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Lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEN-hamartoma-tumor syndrome

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Genes & Diseases 2024年第2期11卷 524-527页

作者： Noemi Gonzalez-Abuin Tirso Pons Teresa Fuster Isabel Quintana Mariona Terradas Gemma Aiza Joan Brunet Gabriel Capellá heather Hampel Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an E3 ubiquitin ligase that antagonizes PTEN tumor suppressive function,have been proposed as an alternative mechanism of PTEN inactivation in PTEN-hamartoma-tumor syndrome(PHTs)-like patients with wildtype PTEN.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by Lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).subsequently,based on the PHTs phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(AsD),3 where germline WWP1 variants were also identified(Table s1).

关键词： WWP1 gastrointestinal polyposis

The new kid on the block in insect pest management:sprayable RNAi goes commercial

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science China(Life sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen stuart Reitz Andrei Alyokhin Jiang Zhang David Mota-sanchez Yonggyun Kim subba Reddy Palli silvia I.Rondon Brian A.Nault Juan Luis Jurat-Fuentes Michael s.Crossley William E.snyder Angharad M.R.Gatehouse Myron P.Zalucki Bruce E.Tabashnik Yulin Gao state Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Department of Crop and soil science Oregon State UniversityOntario 97914USA school of Biology and Ecology University of MaineOrono 04469USA shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Department of Entomology Michigan State UniversityEast Lansing 48864USA Department of Plant Medicals Andong National UniversityAndong 36729Republic of Korea Department of Entomology University of KentuckyLexington 40503USA Oregon state University Oregon Integrated Pest Management CenterCorvallis 97838USA Department of Entomology Cornell UniversityCornell AgriTechGeneva 14456USA Department of Entomology and Plant Pathology University of TennesseeKnoxville 37996USA Department of Entomology and Wildlife Ecology University of DelawareNewark 19716USA Department of Entomology University of GeorgiaAthensGeorgia 30602USA school of Natural and Environmental sciences Newcastle UniversityNewcastle upon TyneNE17RUUK school of the Environment University of QueenslandBrisbane 4072Australia shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Department of Entomology University of ArizonaTucson 85721USA National Center of Excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crops damage pest

Tree structure and diversity shape the biomass of primary temperate mountain forests

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Forest Ecosystems 2024年第4期11卷 568-579页

作者： Dheeraj Ralhan Ruffy Rodrigo heather Keith Annemiek Irene stegehuis Jakob Pavlin Yumei Jiang Milos Rydval Juliana Nogueira Alexandre Fruleux Marek svitok Martin Mikolas Daniel Kozak Martin Dusatko Pavel Janda Oleh Chaskovsky Catalin-Constantin Roibu Miroslav svoboda Czech University of Life sciences Prague Faculty of Forestry and Wood SciencesKamycka 129Suchdol16521 Praha 6Czech Republic Department of Forest science Biliran Province State UniversityBiliran6549Philippines Griffith Climate Action Beacon Griffith UniversityParklands DriveSouthportGold CoastQueensland4222Australia Laboratoire de Geologie IPSLCNRSUMR 8538Ecole Normale SuperieurePSL UniversityParisFrance Univ.Lille Institut Mines-TelecomUniv.ArtoisJuniaULR 4515LGCgELaboratoire de Genie Civil et Geo-EnvironnementF-59000LilleFrance Department of Biology and General Ecology Faculty of Ecology and Environmental SciencesTechnical University in ZvolenMasaryka 2496001ZvolenSlovakia Institute of Forest Management Ukrainian National Forestry UniversityLvivUkraine Forest Biometrics Laboratory–Faculty of Forestry Stefan Cel Mare University of SuceavaUniversitații Street Number.13Suceava720229Romania

Primary forests are spatially diverse terrestrial ecosystems with unique characteristics,being naturally regenerative and heterogeneous,which supports the stability of their carbon storage through the accumulation of live and dead ***,little is known about the interactions between biomass stocks,tree genus diversity and structure across a temperate montane primary ***,we investigated the relationship between tree structure(variability in basal area and tree size),genus-level diversity(abundance,tree diversity)and biomass stocks in temperate primary mountain forests across Central and Eastern *** used inventory data from726 permanent sample plots from mixed beech and spruce across the Carpathian *** used nonlinear regression to analyse the spatial variability in forest biomass,structure,and genus-level diversity and how they interact with plot-level tree age,disturbances,temperature and *** found that the combined effects of genus and structural indices were important for addressing the variability in biomass across different spatial *** processes in disturbance regimes and uneven tree age support forest hete rogeneity and the accumulation of live and dead biomass through the natural regeneration,growth and decay of the forest *** complexities in basal area index,supporte d by genus-level abundance,positively influence total biomass stocks,which was modulated by tree age and *** forests showed higher tree density and basal area than mixed beech forests,though mixed beech still contributes significantly to biomass across *** heterogeneity was strongly influenced by complexities in forest composition(tree genus diversity,structure).We addressed the importance of primary forests as stable carbon stores,achieved through structure and *** such ecosystems is critical for ensuring the stability of the primary forest,carbon store and biodiversity into the future.

关键词： Biodiversity indicators Biomass carbon stock Ecosystem functioning Forest composition Primary forest structure Tree size distribution

睾酮治疗性腺功能减退症男性患者对骨折风险影响的临床研究

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中国临床药理学杂志 2024年第5期40卷 731-731页

作者： snyder P J BAUER D C ELLENBERG s s 孟海峰

男性性腺功能减退症患者的睾酮治疗可以改善骨密度和骨质量,但需要足够大的样本和足够长的持续时间来确定睾酮对骨折发生率的影响。

关键词：骨折发生率性腺功能减退症骨质量骨折风险睾酮治疗骨密度持续时间男性患者

No country is an island in regulating food safety:How the WTO monitors Chinese food safety laws through the Trade Policy Review Mechanism(TPRM)

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Journal of Integrative Agriculture 2015年第11期14卷 2142-2156页

作者： Francis.snyder Northwest A&F University school of Transnational Law Peking University Shenzhen Graduate School College of Europe

Established within the framework of the World Trade Organization （WTO）, the Trade Policy Review Mechanism （TPRM） reviews periodically the trade policies of all WTO Members. The review includes many aspects of food safety regulation. China＇s trade policy is reviewed every two years. This paper analyses in detail the reviews of China＇s trade policy in 2006, 2008, 2010, 2012 and 2014. It focuses in particular on food safety laws and types of standards, alignment of domestic standards with international standards, the role of different domestic institutions, transparency and notification of food safety measures under the WTO agreements on sanitary and Phytosanitary Measures （sPs） and on Technical Barriers to Trade （TBTAgreement）, import and export, and geographical indications （GIs）. It concludes that the WTO TPRM can contribute, within its mandate, to reform of Chinese food safety laws and improvement of food safety in China. it notes that China has already undertaken substantial reforms of its system for regulating food safety. It recommends that China should continue to participate actively in the TPRM, follow its own path with regard to alignment and learn selectively from other WTO Members.

关键词： food safety food standards public health consumer welfare China Chinese food safety laws World Trade Organization WTO law Trade Policy Review Mechanism (TPRM) sPs Agreement TBT Agreement

MicroRNA-based therapeutics for optic neuropathy:opportunities and challenges

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Neural Regeneration Research 2021年第10期16卷 1996-1997页

作者： heather K.Mak Christopher K.s.Leung Department of Ophthalmology and Visual sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Optic nerve degeneration is a major cause of irreversible blindness worldwide with glaucoma being the most common optic neuropathy,affecting approximately 76 million people worldwide in *** optic nerve comprises axons of retinal ganglion cells(RGCs),the output neurons of the inner *** RGCs and axons from degeneration and regenerating RGC axons to preserve and recover vision in patients with progressive optic neuropathy is an unmet *** embryonic neurons,mature neurons of the mammalian central nervous system fail to regenerate their axons following *** age-related loss of axon regenerative capacity of RGCs over time renders vision loss from optic neuropathy *** failure of injured RGCs to regenerate axons is largely attributed to inhibitory molecules in the extrinsic environment and a change in the intrinsic molecular makeup of aging *** studies have demonstrated that RGCs require specific molecular signals for the stimulation of axon growth even without inhibitory molecules in the extrinsic environment,leading successive efforts to focus on uncovering the intrinsic signaling pathways that control axon extension during RGC development.

关键词： neuropathy degeneration stimulation

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巴勒收藏博物馆英国格拉斯哥

世界建筑导报 2024年第4期39卷 75-79页

作者： Chris Ravenscroft heather Macey Katherine Watts Tom Roberts Paddy Pugh Hannah Lawson 约翰•麦卡兰建筑事务所

巴勒珍藏馆是欧洲最好的博物馆之一,也是为数不多的A类苏格兰战后建筑之一。珍藏馆拥有约9000件精美和装饰性的艺术作品,极其丰富的藏品来自的年代横跨6 000年。1983年,巴勒珍藏馆被置于由三位年轻剑桥建筑师学者巴里·加松、布力特·... 详细信息

巴勒珍藏馆是欧洲最好的博物馆之一,也是为数不多的A类苏格兰战后建筑之一。珍藏馆拥有约9000件精美和装饰性的艺术作品,极其丰富的藏品来自的年代横跨6 000年。1983年,巴勒珍藏馆被置于由三位年轻剑桥建筑师学者巴里·加松、布力特·安德烈森和约翰·梅乌涅尔设计的、广受好评的博物馆建筑中。这座20世纪开创性的建筑由红色邓弗里斯郡砂岩、抛光混凝土、不锈钢、木材和玻璃建成,位于距格拉斯哥市中心4英里的波洛克郊野公园的环境中。2016年,代表格拉斯哥市议会提供文化、体育和学习活动的慈善机构格拉斯哥慈善组织指定约翰·麦卡兰建筑事务所为建筑师和景观设计师,负责博物馆的五年翻新和提升项目。

关键词：建筑事务所博物馆建筑郊野公园格拉斯哥安德烈波洛克慈善机构市议会

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Analysis of gateroad stability at two longwall mines based on field monitoring results and numerical model analysis

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International Journal of Mining science and Technology 2019年第1期29卷 35-43页

作者： Gabriel s.Esterhuizen David F.Gearhart Ted Klemetti heather Dougherty Mark van Dyke National Institute for Occupational safety and Health

Coal mine longwall gateroads are subject to changing loading conditions induced by the advancing longwall face. The ground response and support requirements are closely related to the magnitude and orientation of the stress changes, as well as the local geology. This paper presents the monitoring results of gateroad response and support performance at two longwall mines at a 180-m and 600-m depth of *** the first mine, a three-entry gateroad layout was used. The second mine used a four-entry, yieldabutment-yield gateroad pillar system. Local ground deformation and support response were monitored at both sites. The monitoring period started during the development stage and continued during first panel retreat and up to second panel retreat. The two data sets were used to compare the response of the entries in two very different geotechnical settings and different gateroad layouts. The monitoring results were used to validate numerical models that simulate the loading conditions and entry response for these widely differing conditions. The validated models were used to compare the load path and ground response at the two mines. This paper demonstrates the potential for numerical models to assist mine engineers in optimizing longwall layouts and gateroad support systems.

关键词： Coal mining Longwall Gateroad support Numerical models

surveillance for gastrointestinal malignancies

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World Journal of Gastroenterology 2012年第33期18卷 4507-4516页

作者： Ashish K Tiwari heather s Laird-Fick Ramesh K Wali Hemant K Roy Department of Internal Medicine Michigan State University East Lansing MI 48824 United States Department of Internal Medicine North Shore University Health System Evanston IL 60021 United States

Gastrointestinal (GI) malignancies are notorious for frequently progressing to advanced stages even in the absence of serious symptoms, thus leading to delayed diagnoses and dismal prognoses. secondary prevention of GI malignancies through early detection and treatment of cancer-precursor/premalignant lesions, therefore, is recognized as an effective cancer prevention strategy. In order to efficiently detect these lesions, systemic application of screening tests (surveillance) is needed. However, most of the currently used non-invasive screening tests for GI malignancies (for example, serum markers such as alpha-fetoprotein for hepatocellular carcinoma, and fecal occult blood test, for colon cancer) are only modestly effective necessitating the use of highly invasive endoscopy-based procedures, such as esophagogastroduodenoscopy and colonoscopy for screening purposes. Even for hepatocellular carcinoma where non-invasive imaging (ultrasonography) has become a standard screening tool, the need for repeated liver biopsies of suspicious liver nodules for histopathological confirmation can't be avoided. The invasive nature and high-cost associated with these screening tools hinders implementation of GI cancer screening programs. Moreover, only a small fraction of general population is truly predisposed to developing GI malignancies, and indeed needs surveillance. To spare the average-risk individuals from superfluous invasive procedures and achieve an economically viable model of cancer prevention, it's important to identify cohorts in general population that are at substantially high risk of developing GI malignancies (riskstratification), and select suitable screening tests for surveillance in these cohorts. We herein provide a brief overview of such high-risk cohorts for different GI malignancies, and the screening strategies that have commonly been employed for surveillance purpose in them.

关键词： Gastrointestinal malignancies surveillance screening Biomarkers Cancer prevention