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Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer

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World Journal of Clinical Cases 2022年第28期10卷 10066-10076页

作者： hee ryeong jang Hui-Young Lee Seo-Young Song Kyu-Hyoung Lim Department of Internal Medicine Kangwon National University HospitalKangwon National University School of MedicineChuncheon-siGangwon-do 24289South Korea

BACKGROUND The 5-fluorouracil-based chemotherapy combined with oxaliplatin or irinotecan is usually used in colorectal cancer(CRC).The addition of a targeted agent(TA) to this combination chemotherapy is currently the standard treatment for metastatic ***,the efficacy and safety of combination chemotherapy for metastatic CRC in patients aged above 80 years has yet to be *** To assess the clinical outcomes and feasibility of combination chemotherapy using a TA in extremely elderly patients with *** Eligibility criteria were:(1) Age above 80 years;(2) Metastatic colorectal cancer;(3) Palliative chemotherapy na?ve;(4) Eastern Cooperative Oncology Group performance status 0-1;and(5) Adequate organ *** received at least one dose of combination chemotherapy with or without *** was evaluated every 8 *** Of 30 patients,the median age of 15 patients treated with TA was 83.0 years and that of those without TA was 81.3 *** median progression-free survival(PFS) and overall survival(OS) in patients treated with TA were 7.4 mo and 15.4 mo,respectively,compared with 4.4 mo and 15.6 mo,respectively,in patients treated without *** was no significant difference in PFS(P:0.193) and OS(P:0.748) between patients treated with and without *** grade 3/4 hematologic toxicities were anemia(16.7%) and neutropenia(10.0%).After disease progression,the median OS of patients who were treated with and without salvage chemotherapy were 23.5 mo and 7.0 mo,respectively,suggesting significant difference in OS(P = 0.001).CONCLUSION Combination chemotherapy with TA for metastatic CRC may be considered feasible in patients aged above 80 years,when with careful *** chemotherapy can help improve OS in some selected of these elderly patients.

关键词： Combination chemotherapy Targeted agent Colorectal cancer Salvage chemotherapy Elderly patient

Ionizing terahertz waves with 260 MV/cm from scalable optical rectification

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Light(Science & Applications) 2024年第6期13卷 1075-1087页

作者： Hyeongmun Kim Chul Kang Dogeun jang Yulan Roh Sang Hwa Lee Joong Wook Lee Jae hee Sung Seong Ku Lee Ki-Yong Kim Advanced Photonics Research Institute GISTGwangju61005Korea Department of Physics and Optoelectronics Convergence Research Center Chonnam National UniversityGwangju61186Korea Pohang Accelerator Laboratory POSTECHPohang37673Korea Center for Relativistic Laser Science Institute for Basic ScienceGwangju61005Korea Institute for Research in Electronics and Applied Physics Department of PhysicsUniversity of MarylandCollege ParkMaryland20742USA

Terahertz(THz)waves,known as non-ionizing radiation owing to their low photon energies,can actually ionize atoms and molecules when a sufficiently large number of THz photons are concentrated in time and ***,we demonstrate the generation of ionizing,multicycle,15-THz waves emitted from large-area lithium niobate crystals via phase-matched optical rectification of 150-terawatt laser pulses.A complete characterization of the generated THz waves in energy,pulse duration,and focal spot size shows that the field strength can reach up to 260 megavolts per *** particular,a single-shot THz interferometer is employed to measure the THz pulse duration and spectrum with complementary numerical *** intense THz pulses are irradiated onto various solid targets to demonstrate THz-induced tunneling ionization and plasma *** study also discusses the potential of nonperturbative THz-driven ionization in gases,which will open up new opportunities,including nonlinear and relativistic THz physics in plasma.

关键词： optical interferometer matched

ELK3-ID4 axis governs the metastatic features of triple negative breast cancer

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Oncology Research 2024年第1期32卷 127-138页

作者： JIN-HO CHOI JOO DONG PARK SEUNG hee CHOI EUN-SU KO HYE JUNG jang KYUNG-SOON PARK Department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that ELK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the ELK3-ID4 axis regulates the metastatic features of ***:We found that ELK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of E-cadherin in TNBC was regulated by the ELK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in ELK3-knockdown MDA-MB-231(ELK3KD)cells restored the ability to extravasate and ***:The results indicate that the ELK3 regulates ID4 promoter activity,and that the ELK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the ELK3-ID4 axis regulates metastasis of TNBCs by modulating expression of E-cadherin.

关键词： E-cadherin Extravasation Colonization

Unravelling the role of the combined effect of metallic charge transfer channel and SiO_(x) overlayer in the Zr/Si-Fe_(2)O_(3):Au:SiO_(x) nanorod arrays to boost photoelectrochemical water splitting

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Journal of Energy Chemistry 2024年第3期90卷 370-379,I0009页

作者： Tae Sik Koh Periyasamy Anushkkaran Love Kumar Dhandole Mahadeo A.Mahadik Weon-Sik Chae Hyun Hwi Lee Sun hee Choi Jum Suk jang Division of Biotechnology SafetyEnvironment and Life Science InstituteCollege of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54896Republic of Korea Department of Integrative Environmental Biotechnology College of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54596Republic of Korea Extreme Materials Research Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Daegu Center Korea Basic Science InstituteDaegu 41566Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Hematite(α-Fe_(2)O_(3)) based photoanodes have been extensively studied due to various intriguing features that make them viable candidates for a photoelectrochemical(PEC) water splitting ***,we propose a Zr-doped Fe_(2)O_(3) photoanode decorated with facilely spin-coated Au nanoparticles(NPs) and microwave-assisted attached Si co-doping in conjunction with a SiO_(x) overlayer that displayed a remarkable photocurrent density of 2.01 mA/cm^(2) at 1.23 V *** kinetic dynamics at the photoelectrode/-electrolyte interface was examined by employing systematic electrochemical *** Au NPs played a dual role in increasing PEC water ***,the Schottky interface that was formed between Au NPs and Zr-Fe_(2)O_(3) lectrode ensured the prevention of electron flow from the photoanode to the metal,increasing the number of available charges as well as suppressing surface charge ***,Au extracted photoholes from the bulk of the Zr-Fe_(2)O_(3) and transported them to the outer SiO_(x) overlayer,while the SiO_(x) overlayer efficiently collected the photoholes and promoted the hole injection into the ***,Si co-doping enhanced bulk conductivity by reducing bulk charge transfer resistance and improving charge carrier *** study outlines a technique to design a metallic charge transfer path with an overlayer for solar energy conversion.

关键词： Hematite Microwave attachment Au nanoparticles SiO_(x) overlayer Water splitting

High Na-ion conductivity andmechanical integrity of anion-exchanged polymeric hydrogel electrolytes for flexible sodium ion hybrid energy storage

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SusMat 2024年第1期4卷 140-153页

作者： JungWoo Hong Harpalsinh H.Rana Jeong hee Park Jun Su Kim Sang Joon Lee Gun jang Tae Hoon Kang Kang Ho Shin Sang Ha Baek Wooseok Yang Kwang Ho Kim Ju-Hyuk Lee Ho Seok Park School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Clean Energy Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)SuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea COSMOS LAB/92 Jomaru-ro 385beon-gilBucheon-siRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

The polymeric gel electrolytes are attractive owing to their higher ionic conductivities than those of dry polymer electrolytes and lowered water activity for enlarged potential ***,the ionic conductivity and mechanical strength of the Na-ion conducting polymeric gel electrolytes are limited by below 20 mS cm−1 and 2.2 ***,we demonstrate Na-ion conducting and flexible polymeric hydrogel electrolytes of the chemically coupled poly(diallyldimethylammonium chloride)-dextrin-N,N′-methylene-bisacrylamide film immersed in NaClO_(4) solution(ex-DDA-Dex+NaClO_(4))for flexible sodium-ion hybrid capacitors(f-NIHC).In particular,the anion exchange reaction and synergistic interaction of ex-DDA-Dex with the optimum ClO_(4)−enable to greatly improve the ionic conductivity up to 27.63 mS cm−1 at 25◦C and electrochemical stability window up to 2.6 V,whereas the double networking structure leads to achieve both the mechanical strength(7.48 MPa)and softness of hydrogel ***,the f-NIHCs with the ex-DDA-Dex+NaClO_(4) achieved high specific and high-rate capacities of 192.04 F g^(−1)at 500 mA g^(−1)and 116.06 F g^(−1)at 10000 mA g^(−1),respectively,delivering a large energy density of 120.03Wh kg^(−1)at 906Wkg^(−1)and long cyclability of 70%over 500 cycles as well as demonstrating functional operation under mechanical stresses.

关键词： anion exchange chemistry flexible energy storage hybrid energy storage hydrogel electrolytes renewable electrolytes sodium storage

SMARCA4-deficient undifferentiated thoracic tumor:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2521-2527页

作者： hee Jung Kwon Min Hye jang Department of Pathology Yeungnam University Medical CenterDaegu 42415South Korea

BACKGROUND SMARCA4-deficient undifferentiated tumors(SMARCA4-DUTs)present with diverse clinical manifestations and progress to metastasis and even cause death within a few *** novel subset of undifferentiated tumors occurs in the middle-aged population and is strongly associated with a smoking ***-guishing it from other malignancies is *** SUMMARY A 62-year-old man presented with chest pain for 7 *** patient had no respiratory symptoms and normal pulmonary function test *** patient had been a smoker for 8 years and quit smoking 2 years *** computed tomography revealed a huge mass involving the left upper and lower lung lobes with pericardial invasion and multiple *** samples were obtained using open frozen biopsy,after several unsuccessful *** tumor was composed of sheets of undifferentiated disclosive cells with vesicular nuclei and prominent *** differential diagnosis included high-grade lymphoma,germ cell tumor,NUT carcinoma,undifferentiated carcinoma,and *** tumor cells were large,arranged in sheets,and did not exhibit glandular or squamous *** foci of necrosis were *** was no evidence of epithelial differentiation on immunohistochemical *** SMARCA4 stain showed complete loss of expression of SMARCA4,which is *** In the present case,thoracic SMARCA4-DUT was diagnosed based on clinical features,absence of epithelial differentiation,and negative SMARCA4 expression.

关键词： SMARCA4 BRG1 Deficient Undifferentiated tumor Thoracic Case report

Enhancing ammonia production rates from electrochemical nitrogen reduction by engineering three-phase boundary with phosphorus-activated Cu catalysts

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Journal of Energy Chemistry 2023年第9期84卷 394-401页

作者： Jeehye Kim Cho hee Lee Yong Hyun Moon Min hee Lee Eun Hyup Kim Sun hee Choi Youn Jeong jang Jae Sung Lee School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Chemical Engineering Hanyang UniversitySeoul 04763Republic of Korea Pohang Accelerator Laboratory(PAL) Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Electrochemical N_(2) reduction reaction(eNRR) over Cu-based catalysts suffers from an intrinsically low activity of Cu for activation of stable N_(2) molecules and the limited supply of N_(2) to the catalyst due to its low solubility in aqueous ***,we propose phosphorus-activated Cu electrocatalysts to generate electron-deficient Cu sites on the catalyst surface to promote the adsorption of N_(2) *** eNRR system is further modified using a gas diffusion electrode(GDE) coated with polytetrafluoroethylene(PTFE) to form an effective three-phase boundary of liquid water-gas N_(2)-solid catalyst to facilitate easy access of N_(2) to the catalytic *** a result,the new catalyst in the flow-type cell records a Faradaic efficiency of 13.15% and an NH_(3) production rate of 7.69 μg h^(-1) cm^(-2) at-0.2 V_(RHE),which represent 3.56 and 59.2 times increases from those obtained with a pristine Cu electrode in a typical electrolytic *** work represents a successful demonstration of dual modification strategies;catalyst modification and N_(2) supplying system engineering,and the results would provide a useful platform for further developments of electrocatalysts and reaction systems.

关键词： Electrochemical nitrogen reduction reaction Ammonia production Phosphorous modified copper electrodes Gas diffusion electrodes Three-phase boundary PTFE coating

Uncontrolled high blood pressure under total intravenous anesthesia with propofol and remifentanil:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9411-9416页

作者： Min Jung jang Jee hee Kim Hae Jeong Jeong Anesthesiology and Pain Medicine National Cancer CenterGoyang 10408South Korea

BACKGROUND Although propofol generally reduces blood pressure,rarely,it causes ***,the mechanism by which propofol increases blood pressure has not been established,and so far,there are only a few reported *** SUMMARY A 46-year-old woman,diagnosed with thyroid cancer,was administered general anesthesia with propofol and remifentanil for a thyroid *** increase in the concentrations of intravenous anesthetics further increased her blood *** blood pressure remained stable when anesthesia was maintained with sevoflurane and remifentanil after the interruption of propofol *** We concluded that propofol administration was the cause of increased blood pressure.

关键词： Anesthesia Intravenous Hypertension Propofol Remifentanil Tachycardia Case report

Gradient Si-and Ti-doped Fe_(2)O_(3) hierarchical homojunction photoanode for efficient solar water splitting:Effect of facile microwave-assisted growth of Si-FeOOH on Ti-FeOOH nanocorals

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Journal of Energy Chemistry 2023年第2期77卷 27-37,I0002页

作者： Tae Sik Koh Periyasamy Anushkkaran Weon-Sik Chae Hyun Hwi Lee Sun hee Choi Jum Suk jang Division of Biotechnology College of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54596Republic of Korea Daegu Center Korea Basic Science InstituteDaegu 41566Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

The construction of a homojunction is an effective approach for addressing issues such as slow charge separation and charge-transfer kinetics in *** the present work,we designed a gradient Si-and Ti-doped Fe_(2)O_(3) homojunction photoanode to improve the photoelectrochemical(PEC)performance of a Ti-doped Fe_(2)O_(3) ***-FeOOH nanocorals were synthesized using a hydrothermal process,and Si-FeOOH was grown on Ti-FeOOH nanocorals using a rapid and facile microwaveassisted(MW)*** varying the MW irradiation time,the thickness of the Si/Ti:Fe_(2)O_(3) photoanode was adjusted and an optimized 3-Si/Ti:Fe_(2)O_(3) photoelectrode was achieved with a significantly enhanced photocurrent density(1.37 mA cm^(-2) at 1.23 V ***)and a cathodic shift of the onset potential(150 mV)compared with that of bare Ti-Fe_(2)O_(3).This enhanced PEC performance can be ascribed to homojunction formation and Si gradient *** Si dopant increased the donor concentration and the formation of a homojunction improved the intrinsic built-in electric field,thereby promoting charge separation and charge ***,the as-formed homojunction passivated the surfacetrapping states,consequently improving the charge transfer efficiency(60%at 1.23 VRHE)at the photoanode/electrolyte *** findings could pave the way for the microwave-assisted fabrication of diverse efficient homojunction photoanodes for PEC water splitting applications.

关键词： Homojunction Microwave-assisted Hematite Gradient doping PEC water splitting