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Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease:A Single-Center Retrospective Study

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Congenital Heart Disease 2021年第3期16卷 233-244页

作者： Se Yong jung Doyoung jung Ah Young Kim Jae hee Seol jung Min Park Jo Won jung Jae Young Choi Division of Pediatric Cardiology Congenital Heart Disease CenterSeverance Cardiovascular HospitalDepartment of PediatricsYonsei University College of MedicineSeoulKorea

Purpose:This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension(PAH)associated with congenital heart disease(CHD).Materials and Methods:We conducted a retrospective study of patients with CHD-associated PAH,treated with selexipag since December *** adult patients(mean age,45.4 years;women,77%)were treated with selexipag as add-on *** characteristics,World Health Organization functional class,6-minute walking distance(6MWD)test results,N-terminal pro-B-type natriuretic peptide levels,echocardiographic data,and incidence of side effects were ***:The majority of patients(12/13,92.3%)experienced more than one treatment-associated complication;one patient dropped out of the study due to intolerable *** results of 6MWD test(from 299.2±56.2 m to 363.8±86.5 m,p=0.039)and tricuspid regurgitation(TR)pressure gradient(from 84.7±20.5 mmHg to 61.6±24.0 mmHg,p=0.018)improved and remained improved after selexipag treatment in 12 *** on the results of a non-invasive risk assessment,8(66.7%)patients showed improvement,3(25.0%)showed no interval change,and the status of one patient(8.3%)***,compared to patients treated with a low dosage,patients treated with a medium-to-high dosage showed a greater increase in 6MWD results(88.3±26.4 m vs.55.3±27.6 m,p=0.043)and a greater reduction in the TR pressure gradient(-33.7±10.9 mmHg vs.-12.5±12.0 mmHg,p=0.015).Conclusion:Selexipag is an efficient pulmonary vasodilator as add-on therapy in treating CHD-associated PAH.

关键词： Selexipag congenital heart disease pulmonary arterial hypertension

Trap and 1/f-noise effects at the surface and core of GaN nanowire gateall-around FET structure

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Nano Research 2019年第4期12卷 809-814页

作者： Mallem Siva Pratap Reddy Ki-Sik Im jung-hee Lee Raphael Caulmione Sorin Cristoloveanu School of Electronics Engineering Kyungpook National University Daegu 41566 Republic of Korea Advanced Material Research Center Kumoh National Institute of Technology Gumi 39177 Republic of Korea SOITEC Bernin 38190 France Institute of Microelectronics Electromagnetism and Photonics Grenoble Polytechnic Institute Minatec Grenoble 38016 France

Using capacitance,conductance and noise measurements,we investigate the trapping behavior at the surface and in the core of triangular-shaped one-dimensional (1 D) array of GaN nanowire gate-all-around field effect transistor (GAA FET),fabricated via a top-down *** surface traps in such a low dimensional device play a crucial role in determining the device *** estimated surface trap density rapidly decreases with increasing frequency,ranging from 6.07 × 1012 cm-2·eV-1 at 1 kHz to 1.90 × 1011 cm-2·eV-1 at 1 MHz,*** noise results reveal that the power spectral density increases with gate voltage and clearly exhibits 1/f-noise signature in the accumulation region (Vgs > Vth =3.4 V) for all *** the surface depletion region (1.5 V < Vgs < Vth),the device is governed by 1/fat lower frequencies and 1/f2 noise at frequencies higher than ~ 5 *** 1/f2 noise characteristics is attributed to additional generation-recombination (G-R),mostly caused by the electron trapping/detrapping process through deep traps located in the surface depletion region of the *** cutoff frequency for the 1/f2 noise characteristics further shifts to lower frequency of 102-103 Hz when the device operates in deep-subthreshold region (Vgs < 1.5 V).In this regime,the electron trapping/detrapping process through deep traps expands into the totally depleted nanowire core and the G-R noise prevails in the entire nanowire channel.

关键词： gate-all-around field effect transistor (FET) nanowire GaN trap 1/f-noise

Risk factors for immediate post-operative fatal recurrence after curative resection of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第1期12卷 99-104页

作者： Bong-Wan Kim Young-Bae Kim hee-jung Wang Myung-Wook Kim Department of Surgery Ajou University School of MedicineWonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea Department of Pathology Ajou University School of Medicine.Wonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea

AIM： To investigate the clinicopathological risk factors for immediate post-operative fatal recurrence of hepatocellular carcinoma （HCC）, which may have practical implication and contribute to establishing high risk patients for pre- or post-operative preventive measures against HCC recurrence. METHODS： From June 1994 to May 2004, 269 patients who received curative resection for HCC were reviewed. Of these patients, those who demonstrated diffuse intrahepatic or multiple systemic recurrent lesions within 6 mo after surgery were investigated （fatal recurrence group）. The remaining patients were designated as the control group, and the two groups were compared for clinicopathologic risk factors. RESULTS： Among the 269 patients reviewed, 30 patients were enrolled in the fatal recurrence group. Among the latter, 20 patients showed diffuse intrahepatic recurrence type and 10 showed multiple systemic recurrence type. Multivariate analysis between the fatal recurrence group and control group showed that preoperative serum alpha-fetoprotein （AFP） level was greater than 1 000 μg/L （P= 0.02; odds ratio = 2.98）, tumor size greater than 6.5 cm （P= 0.03; OR= 2.98）, and presence of microvascular invasion （P= 0.01; OR=4.89） were the risk factors in the fatal recurrence group. The 48.1% of the patients who had all the three risk factors and the 220 of those who had two risk factors experienced fatal recurrence within 6 mo after surgery. CONCLUSION： Three distinct risk factors for immediate post-operative fatal recurrence of HCC after curative resection are pre-operative serum AFP level 〉 1 000 μg/L,tumor size〉6.5 cm, and microvascular invasion. The high risk patients with two or more risk factors should be the candidates for various adjuvant clinical trials.

关键词： Hepatocellular carcinoma Hepatectomy Early recurrence Risk factors

The CONSTANS-like 4 transcription factor,AtCOL_4,positively regulates abiotic stress tolerance through an abscisic acid-dependent manner in Arabidopsis

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Journal of Integrative Plant Biology 2015年第3期57卷 313-324页

作者： Ji-hee Min jung-Sung Chung Kyeong-Hwan Lee Cheol Soo Kim Department of Plant Biotechnology Chonnam National University Department of Agronomy Gyeongsang National University Department of Rural and Biosystems Engineering Chonnam National University

The precise roles of the B-box zinc finger family of transcription factors in plant stress are poorly *** analysis was performed on AtCOL4,an Arabidopsis thaliana ***-like 4 protein that is a putative novel transcription factor,and which contains a predicted transcriptional activation *** of an AtCOL4 promoter-b-glucuronidase（GUS） construct revealed substantial GUS activity in whole *** expression of AtCOL4 was strongly induced by abscisic acid（ABA）,salt,and osmotic *** in atcol4 resulted in increased sensitivity to ABA and salt stress during seed germination and the cotyledon greening *** contrast,AtCOL4-overexpressing plants were less sensitive to ABA and salt stress compared to the wild ***,in the presence of ABA or salt stress,the transcript levels of other ABA biosynthesis and stress-related genes were enhanced induction in AtCOL4-overexpressing and WT plants,rather than in the atcol4 ***,AtCOL4 is involved in ABA and salt stress response through the ABA-dependent signaling *** together,these findings provide compelling evidence that AtCOL4 is an important regulator for plant tolerance to abiotic stress.e

关键词： Abscisic acid B-box zinc finger family transcription factor salt stress

Uncertainty analysis of flow rate measurement for multiphase flow using CFD

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Acta Mechanica Sinica 2015年第5期31卷 698-707页

作者： Joon-Hyung Kim Uk-hee jung Sung Kim Joon-Yong Yoon Young-Seok Choi Department of Mechanical Design Engineering Hanyang University Thermal & Fluid System R&BD Group Korea Institute of Industrial Technology Energy System Engineering University of Science and Technology

The venturi meter has an advantage in its use,because it can measure flow without being much affected by the type of the measured fluid or flow ***,it has excellent versatility and is being widely applied in many *** flow of a liquid containing air is a representative example of a multiphase flow and exhibits complex flow *** particular,the greater the gas volume fraction（GVF）,the more inhomogeneous the flow *** a result,using a venturi meter to measure the rate of a flow that has a high GVF generates an *** this study,the cause of the error occurred in measuring the flow rate for the multiphase flow when using the venturi meter for analysis by *** ensure the reliability of this study,the accuracy of the multiphase flow models for numerical analysis was verified through comparison between the calculated results of numerical analysis and the experimental *** a result,the Grace model,which is a multiphase flow model established by an experiment with water and air,was confirmed to have the highest ***,the characteristics of the internal flow Held about the multiphase flow analysis result generated by applying the Grace model were analyzed to find the cause of the uncertainty occurring when measuring the flow rate of the multiphase flow using the venturi meter.A phase separation phenomenon occurred due to a density difference of water and air inside the venturi,and flow inhomogeneity happened according to the flow velocity difference of each *** was confirmed that this flow inhomogeneity increased as the GVF increased due to the uncertainty of the flow measurement.

关键词： Multiphase flow Measurement Numerical analysis Venturi meter Gas volume fraction(GVF) Uncertainty Multiphase flow model Grace model

Comparable electrocatalytic performances of carbon-and Rh-loaded SrTiO_3 nanoparticles

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Chinese Chemical Letters 2018年第6期29卷 800-804页

作者： hee jung Yoon Seog K.Kim Weixin Huang Youngku Sohn Department of Chemistry Yeungnam University Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy Conversion Department of Chemical PhysicsUniversity of Science and Technology of China Department of Chemistry Chungnam National University

Carbon-and Rh-loaded strontium titanate（SrTiO3） nanoparticles（NPs） were synthesized respectively by the wet impregnation method and the aerobic and anaerobic ethanol oxidation methods, and characterized by scanning electron microscopy, high resolution transmission electron microscopy, X-ray diffraction crystallography, UV–vis absorption, Raman spectroscopy, and X-ray photoelectron spectroscopy. Carbon was shown to be uniformly coated on SrTiO3 NPs by the aerobic and anaerobic ethanol oxidation methods Electrocatalytic activities of unmodified and modified SrTiO3 NPs were tested for water splitting and CO2 reduction. The aerobic C-coated and Rh-loaded SrTiO3 catalysts showed comparable activity that was increased by 〉10-fold of that of unmodified SrTiO3 catalyst. These results demonstrate that both metallic and nonmetallic surface modifications can highly improve the electrocatalytic activity of SrTiO3 NPs and point to highlight a more important role of the modifier in the electrocatalytic reactions than of the SrTiO3 structure.

关键词： SrTiO3 Carbon Rhodium Ethanol oxidation Electrocatalytic water splitting Electrocatalytic CO2 reduction

Development of an analytical method for multi-residue quantification of 18 anthelmintics in various animal-based food products using liquid chromatography-tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2021年第1期11卷 68-76页

作者： Kyung-hee Yoo Da-hee Park A.M.Abd El-Aty Seong-Kwan Kim Hae-Ni jung Da-Hye Jeong hee-jung Cho Ahmet Hacimuftuoglu Jae-Han Shim Ji Hoon Jeong Ho-Chul Shin Department of Veterinary Pharmacology and Toxicology College of Veterinary MedicineKonkuk UniversitySeoul143-701Republic of Korea State Key Laboratory of Biobased Material and Green Papermaking College of Food Science and EngineeringQilu University of TechnologyShandong Academy of ScienceJinan250353China Department of Pharmacology Faculty of Veterinary MedicineCairo University12211GizaEgypt Department of Medical Pharmacology Medical FacultyAtaturk UniversityErzurum25240Turkey Department of Veterinary Physiology College of Veterinary MedicineKonkuk UniversitySeoul143-701Republic of Korea Natural Products Chemistry Laboratory College of Agriculture and Life SciencesChonnam National UniversityGwangju500-757Republic of Korea Department of Pharmacology College of MedicineChung-Ang UniversitySeoul156-756Republic of Korea

In this study,we developed a simple screening procedure for the determination of 18 anthelmintics(including benzimidazoles,macrocyclic lactones,salicylanilides,substituted phenols,tetrahydropyrimidines,and imidazothiazoles)in five animal-derived food matrices(chicken muscle,pork,beef,milk,and egg)using liquid chromatography-tandem mass *** were extracted using acetonitrile/1% acetic acid(milk and egg)and acetonitrile/1% acetic acid with 0.5 mL of distilled water(chicken muscle,pork,and beef),and purified using saturated n-hexane/acetonitrile.A reversed-phase analytical column and a mobile phase consisting of(A)10 mM ammonium formate in distilled water and(B)methanol were used to achieve optimal chromatographic ***-matched standard calibration curves(R^(2)≥0.9752)were obtained for concentration equivalent to ×1/2,×1,×2,×3,×4,and×5 fold the maximum residue limit(MRL)stipulated by the Korean Ministry of Food and Drug *** of 61.2e118.4%,with relative standard deviations(RSDs)of ≤19.9%(intraday and interday),were obtained for each sample at three spiking concentrations(×1/2,×1,and ×2 the MRL values).Limits of detection,limits of quantification,and matrix effects were 0.02e5.5 mg/kg,0.06e10 mg/kg,and -98.8 to 13.9%(at 20 μg/kg),*** five samples of each food matrix(chicken muscle,pork,beef,milk,and egg)purchased from large retailers in Seoul that were tested,none of the target analytes were *** has therefore been shown that this protocol is adaptable,accurate,and precise for the quantification of anthelmintic residues in foods of animal origin.

关键词： Anthelmintics Tandem mass spectrometry Animal-based food products Residue analysis Method validation

Direct modification of spermatogonial stem cells using lentivirus vectors in vivo leads to efficient generation of transgenic rats

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Asian Journal of Andrology 2019年第2期21卷 190-195页

作者： Bang-Jin Kim Yong-hee Kim Myeong-Geun Oh Ki-jung Kim Sang-Eun jung Ju-hee Jin Sun-Uk Kim Kwan-Sik Min Buom-Yong Ryu Department of Animal Scienee and Technology College of Biotechnology and Natural ResourcesChung-Ang UniversityAnseongGyeonggi-do 17546Korea National Primate Research Center Korea Research Institute of Bioscienee and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Animal Biotechnology Graduate School of Future Con verge nee Tech no logyDepartment of Animal Life ScienceInstitute of Genetic Engi neeringHankyong National UniversityAnseongGyeon ggi-do 17579Korea Department of Cancer Biology University of PennsylvaniaPhiladelphiaPA 19104USA.

Spermatogonial stem cells(SSCs)transmit genetic information to the next progeny in ***,SSCs are a potential target for germ I i ne modifications to gen erate tran sgenic an *** this study,we report a technique for the gen erati on of tran sgenic rats by in vivo manipulation of SSCs with a high success *** in juvenile rats were transduced in vivo with high titers of lentivirus harbori ng enhan ced green fluoresce nt protei n and mated with wild-type females to create foun der *** founder rats expressed the transgene and passed on the transgene with an overall success rate of 50.0%.Subsequent generations of progeny from the founder rats both expressed and passed on the ***,direct modification of SSCs in juvenile rats is an effective means of generating transgenic rats through the male *** technology could be adapted to larger animals,in which existing methods for gene modificatio n are in adequate or in applicable,resulti ng in the gen eration of tran sge nic an imals in a variety of species.

关键词： germline modification lentivirus spermatogonial stem cell testis transgenic animal

Process control factors for continuous microbial perchlorate reduction in the presence of zero-valent iron

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Frontiers of Environmental Science & Engineering 2014年第3期8卷 386-393页

作者： Robert D. ARTHUR Jagadish TORLAPATI Kyung-hee SHIN Daniel K. CHA Yeomin YOON Ahjeong son Department of Civil Engineering Auburn University Auburn AL 36849 USA Korea Environment Institute Seoul 122-706 Republic of Korea Department of Civil and Environmental Engineering University of Delaware Newark DE 19716 USA Department of Civil and Environmental Engineering University of South Carolina Columbia SC 29208 USA Department of Environmental Science and Engineering Ewha Womans University Seoul 120-750 Korea

Process control parameters influencing microbial perchlorate reduction via a flow-through zero-valent iron （ZVI） column reactor were investigated in order to optimize perchlorate removal from water. Mixed perchlorate reducers were obtained from a wastewater treatment plant and inoculated into the reactor without further acclimation. Examined parameters included hydraulic residence time （HRT）, pH, nutrients requirement, and perchlorate reduction kinetics. The minimum HRT for the system was concluded to be 8 hr. The removal efficiency of 10 mg. L-1 influent perchlorate concentration was reduced by 20%-80% without control to the neutral pH （HRT = 8 hr）. Therefore pH was determined to be an important parameter for microbial perchlorate reduction. Furthermore, a viable alternative to pH buffer was discussed. The microbial perchlorate reduction followed the first order kinetics, with a rate constant （K） of 0.761 hr-1. The results from this study will contribute to the implementation of a safe, cost effective, and efficient system for perchlorate reduction to below regulated levels.

关键词： perchlorate zero-valent iron (ZVI) microbial reduction hydrogen