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Metal stents placement for refractory pancreatic duct stricture in children

World Journal of Gastroenterology 2018年第3期24卷 408-414页

作者： In Sook Jeong sung hee Lee Seak hee Oh Do Hyun Park Kyung Mo kim Department of Pediatrics University of Ulsan College of MedicineAsan Medical Center Children’s Hospital Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center

AIM To evaluate the use of fully covered self-expandable metal stents(FCSEMSs) for pancreatic duct strictures in children with chronic *** Eight patients with refractory benign dominant stricture of the main pancreatic duct(MPD) were enrolled through chart reviews between December 2014 and June 2017 in a single center. Endoscopic retrograde cholangiopancreatography(ERCP) with placement of a 6-mm FCSEMS with dual flaps was performed. Endoscopic removal of FCSEMSs was performed with a snare or rat-tooth forceps. All procedures were performed by a pediatric gastroenterologist. For the assessment of outcomes, technical and clinical success, adverse events, and stent patency were evaluated *** The placement and removal of the FCSEMSs were successful in all 8 patients. Five patients were boys and 3 were girls. The median age at initial FCSEMS placement was 12 years(range, 5-18 years). The diameters of all the inserted stents were 6 mm, and the lengths were 4-7 cm. The median indwelling time was 6 mo(range, 3-10 mo). No pancreatic sepsis, pancreatitis, cholestasis, or mortality occurred. There was no proximal and distal migration. All subjects showed a patent stent. On follow-up ERCP, the mean diameter of the stricture improved from 1.1 mm to 2.8 mm(P < 0.05), whereas that of upstream dilation improved from 8.4 mm to 6.3 mm(P < 0.05).CONCLUSION This initial experience showed that temporary FCSEMS placement is feasible and safe for the management of refractory benign MPD stricture in children.

关键词： Chronic pancreatitis Pancreatic duct Selfexpandable metal stent Child Endoscopic retrograde cholangiopancreatography

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Primary duodenal dedifferentiated liposarcoma:A case report and literature review

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World Journal of Clinical Cases 2022年第6期10卷 2007-2014页

作者： Nah Ihm kim Ji Shin Lee Chan Choi Jong hee Nam Yoo Duk Choi hee Joon kim sung Sun kim Department of Pathology Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Surgery Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Dedifferentiated liposarcoma(DDLPS)is an extremely rare neoplasm that exhibits various *** tumor is characterized by immunoreactivity to MDM2 and CDK4 and can be confirmed by detecting MDM2 amplification via fluorescence in situ hybridization(FISH).Herein,we report an unusual case of DDLPS arising from the *** SUMMARY A 64-year-old man presented with repeated abdominal pain and weight *** studies revealed a mass of the duodenum involving the *** patient was treated with pylorus-preserving ***,the tumor showed a high-grade *** demonstrated that the tumor cells were positive for MDM2 and CDK4 ***2 amplification was detected via FISH,leading to the final diagnosis of *** surgery,the patient was treated in the intensive care unit due to peritonitis,and died 60 d after *** To the best of the authors’knowledge,this is the first case of primary duodenal DDLPS in Korea and the third case in the English-language *** must be taken not to misdiagnose DDLPS as another high-grade *** should be in the differential diagnosis list.

关键词： Liposarcoma Primary Small bowel Duodenum Immunohistochemistry Case report

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A case study of customer satisfaction for information technology solutions

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Journal of Central South University 2014年第11期21卷 4279-4285页

作者： sung Yun YU Jinsoo PARK Jin kim Hyung Jin LEE hee Jun YOON Supercomputing Center Korea Institute of Science and Technology InformationDaejeon 305-806 Korea Department of Management Information Systems Yong In UniversityYongin 449-714 Korea

There are numerous information technology solutions including hardware and software. A company that provides the solution should have knowledge of the customer needs in the purpose of sailing strategy or upgrade policy. The needs are also directly connected to the user satisfaction. However, the users have respective points of view in the needs as well as they may not identify the requirements to improve the solution. SERVQUAL can be an appropriate method to define and measure the customer satisfaction for the information technology solutions. As a case study of the customer satisfaction, the modified SERVQUAL items and scoring method are applied to a cyber-infrastructure system named CyberL ab in Korea. The measurement results of user satisfaction for CyberL ab are provided to confirm that our proposed method performs as we intended. From the results, we can score the satisfaction level of users and identify their needs in the various aspects. The total user satisfaction level for CyberL ab is scored by 88.3.

关键词： cyber-infrastructure customer satisfaction user satisfaction SERVQUAL

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Multi-millijoule terahertz emission from laser- wakefield-accelerated electrons

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Light(Science & Applications) 2023年第2期12卷 248-258页

作者： Taegyu Pak Mohammad Rezaei-Pandari Sang Beom kim Geonwoo Lee Dae hee Wi Calin loan Hojbota Mohammad Mirzaie Hyeongmun kim Jae hee sung Seong Ku Lee Chul Kang Ki-Yong kim Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Korea Department of Physics and Photon Science Gwangju Institute of Science and Technology(GIST)Gwangju 61005Korea Laser and Plasma Research Institute Shahid Beheshti UniversityTehranIran Advanced Photonics Research Institute GISTGwangju 61005Korea Institute for Research in Electronics and Applied Physics and Department of Physics University of MarylandCollege ParkMaryland 20742USA

High-power terahertz radiation was observed to be emitted from a gas jet irradiated by 100-terawatt-class laser pulses in the laser-wakefield acceleration of *** emitted terahertz radiation was characterized in terms of its spectrum,polarization,and energy dependence on the accompanying electron bunch energy and charge under various gas target *** a nitrogen target,more than 4 mJ of energy Was produced at<10 THz with a laser-to-terahertz conversion efficiency of~0.15%.Such strong terahertz radiation is hypothesized to be produced from plasma electrons accelerated by the ponderomotive force of the laser and the plasma wakefelds on the time scale of the laser pulse duration and plasma *** model is examined with analytic calculations and particle-in-cell simulations to better understand the generation mechanism of high-energy terahertz radiation in laser-wakefield acceleration.

关键词： laser polarization acceleration

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

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Postmortem ^(7)Li NMR analysis for assessing the reversibility of lithium metal electrodes in lithium metal batteries

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Journal of Energy Chemistry 2024年第7期94卷 430-440页

作者： Jaewon Baek Sunha kim hee-Tak kim Oc hee Han Department of Chemical&Biomolecular Engineering KAISTDaejeon 34141Republic of Korea Metropolitan Seoul Center Korea Basic Science InstituteSeoul 03759Republic of Korea Graduate School of Analytical Science&Technology Chungnam National UniversityDaejeon 34134Republic of Korea

Despite the proficiency of lithium(Li)-7 NMR spectroscopy in delineating the physical and chemical states of Li metal electrodes,challenges in specimen preparation and interpretation impede its *** this study,we conducted a comprehensive postmortem analysis utilizing ^(7)Li NMR,employing a stan-dard magic angle spinning probe to examine protective-layer coated Li metal electrodes and LiAg alloy electrodes against bare Li metal electrodes within Li metal batteries(LMBs).Our investigation explores the effects of sample burrs,alignment with the magnetic field,the existence of liquid electrolytes,and precycling on the ^(7)Li NMR *** contrasting NMR spectra before and after cycling,we identi-fied alterations in Li^(0) and Li^(+) signals attributable to the degradation of the Li metal *** NMR analyses decisively demonstrate the efficacy of the protective layer in mitigating dendrite and solid elec-trolyte interphase ***,we noted that Li*ions near the Li metal surface exhibit magnetic susceptibility anisotropy,revealing a novel approach to studying diamagnetic species on Li metal elec-trodes in *** study provides valuable insights and practical guidelines for characterizing distinct lithium states within LMBs.

关键词： NMR spectroscopy Lithium-7 Lithium metal battery Electrolyte Electrode-protective layer Solid electrolyte interface Magnetic susceptibility anisotropy Lithium-metal NMR signal Diamagnetic^(7)Li NMR signal

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A comparative study on machine learning-based classification to find photothrombotic lesion in histological rabbit brain images

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Journal of Innovative Optical Health Sciences 2021年第6期4卷 81-89页

作者： Sang hee Jo Yoonhee kim Yoon Bum Lee sung Suk Oh Jong-ryul Choi School of Biomedical Engineering Daegu Catholic University(DCU)Gyeongsan 38430Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF) Daegu 41061Republic of Korea Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF) Daegu 41061Republic of Korea

Recently,research has been conducted to assist in the processing and analysis of histopathological images using machine learning *** this study,we established machine learning-based algorithms to detect photothrombotic lesions in histological images of photothrombosis-induced rabbit *** machine learning-based algorithms for binary classification were applied,and the accu-racies were compared to classify normal tissues and photothrombotic *** lesion classification model consisting of a 3-layered neural network with a rectified linear unit(ReLU)activation function,Xavier initialization,and Adam optimization using datasets with a unit size of 128×128 pixels yielded the highest accuracy(0.975).In the validation using the tested histological images,it was confirmed that the model could identify regions where brain damage occurred due to photochemical ischemic *** the development of machine learning-based photothrombotic lesion classi-fication models and performance comparisons,we confirmed that machine learning algorithms have the potential to be utilized in histopathology and various medical diagnostic techniques.

关键词： Machine learning histopathological images photothrombotic lesion rabbit brain binary classification logistic regression multi-layer neural networks

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Formation of photo-reactive heterostructure from a multicomponent amorphous alloy with atomically random distribution

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Journal of Materials Science & Technology 2022年第14期109卷 245-253页

作者： Hae Jin Park hee Jin Lee Tae Kyung kim sung Hwan Hong Wei-Min Wang Taek Jib Choi Ki Buem kim Department of Nanotechnology and Advanced Materials Engineering Sejong University209 Neung dong-roGwangjin-guSeoul 05006Republic of Korea Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China

In this study,metallic glass is designed tunable for promising functional applications via a facile and stable,one-step *** approach about alloy design and process is based on the unique properties of the Ti-Cu-Ni-Sn metallic glass that are afforded by the varying oxygen affinities of the four constituent *** metallic glass exhibits homogeneous nucleation of oxides and uniform formation of the various metal *** alloy design and hydrothermal synthesis to customize the metallic glasses are the most critical factors that determine the characteristics of the metal oxides and the resulting nanostructures and photoelectrode *** enables the desired element to be selectively grown via a facile single-step *** results provide a promising road map for the application of metallic glasses to photoelectrochemical(PEC)solar water splitting,as well as various other new possibilities.

关键词： Metallic glass Alloy design Hydrothermal synthesis Metal oxide Water splitting

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Comprehensive molecular analysis to predict the efficacy ofchemotherapy containing bevacizumab in patients with metastaticcolorectal cancer

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Oncology Research 2023年第6期31卷 855-866页

作者： sung hee LIM hee JIN CHO KYOUNG-MEE kim HO YEONG LIM WON KI KANG JEEYUN LEE YOUNG SUK PARK hee CHEOL kim SEUNG TAE kim Division of Hematology/Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea Precision Medicine Research Institute Samsung Medical CenterGangnam-guSeoul06351Korea Department of Biomedical Convergence Science and Technology Kyungpook National UniversityDaegu41566Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul06351Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea

Background:Although bevacizumab is an important treatment for metastatic colorectal cancer(CRC),not allpatients with CRC benefit from it;in unselected patient populations,only modest survival benefits have been ***:We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identifybiomarkers for a response to bevacizumab-containing *** molecular analysis comprised whole-exomesequencing,ribonucleic acid sequencing,and a methylation array on patient ***:Genomic and molecularcharacterization was successfully conducted in 103 *** of 103 CRC samples were hypermutated,and none ofthe non-hypermutant tumors were microsatellite *** those 103 patients,89 had adenocarcinoma(ADC),15 were diagnosed with mucinous ADC,and six had signet-ring cell carcinoma(SRCC).Consensus molecular subtype(CMS)2 was unique to *** the four SRCCs,two were CMS1,one was CMS4,and the other was *** status was a significantly enriched factor in responders to bevacizumab *** growth factorreceptor(FGFR)1/2 signaling was upregulated in non-responders,whereas cell cycle,transfer ribonucleic acidprocessing,nucleotide excision repair,and oxidative phosphorylation pathways were enriched in ***,IGF1 was differentially expressed in non-responders(log2 fold change=−1.43,p=4.11×10^(−5),falsediscovery rate=0.098),and FLT1 was highly methylated in non-responders(p=7.55×10^(−3)).When the molecularpathways were reanalyzed separately according to the backbone chemotherapy(FOLFOX ***),thesignificance of the molecular pathways varied according to the backbone ***:This studysought a subset of CRC patients with a distinct clinical response to chemotherapy containing *** need to be validated in a large group of homogenous patient cohort and examined according to the differentchemotherapy backbones to create personalized therapeutic oppor

关键词： Bevacizumab Whole-exome sequencing Ribonucleic acid sequencing Methylation array Colorectal cancer

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Neuroprotective effects of tamsulosin on intracerebral hemorrhage

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Neural Regeneration Research 2011年第32期6卷 2505-2510页

作者： Hong-Jin Suh sung-Min So Young-Gil Na Il-Gyu Ko sung-Eun kim Yun-hee sung Mal-Soon Shin Chang-Ju kim Young-Sam Cho Khae-Hawn kim Department of Urology Incheon St. Mary's Hospital the Catholic University of Korea School of Medicine Department of Urology Chungnam National University School of Medicine Department of Physiology Kyung Hee University School of Medicine Department of Urology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Urology Gachon University Gil Hospital Gachon University of Medicine and Science

The alpha1 adrenoreceptor antagonist tamsulosin is primarily used to treat benign prostatic hypertrophy. In this study, we intragastrically administered rats with 0.01,0.1 and 1 mg/kg tamsulosin to investigate the effects of tamsulosin on memory function, and hippocampal cell apoptosis and proliferation following intracerebral hemorrhage. Step-down avoidance task results showed that tamsulosin treatment markedly alleviated intracerebral hemorrhage- induced short-term memory impairment. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling results showed that tamsulosin treatment markedly suppressed intracerebral hemorrhage-induced caspase-3 expression in the hippocampal CA1 region and cell proliferation in the hippocampal dentate gyrus. Tamsulosin treatment at a dose of 0.01 mg/kg exhibited the most potent inhibitory effects on cell apoptosis and proliferation. These findings suggest that tamsulosin treatment facilitates the recovery of rat memory function by inhibiting hippocampal cell apoptosis and proliferation followincl intracerebral hemorrhaQe.

关键词： tamsulosin, intracerebral hemorrhage short-term memory apoptosis cellproliferation hippocampus neural regeneration

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