检索结果-南通市图书馆

Prognostic Value of Lymphocyte Vascular density and E-Cadherin in Inflammatory Breast Cancer

Journal of Cancer Therapy 2014年第14期5卷 1380-1387页

作者： Paul H. Levine heather J. Hoffman Audra MacNeil Salman Hashmi Sherry X. Yang Stephen Hewitt Kenneth L. van Golen Sandra M. Swain department of Epidemiology and Biostatistics Milken Institute School of Public Health The George Washington University Washington DC USA National Clinical Target Validation Laboratory Division of Cancer Treatment & Diagnosis National Cancer Institute Bethesda USA Laboratory of Pathology Center for Cancer Research National Cancer Institute Bethesda USA department of Biological Sciences Center for Translational Cancer Research The University of Delaware Newark USA Washington Cancer Institute MedStar Washington Hospital Center Washington DC USA

Background: We recently evaluated four laboratory assays, vascular endothelial growth factor d (VEGF-d), E-cadherin, lymphatic vessel density (LVd) measured by podoplanin, and intra-lymphatic tumor emboli (ILTE), which showed notable differences between inflammatory breast cancer (IBC) and non-inflammatory locally advanced breast cancer (LABC). In this study we investigated the potential of the three most quantitatively measured markers, E-cadherin, LVd and VEGF-d, to predict survival in the IBC patients. Materials and Methods: This study involved the 100 cases identified in the Inflammatory Breast Cancer Registry (IBCR) whose tumors were previously evaluated for the four assays noted above. Living patients were recontacted and survival data were available for up to 17 years. Overall survival (OS) was analyzed through the Kaplan-Meier method stratified by E-cadherin, LVd, VEGF-d, and response to chemotherapy. The differences in OS curves were compared using the log-rank test. Results: The median OS for patients with high LVd was 6.63 years (95% CI: 4.06 to 10.14), compared to median at 10 years not reached in those with low LVd (p = 0.03). There was a trend towards a longer median OS in patients with high E-cadherin (10.14, 95% CI: 6.63 to 11.67), compared with those with low E-cadherin (6.26, 95% CI: 3.42 to undeterminable). VEGF-d levels showed no correlation with survival. Conclusion: Low LVd significantly predicts better survival. High E-cadherin expression, as with non-IBC breast cancer and several other malignancies, tends to be associated with a better prognosis.

关键词： IBC Prognostic Markers E-Cadherin Lymphocyte Vascular density

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Milk Replacer Acidification for Free-Access Feeding: Effects on the Performance and Health of Veal Calves

引用

Open Journal of Animal Sciences 2016年第3期6卷 234-246页

作者： Cynthia G. Todd Ken E. Leslie Suzanne T. Millman Jan M. Sargeant heather Migdal Kathleen Shore Neil G. Anderson Trevor J. deVries department of Population Medicine Ontario Veterinary College University of Guelph Guelph ON Canada department of Veterinary diagnostic & Production Animal Medicine Iowa State University Ames IA USA Centre for Public Health and Zoonoses University of Guelph Guelph ON Canada department of Animal Biosciences University of Guelph Guelph ON Canada Grober Nutrition Cambridge ON Canada Ontario Ministry of Agriculture Food and Rural Affairs Veterinary Science and Policy Unit Elora ON Canada

Objectives of this study were to investigate the effects of milk replacer (MR) acidification for free- access feeding on pre- and post-weaning performance, morbidity and mortality of calves. Calves were randomly assigned to free-access feeding of acidified (ACId, n = 31) or non-acidified (NON, n = 31) MR, and weaned at 42 days. ACIdMR was prepared to pH 4.0 - 4.5 using formic acid. Intakes were measured daily and weights weekly. Samples of ACId and NON MR were analyzed for coliform and aerobic bacterial growth. After weaning, calves transitioned to a grain-fed veal diet, weighed every 2 weeks. At slaughter (approximately 6 months of age), lungs were evaluated for gross pathological changes and dressed carcass weights were obtained. Generalized linear mixed models were constructed to examine the effects of MR acidification. differences by treatment group for pre- and post-weaning morbidity and mortality were tested using Pearson’s χ2 and Fisher’s exact tests. ACId calves consumed less MR than NON (10.6 vs. 11.7 L/d, P = 0.02). Acidification tended to promote earlier onset of starter ration consumption (32.0 vs. 39.5 d, hazard ratio = 1.5, P = 0.07), but did not affect average daily starter ration or water intakes across the pre-weaning period. ACId and NON calves did not differ for BW at weaning, pre- or post-weaning AdG or dressed carcass weight. ACId MR had less coliform (P d aerobic bacterial growth (P dds of disease treatment and mortality did not differ. ACId calves tended to have lower odds of pulmonary lesions during post-mortem inspection than NON calves (OR = 0.3, P = 0.07). These results indicate that under free-access feeding conditions, acidification limited bacterial growth and MR intake, but there were no long-term impacts of acidification on calf performance or health. In conclusion, acidification to pH 4.0 - 4.5 will significantly reduce bacterial growth in milk fed to calves.

关键词： Acidified Milk Feeding Free-Access Milk Feeding Health Growth Veal Calves

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Postoperative mometasone irrigations improve quality of life in skull base tumor patients

引用

World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第4期9卷 314-319页

作者： Mandy K.Salmon Rijul S.Kshirsagar Jacob G.Eide Auddie M.Sweis Kathleen davin Aman Prasad heather Ungerer Elizabeth Stevens Kevin Ig‐Izevbekhai Siddhant Tripathi Tran B.Locke Theodore Lin Brian M.Sweis Michael A.Kohanski Nithin d.Adappa James N.Palmer department of Otorhinolaryngology—Headand Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA division of Otolaryngology—Head and Neck Surgery North Shore University Health SystemThe University of ChicagoEvanstonIllinoisUSA University of Cincinnati School of Medicine CincinnatiOhioUSA department of Otolaryngology Baylor College of MedicineHoustonTexasUSA Lewis Katz School of Medicine Temple UniversityPhiladelphiaPennsylvaniaUSA department of Neuroscience University ofMinnesotaMinneapolisMinnesotaUSA

Objectives:The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well *** quantified long‐term impact of postoperative steroid irrigations (SIs) on quality of life of patients after ***:Retrospective review of patients at the University of Pennsylvania undergoing ESBS from 2010 to *** on patient demographics and postoperative treatment with nasal saline irrigation twice daily with and without dissolved steroids (mometasone or budesonide) was ***,and 1‐,3‐,6‐,12‐,18‐,and 24‐month postoperative Sino‐Nasal Outcome Test (SNOT‐22) scores were ***:A total of 727 patients were assessed (53.4% males),with 479 patients in the no SI group and 248 patients in the SI *** SNOT‐22 scores did not differ significantly (P = 0.19).1‐,3‐,6‐,12‐,18‐,and 24‐month post‐op SNOT‐22 scores did not significantly differ between ***,mometasone irrigations resulted in significantly lower postoperative 2‐year SNOT‐22 scores compared to budesonide (P d saline (P = 0.03).Conclusions:Though corticosteroid irrigations are routine in managing inflammatory sinus disease,their role in postoperative management after ESBS for tumors is *** findings suggest that mometasone irrigation may be effective at improving postoperative quality of life in patients after ESBS.

关键词： postoperative steroid irrigations skull base tumors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In vivo analysis of hybrid hydrogels containing dual growth factor combinations,and skeletal stem cells under mechanical stimulation for bone repair

引用

Mechanobiology in Medicine 2024年第4期2卷 97-109页

作者： david Gothard Michael Rotherham Emma L.Smith Janos M.Kanczler James Henstock Julia A.Wells Carol A.Roberts Omar Qutachi heather Peto Hassan Rashidi Luis Rojo Lisa J.White Molly M.Stevens Alicia J.El Haj Felicity R.J.ose Richard O.C.Oreffo Bone and Joint Research Group Centre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthamptonSO166YDUK Institute for Science and Technology in Medicine Keele UniversityGuy Hilton Research CentreStoke-on-TrentST47BQUK Healthcare Technologies Institute School of Chemical EngineeringInstitute of Translational MedicineUniversity of BirminghamBirminghamB152THUK department of Applied Sciences Pandon BuildingNorthumbria UniversityNewcastle-upon-TyneNE21XEUK Wolfson Centre for Stem Cells Tissue Engineering and ModellingUniversity of NottinghamCentre for Biomolecular SciencesUniversity ParkNottinghamNG72RDUK Leicester Institute for Pharmaceutical Innovation(LIPI) Leicester School of PharmacyFaculty of Health and Life SciencesDe Montfort UniversityThe GatewayLeicesterLE19BHUnited Kingdom Stem Cells and Regenerative Medicine Section UCL Great Ormond Street Institute of Child HealthUniversity College LondonLondonWC1N 1EHUK department of Materials Imperial College LondonRoyal School of MinesLondonSW72AZUK department of Bioengineering Imperial College LondonSouth Kensington CampusLondonSW72AZUK Instituto de Ciencia y Tecnología de Polímeros(ICTP) CSICCalle Juan de la Cierva328006 MadridSpain Consorcio Centro de Investigacion Biomedica en Red CIBER-BBNInstituto de Salud Carlos IIICalle Monforte de Lemos 3-51128029 PabellonMadridSpain Nottingham Biodiscovery Institute School of PharmacyUniversity of NottinghamNottinghamNG72RDUK Institute for Biomedical Engineering Imperial College London South Kensington CampusLondonSW72AZUK department of Physiology Anatomy&GeneticsDepartment of Engineering Scienceand Kavli Institute for Nanoscience DiscoveryUniversity of OxfordOxfordOX13QUUK

Bone tissue engineering requires a combination of materials,cells,growth factors and mechanical cues to recapitulate bone *** this study we evaluated hybrid hydrogels for minimally invasive bone formation by combining biomaterials with skeletal stem cells and staged release of growth factors together with *** hydrogels consisting of alginate and decellularized,demineralised bone extracellular matrix(ALG/ECM)were seeded with Stro-1t human bone marrow stromal cells(HBMSCs).dual combinations of growth factors within staged-release polylactic-co-glycolic acid(PLGA)microparticles were added to hydrogels to mimic,in part,the signalling events in bone regeneration:VEGF,TGF-β_(3),PTHrP(fast release),or BMP-2,vitamin d_(3)(slow release).Mechanotransduction was initiated using magnetic fields to remotely actuate superparamagnetic nanoparticles(MNP)targeted to TREK1 ion *** hydrogels were implanted subcutaneously within mice for 28 days,and evaluated for bone formation using micro-CT and *** hydrogels lacking HBMSCs,growth factors,or MNP became mineralised,and neither growth factors,HBMSCs,nor mechanotransduction increased bone ***,structural differences in the newly-formed bone were influenced by growth *** release of BMP-2 induced thick bone trabeculae and PTHrP or Vitd_(3)increased bone ***,fast-release of TGF-β_(3)and VEGF resulted in thin *** reversed the trabecular thinning and increased collagen deposition with PTHrP and Vitd_(3).Our findings demonstrate the potential of hybrid ALG/ECM hydrogel–cell–growth factor constructs to repair bone in combination with mechanotransduction for fine-tuning bone *** approach may form a minimally invasive reparative strategy for bone tissue engineering applications.

关键词： Growth factors Controlled release Bone ECM Bone formation Mechanotransduction Skeletal stem cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一个从酸化和金属污染中恢复的湖泊历史悠久的水蚤属(daphnia)群落的重现

引用

AMBIO－人类环境杂志 2003年第3期32卷 214-218页

作者： heather G. Pollard John K. Colbourne Wendel (Bill) Keller 林宝法安大略省环境部欧文桑德地区办事处印第安纳那大学基因学和生物信息学中心供职于安大略省环境部

通过综合采用古湖泊学技术和分子遗传技术重现汉纳(Hannah)湖——一个从工业酸化,金属污染及动物灭绝中恢复的湖泊——中水蚤属(daphnia)群落组成的长期型式。像许多浮游动物一样,水蚤属可以产出能生存几十年,甚至一百年以上的滞育卵。... 详细信息

通过综合采用古湖泊学技术和分子遗传技术重现汉纳(Hannah)湖——一个从工业酸化,金属污染及动物灭绝中恢复的湖泊——中水蚤属(daphnia)群落组成的长期型式。像许多浮游动物一样,水蚤属可以产出能生存几十年,甚至一百年以上的滞育卵。然而,过去20年***在汉纳湖中的出现可能是从其他附近湖泊扩散的结果,而不是从沉积物卵库移居而来的。我们利用聚合酶连锁反应(PCR),单股构象多形现象(SSCP)以及排序进行的成因测试结果表明,***滞育卵在过去250年沉积物记录中没有发现,在该地区金属冶炼作业之前,该生物群落由***控制。在湖泊化学复原之后这一物种的变化与早期湖泊酸性的历史变化一致。在汉纳湖的整个远古历史中,环境波动可能决定了群落组成。将这一分子—古湖泊学方法扩展到其他湖泊应该有助于更准确地阐述生物复原过程。

关键词：酸化金属污染恢复湖泊水蚤属群落古湖泊学技术分子遗传技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A multi-purpose National Forest Inventory in Bangladesh:design,operationalisation and key results

引用

Forest Ecosystems 2021年第1期8卷 151-172页

作者： Matieu Henry Zaheer Iqbal Kristofer Johnson Mariam Akhter Liam Costello Charles Scott Rashed Jalal Md.Akhter Hossain Nikhil Chakma Olaf Kuegler Hossain Mahmood Rajib Mahamud Mohammad Raqibul Hasan Siddique Khaled Misbahuzzaman Mohammad Main Uddin Mohammed Al Amin Farid Uddin Ahmed Gael Sola Md.Baktiar Siddiqui Luca Birigazzi Mahmudur Rahman Ilias Animon Saimunnahar Ritu Laskar Muqsudur Rahman Aminul Islam heather Hayden Frida Sidik Mondal Falgoonee Kumar Rakibul Hassan Mukul Hossain Nishad Ariful Hoque Belal Asif Reza Anik Abdul Khaleque Md.Shaheduzzaman Syed Shahadat Hossain Tariq Aziz Md.Tauhidor Rahaman Ruhul Mohaiman Patrick Meyer Purnata Chakma A.Z.M.Manzoor Rashid Sourav das Shrabanti Hira Mohammed Jashimuddin Mohammad Mahfuzur Rahman Karl Wurster Sarder Nasir Uddin Abul Kalam Azad S.M.Zahirul Islam Laurent Saint-André Food and Agriculture Organization of the United Nations Viale delle Terme di Caracalla00153 RomeItaly Forest department Ministry of EnvironmentForests and Climate ChangeBan BhabanShere Bangla NagarAgargaonDhaka 1207Bangladesh School of Ecosystem and Forest Sciences University of MelbourneParkville VictoriaMelbourne 3010Australia United States Forest Service(USFS)/SilvaCarbon WashingtonD.CUSA Institute of Forestry and Environmental Sciences(IFES) University of ChittagongChattogramBangladesh department of Forestry and Environmental Science Rangamati Science and Technology UniversityRangamatiBangladesh Forestry and Wood Technology discipline Khulna UniversityKhulnaBangladesh School of Biological Sciences The University of QueenslandQLDBrisbane 4072Australia Arannyak Foundation DhakaBangladesh United Nations Framework Convention on Climate Change(UNFCCC) BonnGermany Bangladesh Space Research and Remote Sensing Organization(SPARRSO) DhakaBangladesh Institute for Marine Research and Observation Ministry of Marine Affairs and FisheriesNegaraBaliIndonesia department of Agricultural Economics Bangabandhu Sheikh Mujibur Rahman Agricultural University(BSMRAU)GazipurBangladesh Bangladesh Bureau of Statistics(BBS) DhakaBangladesh Institute of Statistical Research and Training University of DhakaDhakaBangladesh United States Agency for International development(USAId) DhakaBangladesh department of Forestry and Environmental Science Shahjalal University of Science and TechnologyKumargaonSylhetBangladesh department of Biological Sciences Faculty of Science and EngineeringMacquarie UniversitySydneyAustralia Bangladesh National Herbarium(BNH) Zoo RoadMirpurDhakaBangladesh Bangladesh Forest Research Institute(BFRI) SholoshaharChottogramBangladesh National Research Institute for Agriculture Food and Environment(INRAE)ParisFrance

Background:National forest inventory and forest monitoring systems are more important than ever considering continued global degradation of trees and *** systems are especially important in a country like Bangladesh,which is characterised by a large population density,climate change vulnerability and dependence on natural *** the aim of supporting the Government’s actions towards sustainable forest management through reliable information,the Bangladesh Forest Inventory(BFI)was designed and implemented through three components:biophysical inventory,socio-economic survey and remote sensing-based land cover *** article documents the approach undertaken by the Forest department under the Ministry of Environment,Forests and Climate Change to establish the BFI as a multipurpose,efficient,accurate and replicable national forest *** design,operationalization and some key results of the process are ***:The BFI takes advantage of the latest and most well-accepted technological and methodological ***,it was designed through a collaborative process which drew from the experience and knowledge of multiple national and international ***,1781 field plots were visited,6400 households were surveyed,and a national land cover map for the year 2015 was *** technological enhancements include a semi-automated segmentation approach for developing the wall-to-wall land cover map,an object-based national land characterisation system,consistent estimates between sample-based and mapped land cover areas,use of mobile apps for tree species identification and data collection,and use of differential global positioning system for referencing plot ***:Seven criteria,and multiple associated indicators,were developed for monitoring progress towards sustainable forest management goals,informing management decisions,and national and international reporting needs.A wide range of biophysica

关键词： South-Asia Forest monitoring Innovation Remote sensing Socio-economic Partnership Ecosystem services Carbon sequestration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity

引用

Molecular Plant 2022年第3期15卷 520-536页

作者： Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke david douches Herman Jvan Eck dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.de Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers department of Plant Biology Michigan State UniversityEast LansingMI 48824USA department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA department of Plant Science McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada Plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBG-4 Bioinformatics Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany department of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer Crop Science WoodlandCA 95695USA Averis Seeds B.V. 9640 AA Veendamthe Netherlands International Potato Center 1895 Avenida La MolinaLimaPeru USdA-ARS ProsserWA 99350USA Agriculture and Agri-Food Canada Fredericton Research and development Centre FrederictonNB E3B 4Z7Canada School of Integrative Plant Science Cornell UniversityIthacaNY 14853-1901USA department of Plant Sciences University of IdahoMoscowID 83844USA USdA-ARS Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZPC Research B.V. Edisonweg 58501 XG Jourethe Netherlands department of Crop and Soil Science Oregon State UniversityHermistonOR 97838USA School of Biology and Ecology University of Maine5735 Hitchner Hall OronoME 04469USA department of Horticultural Sciences Texas A&M UniversityCollege StationTX 77843-2133USA department of Horticulture Oregon State UniversityCorvallisOR 97331USA department of Horticultural Science North Carolina State UniversityRaleighNC 27695-7609USA department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA department of Horticulture Michigan State UniversityEast LansingMI 48824USA Institute for Biological data Science Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA Present address:GenNovation B.V. Wageningenthe Netherlands

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous *** assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous *** species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding *** a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid *** a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic *** StCdF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCdF1 are correlated with maturity in a dosage-dependent *** of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids.

关键词： potato allele diversity phased assembly polyploid pan-genome wild introgressions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2019年全球、地区和国家5岁以下儿童呼吸道合胞病毒引发急性下呼吸道感染疾病负担研究的系统分析

引用

中国病毒病杂志 2023年第2期13卷 81-95页

作者： You Li Xin Wang dianna M.Blau Mauricio T.Caballero daniel R.Feikin Christopher J.Gill Shabir A.Madhi Saad B.Omer Eric A.F Simoes Harry Campbell Ana Bermejo Pariente darmaa Bardach Quique Bassat Jean-Sebastien Casalegno Giorgi Chakhunashvili Nigel Crawford daria danilenko Lien Anh Ha do Marcela Echavarria Angela Gentile Aubree Gordon Terho Heikkinen QSue Huang Sophie Jullien Anand Krishnan Eduardo Luis Lopez Josko Markic Ainara Mira-Iglesias Hannah CMoore Jocelyn Moyes Lawrence Mwananyanda dJames Nokes Faseeha Noordeen Evangeline Obodai Nandhini Palani Candice Romero Vahid Salimi Ashish Satav Euri Seo Zakhar Shchomak Rosalyn Singleton Kirill Stolyarov Sonia K Stoszek Anne von Gottberg danielle Wurzel Lay-Myint Yoshida Chee Fu Yung heather J Zar Harish Nair 张甜甜从兵兵邓舒予不详南京医科大学公共卫生学院江苏南京211166

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RS... 详细信息

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RSV相关社区死亡的更精确估计。本文旨在更新2019年全球、地区和国家层面60月龄以下儿童RSV相关急性下呼吸道感染的发病率和死亡率,重点关注总体死亡率和在研RSV免疫制剂针对的更窄的婴儿年龄组。方法检索获得MEdLINE、Embase、Global Health、CINAHL、Web of Science、LILACS、OpenGrey、中国知网、万方和维普数据库2017—2020年发表文献中的新数据,并纳入RSV GEN合作者提供的未发表数据,以扩展全球RSV疾病负担数据集。纳入的研究符合以下条件:报告了社区中或需要住院治疗的60月龄以下儿童RSV原发性急性下呼吸道感染的数据;报告了至少连续12个月的数据,但院内病死率或RSV季节性定义明确的地区除外;报告了RSV相关急性下呼吸道感染的发病率、住院率、院内病死率或急性下呼吸道感染住院的RSV阳性比例。如果病例定义不明或应用不一致、RSV感染未经实验室确认或仅基于血清学检测、报告的急性下呼吸道感染病例少于50例,则排除该研究。本研究应用广义线性混合效应模型(generalized linear mixed-effects model,GLMM)估计了2019年全球和地区(按国家发展状况和世界银行收入分类)RSV相关急性下呼吸道感染的发病率、住院率和院内病死率;通过基于危险因素的模型估计了国家层面RSV相关急性下呼吸道感染的发病率;通过GLMM开发了新模型,纳入最新的RSV社区死亡率数据,用于估计RSV的总体死亡率。本综述已在PROSPERO注册(CRd42021252400)。结果除了先前综述中纳入的317项研究外,还纳入了113项符合条件的新研究以及51项未发表的研究,共计481项研究。据估计,2019年全球60月龄以下儿童中,共发生3 300万(置信区间为2 540万~4 460万)次RSV相关急性下呼吸道感染,导致360万(290万~460万)例住院、26 300(15 100~49 100)例院内死亡以及101 400(84 500~125 200)例可归因于RSV的总死亡数。在0~6个月的婴儿中,共发生660万(460万~970万)次RSV相关急性下呼吸道感染,导致140万(100万~200万)例住院、13 300(6 800~28 100)例院内死亡以及45 700(38 400~55 900)例可归因于RSV的总死亡数。60月龄以下和28 d~6月龄儿童的死亡中分别有2.0%(置信区间为1.6%~2.4%)和3.6%(3.0%~4.4%)归因于RSV。在各年龄组中,95%以上的RSV相关急性下呼吸道感染事件和97%以上的可归因于RSV的死亡事件都发生在中低收入国家。结论 RSV显著增加了全球60月龄以下儿童的发病和死亡负担,尤其是在出生后前6个月和中低收入国家。本研究强调了全球RSV疾病的总体死亡率负担,60月龄以下儿童中,每50例死亡就有1例可归因于RSV;28 d至6个月大的婴儿中,每28例死亡就有1例可归因于RSV。每1例RSV相关急性下呼吸道感染院内死亡,对应社区中约3例可归因于RSV的死亡。对6月龄内婴儿提供保护的RSV被动免疫计划有望对减轻RSV疾病负担,但实施计划时,仍需要更多数据来了解RSV疾病负担高峰可能向大龄转移的影响。

关键词：呼吸道合胞病毒下呼吸道感染儿童疾病负担住院发病率死亡率病死率模型估计系统分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：