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食欲素对BPH/2J小鼠神经源性高血压的影响

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中华高血压杂志 2016年第5期24卷 408-408页

作者：刘莉叶鹏 Jackson KL Dampney BW Moretti JL Stevenson ER Davern PJ Carrive P head ga

BPH/2J小鼠是一种与交感神经过度敏感相关的高血压遗传模型。食欲素是影响交感神经活动和血压的神经肽。与正常血压的BPN/3J小鼠相比,BPH/2J小鼠下丘脑组织的食欲素前体mRNA表达增强。该研究旨在确定增强的食欲素基因信号传递是否促进... 详细信息

BPH/2J小鼠是一种与交感神经过度敏感相关的高血压遗传模型。食欲素是影响交感神经活动和血压的神经肽。与正常血压的BPN/3J小鼠相比,BPH/2J小鼠下丘脑组织的食欲素前体mRNA表达增强。该研究旨在确定增强的食欲素基因信号传递是否促进高血压发展,BPH/2J和BPN/3J小鼠预先植入无线电遥测探头,比较阿莫伦特（almorexant,食欲肽受体拮抗剂）给药前1h和给药后5h的血压水平。

关键词：食欲素 BPH/2J 神经源性高血压正常血压无线电遥测食欲肽神经肽受体拮抗剂信号传递过度敏感

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家庭血压监测:澳大利亚专家共识说明

中华高血压杂志 2015年第8期23卷 708-708页

作者：罗雪琚叶鹏 Sharman JE Howes FS head ga McGrath XY Stowasser M Schlaich M Glasziou P Nelson MR

医生所测诊室血压可能获取到并无代表性的血压测量结果,从而影响对高血压的准确评估和治疗。家庭血压监测（home blood pressure monitoring,HBPM）是在医疗保健工作者指导下,在一定的时间内（比如7d）患者在家里自行测量血压（通常在... 详细信息

医生所测诊室血压可能获取到并无代表性的血压测量结果,从而影响对高血压的准确评估和治疗。家庭血压监测（home blood pressure monitoring,HBPM）是在医疗保健工作者指导下,在一定的时间内（比如7d）患者在家里自行测量血压（通常在早晨和晚间）。当患者不能进行24 h动态血压监测（ambulatory blood pressure monitoring，ABPM）时，HBPM则为诊治高血压提供了另一种方法。HBPM有良好的重复性，良好的耐受性，比较便宜，且对心血管病发病和死亡的预测均优于诊室血压。HBPM可结合诊室血压测量用来识别“白大衣性高血压”和“隐蔽性高血压”。HBPM平均血压≥135／85mmHg（1mmHg=0．133kPa）是高血压诊断的适合阈值。HBPM还有利于患者管理血压，增强药物治疗依从性，达到目标血压水平。该文建议，在合适情况下，应考虑将HBPM常规应用于高血压的临床管理中。

关键词：动态血压监测澳大利亚白大衣性高血压家庭药物治疗依从性专家血压测量患者管理

A Note on Solutions for Asymptotically Linear Elliptic Systems

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 511-522页

作者： Lei-ga Zhao Department of Mathematics Beijing University of Chemical Technology 100029 Beijing China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Department of Mathematics Yunnan Normal University Kunming 650092 China

In this paper, we are concerned with the elliptic system of{ -△u＋V（x）u=g（x,v）, x∈R^N, -△v＋V（x）v=f（x,u）, x∈R^N, where V（x） is a continuous potential well, f, g are continuous and asymptotically linear as t→∞. The existence of a positive solution and ground state solution are established via variational methods.

关键词： Elliptic system ground state solution variational methods concentration-compactness principle

Failure behavior of soil-rock mixture slopes based on centrifuge model test

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Journal of Mountain Science 2019年第8期16卷 1928-1942页

作者： WANG Teng ZHANG ga State Key Laboratory of Hydroscience and Engineering Tsinghua University

The stability of soil-rock mixtures(SRMs) that widely distributed in slopes is of significant concern for slope safety evaluation and disaster prevention. The failure behavior of SRM slopes under surface loading conditions was investigated through a series of centrifuge model tests considering various volumetric gravel contents. The displacement field of the slope was determined with image-based displacement system to observe the deformation of the soil and the movement of the block during loading in the tests. The test results showed that the ultimate bearing capacity and the stiffness of SRM slopes increased evidently when the volumetric block content exceeded a threshold value. Moreover, there were more evident slips around the blocks in the SRM slope. The microscopic analysis of the block motion showed that the rotation of the blocks could aggravate the deformation localization to facilitate the development of the slip surface. The high correlation between the rotation of the key blocks and the slope failure indicated that the blocks became the dominant load-bearing medium that influenced the slope failure. The blocks in the sliding body formed a chain to bear the load and change the displacement distribution of the adjacent matrix sand through the block rotation.

关键词： Soil rock mixture Slope stability Slope failure Centrifuge model test

Centrifuge model tests on pile-reinforced slopes subjected to drawdown

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1290-1300页

作者： Sujia Liu Fangyue Luo ga Zhang State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing100084China

Piles are generally an effective way to reduce the risk of slope ***,previous approaches for slope stability analysis did not consider the effect of the piles coupled with the decrease of the water level(drawdown).In this study,a series of centrifuge model tests was performed to understand the deformation and failure characteristics of slopes reinforced with various pile *** the centrifuge model tests,the pile-reinforced slopes exhibited two typical failure modes under drawdown conditions:across-pile failure and through-pile *** the through-pile slope failure,a discontinuous slip surface was observed,implying that the assumption of the slip surface in previous stability analysis methods was *** test results showed that drawdown led to instability of the piles in cohesive soil,as the saturated cohesive soil failed to provide sufficient constraint for *** slope exhibited progressive failure,from top to bottom,during *** deformation of the piles was reduced by increasing the embedment depth and row number of *** addition,the deformation of soils outside the piles was influenced by the piles and showed a similar distribution shape as the piles,and the similarity degree weakened as the distance from the piles *** study also found that the failure mechanism of unreinforced and pile-reinforced slopes induced by drawdown could be described by coupling between the deformation localization and local failure,and it revealed that pile-reinforced slopes could reduce slope deformation localization during drawdown.

关键词： Slope Pile Drawdown Failure Reinforcement Centrifuge model test

Simplified method for analyzing soil slope deformation under cyclic loading

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第6期14卷 1967-1976页

作者： ga Zhang Yaliang Wang Fangyue Luo State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing100084China

Reasonable assessment of slope deformation under cyclic loading is of great significance for securing the safety of slopes. The observations of centrifuge model tests are analyzed on the slope deformation behavior under cyclic loading conditions. The potential slip surface is the key for slope failure and follows two rules:(i) the relative horizontal displacement along the potential slip surface is invariable at an elevation, and(ii) the soil along the slip surface exhibits the same degradation pattern. These rules are effective regardless of the location of the potential slip surface throughout the entire deformation process of a homogeneous slope, ranging from the initial deformation stage to the failure process and to the post-failure stage. A new, simplified method is proposed by deriving the displacement compatibility equation and unified degradation equation according to the fundamental rules. The method has few parameters that can be determined through traditional element tests. The predictions from the proposed method agree with the centrifuge test results with vertical loading and shaking table loading. This result confirms that the proposed method is effective in predicting the full deformation process of slopes under different cyclic loading conditions.

关键词： Soil slope Cyclic load Deformation Centrifuge model test Slice method

On n-Widths of a Sobolev Function Class in Orlicz Spaces

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Acta Mathematica Sinica,English Series 2015年第9期31卷 1475-1486页

作者： Xiao Li WANG ga Ridi WU College of Statistics and Mathematics Inner Mongolia University of Finance and Economics College of Mathematics Science Inner Mongolia Normal University

This paper considers the problem of n-widths of a Sobolev function class Ωr∞ determined by Pr（D） = DσПlj=1 （D2 - tj2I） in Orlicz spaces. The relationship between the extreme value problem and width theory is revealed by using the methods of functional analysis. Particularly, as σ = 0 or σ = 1, the exact values of Kolmogorov＇s widths, Gelfand＇s widths, and linear widths are obtained respectively, and the related extremal subspaces and optimal linear operators are given.

关键词： n-width extremal subspace optimal linear operator Orlicz space

Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake

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Genes & Diseases 2024年第1期11卷 23-25页

作者： Andrew Fesler ga-Ram Hwang Jingfang Ju Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA The Northport Veteran's Administration Medical Center NorthportNY 11768USA Curamir Therapeutics Inc. WoburnMA 01801USA

One of the major obstacles for nucleic acid-based medicine is cellular uptake due to the concern of efficiencyand potential toxicity of the *** this work,we developed a novel approach to eliminate the need for a vehicle to allow for the cellular uptake of siRNA-based therapy with a unique modification strategy that also further enhances therapeutic *** discovery may be of great importance for the development of siRNA-based therapeutics as cellular uptake remains a critical *** this study,we have tested the potential of this modification strategy for siRNA using a siRNA that targets B-cell lymphoma-2(BCL-2).

关键词： eliminate uptake modified

Tribological properties of polyimide composites reinforced with fibers rubbing against Al_(2)O_(3)

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Friction 2021年第2期9卷 301-314页

作者： Huimin QI ga ZHANG Zhiqin ZHENG Jiaxin YU Chao HU Key Laboratory of Testing Technology for Manufacturing Process in Ministry of Education State Key Laboratory of Environment-friendly Energy MaterialsSouthwest University of Science and TechnologyMianyang 621010China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Qingdao Center of Resource Chemistry&New Materials Qingdao 266071China Fundamental Science on Nuclear Wastes and Environmental Safety Laboratory Southwest University of Science and TechnologyMianyang 621010China

Reinforcing fillers are of great importance in tribological performance and tribofilm formation of polymeric *** this study,the tribological properties of aramid particle(AP)and short carbon fiber(SCF)reinforced polyimide(PI)composites were added to hexagonal boron nitride(h-BN),and silica(SiO_(2))nanoparticles sliding against alumina were comprehensively *** sliding occurred with AP-reinforced PI composites,the tribological properties were not closely depended on the pressure×velocity(p×v)factors and the *** interactions between AP and its counterpart could not induce tribo-sintering of the transferred wear *** such,the tribofilm seemed to be in a viscous state,leading to higher friction and ***,the inclusion of hard SCF into the PI matrix changed the interfacial interactions with alumina.A robust tribofilm consisting of a high fraction of silica was generated when the SCF-reinforced PI was added to the SiO_(2) *** exhibited a high load-carrying capability and was easily *** caused a significant decrease in the friction and wear of the PI composite at 8 MPa·1m/***,due to their high melting point,few h-BN nanoparticles were observed in the tribofilm of the SCF-reinforced PI when hexagonal boron nitride was added.

关键词： reinforcing filler polyimide composite tribofilm Al_(2)O_(3)