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Induction of Apoptosis and Anoikis by Bit1 in Pancreatic Cancer Cells

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Journal of Cancer Therapy 2013年第4期4卷 815-824页

作者： Kelly Leleux Tri Pham Mya Davis Priya Karmali hector Biliran Department of Biology Xavier University of Louisiana New Orleans USA Sanford-Burnham Medical Research Institute La Jolla USA.

Pancreatic cancer is a highly aggressive disease with a very high mortality rate among all human cancers. The poor prognosis is in part due to intrinsic resistance to the apoptosis-inducing effects of radio- and chemotherapy. To find alternative cell death pathways that can bypass the apoptotic resistance of pancreatic cancer cells, we examined the role of the novel anoikis effector Bit1 (Bcl-2 inhibitor of transcription) in the survival and apoptotic resistance of pancreatic cancer cells. Bit1 is a mitochondrial protein that induces a caspase-independent apoptosis upon its release into the cytosol following loss of integrin-mediated attachment to extracellular matrix (anoikis). In this report, we observed that ectopic expression of Bit1 in the cytosol reduced viability and induced caspase-independent apoptosis in human pancreatic cancer cell lines, Miapaca-2 and PANC-1. While increased expression of mitochondrial Bit1 in these cells did not induce apoptosis under attached conditions, detachment significantly induced higher level of apoptosis in mitochondrial Bit1-transfected cells than in control transfected cells. Conversely, downregulation of endogenous Bit1 in PANC-1 cells further enhanced their anoikis resistance. Furthermore, exogenous expression of mitochondrial Bit1 in Miapaca-2 cells inhibited their anchorage-independent growth and enhanced their sensitivity to etoposide-mediated apoptosis. Mechanistically, we found that the Bit1 apoptosis function is in part dependent on the groucho related Amino-terminal Enhancer of Split (AES) expression and is abrogated by the transcriptional corepressor TLE1 protein. Consistent with our in vitro findings that Bit1 is an effector of apoptosis in pancreatic tumor cells, we find that Bit1 is significantly downregulated in a fraction of advanced stages of human pancreatic carcinoma tissues. Taken together, these findings indicate that the Bit1-apoptotic pathway can be targeted to trigger cell death in pancreatic cancer cel

关键词： Anoikis Apoptosis Integrin Pancreatic Cancer

Experience with the surgical treatment of hepatic hydatidosis: Case series with follow-up

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World Journal of Gastroenterology 2010年第26期16卷 3305-3309页

作者： hector Losada Morales Luis Burgos San Juan Jorge Silva Abarca Cesar Muoz Castro Department of Surgery Universidad de La Frontera Hepato Pancreatic and Biliary Surgery Hospital Hernán Henríquez Aravena Department of Surgery Clínica Alemana de Temuco

AIM: To describe patient characteristics and the results of surgical treatment for hepatic hydatidosis (HH) in the Hospital Hernán Henríquez Aravena from December 2001 to March 2005. METHODS: Subjects older than 16 years with suspected HH were included based on the clinical picture and radiological studies. Variables examined included clinical and laboratory aspects, outcome, features of the parasite and surgical aspects. Descriptive statistics were used, calculating central tendency, dispersion and extreme tendency. RESULTS: The series was comprised of 122 patients, with an average age of 44 ± 16.9 years. The most frequently used surgical technique was subtotal cys-tectomy in 90% of the patients, followed by hepatic resection (hepatectomy, segmentectomy and subsegmentectomy) in 5%. In 2%, a combination of subtotal cystectomy and segmentectomy was performed. In addition, 28% of the series presented complications in the postoperative period and mortality was 2%. CONCLUSION: The most frequently used surgical technique for HH was subtotal cystectomy and the morbidity and mortality rates in this Chilean series are comparable to other national and international series.

关键词： Echinococcosis of liver Surgery Cases series Mortality Morbidity

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饲用抗生素在家禽生产中的应用进展

中国家禽 2013年第4期35卷 41-44页

作者： hector M. Cervantes 曹玉娟美国佐治亚大学

在畜禽饲料中加入亚治疗量抗生素来提高动物生产性能的做法已有60多年历史,然而,抗生素添加剂的安全性问题一直是争论焦点。支持和反对使用抗生素添加剂都还未有足够证据。但考虑到抗生素"潜在"或"可能"对人类健康存在危害性,许多国家... 详细信息

在畜禽饲料中加入亚治疗量抗生素来提高动物生产性能的做法已有60多年历史,然而,抗生素添加剂的安全性问题一直是争论焦点。支持和反对使用抗生素添加剂都还未有足够证据。但考虑到抗生素"潜在"或"可能"对人类健康存在危害性,许多国家或地区正在着手限制甚至完全禁止抗生素添加剂的使用。最近,美国食品和药物管理中心颁布一系列"产业指导文件"以解决耐药性和药物残留问题。事实上,如果对抗生素添加剂进行良好控制,促生长类抗生素以亚治疗剂量应用于动物饲料,可以预防和控制肠道疾病、改善动物营养状况、促进动物生长、提高饲料效率、加强食品安全和提高动物福利。美国佐治亚大学hector ***在第24届世界家禽大会上对此进行了概述。

关键词：饲用抗生素家禽耐药性

Dealloying study of Cu3Pt/C Intermetallic Nanoparticles as ORR Electrocatalysts:Electrochemically ***

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Dealloying study of Cu3Pt/C Intermetallic Nanoparticles as O...

Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

中国化学会第28届学术年会

作者： David A.Muller hector D.Abrua School of Applied and Engineering Physics Kavli Institute at Cornell for Nanoscale Science Cornell UniversityIthacaNY14850

＜正＞Dealloyed Pt bimetallic nanoparticles have attracted much attention as electrocatalytic materials for the oxygen reduction reaction（ORR）,one of the key barriers for the commercial deployment of polymer electro... 详细信息

关键词： Fuel cells ORR Dealloying Intermetallic nanoparticles Electrocatalysts

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 20-23页

作者： Ana Vargas-Calla Luis A.Gomez-Puerta Juan Calcina Omar Gonzales-Viera Cesar Gavidia Maria T.Lopez-Urbina hector H.Garcia Armando E.Gonzalez School of Veterinary Medicine Universidad Nacional Mayor de San Marcos Cysticercosis Elimination Program and Center for Global Heath Tumbes Universidad Peruana Cayetano Heredia Department of Microbiology School of SciencesUniversidad Peruana Cayetano Heredia

Objective:To assess the efficacy of triclabendazole(TCBZ) in porcine ***:Eighteen naturally infected cysticercotic pigs were divided into 3 groups of 6 individuals *** first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight,the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo(control group).All animals were kept under the same management *** pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between ***:All pigs treated with oxfendazole had only degenerated cysts in their *** contrast,TCBZ had very little effect against the parasitic *** from pigs in the TCBZ group looked apparently normal after ***,histological evaluation showed a mild to moderate degree of ***:TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.

关键词： Taenia solium Cysticercosis Triclabendazole Oxfendazole Treatment

Chemical Composition of Meat in Castrated Male Brahman Cattle in Venezuela

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Journal of Life Sciences 2011年第7期5卷 562-568页

作者： Jose A. Miguel Jestls Ciria Begofia Asenjo hector Pargas David Colmenarez College of Agricultural Engineers University of Valladolid Soria 42004 Spain University Centroccidental Lisandro Alvarado Barquisimeto 87220 Venezuela

Chemical composition of Brahman cattle was studied and determined in this study. Fifty males had been castrated at birth, farmed semi-intensively on the Venezuelan plain and then slaughtered at the age of 31 months with an approximate weight of 500 kilograms. The average pH value of beef was 5,84 after obtained for 24 hours after staughtering, which matches the ~atue found in similar studies made on the same breed in Venezuela （5.8）. The moisture, crude protein and ash contents correspond to the expected values of cattle, while the intramuscular fat values are slightly higher than those of the different breeds ofBos indicus. The total collagen values found in this study are either similar or lower than those found by other researches from the different breeds ofBos indicus and their crossbreeds, while the collagen solubility value （39%） was higher than the one found in other studies on the Brahman breed.

关键词： Bos Indicus Brahman cattle castrated collagen pH meat.

Design and Construction of an Equipment for the Radiochemistry Process of Molecules Marked for the Sector Health

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Journal of Environmental Science and Engineering(A) 2015年第4期4卷 196-202页

作者： Jose Alanis hector Flores Simon de la Cruz Jose Carlos Vazquez Department of Radioactive Waste Nuclear Center of Mexico ININ Oeoyoacac Edo. de Mexico 52 750 Mexico Department of Chemical Analyses Nuclear Center of Mexico ININ Ocoyoacac Edo. de Mexico 52750 Mexico Department Manufacture of Prototypes Nuclear Center of Mexico ININ Ocoyoacac Edo. de Mexico 52750 Mexico Department of A utomation Nuclear Center of Mexico ININ Ocoyoacac Edo. de Mexico 52750 Mexico

At the Plant of Production of Radioisotopes part of Nuclear Center of Mexico （ININ）, weekly radiofarmaceutics of sodium iodohippurate and meta-iodobenzyl-guanidine are prepared, these compounds are known as marked molecules with iodine-131. Currently the processes for the preparation of these compounds are carried out individually and in manual form, in box of gloves, presenting radiological risks. To avoid these risks, this work, shows equipment that is inside a warm cell with the finality of minimizing the radiological risks. Also, this semi-automated equipment has the purpose of to reduce the radiation exposure of personnel involved in the process of marking molecules. The routine industrial production with this equipment starts with the preparation of 9 marked doses of sodium iodohippurate of 2.73 mCi of iodine-131, each of the vials with saline solution of 4.5 mL and the product that containing the marked molecules of 0.5 mL with a percentage of marked of 95.6%. The innovation of this work consists in presenting a new design of equipment, for marked molecules, formed by electrical, mechanical, vacuum systems, and air extraction system.

关键词： Construction equipment molecules marked sector health

Efficacy of Reduced-Risk Insecticides to Control Flower Thrips in Early-Season Blueberries and Their Effect on <i>Orius insidiosus</i>, a Natural Enemy of Flower Thrips

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Agricultural Sciences 2017年第5期8卷 356-370页

作者： Oscar E. Liburd hector Alejandro Arevalo Elena M. Rhodes Entomology and Nematology Department University of Florida Gainesville FL USA

Flower thrips are one of the key pests in production of southern highbush blueberries (Vaccinium corymbosum L. × V. darrowi Camp). They feed on the reproductive parts of the flower and reduce yield. Very few insecticides are available to manage thrips population. Therefore, it is necessary to evaluate pre-existing and experimental insecticides for their efficacy against thrips. There is also a high demand for reduced-risk insecticides that are less toxic to beneficial insects and the environment. In this study, a number of conventional and reduced-risk insecticides were evaluated against flower thrips on farms in Florida and Georgia and in the laboratory. The best performing insecticides were also evaluated in the laboratory for their effects on Orius insidiosus Say, which is a common thrips’ predator in Florida. Assail 70WP (Acetamiprid) and SpinTor 2SC (Spinosad) were the most promising insecticides in reducing thrips numbers in the field as well as in laboratory experiments. SpinTor 2SC killed all of the thrips in laboratory arenas within 4 hours of application and showed low toxicity toward O. insidiosus. All of the compounds tested performed as well as the conventional pesticide malathion.

关键词： Blueberries Flower Thrips Frankliniella Insecticides Orius insidiosus

Spectrally resolved Hong-Ou-Mandel interferometry for quantum-optical coherence tomography

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Photonics Research 2020年第6期8卷 1023-1034页

作者： PABLO YEPIZ-GRACIANO ALI MICHEL ANGULO MARTINEZ DORILIAN LOPEZ-MAGO hector CRUZ-RAMIREZ ALFRED B.U'REN Instituto de Ciencias Nucleares Universidad Naciona/Autonoma de MexicoApdo.Postal 70-543Ciudad de Mexico 04510Mexico Tecnologico de Monterrey Escuela de Ingenieria y CienciasAve.Eugenio Garza Sada 2501MonterreyN.L.64849Mexico

In this paper,we revisit the well-known Hong_Ou-Mandel(HOM)effect in which two photons,which meet at a beamsplitter,can interfere destructively,leading to null in coincidence *** a standard HOM measurement,the coincidence counts across the two output ports of the beamsplitter are monitored as the temporal delay be-tween the two photons prior to the beamsplitter is varied,resulting in the well-known HOM *** show,both theoretically and experimentally,that by leaving the delay fixed at a particular value while relying on spectrally resolved coincidence photon counting,we can reconstruct the HOM dip,which would have been obtained through a standard delay-scanning,non-spectrally resolved HOM *** show that our numerical reconstruction procedure exhibits a novel dispersion cancellation effect,to all *** discuss how our present work can lead to a drastic reduction in the time required to acquire a HOM interferogram,and specifically discuss how this could be of particular importance for the implementation of fficient quantum optical coherence tomog-raphy devices.

关键词： resolved coincidence quantum