucheon 14584 Korea Department of Internal Medicine SoonChunHyang University Cheonan Hospital SoonChunHyang University Cheonan 31151 Korea Department of Internal Medicine Kyung Hee University Hospital Kyung Hee University Seoul 02453 Korea Department of Internal Medicine Chuncheon Sacred Heart Hospital Hallym University Chuncheon 24252 Korea Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University Seou105355 Korea Department of Internal Medicine Gangnam Severance Hospital Yonsei University Seou106273 Korea Department of Internal Medicine CHA Bundang Medical Center CHA University Seongnam 13496 Korea Department of Internal Medicine Sanggye Paik Hospital Inje University Seoul 01757 Korea Department of Internal Medicine Kyungpook National University Hospital Kyungpook National University Daegu 41944 Korea Department of Internal Medicine Yeungnam University Medical Center Yeungnam University Daegu 42415 Korea Department of Internal Medicine Pusan National University Yangsan Hospital Pusan National University Yangsan 50612 Korea Department of Internal Medicine Kosin University Gospel Hospital Kosin University Pusan 49267 Korea Department of Internal Medicine Dong A University Medical Center Dong A University Pusan 49201 Korea Department of Internal Medicine Wonju Severance Christian Hospital Yonsei University Wonju 26426 Korea Department of Internal Medicine Haeundae Paik Hospital Inje University Pusan 48108 Korea Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University Anyang 14068 Korea Department of Cli

Background： Until now, various types of combined therapy with nucleotide analogs and pegylated interferon （Peg-INF） in patients with hepatitis B patients have been tried. Howe6ver, studies regarding the benefits of de novo combination, late-add on, and sequential treatmentare very limited. The objective of the current study was to identify the efficacy of sequential treatment of Peg-INF after short-term antiviral treatment. Methods： Between june 2010 and june 2015, hepatitis 13 e antigen （HBeAg）-positive patients （n = 162） received Peg-IFN for 48 weeks （mono-treatment group, n = 81） and entecavir （ETV） for 12 weeks with a 48-week course of Peg-IFN starting at week 5 of ETV therapy （sequential treatment group, n = 81）. The primary endpoint was HBeAg seroconversion at the end of follow-up period after the 24-week treatment. The primary endpoint was analyzed using Chi-square test, Fisher＇s exact test, and regression ***： HBeAg seroconversion rate （18.2% vs. 18.2%, t = 0.03, P = 1.000） and seroclearance rate （19.7% vs. 19.7%, t = 0.03, P = 1.000） were same in both mono-treatment and sequential treatment groups. The rate of alanine aminotransferase （ALT） normalization （45.5% vs. 54.5%, t = 1.12, P = 0.296） and serum hepatitis B virus （HBV）-DNA 〈2000 U/L （28.8% vs. 28.8%, t = 0.10, P = 1.000） was not different in sequential and mono-treatment groups at 24 weeks of Peg-INF. Viral response rate （HBeAg seroconversion and serum HBV-DNA 〈2000 U/L） was not different in the two groups （12.1% vs. 16.7%, t = 1.83, P = 0.457）. Baseline HBV-DNA level （7 log10 U/ml vs. 7.5 log10 U/ml, t = 1.70, P = 0.019） and hepatitis B surface antigen titer （3.6 log10 U/ml vs. 4.0 log10 U/ml, t = 2.19, P = 0.020） were lower and predictors of responder in mono-treatment and sequential treatment groups, respectively. Conclusions： The current study shows no differences in HBeAg seroconversion rate, ALT normalization, and HBV-DNA levels between mono-therapy and sequential therapy regimens.

关键词： Entecavir Hepatitis B Peginterferon Alfa-2a

基于CiteSpace可视化分析针刺抗抑郁研究热点和趋势

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中医药导报 2022年第5期28卷 138-146页

作者：孟超图娅李军焦倩谭雨晴姜会梨北京中医药大学针灸推拿学院北京100029 中国中医科学院广安门医院北京100053 北京中医药大学国际精神疾患研究中心北京100029

目的:基于CiteSpace软件可视化分析针刺抗抑郁领域的研究热点和趋势。方法:以中国知网、万方数据库、维普网及WOS中2005—2020年收录的针刺抗抑郁研究相关文献为研究对象,采用CiteSpace进行文献计量学分析。结果:纳入中文文献723篇、英... 详细信息

目的:基于CiteSpace软件可视化分析针刺抗抑郁领域的研究热点和趋势。方法:以中国知网、万方数据库、维普网及WOS中2005—2020年收录的针刺抗抑郁研究相关文献为研究对象,采用CiteSpace进行文献计量学分析。结果:纳入中文文献723篇、英文文献870篇;中文发文量最多的作者为图娅,WOS发文量最多的作者为劳力行(LAO L X);中文发文量最多的研究机构为北京中医药大学,WOS发文量最多的研究机构为庆熙大学;WOS发文量最多的国家为中国,中心性最高的为美国;中文高频关键词有“抑郁症”“针刺”“电针”等,WOS高频关键词有“acupuncture(针刺)”“depression(抑郁症)”“electroacupuncture(电针)”等;中文关键词形成9个聚类,WOS中文献关键词形成8个聚类;中文文献得到8个突现词,WOS文献得到18个突现词;WOS最高被引频次与最高中心性的文献均为Acupuncture for depression。结论:在针刺抗抑郁的临床研究方面,研究热点首先从临床疗效评价和针刺取穴研究,转移到高质量随机对照试验,然后进一步转移到针刺治疗伴随抑郁的其他疾病;在基础研究方面,研究热点由神经元调亡机制转移到了免疫炎症机制。

关键词：抑郁症针刺研究热点 CiteSpace 文献计量学疗效

ACUPUNCTURE MODULATES THE FUNCTIONAL CONNECTIVITY OF PRIMARY SOMATOSENSORY CORTEX ONLY IN CERTAIN PATHOLOGICAL STAGES OF BELL'S PALSY

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Journal of Integrative Medicine 2014年第3期 263-263页

作者： Yi-fang Zhu Kyungmo Park Chuan-fu Li Jeungchan Lee Seulgi Eun Yuan-yuan Wu Chun-sheng Xu Hong-li Wu Wei Zhang Qi Lu jun-ping Liu Lin-ying Wang Chun-yun Zhang jun Yang Laboratory of Digital Medical Imaging First Affiliated Hospital of Anhui TCM University Department of Biomedical Engineering Kyung Hee University

Objective: Bell’s palsy(BP) is a common peripheral idiopathic facial nerve palsy and acupuncture is a popular *** aim of this study is to investigate acupuncture effect on primary somatosensory cortex(SI) functional connectivity(FC) in different pathological stages of ***: Three runs of fMRI data(before, during and after acupuncture treatment) were acquired in healthy control(normal group, n=35) and patients with *** were classified into three groups according to disease duration(DD) and House Brackmann score(HB) of BP, including early group(n=39, HB>I, DDI, DD>14 d), andhealed group(n=37, HB=I).Seed point of SI from the lesion side was first decided by analysis of fMRI data during acupuncturing at Hegu(LI4), and then FC of SI was *** FC changes between post-acupuncture and pre-acupuncture were analyzed with pair ***: By comparing FC of post-acupuncture with that of pre-acupuncture, significantly decreased FC of SI was found in early stage in left primary somatosensory cortex, secondary somatosensory cortex, primary motor cortex, middle insula and posterior insula and increased connectivity was found in later stage in bilateral primary motor cortex, motor cingulate cortex, supplement motor area, premotor, cuneus, precuneus, lingual gyrus and right occipital *** significant differences in FC changes between pre-acupuncture and post-acupuncture were found in the normal group and in the healed ***: Although the same paradigm of acupuncture stimulation was applied to the four groups, changes in FC of SI were only found in early and later stages of BP while no changes were found in healthy control and healed *** was concluded that acupuncture induced changes of FC of SI depending on the pathological status in patients with BP which is consistent with the acupuncture role in homeostasis.

关键词： FC ACUPUNCTURE MODULATES THE FUNCTIONAL CONNECTIVITY OF PRIMARY SOMATOSENSORY CORTEX ONLY IN CERTAIN PATHOLOGICAL STAGES OF BELL’S PALSY