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Pharmacokinetic comparison with different assays for simultaneous determination of cis-,trans-cefprozil diastereomers in human plasma

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Journal of Pharmaceutical Analysis 2021年第3期11卷 351-363页

作者： Seung-Hyun Jeong Ji-Hun Jang hea-young cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-Do13488Republic of Korea

The purpose of this study was to compare pharmacokinetic(PK)parameters obtained using two newly developed assays,HPLC-UV and UPLC-ESI-MS/*** of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage *** this study,we developed two new methods that are most commonly used in biosample analysis and focused on PK parameters obtained from *** HPLC-UV equipped with a Luna-C8 column using UV detector,cefprozil diastereomers were separated using water containing 2%(V/V)acetic acid and acetonitrile as a mobile *** UPLC-ESI-MS/MS equipped with a HALO-C18 column,cefprozil diastereomers were separated using 0.5%(V/V)aqueous formic acid containing 5 mM ammoniumformate buffer and methanol as a mobile *** showed high resolution,sensitivity,and selectivity without interference by plasma *** intra-and inter-day precisions(CV,%)were within 8.88%for HPLC-UV and UPLC-ESI-MS/*** of both methods was 95.67%-107.50%.These two analytical methods satisfied the criteria of international guidance and could be successfully applied to PK *** of PK parameters between two assays confirmed that there is a difference in the predicted minimum plasma concentrations at steady state,which may affect clinical dose and usage ***,we confirmed possible correlation between PK parameters and various biochemical parameters after oral administration of 1000 mg cefprozil to humans.

关键词： Cefprozil diastereomers Comparison HPLC-UV UPLC-ESI-MS/MS Pharmacokinetic parameter Biochemical parameters

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Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study

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Journal of Pharmaceutical Analysis 2021年第4期11卷 444-457页

作者： Seung-Hyun Jeong Ji-Hun Jang Guk-Yeo Lee Seung-Jung Yang hea-young cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea National Development Institute of Korean Medicine 288 Udeuraendeu-gilAnyang-myeonJangheung-gunJeollanam-do59338Republic of Korea Department of Oriental Rehabilitation Medicine Dongshin University Gwangju Korean Medicine Hospital141 Wolsan-roNam-guGwangju61619Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-do13488Republic of Korea

Gumiganghwal-tang is a traditional herbal medicine widely used for its anti-inflammatory,analgesic,and antipyretic ***,the safety and efficacy of its active ingredients based on an in vivo pharmacokinetic(PK)study have yet been *** have established a sensitive and accurate UPLC-ESI-MS/MS method and conducted a PK study on 14 constituents of Gumiganghwal-tang through human plasma *** conditions were optimized according to the physicochemical properties of the 14 compounds to facilitate efficient separation and eliminate overlap or interference between ***-C18 and Inertsil-C8 columns were used as UPLC stationary phases,and acetonitrile and aqueous formic acid were used as mobile *** the analytes were quantified with a triple quadrupole mass spectrometer using electrospray ionization in multiple reaction monitoring *** chromatograms of 14 bioactive compounds showed excellent elution and sensitivity,and each peak was selectively separated and quantified without interference with each other or *** established analytical method was based on international guidelines and was successfully used to perform PK studies of 14 herbal ingredients in humans after oral administration with Gumiganghwal-tang *** oral absorption of most active components of Gumiganghwal-tang was relatively rapid and remained considerably long in the body to be quantified in plasma up to 48 h after administration.

关键词： Gumiganghwal-tang Fourteen bioactive ingredients Simultaneous analysis UPLC-ESI-MS/MS Pharmacokinetics Clinical study

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A New Encryption Mechanism Supporting the Update of Encrypted Data for Secure and Efficient Collaboration in the Cloud Environment

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 813-834页

作者： Chanhyeong cho Byeori Kim Haehyun cho Taek-young Youn Department of Cyber Security Dankook UniversityYongin16890Republic of Korea Department of Software Soongsil UniversitySeoul07027Republic of Korea

With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly ***,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient *** paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative *** bundle includes updated information,allowing only the updated portions to be reencrypted when changes *** encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates *** proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext *** utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those *** approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data *** validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size *** show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size ***,our security evaluation confirms that this method provides robust protection against both passive and active attacks.

关键词： Cloud collaboration mode of operation data update efficiency

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin cho Xuelian Jin Byung Gon Kim Jun young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Ever-changing endoscopic treatment for early gastric cancer:Yesterday-today-tomorrow

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World Journal of Gastroenterology 2014年第37期20卷 13273-13283页

作者： Mi-young Kim Jun-Hyung cho Joo young cho Digestive Disease Center Soonchunhyang University Hospital

Endoscopic resection has been an optimal treatment for selected patients with early gastric cancer(EGC) based on advances in endoscopic instruments and techniques. As endoscopic submucosal dissection(ESD) has been widely used for treatment of EGC along with expanding ESD indication, concerns have been asked to achieve curative resection for EGC while guaranteeing precise prediction of lymph node metastasis(LNM). Recently, new techniques including ESD or endoscopic full-thickness resection combined with sentinel node navigation enable minimal tumor resection and a laparoscopic lymphadenectomy in cases of EGC with high risk of LNM. This review covers the development and challenges of endoscopic treatment for EGC. Moreover, a new microscopic imaging and endoscopic techniques for precise endoscopic diagnosis and minimally invasive treatment of EGC are introduced.

关键词： Endoscopic resection Early gastric cancer Confocal laser endomicroscopy Sentinel node navigation Hybrid natural orifice transluminal endoscopic surgery

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CONVERGENCE ANALYSIS OF A MONOTONE PROJECTION ALGORITHM IN REFLEXIVE BANACH SPACES

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Acta Mathematica Scientia 2017年第2期37卷 488-502页

作者：秦小龙 Sun young cho Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Department of Mathematics Gyeongsang National University

In this article, fixed points of generalized asymptotically quasi-Ф-nonexpansive mappings and equilibrium problems are investigated based on a monotone projection algo- rithm. Strong convergence theorems are establis... 详细信息

关键词： Asymptotically quasi-Ф-nonexpansive mapping Banach space equilibrium problem fixed point Generalized projection

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Reinforced CNN Forensic Discriminator to Detect Document Forgery by DCGAN

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Computers, Materials & Continua 2022年第6期71卷 6039-6051页

作者： Seo-young Lim Jeongho cho Department of Electrical Engineering Soonchunhyang UniversityAsan31538Korea

Recently,the technology of digital image forgery based on a generative adversarial network(GAN)has considerably improved to the extent that it is difficult to distinguish it from the original image with the naked eye by compositing and editing a person’s face or a specific part with the original ***,much attention has been paid to digital image forgery as a social ***,document forgery through GANs can completely change the meaning and context in a document,and it is difficult to identify whether the document is forged or not,which is ***,few studies have been conducted on document forgery and new forgery-related attacks have emerged ***,in this study,we propose a novel convolutional neural network(CNN)forensic discriminator that can detect forged text or numeric images by GANs using CNNs,which have been widely used in image classification for many *** strengthen the detection performance of the proposed CNN forensic discriminator,CNN was trained after image preprocessing,including salt and pepper as well asGaussian ***,we performed CNN optimization to make existing CNN more suitable for forged text or numeric image detection,which have mainly focused on the discrimination of forged faces to *** test evaluation results using Hangul texts and numbers showed that the accuracy of forgery discrimination of the proposed method was significantly improved by 20%in Hangul texts and 5%in numbers compared with that of existing state-of-the-art methods,which proved the proposed model performance superiority and verified that it could be a useful tool in reducing crime potential.

关键词： Digital forensics CNN GAN discriminator image processing

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Evaluation of ring surfaces with several coatings for friction,wear and scuffing life

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中国有色金属学会会刊：英文版 2009年第4期19卷 992-996页

作者： Dae-Hyun cho young-Ze LEE School of Mechanical Engineering Sungkyunkwan University

Friction and wear of the sliding components in an automobile cause an increase in both fuel consumption and *** engine components involved with sliding contact are all susceptible to scuffing failure at some points during their operating ***,it is important to evaluate the effects of various surface coatings on the tribological characteristics of the piston ring and cylinder block surface of a diesel *** and scuffing tests were conducted using a friction and wear measurement of the piston ring and cylinder block in a low friction diesel *** frictional forces,wear amounts and cycles to scuffing in the boundary lubricated sliding condition were measured using the reciprocating wear *** tester used a piece of the cylinder block as the reciprocating specimen and a segment of the piston ring material as the fixed *** coatings on the ring specimen were used,such as DLC,TiN,Cr-ceramic and TiAlN,in order to improve the tribological characteristics of the *** coefficients of friction were monitored during the tests,and the wear volumes of the piston ring surfaces with various coatings were *** results show that the DLC coating exhibits better tribological properties than the other *** graphite structure of this coating is responsible for the low friction and wear of the DLC *** TiN and DLC coatings show better scuffing resistance than the other *** TiN and Cr-ceramic coated rings show good wear resistance and high friction.

关键词：涂层表面摩擦评价生活划伤磨损

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Time-dependent effect of combination therapy with erythropoietin and granulocyte colony-stimulating factor in a mouse model of hypoxic-ischemic brain injury

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Neuroscience Bulletin 2014年第1期30卷 107-117页

作者： Ji hea Yu Jung Hwa Seo Jong Eun Lee Ji Hoe Heo Sung-Rae cho Department and Research Institute of Rehabilitation Medicine Yonsei University College of Medicine Brain Korea 21 PLUS Project for Medical Science Yonsei University Graduate Program of Nano Science and Technology Yonsei University Department of Anatomy Yonsei University College of Medicine Department of Neurology Yonsei University College of Medicine Yonsei Stem Cell Center Avison Biomedical Research CenterYonsei University College of Medicine Rehabilitation Institute of Neuromuscular Disease Yonsei University College of Medicine

Erythropoietin （EPO） and granulocyte colony- stimulating factor （G-CSF） are likely to play broad roles in the brain. We investigated the effects of combination therapy with EPO and G-CSF in hypoxic- ischemic brain injury during the acute, subacute, and chronic phases. A total of 79 C57BL/6 mice with hypoxic-ischemic brain injury were randomly assigned acute （days 1-5）, subacute （days 11-15）and chronic （days 28-32） groups. All of them were treated with G-CSF （250 μg/kg） and EPO （5 000 U/kg） or saline daily for 5 consecutive days. Behavioral assessments and immunohistochemistry for angiogenesis, neuro- genesis, and astrogliosis were performed with an 8-week follow-up. Hypoxia-inducible factor-1 （HIF-1） was also measured by Western blot analysis. The results showed that the combination therapy with EPO and G-CSF in the acute phase significantly improved rotarod performance and forelimb-use symmetry compared to the other groups, while subacute EPO and G-CSF therapy exhibited a modest improvement compared with the chronic saline controls. The acute treatment significantly increased the density of CD31^＋（PECAM-1） and a-smooth muscle actin^＋ vessels in the frontal cortex and striatum, increased BrdU^＋/PSA- NCAM^＋ neurogenesis in the subventricular zone, and decreased astroglial density in the striatum. Furthermore, acute treatment significantly increased the HIF-1 expression in the cytosol and nucleus, whereas chronic treatment did not change the HIF-1 expression, consistent with the behavioral outcomes. These results indicate that the induction of HIF-1 expression by combination therapy with EPO and G-CSF synergistically enhances not only behavioral function but also neurogenesis and angiogenesis while decreasing the astroglial response in a time- dependent manner.

关键词： erythropoietin granulocyte colony-stimulating factor hypoxia-inducible factor-1 hypoxic-ischemic brain injury

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Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo young cho Dong Hae Ho Sae Byeok Jo Jeong Ho cho Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

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