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Cutaneous Manifestations of Sickle Cell Disease

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Open Journal of Blood Diseases 2013年第3期3卷 94-99页

作者： heather jones Morey Blinder Milan Anadkat Division of Dermatology Washington University in St. Louis St. Louis USA. Division of Hematology Washington University in St. Louis St. Louis USA Division of Internal Medicine Washington University in St. Louis St. Louis USA

Sickle cell disease is an inherited erythrocyte disorder affecting multiple organ systems. As individuals are living well into middle age due to advances in diagnosis and treatment, further disease-related complications are being recognized. This article reviews the cutaneous manifestations of sickle cell disease including leg ulcers and acquired pseudoxanthoma elasticum.

关键词： Sickle Cell Disease Leg Ulcers Pseudoxanthoma Elasticum Nitric Oxide Deficiency Hydroxyurea

A functional type I interferon pathway drives resistance to cornea herpes simplex virus type 1 infection by recruitment of leukocytes

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The Journal of Biomedical Research 2011年第2期25卷 111-119页

作者： Christopher D. Conrady heather jones Min Zheng Daniel J.J. Carr Departments of Microbiology Immunology The University of Oklahoma Health Science Center Oklahoma City OK 73104 USA Departments of Ophthalmology The University of Oklahoma Health Science Center Oklahoma City OK 73104 USA

Type I interferons are critical antiviral cytokines produced following herpes simplex virus type-1 （HSV-1） infection that act to inhibit viral spread. In the present study, we identify HSV-infected and adjacent uninfected corneal epithelial cells as the source of interferon-a. We also report mice deficient in the A1 chain of the type I IFN receptor （CDl18-/） are extremely sensitive to ocular infection with low doses （100 PFU） of HSV-1 as seen by significantly elevated viral titers in the cornea Compared to wild type （WT） controls. The enhanced susceptibil- ity correlated with a loss of CD4＋ and CD8＋ T cell recruitment and aberrant chemokine production in the cornea despite mounting an adaptive immune response in the draining mandibular lymph node of CDll8/ mice. Taken together, these results highlight the importance of IFN production in both the innate immune response as well as eliciting chemokine production required to facilitate adaptive immune cell trafficking.

关键词： herpes simplex virus type 1 type I interferon comea viral infection leukocytes ocular immunology

Use of platelet lysate for bone regeneration-are we ready for clinical translation?

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World Journal of Stem Cells 2016年第2期8卷 47-55页

作者： Ala Altaie heather Owston Elena jones Leeds Institute of Rheumatic and Musculoskeletal Medicine University of LeedsSt.James's University Hospital

Current techniques to improve bone regeneration following trauma or tumour resection involve the use of autograft bone or its substitutes supplemented with osteoinductive growth factors and/or osteogenic cells such as mesenchymal stem cells(MSCs).Although MSCs are most commonly grown in media containing fetal calf serum,human platelet lysate(PL) offers an effective *** marrow- derived MSCs grown in PLcontaining media display faster proliferation whilst maintaining good osteogenic differentiation *** pre-clinical investigations using PL-expanded MSCs seeded onto osteoconductive scaffolds indicate good potential of such constructs to repair bone in *** an alternative approach,nude PL-coated scaffolds without seeded MSCs have been proposed as novel regenerative medicine *** though methods to coat scaffolds with PL vary,in vitro studies suggest that PL allows for MSC adhesion,migration and differentiation inside these *** new bone formation and vascularisation in comparison to uncoated scaffolds have also been observed in *** review outlines the state-of-the-art research in the field of PL for ex vivo MSC expansion and in vivo bone *** minimise inconsistency between the studies,further work is required towards standardisation of PL preparation in terms of the starting material,platelet concentration,leukocyte depletion,and the method of platelet *** quality control procedures and its "potency" assessment are urgently needed,which could include measurements of key growth and attachment factors important for MSC maintenance and ***,different PL formulations could be tailor-made for specific bone repair *** measures would undoubtedly speed up clinical translation of PL-based treatments for bone regeneration.

关键词： Mesenchymal stem cells Platelet lysate Bone regeneration

Bile acid signaling and biliary functions

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Acta Pharmaceutica Sinica B 2015年第2期5卷 123-128页

作者： Hannah jones Gianfranco Alpini heather Francis Baylor Scott & White Digestive Disease Research Center Division Research Central Texas Veterans Health Care System Department of Medicine Texas A&M University

This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor(TGR5), farnesoid X receptor(FXR), ursodeoxycholic acid(UDCA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids,we will expand the review and include sections that are most recently known(within 5–7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.

关键词： Bile acids Cholangiocytes Receptors Signaling

超重和肥胖的诊断、评估及管理：NICE指南更新概要

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英国医学杂志中文版 2015年第9期18卷 531-535页

作者： heather Stegenga Alexander Haines Katie jones John Wilding 蔡晓凌 National Collaborating Centrefor Mental Health Royal College of PsychiatristsLondon UK National Clinical Guideline Centre Royal College of Physicians of LondonLondon NWI 4LEUK University of Liverpool and University Hospital Aintree LiverpoolUK 北京大学人民医院内分泌科

超重和肥胖带来严重的健康及社会问题。在英国，肥胖的患病率从1980年的男性6％和女性8％增至2012年的男性24％和女性25％。重度肥胖[体质指数（BMI）〉40]在1980年非常少见，而目前已有2．4％的患病率。2012年，年龄在2～15岁的儿童中... 详细信息

超重和肥胖带来严重的健康及社会问题。在英国，肥胖的患病率从1980年的男性6％和女性8％增至2012年的男性24％和女性25％。重度肥胖[体质指数（BMI）〉40]在1980年非常少见，而目前已有2．4％的患病率。2012年，年龄在2～15岁的儿童中，每10名就有大约3名为超重或肥胖儿童。肥胖相关疾病包括2型糖尿病、高血压、阻塞性呼吸睡眠暂停综合征及胃食管反流性疾病。

关键词：识别肥胖超重指南管理评估