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Stem cell therapy applied for digestive anastomosis: Current state and future perspectives

World Journal of Stem Cells 2022年第1期14卷 117-141页

作者： Jacobo Trébol Tihomir Georgiev-Hristov Isabel Pascual-Miguelañez hector guadalajara Mariano García-Arranz Damian García-Olmo Servicio de Cirugía General y del Aparato Digestivo Complejo Asistencial Universitario de SalamancaSalamanca 37007Spain Departamento de Anatomía e Histología Humanas Universidad de SalamancaSalamanca 37007Spain Servicio de Cirugía General y del Aparato Digestivo Hospital General Universitario de VillalbaMadrid 28400Spain Servicio de Cirugía General y del Aparato Digestivo Hospital Universitario La PazMadrid 28046Spain Servicio de Cirugía General y del Aparato Digestivo Hospital Universitario Fundación Jiménez DíazMadrid 28040Spain Grupo de Investigación en Nuevas Terapias Instituto de Investigación Sanitaria-Fundación Jiménez DíazMadrid 28040Spain Damian García-Olmo Departamento de CirugíaUniversidad Autónoma de MadridMadrid 28029Spain Servicio de Cirugía General y del Aparato Digestivo Hospital Universitario Fundación Jiménez Díaz y Grupo Quiron-Salud MadridMadrid 28040Spain

BACKGROUND Digestive tract resections are usually followed by an *** leakage,normally due to failed healing,is the most feared complication in digestive surgery because it is associated with high morbidity and *** technical and technological advances and focused research,its rates have remained almost unchanged the last *** the last two decades,stem cells(SCs)have been shown to enhance healing in animal and human studies;hence,SCs have emerged since 2008 as an alternative to improve anastomoses *** To summarise the published knowledge of SC utilisation as a preventative tool for hollow digestive viscera anastomotic or suture *** PubMed,Science Direct,Scopus and Cochrane searches were performed using the key words“anastomosis”,“colorectal/colonic anastomoses”,“anastomotic leak”,“stem cells”,“progenitor cells”,“cellular therapy”and“cell therapy”in order to identify relevant articles published in English and Spanish during the years of 2000 to *** employing SCs,performing digestive anastomoses in hollow viscera or digestive perforation sutures and monitoring healing were finally *** lists from the selected articles were reviewed to identify additional pertinent *** Given the great variability in the study designs,anastomotic models,interventions(SCs,doses and vehicles)and outcome measures,performing a reliable meta-analysis was considered impossible,so we present the studies,their results and *** Eighteen preclinical studies and three review papers were identified;no clinical studies have been published and there are no registered clinical *** studies,mainly in rat and porcine models and occasionally in very adverse conditions such as ischaemia or colitis,have been demonstrated SCs as safe and have shown some encouraging morphological,functional and even clinical *** SCs are mostly employed,and delivery routes are mainly local

关键词： Surgical anastomosis Anastomotic leak Digestive system surgical procedure Cell transplantation Cell therapy Stem cells Tissue engineering

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Recurrent anal fistulae:Limited surgery supported by stem cells

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World Journal of Gastroenterology 2015年第11期21卷 3330-3336页

作者： Damian Garcia-Olmo hector guadalajara Ines Rubio-Perez Maria Dolores Herreros Paloma de-la-Quintana Mariano Garcia-Arranz Hospital Fundación Jimenez Díaz Colorectal Surgery Unit University Hospital Fundación Jiménez Díaz Colorectal Surgery Unit La Paz University Hospital Cell Therapy Laboratory University Hospital Fundación Jiménez Díaz

AIM:To study the results of stem-cell therapy under a Compassionate-use Program for patients with recurrent anal ***:Under controlled circumstances,and approved by European and Spanish laws,a Compassionate-use Program allows the use of stem-cell therapy for patients with very complex anal *** had previously undergone multiple surgical interventions that had failed to resolve the fistulae,and presented symptomatic *** intervention consisted of limited surgery(with closure of the internal opening),followed by local implant of stem cells in the fistula-tract *** expanded adipose-derived stem cells were the main cell type selected for *** first evaluation was performed on the 8th postoperative week;outcome was classified as response or partial *** one year after the intervention confirmed if complete healing of the fistula was ***:Ten patients(8 male)with highly recurrent and complex fistulae were treated(mean age:49years,range:28-76 years).Seven cases were nonCrohn’s fistulae,and three were Crohn’s-associated *** surgical attempts ranged from 3to *** patients presented with preoperative incontinence(Wexner scores of 12 and 13 points).After the intervention,six patients showed clinical response on the 8th postoperative week,with a complete cessation of suppuration from the *** patients presented a partial response,with an evident decrease in suppuration.A year later,six patients(60%)remained healed,with complete reepithelization of the external *** Wexner Scores were 0 in six *** two patients with previous incontinence improved their scores from12 to 8 points and from 13 to 5 *** adverse reactions or complications related to stem-cell therapy were reported during the study ***:Stem cells are safe and useful for treating anal *** can be achieved in severe cases,sparing fecal incontinence risk,and impr

关键词： Adipose-derived stem cells Cell therapy Compassion

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Factors associated with tobacco, alcohol, and other drug use among youth living in West Central Mexico

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World Journal of Psychiatry 2018年第1期8卷 33-42页

作者： Octavio Campollo Payam Sheikhattari Cesar Alvarez Jaime Toro-Guerrero hector Sanchez Avila Fernando A Wagner Center of Studies on Alcohol and Addictions Antiguo Hospital Civil de Guadalajara Department of Medical ClinicsUniversidad de Guadalajara Prevention Sciences Research Center and School of Community Health and Policy Morgan State University Charité-Universit?tsmedizin Berlin NeuroCure Clinical Research Center School of Social Work University of Maryland

AIM To determine the prevalence of drug and substance abuse among high school students in Jalisco and its association with the severity of health, behavior and psychosocial problems in order to provide evidence for possible prevention and treatment needs. METHODS A multi-stage random sample of Jalisco high school students was given a paper-and-pencil survey based upon an adapted version of the drug use screening inventory(DUSI)(n = 24699; n = 2832). The DUSI showed adequate psychometric characteristics in this population. The statistical analyses accommodated the complex survey design with attention to unequal probability of selection and clustering of participants within schools and regions. RESULTS An estimated 44% of the students had smoked tobacco, one in five students was a current smoker, and one in four students used to smoke but had not smoked for one year or more. By contrast, 6.8% of the students reported having used marijuana, cocaine, or both. Behavioral problems, deviant peer affiliation, and troubled families were independently associated with drug use. One in two students who used tobacco or alcohol had used these drugs in the past year(46% and 54%, respectively), and one in four students who used marijuana or cocaine in their lifetime had used those drugs in the past year(28% in both cases). CONCLUSION The rates of cocaine use as well as the proportion of current users were higher than expected among high school students and indicate changing patterns of drug use in Mexico. These results corroborate that the general trend of drug use by youth in Mexico is increasing. Results from this study help us better understand the needs of at-risk youth and the need for new treatment and prevention strategies.

关键词： Tobacco Alcohol Marijuana Illegal drugs Mexico Students Epidemiology

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Histological Analysis and Morphometric Changes after Autologous Fat Grafting in Large Volumes on Pigs

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第4期11卷 371-380页

作者： hector Giancarlo Torres-Nuño Walter Angel Trujillo-Rangel Jorge Barrera-Alcocer Miriam Méndez del Villar Diana Mercedes Hernández-Corona Sylvia Elena Totsuka-Sutto Leonel García Benavides Institute of Therapeutics and Clinical Experimentation Department of Physiology Health Sciences University Center (CUCS) University of Guadalajara (UDG) Guadalajara Mexico Obesity and Diabetes Research Laboratory Faculty of Chemistry and Biological Sciences Autonomous University of Guerrero (UAGro) Chilpancingo Mexico Multidisciplinary Health Research Center Biomedical Sciences Department Tonala University Center (CUT) University of Guadalajara (UDG) Guadalajara Mexico

Nowadays, fat transfer is an accepted technique that has been popularized in clinical practice, during which large volumes of fat are strategically relocated to increase and improve the contour of the body. In the present study, we investigated the histological and morphometric changes after large volumes of fat were grafted within the subcutaneous cellular tissue. An experimental study was designed using four 3-month-old male pigs. One hundred cc of decanted fat tissue was transferred into the right leg. Volume augmentation achieved by auto lipo-injecting within the subcutaneous cellular tissue persisted up to two months. Although there is a reduction in cell number and size, an increased amount of extracellular matrix and the presence of oily cysts and microcalcifications were observed. Conclusion: The volume augmentation, which is achieved by autologous fat transfer in large quantities in subcutaneous cellular tissue, can remain for months.

关键词： Autologous Fat Transfer Adipose Tissue Transplant Autologous Fat Injection Gluteal Augmentation

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Temperature Inversions,Meteorological Variables and Air Pollutants and Their Influence on Acute Respiratory Disease in the guadalajara Metropolitan Zone,Jalisco,Mexico

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Journal of Environmental Protection 2013年第8期4卷 142-153页

作者： Hermes U.Ramirez-Sanchez Mario E.García-Guadalupe hector H.Ulloa-Godinez Angel R.Meulenert-Pena Omar Garcia-Concepcion Jaime Alcala Gutierrez Sarahi J.Lizarraga Brito Department of Physics Institute of Astronomy and MeteorologyUniversity Center of Exact Sciences and Engineering(CUCEI)University of GuadalajaraGuadalajaraMexico

The presence of temperature inversions (TI), concentration of air pollutants (AP) and meteorological variables (MV) affect the welfare of the population, creating public health problems (acute respiratory diseases ARDs, among others). The guadalajara Metropolitan Zone (GMZ) experiences high levels of air pollution, which associated with the presence of temperature inversions and meteorological variations is conducive to the incidence of ARDs in children. The aim of this work is to evaluate the TI, MV, AP and their influence on the ARDs in children under five years in the GMZ from 2003 to 2007. In this period, the moderate and strong TI are the most frequent presenting from November to May. The AP shows a variable behavior during the year and between years, with the highest concentration of particles less than 10 microns (PM10), followed by ozone (O3), nitrogen dioxide (NO2), nitrogen oxides (NOX), carbon monoxide (CO) and sulfur dioxide (SO2), the most affected areas are the southeast of the GMZ. Annual arithmetic mean is 213,510 ± 41,209 ARDs consultations. The most important diseases are acute respiratory infections (98.0%), followed by pneumonia and bronchopneumonia (1.1%), asthma and status asthmaticus (0.5%) and streptococcal pharyngitis and tonsillitis (0.4%). Months with most inquiries were from October to March, mainly in the southeast, south and center of the city, coinciding with high levels of AP. Statistical analysis shows that the TI have significant correlation with ARDs in three years, temperature (Temp) in two, relative humidity (RH) in two, wind speed (WS) in three, wind direction (WD) in two, while that air pollutants NOX and NO2 showed significant correlation with ARDs throughout the period. CO and SO2 showed significance in two years, while the PM10 and O3 in one.

关键词： Temperature Inversions Meteorological Variables Air Pollutants Acute Respiratory Diseases

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