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Current protective strategies in liver surgery

World Journal of Gastroenterology 2010年第48期16卷 6098-6103页

作者： Kurinchi S Gurusamy hector D Gonzalez Brian r Davidson HPB and Liver Transplantation Royal Free CampusUniversity College London Medical SchoolRoyal Free Hospital

During liver resection surgery for cancer or liver transplantation,the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow),which results in liver injury [ischemiareperfusion (Ir) or Ir injury]. Modulation of Ir injury can be achieved in various ways. These include hypothermia,ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response),ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion),pharmacological agents to decrease Ir injury,genetic modulation of Ir injury,and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces Ir injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC,ischaemic postconditioning,various pharma-cological agents,gene therapy,and machine perfusion decrease Ir injury,none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning,gene therapy,and machine perfusion. randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection.

关键词： Liver Hepatectomy Liver transplantation Ischemia-reperfusion injury Hypothermia Ischaemic preconditioning

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The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines

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Asian Journal of Andrology 2018年第3期20卷 294-299页

作者： Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon hector r contrera. Department of Basic and Clinical Oncology Faculty of Medicine University of Chile Independencia Santiago 8380453 Chile.

It has been reported that one of the factors that promotes tumoral progression is the abnormal activation of the epithelial-mesenchymal transition program. This process is associated with tumoral cells acquiring invasive and malignant properties and has the transcription factor zinc finger E-box-binding homeobox 1 （ZEB1） as one of its main activators. However, the role of ZEB1 in promoting malignancy in prostate cancer （PC, a） is still unclear. Here, we report that ZEB1 expression correlates with Gleason score in PCa samples and that expression of ZEB1 regulates epithelial-mesenchymal transition and malignant characteristics in PCa cell lines. The results showed that ZEB1 expression is higher in samples of higher malignancy and that overexpression of ZEB1 was able to induce epithelial-mesenchymal transition by upregulating the mesenchymal marker Vimentin and downregulating the epithelial marker E-Cadherin. On the contrary, ZEB 1 silencing repressed Vimentin expression and upregulated E-Cadherin. ZEB1 expression conferred enhanced motility and invasiveness and a higher colony formation capacity to 22rvl cells whereas DU145 cells with ZEB1 silencing showed a decrease in those same properties. The results showed that ZEB1 could be a key promoter of tumoral progression toward advanced stages of PC, a.

关键词： epithelial-mesenchymal transition prostate cancer transcriptional repression ZEB1

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The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines

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Asian Journal of Andrology 2019年第5期21卷 460-467页

作者： Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon hector r contrera. Department of Basic and Clinical Oncology Faculty of MedicineUniversity of ChileIndependenciaSantiago 8380453Chile

One of the factors promoting tumoral progress is the abnormal activation of the epithelial-mesenchymal transition(EMT)program which has been associated with chemoresistance in tumoral *** transcription factor zinc finger E-box-binding homeobox 1(ZEB1),a key EMT activator,has recently been related to docetaxel resistance,the main chemotherapeutic used in advanced prostate cancer *** mechanisms involved in this protective effect are still *** a previous work,we demonstrated that ZEB1 expression induced an EMT-like phenotype in prostate cancer cell *** this work,we used prostate cancer cell lines 22rvl and DU145 to study the effect of ZEB1 modulation on docetaxel resistance and its possible *** results showed that ZEB1 overexpression conferred to 22rvl cell resistance to docetaxel while its silencing made DU145 cells more sensitive to *** of resistance markers showed no presenee of ATP-binding cassette subfamily B member 1(MDr1)and no changes in breast cancer resistance protein(BCrP)or ATP-binding cassette subfamily C member 10(MrP7).However,a correlation between ZEB1,multidrug resistance-associated protein 1(MrP1),and ATP-binding cassette subfamily C member 4(MrP4)expression was ***4 inhibition,using MK571,resensitized cells with ZEB1 overexpression to docetaxel *** addition,modulation of ZEB1 and subsequent change in MrP4 expression correlated with a lower apoptotic response to docetaxel,characterized by lower B-cell lymphoma 2(Bcl2),high BCL2-associated X protein(Bax),and high active caspase 3 *** response to docetaxel in our model seems to be mediated mainly by activation of the apoptotic death *** results showed that modulation of MrP4 could be a mediator of ZEBl-related resistance to docetaxel in prostate cancer,making it a possible marker for chemotherapy response in patients who do not express MDr1.

关键词： chemoresistance prostate cancer ZEB1

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Locomotor recovery after spinal cord injury:intimate dependence between axonal regeneration and re-connection

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Neural regeneration research 2022年第3期17卷 553-554页

作者： hector ramiro Quintá Consejo Nacional de Investigaciones Científicas y Técnicas CONICET Laboratorio de Medicina Experimental“Dr.Jorge E.Toblli” Hospital AlemánBuenos AiresArgentina

Traumatic spinal cord injuries(SCI) are characterized by damage in the integrity of the spinal cord,which results in either temporary or permanent alterations in the locomotor,sensory and/or autonomic functions(Yezierski,2009).The traumatic event leads to impairments in voluntary control of movement below the injury by affecting the connection between the brain and the neurons localized in the spinal cord.

关键词： injuries alterations damage

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Secreted protein acidic and rich in cysteine(SPArC)induces epithelial-mesenchymal transition,enhancing migration and invasion,and is associated with high Gleason score in prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 557-564页

作者： Fernanda Lopez-Moncada Maria Jose Torres Enrique A Castellon hector r contrera. Department of Basic and Clinic Oncology Faculty of Medic泊eUniversity of ChileSantiago 8389100Chile

Secreted protein acidic and rich in cysteine(SPArC)is a matricellular protein highly expressed in bone tissue that acts as achemoattractant factor promoting the arrival of prostate cancer(PCa)cells to the bone ***,the contribution of SPArCduring the early stages of tumor progression remains *** this study,we show that SPArC is highly expressed in PCa tissueswith a higher Gleason *** stable knockdown and overexpression of SPArC in PC3 and LNCaP cells,respectively,here wedem on strate that en doge nous SPArC induces the epithelial-mesenchymal tran sition(EMT),decreasing E-cadheri n and cytokeratin18 and increasing N-cadheri n and vime ***,SPArC in duces the expression of EMT regulatory tran scription factors Snailfamily transcriptional repressor 1(Snail),Snail family transcriptional repressor 2(Slug),and zinc finger E-box binding homeobox 1(Zeb1).In addition,SPArC knockdown in PC3 cells decreases migration and invasion in vitro,without modifying cell *** results indicate that SPArC might facilitate tumor progression by modifying the cellular phenotype in cancer cells.

关键词： epithelial-mesenchymal transition invasion migration prostate cancer secreted protein acidic and rich in cysteine(SPArC)

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Beam design for voice coil motors used for energy harvesting purpose with low frequency vibrations:A finite element analysis

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第3期7卷 1-17页

作者： hector A.Tinoco Department of Mechanics and Production Universidad Autonoma de Manizales(UAM)Grupo de Diseno Mecanico y Desarrollo Industrial Antigua Estaci´on del Ferrocarril Edificio Sacatin C.P.170001 Manizales-Caldas Colombia

In this study,a numerical approach is established to design a beam coupled to a Voice Coil Motor(VCM)with the aim to maximize the displacement in the inductive transducer.A finite element model is developed to simulate a VCM with different beams applying a harmonic *** VCM is extracted from a recycled hard disk drive(HDD)and a parametric modal analysis is performed to identify the material parameters of the HDD and the *** parameters are obtained comparing the real vibration modes and natural frequencies(VCM-beam)with those determined from the finite element model.A numerical-experimental case study is carried out to demonstrate that if a beam is designed for a specific low frequency vibration between 0 and 10 Hz,the displacements are maximized in the *** this purpose,real acceleration measurements taken from three individuals are used to provide the vibration signals in the numerical model.A beam is designed for one of the individuals using the natural frequency values determined from the measured *** show that the displacements are maximized in the model which coincides with the natural frequency of the chosen *** main purpose of this research is to establish a design tool for energy harvesting purposes with VCM based on low frequency vibration sources as for example gait motions.

关键词： Hard disk drive HDD energy harvesting finite element analysis Wiimote voice coil motor VCM modal analysis

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Inference for a truncated positive normal distribution

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Applied Mathematics(A Journal of Chinese Universities) 2018年第2期33卷 163-176页

作者： hector J.Gomez Neveka M.Olmos hector Varela Heleno Bolfarine Departamento de Ciencias Matematicas y Ffsicas Facultad de IngenierlaUniversidad Catolica de TemucoTemucoChile Departamento de Matematicas Facultad de Ciencias BasicasUniversidad de AntofagastaAntofagastaChile Departamento de Estatfstica IMEUniversidade de Sao PauloSao PauloBrazil

The main object of this paper is to study an extension of the half normal distribution defined by adding a positive truncation to it. The new model is more flexible than the half-normal distribution and contains the half normal distribution as a special case. Properties of this distribution, such as moments, hazard function and entropy are studied and parameters estimation is dealt with by using inoinents and inaxiinuin likelihood. A real data application indicates good fit performance of the new model when compared to other competitors in litera- tures.

关键词： half-normal distribution maximum likelihood truncation

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Molecular aspects of mammalian fertilization

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Asian Journal of Andrology 2001年第4期3卷 243-249页

作者： hector Serrano Dolores Garcia-Suarez Dept. Health Sciences Dept. Biology Universidad Autonoma Metropoliana-Iztapalapa Ave. Michoacan and Purisima Mexico City DF 09340 Mexico

Mammalian fertilization is a highly regulated process, much of which are not clearly understood. Here we presentsome information in order to elaborate a working hypothesis for this process, beginning with the sperm modifications inthe epidydimis up to sperm and egg plasmalemma interaction and fusion. We also discuss the still poorly understood ca-pacitation process, the phenomenon of sperm chemo-attraction that brings the capacitated sperm to interact with theoocyte vestments and certain aspects of the acrosome reaction. (Asian J Androl 2001 Dec; 3 : 243 - 249)

关键词： fertilization sperm maturation sperm capacitation sperm-ovum interactions membrane fusion

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The implementation and data analysis of an interferometer for intense short pulse laser experiments

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High Power Laser Science and Engineering 2016年第3期4卷 60-66页

作者： Jaebum Park hector A.Baldis Hui Chen Lawrence Livermore National Laboratory University of California

We present an interferometry setup and the detailed fringe analysis method for intense short pulse(SP) laser *** interferometry scheme was refined through multiple campaigns to investigate the effects of pre-plasmas on energetic electrons at the Jupiter Laser Facility at Lawrence Livermore National Laboratory. The interferometer used a frequency doubled(λ=0.527 μm) 0.5 ps long optical probe beam to measure the pre-plasma density, an invaluable parameter to better understand how varying pre-plasma conditions affect the characteristics of the energetic electrons. The hardware of the diagnostic, data analysis and example data are presented. The diagnostic setup and the analysis procedure can be employed for any other SP laser experiments and interferograms, respectively.

关键词： Mach-Zehnder interferometer optical interferometry picosecond probe plasma density short pulse laser

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radicals and Kothe’s Conjecture for Skew PBW Extensions

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Communications in Mathematics and Statistics 2021年第2期9卷 119-138页

作者： Armando reyes hector Suarez Departamento de Matematicas Universidad Nacional de ColombiaSede BogotaColombia Escuela de Matemáticas y Estadística Universidad Pedagogica y Tecnológica de ColombiaSede TunjaColombia

The aim of this paper is to investigate different radicals(Wedderburn radical,lower nil radical,Levitzky radical,upper nil radical,the set of all nilpotent elements,the sum of all nil left ideals)of the noncommutative rings known as skew Poincare–Birkhoff–Witt *** characterize minimal prime ideals of these rings and prove that the Kothe’s conjecture holds for these ***,we establish the transfer of several ring-theoretical properties(reduced,symmetric,reversible,2-primal)from the coefficients ring of a skew PBW extension to the extension itself.

关键词： Armendariz rings Kothe’s conjecture Skew PBW extensions

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