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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Coarse to Fine: The Role of Severe Plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive Review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana R Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko R Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the Republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： Stress concentration

Performance Analysis of the Reconfigurable Intelligent Surfaces Communication Systems

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Journal of Communications and Information Networks 2024年第2期9卷 184-191页

作者： omar Abu ella Department of Electrical and Electronic Engineering Misurata University2659 Zawiat AlmahjoubMisurataLibya

Reconfigurable intelligent surfaces (RIS) play a vital role in meeting the growing demand for higher data rates and reliability in wireless systems. This study focuses on analyzing the performance of RIS systems to gain a deeper understanding of their *** paper presents a mathematical analysis of the RIS system,deriving closed-form formulae that express its characteristics including signal-to-noise ratio(SNR)distribution,ergodic and effective capacity,outage,and error probability. The obtained formulae are newly derived and unconditionally valid solutions. Numerical results demonstrate a close agreement between the derived formulae and MonteCarlo simulation outcomes.

关键词： ergodic capacity effective capacity outage probability bit error rate Rayleigh fading channel RISassisted communication system

Locomotion-based Hybrid Salp Swarm Algorithm for Parameter Estimation of Fuzzy Representation-based Photovoltaic Modules

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Journal of Modern Power Systems and Clean Energy 2021年第2期9卷 384-394页

作者： Rizk M.Rizk-Allah Aboul ella Hassanien the Faculty of Engineering Menoufia UniversityShebin El-KomEgypt Scientific Research Group in Egypt CarioEgypt the Faculty of Computers and Artificial Intelligence Cairo UniversityCairoEgypt

Identifying the parameters of photovoltaic(PV)modules is significant for their design and *** of the instabilities in the weather action and land surface of the earth,which cause errors in measuring,a novel fuzzy representation-based PV module is formulated and *** this paper,a novel locomotion-based hybrid salp swarm algorithm(LHSSA)is presented to identify the parameters of PV modules accurately and *** the LHSSA,better leader salps based on particle swarm optimization(PSo)are incorporated to the traditional salp swarm algorithm(SSA)in a serialized scheme with the aim of providing more valuable information for the leader salps of the *** this integration,the proposed LHSSA can escape the local optima as well as guide the seeking process to attain the promising *** proposed LHSSA is investigated on different PV models,i.e.,single-diode(SD),double-diode(DD),and PV module in crisp and fuzzy *** comparing with different algorithms,the comprehensive results affirm that the LHSSA can achieve a highly competitive performance,especially on quality and reliability.

关键词： Salp swarm algorithm(SSA) particle swarm optimization(PSo) photovoltaic(PV)model hybridization

The Exhausted Narrative in Tsai Ming-Liang＇s Films

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2017年第2期11卷 329-351页

作者： ella Raidel Institute of Fine Arts and Cultural Studies Art University Linz 4020 Linz Austria

This paper sets out to examine the ＂exhausted narrative＂ in aesthetic and poetic experience, revealing the affect and effect of Tsai Ming-Liang＇s film-making. He is notable for his obsession with ruins, defunct construction sites, abandoned buildings, and film itself as a modern ruin. These sites are a reminder of the alienated subjects within its historical context, a fragmented narrative, and an uncertain or failed future to come, just like the ruin--a chapter of a halted story. Tsai＇s films are not only full of ruinous images and bodies, but even the fragmented narratives are ruinous, turning in elliptical circles, aiming toward their morbid ending until their total exhaustion. This cinematic ouroboros ophis will be discussed in two aspects： first, as an aesthetic practice, and second, as the parallelism between the on- and off-screen reality of the mode of production and reception in the cinematic experience. The term ＂exhausted narratives＂ refers to the processes of writing meta-fiction, as that of ＂re-orchestrating＂ and ＂re-editing＂ the past with respect to the present, and to inscribing Tsai＇s own narrative universe.

关键词： Tsai Ming-Liang ruin cinema sinophone cinema exhaustednarrative meta language post-colonial aesthetics

optimized Deep Learning-Inspired Model for the Diagnosis and Prediction of CoVID-19

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Computers, Materials & Continua 2021年第5期67卷 2353-2371页

作者： Sally M.Elghamrawy Aboul ella Hassnien Vaclav Snasel MISR Higher Institute for Engineering and Technology MansouraEgypt Faculty of Computers and Information Cairo UniversityCairoEgypt VSB-Technical University of ostrava Czech Republic

Detecting CoVID-19 cases as early as possible became a critical issue that must be addressed to avoid the pandemic’s additional spread and early provide the appropriate treatment to the affected *** study aimed to develop a CoVID-19 diagnosis and prediction(AIMDP)model that could identify patients with CoVID-19 and distinguish it from other viral pneumonia signs detected in chest computed tomography(CT)*** proposed system uses convolutional neural networks(CNNs)as a deep learning technology to process hundreds of CT chest scan images and speeds up CoVID-19 case prediction to facilitate its *** employed the whale optimization algorithm(WoA)to select the most relevant patient signs.A set of experiments validated AIMDP *** demonstrated the superiority of AIMDP in terms of the area under the curve-receiver operating characteristic(AUC-RoC)curve,positive predictive value(PPV),negative predictive rate(NPR)and negative predictive value(NPV).AIMDP was applied to a dataset of hundreds of real data and CT images,and it was found to achieve 96%AUC for diagnosing CoVID-19 and 98%for overall *** results showed the promising performance of AIMDP for diagnosing CoVID-19 when compared to other recent diagnosing and predicting models.

关键词： Convolutional neural networks coronavirus disease 2019(CoVID-19) CT chest scan imaging deep learning technique feature selection whale optimization algorithm