检索结果-南通市图书馆

TGF-β2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells

International Journal of Oral Science 2018年第4期10卷 232-243页

作者： Soyoun Um joo-hee lee Byoung-Moo Seo Biotooth Engineering Lab Dental Research InstituteDental Regenerative BiotechnologyDepartment of Dental ScienceSchool of DentistrySeoul National University Biotooth Engineering Lab Department of Oral and Maxillofacial Surgery and Craniomaxillofacial Life ScienceDental Research InstituteSchool of DentistrySeoul ational University

Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by *** conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and periodontitis have been shown to inhibit osteoblastic differentiation. This study focussed on dental follicle stem cells(DFSCs), which are found in developing tooth germ and participate in the reconstruction of alveolar bone and periodontal tissue in periodontal disease. After bacterial infection of inflamed dental tissue, the destruction of bone was observed. Currently, little is known about the relationship between the inflammatory environment and bone formation. Osteogenic differentiation of inflamed DFSCs resulted in decreased alkaline phosphatase(ALP) activity and alizarin red S staining compared to normal DFSCs. Additionally, in vivo transplantation of inflamed and normal DFSCs demonstrated severe impairment of osteogenesis by inflamed DFSCs. Protein profile analysis via liquid chromatography coupled with tandem mass spectrometry was performed to analyse the differences in protein expression in inflamed and normal tissue. Comparison of inflamed and normal DFSCs showed significant changes in the level of expression of transforming growth factor(TGF)-β2. Porphyromonas gingivalis(P.g.)-derived lipopolysaccharide(LPS) was used to create in vitro inflammatory conditions similar to periodontitis. The osteogenic differentiation of LPS-treated DFSCs was suppressed, and the cells displayed low levels of TGF-β1 and high levels of TGF-β2. DFSCs treated with TGF-β2 inhibitors showed significant increases in alizarin red S staining and ALP activity. TGF-β1 expression was also increased after inhibition of TGF-β2. By examining inflamed DFSCs and LPS-triggered DFSCs, these studies showed both clinically and experimentally that the increase in TGF-β2 levels that occurs under inflammatory conditions inhibits bone formation.

关键词： TGF downregulates osteogenesis under inflammatory conditions in dental follicle stem cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selective inhibition of cell growth by activin in SNU-16 cells

引用

World Journal of Gastroenterology 2006年第19期12卷 3000-3005页

作者： Young Il Kim hee joo lee Inkoo Khang Byung-Nam Cho Ha Kyu lee East-West Medical Research Institute Kyung hee University SeoulSouth Korea Department of Laboratory Medicine Kyung hee University College of MedicineSeoulSouth Korea School of Biological Sciences Seoul National University SeoulSouth Korea Department of Life Sciences The Catholic University of Korea PuchonSouth Korea

AIM： To investigate whether activin regulates the cell proliferation of human gastric cancer cell line SNU-16 through the mRNA changes in activin receptors, Smads and p21^CIP1/WAF1. METHODS： The human gastric cancer cell lines were cultured, RNAs were purified, and RT-PCRs were carried out with specifically designed primer for each gene. Among them, the two cell lines SNU-5 and SNU-16 were cultured with activin A for 24, 48 and 72 h. The cell proliferation was measured by MTT assay. For SNU-16, changes in ActRIA, ActRIB, ActRIIA, ActRIIB, Smad2, Smad4, Smad7, and p21^CIP1/WAF1 mRNAs were detected with RT-PCR after the cells were cultured with activin A for 24, 48 and 72 h. RESULTS： The proliferation of SNU-16 cells was down regulated by activin A whereas other cells showed no change. Basal level of inhibin/activin subunits, activin receptors, Smads, and p21^CIP1/WAF1 except for activin βB mRNAs was observed to have differential expression patterns in the human gastric cancer cell lines, AGS, KATO III, SNU-1, SNU-5, SNU-16, SNU-484, SNU-601, SNU-638, SNU-668, and SNU-719. Interestingly, significantly higher expressions of ActR IIA and IIB mRNAs were observed in SNU-16 cells when compared to other cells. After activin treatment, ActR IA, IB, and IIA mRNA levels were decreased whereas ActR IIB mRNA level increased in SNU-16 cells. Smad4 mRNA increased for up to 48 h whereas Smad7 mRNA increased sharply at 24 h and returned to the initial level at 48 h in SNU-16 cells. In addition, expression of the p21^CIP1/WAF1 the mitotic inhibitor, peaked at 72 h after activin treatment in SNU-16 cells. CONCLUSION： Our results suggest that inhibition of cell growth by activin is regulated by the negative feedback effect of Smad7 on the activin signaling pathway, and is mediated through p21^CIP1/WAF1 activation in SNU-16 cells.

关键词： Human gastric cancer cell lines, Activin A Cell proliferation Activin receptors Smads p21^CIP1/WAF1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Columbianadin and the Extract of Angelica decursiva Inhibit LPS-induced Inflammatory Responses by Suppressing NF-κB Signaling Pathway in RAW 264.7 Macrophages

Columbianadin and the Extract of Angelica decursiva Inhibit ...

引用

第十四届全国中药和天然药物学术研讨会

作者： joo hee lee Ran joo Choi Jae sue Choi Yeong Shik Kim Natural Products Research Institute Seoul National University

＜正＞The dried root of Angelica decursiva Franchet et Savatier（Umbelliferae）has historically been used as a Korean traditional medicine in antitussive,antipyretic,analgesic,and a cough *** this study,we investigated the anti-inflammatory effects of 70%ethanol extract and columbianadin,a naturally occurring coumarin isolated from the root of Angelica

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

CIM Model Extension for Intelligent DAS of Smart Power Grid in Korea

引用

Journal of Energy and Power Engineering 2012年第8期6卷 1328-1334页

作者： In-Yong Seo Bok-Nam Ha Sang-Ok Kim Dong-Uk Heo hee-joo lee Smart Energy Lab KEPCO Research Institute Daejeon 305-760 Republic of Korea ANYGA TE Corporation Research Center Seoul 152- 742 Republic of Korea

The CIM （common information model） is an abstract information model that can be used to model an electrical network and various equipments used on the network. By using a common model, utilities and vendors can reduce their integration costs, which should allow more resources to be applied toward increased functionality for managing and optimizing the electrical system. As a part of smart grid, the SPG （smart power grid） was built on Jeju Island. The SPG consists of IDAS （intelligent distribution automation system）, substation automation system, intelligent transmission system, and active telemetrics system. To integrate these systems which have different operating systems and platforms CIM standard was used. But IDAS has many functions and advanced algorithms not defined in CIM. In this paper, the authors introduce how to develop and extend the CIM model for managing the IDAS.

关键词： Battery common information model distribution automation system smart grid.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

引用

Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑hee lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models

引用

Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 621-630页

作者： Ju-hee Oh joo Hyun lee Young-joo lee Division of Biopharmaceutics College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea Department of Life and Nanopharmaceutical Sciences College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea

Quercetin is a biologically active flavonoid that has been used as a popular health *** is reported that quercetin may cause flavonoid-drug interaction mediated by P-glycoprotein,the most predominant efflux *** this study,we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2(MRP2),another major efflux ***2-transfected MDCKII cells and LS174T cells were used to evaluate the potential inhibition and induction of MRP2 by quercetin in *** evaluate the induction effect of quercetin on Mrp2 in vivo,Mrp2 mRNA expression in rat liver,kidney,and small intestinal tissues was determined after the oral administration of quercetin(50,100,or 250 mg/kg)for seven ***2-mediated interaction potential was also evaluated by the pharmacokinetic study of phenolsulfonphthalein in rats after single or multiple doses of ***,the effect of quercetin on absorption of docetaxel,a P-glycoprotein and CYP3A4 substrate,was also *** inhibited the function of MRP2 at 10μM and induced the mRNA expression of MRP2 at 50μM in ***,at 100 mg/kg,quercetin markedly increased Mrp2 expression in the small intestine of ***,there was no significant change in phenolsulfonphthalein pharmacokinetics due to single-(50,100,or 250 mg/kg)or multiple-dose(50,100,or 250 mg/kg for seven days)quercetin *** contrast,a significant interaction caused by quercetin(100 mg/kg)was observed in the absorption of *** results suggested that although quercetin modulates the function and expression of MRP2 in vitro,it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction.

关键词： Quercetin P-glycoprotein Multidrug resistance-associated protein 2 Pharmacokinetics Flavonoid-drug interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Observational Study of Surface Wind along a Sloping Surface over Mountainous Terrain during Winter

引用

Advances in Atmospheric Sciences 2018年第3期35卷 276-284页

作者： Young-hee lee Gyuwon lee Sangwon joo Kwang-Deuk AHN Department of Astronomy and Atmospheric Sciences Kyungpook National University Numerical Data Application Division Numerical Modeling Center

The 2018 Winter Olympic and Paralympic Games will be held in Pyeongchang, Korea, during February and March. We examined the near surface winds and wind gusts along the sloping surface at two outdoor venues in Pyeongchang during February and March using surface wind data. The outdoor venues are located in a complex, mountainous terrain, and hence the near-surface winds form intricate patterns due to the interplay between large-scale and locally forced winds. During February and March, the dominant wind at the ridge level is westerly; however, a significant wind direction change is ob- served along the sloping surface at the venues. The winds on the sloping surface are also influenced by thermal forcing, showing increased upslope flow during daytime. When neutral air flows over the hill, the windward and leeward flows show a significantly different behavior. A higher correlation of the wind speed between upper- and lower-level stations is shown in the windward region compared with the leeward region. The strong synoptic wind, small width of the ridge, and steep leeward ridge slope angle provide favorable conditions for flow separation at the leeward toot of the ridge. The gust factor increases with decreasing surface elevation and is larger during daytime than nighttime. A significantly large gust factor is also observed in the leeward region.

关键词： flow separation gust factor leeward region sloping surface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Tropical Cyclone Landfalls on Spatiotemporal Variations in Typhoon Season Rainfall over South China

引用

Advances in Atmospheric Sciences 2010年第2期27卷 443-454页

作者： Min-hee lee Chang-Hoi HO joo-Hong KIM Computational Science and Technology Seoul National University School of Earth and Environmental Sciences Seoul National University Met Office Hadley Centre

This study examined the impact of tropical cyclone (TC) landfalls on the spatiotemporal variations in the rainfall over South China for the period 1957–2005. The target region was selected to show the noteworthy contribution of TC landfalls to the total rainfall during the typhoon season (July–October). Two prevailing spatial variations in the rainfall were obtained from an EOF analysis. The first EOF mode displays singlesign variability over South China with an explained variance of 23.4%. The associated time series of this mode fluctuates on a decadal timescale and was found to be correlated with TC genesis in the South China Sea. The second EOF mode shows a seesaw pattern between Hainan Island/Guangdong Province and the remaining regions with an explained variance of 11.4%. This seesaw pattern results from an anti-correlation in seasonal TC landfalls between the two regions, which was found in previous studies. This is related to the strengthening (weakening) of the upper tropospheric jets and the corresponding development of a massive anticyclonic (cyclonic) circulation over East Asia. The EOF analysis was also conducted using just the data for rainfall caused by landfalling TCs. This revealed that the first EOF mode using just the TC-induced rainfall is nearly identical to the second mode from the total rainfall. The obvious seesaw pattern of the first mode when employing just the TC-induced rainfall in the EOF analysis implies that this pattern has larger temporal variability than the single-signed pattern (i.e., the first EOF mode using the total rainfall) in terms of TC landfalls. This study suggests that TC landfalls over South China and the accompanying rainfall significantly modulate the spatial variation of the typhoon season rainfall there.

关键词： rainfall tropical cyclone South China typhoon season

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Understanding the physical metallurgy of the CoCrFeMnNi high-entropy alloy:an atomistic simulation study

引用

npj Computational Materials 2018年第1期4卷 662-670页

作者： Won-Mi Choi Yong hee Jo Seok Su Sohn Sunghak lee Byeong-joo lee Department of Material Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Although high-entropy alloys(HEAs)are attracting interest,the physical metallurgical mechanisms related to their properties have mostly not been clarified,and this limits wider industrial applications,in addition to the high alloy *** clarify the physical metallurgical reasons for the materials phenomena(sluggish diffusion and micro-twining at cryogenic temperatures)and investigate the effect of individual elements on solid solution hardening for the equiatomic CoCrFeMnNi HEA based on atomistic simulations(Monte Carlo,molecular dynamics and molecular statics).A significant number of stable vacant lattice sites with high migration energy barriers exists and is thought to cause the sluggish *** predict that the hexagonal close-packed(hcp)structure is more stable than the face-centered cubic(fcc)structure at 0 K,which we propose as the fundamental reason for the micro-twinning at cryogenic *** alloying effect on the critical resolved shear stress(CRSS)is well predicted by the atomistic simulation,used for a design of non-equiatomic fcc HEAs with improved strength,and is experimentally *** study demonstrates the applicability of the proposed atomistic approach combined with a thermodynamic calculation technique to a computational design of advanced HEAs.

关键词： alloy alloying entropy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after curative intent surgical resection

引用

Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 450-455页

作者： Nam hee Kim Hong joo Kim Division of Gastroenterology Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

Background: Postoperative early recurrence(ER) in patients with pancreatic ductal adenocarcinoma(PDAC) is frequently encountered after curative intent surgery. Nonetheless, clinical significance and risk factors of ER after surgery for PDAC have not been extensively investigated. The aim of this study was to determine preoperative risk predictors for ER in patients with PDAC after upfront surgery. Methods: Eighty-one consecutive patients with PDAC who underwent curative intent surgical resection at Kangbuk Samsung Hospital between January 2004 and May 2015 were enrolled. ER was defined as tumor relapse within 6 months after surgery. Results: ER occurred in 26 patients(32.1%), whereas 49 patients(60.5%) had late recurrence( ≥ 6 months after surgery), and 6 patients had no recurrence(7.4%). Univariate analysis showed that C-reactive protein(CRP) > 3.0 mg/dL, modified Glasgow prognostic score(mGPS) = 2, decrease of total lymphocyte count by > 50% of baseline value in the preoperative period, prognostic nutritional index(PNI) 3.0 mg/dL, decrease of total lymphocyte count by > 50% of baseline value, and preoperative SUVmax were significant and independent contributors of ER in patients with resectable PDAC who underwent curative intent surgery. Conclusions: Postoperative ER for resectable PDAC was frequent with poor prognosis after curative intent upfront surgery. It is reasonable to suggest that there is a subgroup of resectable PDAC patients at highrisk of ER and neoadjuvant therapy should be considered in these patients in a clinical trial setting.

关键词： Early recurrence Pancreatic ductal adenocarcinoma Preoperative risk factors C-reactive protein Maximum standardized uptake value

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：