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Impacts of statin and metformin on neuropathy in patients with type 2 diabetes mellitus: Korean Health Insurance data

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World Journal of Clinical Cases 2021年第33期9卷 10198-10207页

作者： Hong Ki Min Se hee Kim Jong Han choi Kyomin choi Hae-Rim Kim Sang-Heon Lee Department of Internal Medicine Konkuk University Medical CenterSeoul KS013South Korea Department of Neurology Konkuk University Medical CenterSeoul KS013South Korea Division of Rheumatology Department of Internal MedicineKonkuk University School of MedicineSeoul KS013South Korea

BACKGROUND Neuropathy is a common chronic complication in type 2 diabetes mellitus(T2DM).Statin and metformin are commonly used medications in T2DM patients,and some studies showed statin-or metformin-induced *** To evaluate the incidence of neuropathy among patients with T2DM associated with statin and metformin *** Korean Health Insurance Review and Assessment national patient sample data from 2016 and 2017 were *** with T2DM and no complications were divided into statin/metformin/statin+metformin users and *** incidence was defined by International Statistical Classification of Diseases and Related Health Problems,10th revision codes and concomitant prescriptions for anticonvulsants or *** regression analyses were conducted to examine the associations between statin/metformin/statin+metformin therapies and the incidence of *** score(PS)matching was performed on the basis of age,sex and *** Overall,34964 and 35887 patients with T2DM and no complications were included in the Korean Health Insurance Review and Assessment national patient sample datasets from 2016 and 2017,*** therapy was associated with increased risks of neuropathy in 2016 and 2017[PS-matched odds ratio(OR)=1.22,95%confidence interval(CI):1.08-1.38;PS-matched OR=1.17,95%CI:1.03-1.33,respectively].Metformin therapy was associated with reduced risks of neuropathy in 2016 and 2017(PS-matched OR=0.30,95%CI:0.21-0.42;PSmatched OR=0.44,95%CI:0.32-0.60,respectively).Combined statin+metformin therapy was not significantly associated with neuropathy in 2016 or 2017(PSmatched OR=0.85,95%CI:0.61-1.19;PS-matched OR=0.95,95%CI:0.66-1.38,respectively).CONCLUSION Statin therapy was associated with enhanced risk of new-onset neuropathy in patients with T2DM,but metformin therapy showed the opposite association.

关键词： Diabetes mellitus Neuropathies Hydroxymethylglutaryl-CoA reductase inhibitors Metformin

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Performance Improvements in Temperature Reconstructions of 2-D Tunable Diode Laser Absorption Spectroscopy(TDLAS)

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Journal of Thermal Science 2016年第1期25卷 84-89页

作者： Doo-Won choi Min-Gyu Jeon Gyeong-Rae Cho Takahiro Kamimoto Yoshihiro Deguchi Deog-hee Doh Tokushima University 2-1 Minamijyosanjima TokushimaJapan Korea Maritime&Ocean University Dongsam-dong 1 Youngdo-guBusan 606-791Korea

Performance improvement was attained in data reconstructions of 2-dimensional tunable diode laser absorption spectroscopy(TDLAS). Multiplicative Algebraic Reconstruction Technique(MART) algorithm was adopted for data reconstruction. The data obtained in an experiment for the measurement of temperature and concentration fields of gas flows were used. The measurement theory is based upon the Beer-Lambert law, and the measurement system consists of a tunable laser, collimators, detectors, and an analyzer. Methane was used as a fuel for combustion with air in the Bunsen-type burner. The data used for the reconstruction are from the optical signals of 8-laser beams passed on a cross-section of the methane flame. The performances of MART algorithm in data reconstruction were validated and compared with those obtained by Algebraic Reconstruction Technique(ART) algorithm.

关键词： Data Reconstruction TDLAS MART ART

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Application of 3D bioprinting in the prevention and the therapy for human diseases

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1681-1697页

作者： hee-Gyeong Yi Hyeonji Kim Junyoung Kwon Yeong-Jin choi Jinah Jang Dong-Woo Cho Department of Rural and Biosystems Engineering College of Agriculture and Life SciencesChonnam National University77 Yongbong-RoGwangju 61186Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-RoPohangKyungbuk 37673Korea Department of Advanced Biomaterials Research Korea Institute of Materials Science(KIMS)797 ChangwondaeroChangwonKyungnam 51508Korea Department of Convergence IT Engineering POSTECH77 Cheongam-RoPohangKyungbuk 37673Korea Institute of Convergence Science Yonsei University50 Yonsei-RoSeoul 03722Korea

Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious *** speed up the drug discovery process,the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery *** this regard,layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease *** addition,the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines,therapeutics,and relevant delivery ***,we discuss the potential of 3D bioprinting technologies for the control of infectious *** also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.

关键词： printing prevention introducing

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Understanding the physical metallurgy of the CoCrFeMnNi high-entropy alloy:an atomistic simulation study

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npj Computational Materials 2018年第1期4卷 662-670页

作者： Won-Mi choi Yong hee Jo Seok Su Sohn Sunghak Lee Byeong-Joo Lee Department of Material Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Although high-entropy alloys(HEAs)are attracting interest,the physical metallurgical mechanisms related to their properties have mostly not been clarified,and this limits wider industrial applications,in addition to the high alloy *** clarify the physical metallurgical reasons for the materials phenomena(sluggish diffusion and micro-twining at cryogenic temperatures)and investigate the effect of individual elements on solid solution hardening for the equiatomic CoCrFeMnNi HEA based on atomistic simulations(Monte Carlo,molecular dynamics and molecular statics).A significant number of stable vacant lattice sites with high migration energy barriers exists and is thought to cause the sluggish *** predict that the hexagonal close-packed(hcp)structure is more stable than the face-centered cubic(fcc)structure at 0 K,which we propose as the fundamental reason for the micro-twinning at cryogenic *** alloying effect on the critical resolved shear stress(CRSS)is well predicted by the atomistic simulation,used for a design of non-equiatomic fcc HEAs with improved strength,and is experimentally *** study demonstrates the applicability of the proposed atomistic approach combined with a thermodynamic calculation technique to a computational design of advanced HEAs.

关键词： alloy alloying entropy

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Blood flow Interpretation in Femoral Pseudoaneurysm

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Journal of Thermal Science 2013年第3期22卷 229-233页

作者： Sang-Ho Suh Young Ho choi Hyoung-Ho Kim Min-Gyu Jeon Deog-hee Doh Dept. of Mechanical Engineering Soongsil University Department of Radiology Seoul Nat'l University Boramae Hospital Graduate School Korea Maritime Univ. Division of Mechanical and Energy Systems Engineering Korea Maritime University

A femoral artery pseudoaneurysm is one complication of vascular intervention, and the incidence is increasing. Early management is then needed to avoid potential dangers from it. It differs from a true aneurysm in that it doesn't include any component of the vascular wall, and is not studied as much as a true aneurysm. Here, a model of a femoral pseudoaneurysm was made and a Computational Fluid Dynamics(CFD) simulation was verified with PIV experiment. Afterwards, a CFD simulation with two different models was performed to look for any findings which may help in developing new treatment methods.

关键词： Femoral Artery, Pseudoaneurysm, Numerical and PIV experimental Interpretation

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Real-world comparison of non-vitamin K antagonist oral anticoagulants and warfarin in Asian octogenarian patients with atrial fibrillation

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Journal of Geriatric Cardiology 2016年第7期13卷 566-572页

作者： Chang hee Kwon Minsu Kim Gi-Byoung Nam Kee-Joon choi You-Ho Kim Division of Cardiology Konkuk University Medical Center Konkuk University School of Medicine Seoul South Korea Division of Cardiology Asan Medical Center University of Ulsan College of Medicine Seoul South Korea

Background The efficacy and safety of non-vitamin K antagonist oral anticoagulants （NOACs） and warfarin in Asian octogenarian atrial fibrillation （AF） patients have not been established in a real-world setting. We aimed to evaluate the efficacy and safety of NOACs and warfarin in Korean octogenarian patients. Methods A total of 293 consecutive patients aged 〉 80 years with non-valvular AF who had taken either NOACs 048 cases, 50.5%） or warfarin （145 cases, 49.5%） were retrospectively reviewed. The efficacy outcome was the com- posite of stroke or systemic embolism. The safety outcome was major bleeding. Results The follow-up duration was 375 patient-years （ 172 patient-years with NOACs and 203 patient-years with warfarin）. Patients on NOACs were slightly older （P = 0.006） and had slightly higher HAS-BLED scores （P = 0.034）. The efficacy of both anticoagulants was high （1.16% for NOACs vs. 2.98% for warfarin per 100 pa- tient-years, P = 0.46）. The safety outcome was relatively high in both NOACs and warfarin groups （8.96% vs. 12.46%, P = 0.29）. The effi- cacy and safety outcomes tended to decrease non-significantly in low dose NOACs than in common dose NOACs or warfarin （0.85% vs. 1.84% vs. 2.98% in efficacy outcome, P = 0.69; and 6.97% vs. 13.29% vs. 12.46% in safety outcome, P = 0.34）. Conclusions NOACs were highly effective for prevention of stroke or systemic embolism in Asian octogenarian AF patients. However, major bleeding occurred excessively high in both anticoagulant groups. Further study is required on the optimal anticoagulant regimen in octogenarian population.

关键词： Anticoagulants Atrial fibrillation Efficacy Octogenarian Safety

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Triolein emulsion infusion into the hepatic artery increases vascular permeability to doxorubicin in rabbit liver

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World Journal of Gastroenterology 2021年第2期27卷 152-161页

作者： Yong-Woo Kim Hak Jin Kim Byung Mann Cho Seon hee choi Department of Radiology Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalPusan National University College of MedicineYangsan 50612South Korea Department of Radiology Biomedical Research InstitutePusan National University HospitalPusan National University College of MedicineBusan 49241South Korea Preventive Medicine and Occupational Medicine Pusan National University School of MedicineYangsan 50612South Korea Department of Radiology Pusan National UniversityBusan 49241South Korea

BACKGROUND The infusion of triolein emulsion(TE)induced increased vascular permeability and a negligible and temporary decrease in liver function without specific histopathological *** To assess changes in doxorubicin concentration according to the percentage of TE infused via a hepatic artery to study the vascular permeability in the rabbit *** Thirty-nine healthy rabbits were divided into five groups according to the concentration of emulsified triolein infused into the hepatic arteries:Group 0,saline infusion(control group,n=5);group 1,0.3%TE(n=13);group 2,0.6%TE(n=6);group 3,0.9%TE(n=8);and group 4,1.5%TE(n=6).Doxorubicin(2.4 mg/kg)was infused immediately after TE injection via the hepatic *** 2 h,the livers were harvested,and doxorubicin concentrations were calculated *** doxorubicin concentrations were compared between TE groups and the control group,and the optimal concentrations within the TE groups were *** analysis was performed using the nonparametric Mann-Whitney U test and Kruskal-Wallis test.P0.05).CONCLUSION TE infusion into the hepatic arteries significantly increased the doxorubicin concentration approximately twofold but was not different between the TE *** findings suggest that TE infusion might be a useful adjuvant treatment of liver cancers.

关键词： Triolein emulsion Liver tumor Chemotherapy Drug delivery Vascular permeability Dexorubicin

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Direct approach to thrombosed superior ophthalmic vein of recalcitrant indirect carotid cavernous fistula in thrombocythemia failed with multiple conventional embolization treatment

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 687-692页

作者： Jungyul Park Jae-Il Lee Hyeshin Jeon hee-Young choi Department of Ophthalmology Pusan National University HospitalBusan 49241Korea Biomedical Research Institute of Pusan National University Hospital Busan 49241Korea Department of Neurosurgery Pusan National University HospitalBusan 49241Korea Department of Ophthalmology School of MedicinePusan National UniversityBusan 49241Korea

Dear Editor,I am Dr. Jungyul Park from the Division of Oculoplasty, Department of Ophthalmology, Pusan National University Hospital, Busan, Korea. I am writing to present a case of direct approach to thrombosed superior ophthalmic vein of recalcitrant indirect carotid cavernous fistula which was failed to treat with multiple conventional embolization treatment. To our knowledge this is very challenging procedure to the ophthalmologist, and not well described in literatures, especially in thrombocythemia patient with thrombosed superior ophthalmic vein.

关键词： thrombo fistula carotid

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Text-mining analysis using national R&D project data of South Korea to investigate innovation in graphene environment technology

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International Journal of Innovation Studies 2023年第1期7卷 87-99页

作者： Ji Yeon Lee Jung Woo choi Jae-Hak choi Byeong-hee Lee NTIS Center Korea Institute of Science and Technology InformationDaejeon34141South Korea Department of Science and Technology Management Policy University of Science and TechnologyDaejeon34113South Korea Department of Polymer Science and Engineering Chungnam National UniversityDaejeon34134South Korea

This study investigates the possibilities offered by the development of graphene environment technology that can contribute to new and effective approaches for the transition to an ecologically benign *** analyze the research and development progress in graphene environment technology,graphene environment technology research trends of South Korea for the years 2009e2020 are investigated by acquiring information pertaining to national research and development projects related to graphene environment technology from the National Science and Technology Information *** structured and unstructured data are analyzed using diverse text-mining methods,such as keyword frequency analysis,association rule mining,and topic *** results indicate that graphene research in South Korea is focused primarily on graphene use in batteries and energy-storage devices,such as solar cells,fuel cells,and secondary *** study can help understand the manner by which the South Korean government has been investing in the research and development of graphene environment technology;additionally,it discusses the future applications and prospects of graphene for the next decade.

关键词： Graphene technology Environmental transition National R&D project information Text mining Trend analysis

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Shape-controlled Pt nanocubes directly grown on carbon supports and their electrocatalytic activity toward methanol oxidation

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Science Bulletin 2017年第13期62卷 943-949页

作者： hee Jin Kim Bibi Ruqia Mi Sung Kang Su Bin Lim Ran choi Ki Min Nam Won Seok Seo Gaehang Lee Sang-Il choi Department of Chemistry and Green-Nano Materials Research Center Kyungpook National University Department of Chemistry KAIST Department of Chemistry Mokpo National University Department of Chemistry Sogang University Korea Basic Science Institute(KBSI) and University of Science and Technology

Synthesis of shape-controlled Pt nanocrystals is substantial and important for enhancing chemical and electrochemical ***,the removal of capping agents,shape-controlling chemicals,on Pt surfaces is essential prior to conducting the catalytic *** we report a facile one-pot synthesis of Pt nanocubes directly grown on carbon supports(Pt nanocubes/C) with modulating the kinetic reaction factors for shaping the nanocrystals,but without adding any capping agents for preserving the clean Pt ***-dispersed Pt nanocubes/C shows enhanced activity and long-term stability toward methanol oxidation reaction compared to the commercial Pt/C catalyst.

关键词： Platinum Nanocube Shape-control Kinetic product Methanol oxidation

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