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nhalation of Sevoflurane and Desflurane Can Not Affect QT Interval, Corrected QT, Tp-Te/QT or Tp-Te/JT in Children

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Chinese Medical Journal 2018年第6期131卷 739-740页

作者： Ji-Hyun Lee Eun-hee kim Young-Eun Jang Jin-Tae kim hee-soo kim Department of Anesthesiology and Pain Medicine Seoul National University Hospital Seoul 03080 Korea

To the Editor： Sevoflurane and desflurane are tile most common general anesthetics used in children. Previous study has shown that these agents can affect the electrocardiogram （ECG） markers,i^i leading to fatal ventricular arrhythmia. The followings were identified as useful indices for predicting and estimating the occurrence of a fatal arrhythmia： the interval between the peak and the end of T wave （Tp-Te） the ratio of the Tp-Te interval to the QT interval （[Tp-Te/QT]）, and the JY interval （JT）, which is measured from the end of the QRS complex to Te.

关键词： QT 孩子心电图代理人 QRS 建筑群心律学习

Differences of Heart Rate Variability during Sevoflurane Anesthesia in Children by Age

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Open Journal of Anesthesiology 2012年第3期2卷 74-78页

作者： Yong-hee Park Chang-Hoon Koo Jin-Tae kim hee-soo kim Hyo-Jin Byon College of Medicine Seoul National University Seoul Korea Department of Anesthesiology and Pain Medicine Department of Anesthesiology and Pain Medicine College of Medicine Inha University Incheon Korea Department of Anesthesiology and Pain Medicine College of Medicine Seoul National University Seoul Korea

Background: The child’s central nervous system develops with aging, and heart rate variability (HRV), which is con-trolled by the brain, differs from that of adults. We investigated changes in HRV during sevoflurane anesthesia in children. Methods: One 138 children aged from 2 - 12 years without major underlying problems were enrolled. During maintenance with 2 - 2.5 vol% sevoflurane anesthesia, electrocardiographic data were obtained and power spectral analysis, approximate entropy (ApEn) or Hurst exponent were analyzed and compared in three groups (age 2 - 5 years, 6 - 9 and 10 - 12 years of age). Results: The RR interval increased with aging, but low-frequency powers did not. High- frequency power was greater in the oldest children (P < 0.05), while ApEn and Hurst exponents were lower (P < 0.05). Conclusion: Change in HRV is one of the characteristics of development in children.

关键词： Children Heart Rate Variability Sevoflurane

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑Chang Sung Gwang‑hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑Wan kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL kim JOO KYUNG PARK MINSUK KWON MINAE AN JUNG YONG HONG JOON OH PARK SUNG hee LIM SEUNG TAE kim Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong kim Yeong Geol Lee Won-hee Park Su-hwan Yun Tae-soon Kwon Duckhee Lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi soo-Ho Choi Keun-Young kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Simulation of Storm Surge and Wave Due to Typhoon Isewan(5915)

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China Ocean Engineering 2015年第4期29卷 473-488页

作者： Jin-hee YUK Kyeong Ok kim Han soo LEE Byung Ho CHOI Disaster Management HPC Technology Research Center Korea Institute of Science and Technology Information Marine Radionuclide Research Center Korea Institute of Ocean Science & Technology Graduate School of Science and Engineering Saitama University Department of Civil and Environmental Engineering Sungkyunkwan University

An integrally coupled wave-tide-surge model was developed and then applied to the simulation of the wave-typhoon surge for the typhoon Isewan （typhoon Vera （5915））, which is the strongest typhoon that has struck Japan and caused incalculable damage. An integrally coupled tide-surge-wave model using identical and homogeneous meshes in an unstructured grid system was used to correctly resolve the physics of wave-circulation interaction in both models. All model components were validated independently. The storm surge and wave properties such as the surge height, the significant wave height, wave period and direction were reproduced reasonably under the meteorological forcing, which was reprocessed to be close to the observations. The resulting modeling system can be used extensively for the prediction of the storm surge and waves and the usual barotropic forecast.

关键词： typhoon Isewan storm surge wave tide coupled wave-tide-surge model

Clinical characteristics and treatment of inflammatory bowel disease: A comparison of Eastern and Western perspectives

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World Journal of Gastroenterology 2014年第33期20卷 11525-11537页

作者： soo Jung Park Won Ho kim Jae hee Cheon Department of Internal Medicine and Institute of Gastroenerology Yonsei University College of Medicine Seoul 120-752 South Korea

Inflammatory bowel disease(IBD) is a chronic, relapsing intestinal inflammatory disorder with unidentified causes. Both environmental factors and genetic aspects are believed to be crucial to the pathogenesis of IBD. The incidence and prevalence of IBD have recently been increasing throughout Asia, presumably secondary to environmental changes. This increasing trend in IBD epidemiology necessitates specific health care planning and education in Asia. To this end, we must gain a precise understanding of the distinctive clinical and therapeutic characteristics of Asian patients with IBD. The phenotypes of IBD reportedly differ considerably between Asians and Caucasians. Thus, use of the same management strategies for these different populations may not be appropriate. Moreover, investigation of the Asian-specific clinical aspects of IBD offers the possibility of identifying causative factors in the pathogenesis of IBD in this geographical area. Accordingly, this review summarizes current knowledge of the phenotypic manifestations and management practices of patients with IBD, with a special focus on a comparisonof Eastern and Western perspectives.

关键词： Crohn's disease Ulcerative colitis Inflam-matory bowel disease Clinical characteristics Treat-ment Asia

Thermal-driven gigantic enhancement in critical current density of high-entropy alloy superconductors

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Journal of Materials Science & Technology 2024年第22期189卷 60-67页

作者： Jihyun kim soon-Gil Jung Yoonseok Han Jin hee kim Jong-soo Rhyee Sunmog Yeo Tuson Park Department of Physics Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Physics Education Sunchon National UniversitySuncheon 57922Republic of Korea Department of Applied Physics and Institute of Natural Sciences Integrated Education Institute for Frontier Science and Technology(BK 21 Four)Kyung Hee UniversityYongin17104Republic of Korea Korea Multi-purpose Accelerator Complex Korea Atomic Energy Research InstituteGyeongjuGyeongbuk38180Republic of Korea Center for Quantum Materials and Superconductivity(CQMS) Sungkyunkwan UniversitySuwon 16419Republic of Korea

The high-entropy alloy(HEA)superconductor,Ta_(1/6)Nb_(2/6)Hf_(1/6)Zr_(1/6)Ti_(1/6)(Ta-Nb-Hf-Zr-Ti),is systematically studied to examine changes in superconducting critical properties,critical temperature(T_(c)),critical cur-rent density(J_(c)),and upper critical field(H_(c2)),concerning thermal treatment *** condi-tion affects Jc more significantly than T_(c)and H_(c2),with a large improvement of flux pinning force density(F_(p)).The Jc of bare sample is reduced to 10 A cm^(-2)at an applied magnetic field of approximately 1.5 T,whereas the sample annealed at 550℃for 12 h exhibits J_(c)>100 kA cm^(-2)up to around 4 ***,the Vickers hardness(HVIT)of the Ta-Nb-Hf-Zr-Ti HEA superconductor notably increases from∼384 to 528 HVIT following a 24-h annealing at 500℃.These results demonstrate that thermal annealing is a powerful process to optimize both the superconducting and mechanical properties of high-entropy alloy superconductors.

关键词： High-entropy alloy superconductor Ta-Nb-Hf-Zr-Ti Annealing Critical current density Hardness