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Journal of Forensic Science and Medicine 2018年第3期4卷 129-134页

作者： hedayat a.abdel ghaffar Marie Z.Moftah Alexandre Favereaux Mohamed Swidan Omar Shalaby Sara El Ramah Reda Gamal Department of Zoology Faculty of ScienceAlexandria University department of Life Science University of Bordeauxinterdisciplinary Institute of Neuroscience UMR 5297CNRSBordeauxFrance department of Biology and Geology Faculty of EducationAlexandria UniversityAlexandriaEgypt department of Life Science Faculty of BiologyTechnische Universitat DresdenDresdenGermany

Relying on morphology in the estimation of postmortem intervals is not always accurate for all life phases of flies,especially for immature *** present study demonstrates the application of cytochrome oxidase I sequences,a partial mitochondrial(mt)gene region,to differentiate forensically important flies in Alexandria,***-three adult flies,larvae,and pupae were collected from rabbit *** were used for *** analysis revealed no significant intraspecific divergence in Diptera ***,a neighbor-coining tree using the Kimura 2-parameter model illustrated reciprocal morphology between *** represented five species,four genera,four subfamilies,two families,and one *** herein identify five different species,Chrysomya albiceps,Chrysomya megacephala,Calliphora vicina,Lucilia sericata,and Ophyra capensis,using mt DNA as a species-specific marker for identification in a local database set-up.

关键词： Cytochrome oxidase Diptera mitochondrial DNA phylogenetic analysis

Moisture and Temperature Response of Structural and Lithology based Thermophysical and Energy Saving Traits of Limestone using Experimental and Least-Square Fitting Methods

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Journal of Thermal Science 2021年第2期30卷 551-561页

作者： Farah Anjum Muhammad Yasin Naz Abdul ghaffar Shazia Shukrullah Nasser M abdel-Salam Khalid Aref Ibrahim Department of Physics University of AgricultureFaisalabad 38040Pakistan Arriyadh Community College King Saud UniversityArriyadh 11437Saudi Arabia College of Engineering Muzahimiyah BranchKing Saud UniversityRiyadh 11451Saudi Arabia Department of Physics College of Arts and SciencesUniversity of JhangJhang 35200Pakistan

Thermophysical analysis of the crustal rocks is important for heat transfer determination and insulation purposes to save energy in *** the presented work,thermophysical properties of four limestones were investigated in dry and moist state under ambient conditions by using a transient plane source method.A thermal constant analyzer was used to raise the sample temperature and to measure the thermal properties in the temperature range of 300 K to 433 *** conductivity and diffusivity were measured by developing a linear relationship between temperature response of TPS (transient plane source) sensor and dimensionless time function through least-square fitting *** experimental observations and predicted thermal conductivity of samples have shown that in-situ observations are important to determine the thermal properties *** effect of temperature on thermal properties of limestone was defined by considering the chemical composition of the samples and associated heat transfer *** thermal conductivity and diffusivity of limestone decreased while specific heat capacity increased with a rise in *** overall findings indicate that the spinoff of this research is useful in studying the reliance of thermophysical properties of rocks on their structures and lithology.

关键词： limestone thermophysical properties transient plane source(TPS) thermal conductivity

Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children

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World Journal of Gastroenterology 2014年第16期20卷 4681-4691页

作者： Suzan El Naghi Tawhida Y abdel-ghaffar Hanaa El-Karaksy Elham F abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y abdel-ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira Pediatric Department National Hepatology and Tropical Medicine Research Institute11441 CairoEgypt Yassin abdel ghaffar Charity Center for Liver Disease and Research 2851 CairoEgypt Pediatric Department Ain Shams University11566 CairoEgypt Department of Pediatrics Cairo University Pediatric Hospital11562 CairoEgypt Pediatric Hepatology Department National Liver InstituteMenofiya UniversityShebin El-koom32511 MenofiyaEgypt Biochemistry Department National Liver Institute32511 MenofiyaEgypt Clinical Pathology Department Ain Shams University11566 CairoEgypt Pathology Department National Liver InstituteMenofiya UniversityShebin El-koom32511 MenofiyaEgypt Pathology Department Cairo UniversityFaculty of MedicineKasr El-Aini11562 CairoEgypt

AIM: To investigate the safety and efficacy of a Hansenula-derived PEGylated (polyethylene glycol) interferon (IFN)-alpha-2a (Reiferon Retard) plus ribavirin customized regimen in treatment-naïve and previously treate... 详细信息

关键词： Children Chronic hepatitis C Hansenula polymorpha PEGylated interferon Response rate Ribavirin Treatment

Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study

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World Journal of Gastroenterology 2021年第42期27卷 7362-7375页

作者： Shimaa Afify Basem Eysa Fatma.abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed abdelhalim Muhammad Mostafa.abdel ghaffar Dalia A Omran Hend Ibrahim Shousha Department of Gastroenterology National Hepatology and Tropical Medicine Research InstituteCairo 20222Egypt Department of Endemic Medicine Faculty of MedicineFayoum UniversityEl-Fayoum 13524Egypt Department of Biostatistics and Cancer Epidemiology National Cancer InstituteCairo 20222Egypt Department of Gastroenterology Students HospitalCairo UniversityGiza 12111Egypt The General Organization for Teaching Hospitals and Institutes Cairo 11562Egypt Department of Endemic Medicine Faculty of MedicineCairo UniversityCairo 11562Egypt

BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver *** This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in *** were recruited from May 1,2020,to July 31,***,laboratory,imaging features,and outcomes were *** regression analysis was performed to detect factors affecting *** This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)***,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver ***,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic *** was no difference between patients with and without cirrhosis regarding *** patients(23.40%)with liver cirrhosis presented with hepatic *** with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compar

关键词： COVID-19 Egypt Outcome Liver cirrhosis Chronic hepatitis C

A novel ABHD5 mutation in two Chanarin Dorfman siblings with severe and heterogeneous clinical phenotype

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Genes & Diseases 2023年第3期10卷 690-693页

作者： Solaf Mohamed Elsayed Enza Torre Daniela Tavian Laura Moro Corrado Angelini Tawhida Y.abdel ghaffar Khalid Zalata Enas Ezzeldein Fahmy Sara Missaglia Medical Genetics Department Faculty of MedicineAin Shams UniversityCairoEgypt Yassin abdel ghaffar Center for Liver Disease and Research CairoEgypt Laboratory of Cellular Biochemistry and Molecular Biology CRIBENSCatholic University of the Sacred HeartMilan 20145Italy Department of Psychology Catholic University of the Sacred HeartMilan 20123Italy Department of Pharmaceutical Sciences University of Piemonte OrientaleNovara 28100Italy Neuromuscular Lab Department of NeurosciencesUniversity of PadovaCampus Biomedico Pietro D'AbanoPadova 35131Italy

Chanarin Dorfman Syndrome(CDS;MIM:275630)is a rare autosomal recessive disorder,characterized by triacylglycerol(TG)accumulation in lipid droplets(LDs)within different tissues including skin,liver,skeletal muscle,bone marrow,eyes,ears,and central nervous system.1 In CDS,the prevalent and always observed clinical feature is a non-bullous congenital ichthyosiform erythroderma(NCIE).

关键词： clinical congenital skeletal

Solid-Contact Perchlorate Sensor with Nanomolar Detection Limit Based on Cobalt Phthalocyanine Ionophores Covalently Attached to Polyacrylamide

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American Journal of Analytical Chemistry 2011年第7期2卷 820-831页

作者： Mohammad Nooredeen Abbas abdel Lattief A. Radwan Philippe Bühlmann Mahmud A. Abd El ghaffar 不详

Novel solid-contact perchlorate sensors based on cobalt phthalocyanine-C-monocarboxylic acid (I), and cobalt phthalocyanine-C,C,C,C-tetracarboxylic acid (II) as free ionophores and covalently attached to polyacryla- mide (PAA)—ionophores III and IV, respectively were prepared. The all solid-state sensors were constructed by the application of a thin film of a polymer cocktail containing a phthalocyanine ionophore and cetyltrimethylammonium bromide (CTMAB) as a lipophilic cationic additive onto a gold electrode precoated with the conducting polymer poly (3,4-ethylenedioxythiophene) (PEDOT) as an ion and electron transducer. The sensor with 10.3% of ionophore (III) covalently attached to plasticizer-free poly (butyl methacrylate-co-do- decyl methacrylate) (PBDA) exhibited a good selectivity for perchlorate and discriminated many ions, in- cluding F–, Cl–, Br–, I–, SCN–, , S2– and . The covalent attachment of the ionophore to the polymer resulted in a near-Nernstian anionic slope of –62.3 mV/decade whereas a super-Nernstian slope of –79.9 mV/ decade was obtained for the free ionophore. The sensor covered a linear concentration range of 5 × 10–9 - 1 × 10–2 mol?L–1 with a lower detection limit (LDL) of 1 × 10–9 mol?L–1 and gave a stable response over a pH range of 4 - 10.5. The all-solid state sensors were utilized for the selective flow injection potentiometric determination of perchlorate in natural water and human urine samples in the nanomolar concentration range.

关键词： Ion-Selective Electrode Solid Contact Covalent Ionophore Attachment Perchlorate Flow-Injection Analysis Urine

Hepatitis C genotype 4: The past, present, and future

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World Journal of Hepatology 2015年第28期7卷 2792-2810页

作者： Tawhida Y abdel-ghaffar Mostafa M Sira Suzan El Naghi Pediatric Department Ain Shams University Yassin abdel ghaffar Charity Center for Liver Disease and Research Pediatric Hepatology Department National Liver Institute Menofiya University Pediatric Department National Hepatology and Tropical Medicine Research Institute

Hepatitis C virus(HCV) genotype(GT) 4 represents 12%-15%(15-18 million) of total global HCV infection. It is prevalent in Northern and Equatorial Africa and the Middle East, and is also present in some countries in Europe. GT-4(and subtype 4a in particular) dominates the HCV epidemic in Egypt. In underdeveloped countries, risk factors associated with HCV infection may be due to unsafe medical practices or other factors such as familial transmission, mother's HCV status, or illiteracy. HCV prevention and control programs should include health education, increased community awareness towards the disease, controlling infection distribution in healthcare centers, proper sterilization of medical and dental instruments, and ensuring safe supply of blood and blood-products. Response rates to a 48-wk combined pegylated-interferon(PEG-IFN) and ribavirin(RBV) treatment range from 40%-69%, and HCV-GT-4 has been considered better than GT-1 but worse than GT-2 and GT-3 in treatment with PEG-IFN/RBV. However, with the introduction of the HCV-GT-1 effective protease inhibitors boceprevir and telaprevir in 2011, HCV-GT-4 became the "most difficult(GT) to treat". Recently, the direct-acting antivirals(DAAs) with pan- genotypic activities simeprevir, sofosbuvir, and daclatasvir have been recommended in triple regimens with PEG-IFN/RBV for the treatment of HCV-GT-4. An IFN-free regimen will be available for treatment of all genotypes of HCV in the near future. To date, several DAAs have been developed and are currently being evaluated in various combinations in clinical trials. As new regimens and new agents are being approved by the Food and Drug Administration, we can expect the guidelines for HCV treatment to be changed. The availability of shorter, simpler, and more tolerable treatment regimens can reduce the morbidity and mortality associated with HCV infection. With such a large number of therapeutic agents available, we can end up with a range of choices that we can select from

关键词： Hepatitis C virus Genotypes Transmission Pegylated-interferon Ribavirin Direct acting antivirals Hepatitis C virus vaccine

Effect of buffalo bull breeds on developmental competence and vitrification ofin-vitro produced embryos

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Asian pacific Journal of Reproduction 2018年第6期7卷 270-273页

作者： Walid T.M.Soliman Al-Shimaa Al-H.H.El-Naby Karima Gh.M.Mahmoud Ahmed R.M.El-Khawagah Mohamed M.M.Kandiel Mahmoud E.A.Abouel-Roos Alaa E.abdel-ghaffar abdel Salam I.El Azab Veterinary Department Egyptian Armed ForcesEgypt Department of Theriogenology Faculty of Veterinary MedicineBenha UniversityEgypt Department of Animal Reproduction and Artificial Insemination National Research CenterDokkiGizaEgypt

Objective:To assess effect of buffalo bull breed on the development and cryotolerence of the in vitro produced ***: Three types of frozen semen were adopted;Egyptian, Italian and cross-bred (Egyptian-Italian) breeds were used for in-vitro fertilization and vitrification of their embryos. Oocytes were collected from buffalo ovaries and maturedin vitrofor 24 h, then they were fertilized using the three semen breeds. The produced embryos of morula and blastocysts were vitrified using ethylene glycol and dimethyl sulfoxide then evaluated for their viability after ***: The cleavage and blastocysts rates significantly declined in oocytes fertilized by Egyptian (P<0.01) than in Italian (P<0.05) and crossbred (P<0.05) frozen semen. After embryo vitrification, there were no significant differences among the three breeds in the percentages of morphologically viable embryos evaluated directly after warming and at 24 h post-culture. Conclusions:Thein vitro fertilization response to frozen-thawed semen varies between breeds;however, the resistance of produced embryos to the damage effect of vitrification does not vary.

关键词： In vitro fertilization Buffalo breed Embryo production Vitrification

Cardio-Protective Effects of Oral Nicorandil in Patients Undergoing Cardiac Valve Surgery

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World Journal of Cardiovascular Diseases 2019年第10期9卷 707-717页

作者： Mohamed A. W. Ezzat Essam Elbadry Hashim Mohamed Ayman Mohamed abdel ghaffar abdelhady Ahmed Helmy Wesam abdelgalil Aboelwafa Eman Mohammad Ali Internal Medicine and Cardiology Department Sohag Faculty of Medicine Sohag University Sohag Egypt Cardiothoracic Surgery Department Sohag Faculty of Medicine Sohag University Sohag Egypt Anesthesia and Intensive Care Department Sohag Faculty of Medicine Sohag University Sohag Egypt Pharmacology Department Sohag Faculty of Medicine Sohag University Sohag Egypt

Background: Reduction of myocardial reperfusion injury during cardiopulmonary bypass is an essential requirement for increasing the success rate, decreasing morbidity and mortality of open-heart surgery. Aim: To study the role of pre-operative oral nicorandil in decreasing reperfusion cardiac injury in patients subjected to cardiac valve surgery. Patients and Methods: The study included 62 patients, who were equally randomized into two groups: nicorandil group and control group. Pre-operative, intra-operative and post- operative data were reported and analyzed. Left Ventricle Ejection Fraction (LVEF) was estimated pre-operatively and postoperatively for both groups. Troponin I, creatine kinase-muscle/brain (CK-MB), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were measured before surgery by 24 hours then 4, 12 and 48 hours after aortic cross clamp removal. Results: Nicorandil considerably decreased TNF-α and IL-6 after 4 and 12 hours following the removal of aortic clamping. It also reduced troponin-I and CKMB at the same time points. However, there were no important changes in IL-6, TNF-α, troponin-I and CK-MB levels in control group in comparison to nicorandil group in the next 48 hours following the removal of aortic clamping. Conclusions: Pre-operative oral nicorandil expressively decreased myocardial reperfusion damage during open heart valve operations, this evidenced by the decrease in the postoperative use of inotropic drugs, considerable reduction of postoperative elevation of cardiac enzymes and inflammatory cytokines with no reported complications.

关键词： Nicorandil for Myocardial Protection Cardiopulmonary Bypass Ischemia-Reperfusion Injury Inflammatory Cytokines Cardiac Valvular Surgery

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悬吊桥塔的简化地震分析

世界地震工程 1984年第5期 18-26页

作者： AhmedM.abdel-ghaffar JoelD.Rood 甘幼深

在悬吊桥的地震分析中,最重要的构件分析是塔-墩系统的分析。在强烈地震期间,如果桥塔结构被破坏,整个悬吊桥可能报废,而且,自由振动分析表明,悬吊桥的振型可以分为两组。一组,钢索和加劲结构的位移是主要的;而另一组,桥塔的位移是主要... 详细信息

在悬吊桥的地震分析中,最重要的构件分析是塔-墩系统的分析。在强烈地震期间,如果桥塔结构被破坏,整个悬吊桥可能报废,而且,自由振动分析表明,悬吊桥的振型可以分为两组。一组,钢索和加劲结构的位移是主要的;而另一组,桥塔的位移是主要的。因此,可以分别研究桥梁不同

关键词：桥塔振型剪力索塔方程地震反应地震分析