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Influence of he.b-partitioned moxibustion at Qihai (CV6) and bilateral Tianshu (ST25) and Shangjuxu (ST37) acupoints on toll-like receptors 4 signaling pathways in patients with ulcerative colitis

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Journal of Traditional Chinese Medicine 2021年第3期41卷 478-484页

作者： QI Qin Hyoyoung im LI Kunshan GU Muen WU Huangan YANG Ling HUANG Yan ZHAO Jimeng CUI Yunhua LIU Huirong WU Luyi Key Laboratory of Acupuncture and immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 200030China

OBJECTIVE: To evaluate the.efficacy of he.b-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the.immune regulation of HPM on the.toll-like receptors 4(TLR4) signaling pathway in ulcerative colitis(UC) ***: A randomized, single-blind study was conducted 63 patients to receive HPM or sham HPM treatment. The.efficacy outcomes included scores of the.Mayo, Baron, inflammatory bowel disease questionnaire(IBDQ), self-rating depression scale(SDS), self-rating anxiety scale(SAS). he.staining was used to observe the.histopathological changes of the.colon. The.expression of inflammatory cytokines and TLR4 signaling pathway related molecules were determined by enzyme-linked immunosorbent assay and ***: Baron, SDS, SAS scores were significantly decreased in moxibustion group(P he.moxibustion group than in the.sham moxibustion group(P improved in mucosa after treatment. The.expression levels of tumor necrosis factor-α, interleukin-2, interleukin-12, interferon-γ, and TLR4, lipopolysaccharide, myeloid differentiation factor 88, interleukin receptor associated kinase, tumor necrosis factor receptor associated factor 6 and nuclear factor kappa-B p65 were significantly lower in the.moxibustion group than in the.sham moxibustion group(P improving life quality in UC patients,which may be related to the.immune regulation of HPM on TLR4 signaling pathway.

关键词： colitis ulcerative moxibustion toll-like receptors 4 Mayo score Baron score

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补阳还五汤联合盆底肌电刺激治疗脊髓损伤后神经源性膀胱的疗效及对尿流动力学的影响

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微创泌尿外科杂志 2024年第2期13卷 125-129页

作者：何耿陈仕款沈宏峰解放军联勤保障部队第九二八医院泌尿外科海口570011

目的:探究补阳还五汤与盆底肌电刺激用于脊髓损伤后神经源性膀胱(以下简称脊损后膀胱)的疗效。方法:纳入2020年5月至2022年8月我院收治的脊损后膀胱患者102例,随机数表法分为对照组和观察组,每组51例。对照组给予盆底肌电刺激治疗,观察... 详细信息

目的:探究补阳还五汤与盆底肌电刺激用于脊髓损伤后神经源性膀胱(以下简称脊损后膀胱)的疗效。方法:纳入2020年5月至2022年8月我院收治的脊损后膀胱患者102例,随机数表法分为对照组和观察组,每组51例。对照组给予盆底肌电刺激治疗,观察组给予补阳还五汤联合盆底肌电刺激治疗。比较两组疗效及尿流动力学水平。结果:观察组较对照组治疗总有效率明显升高[90.20%(46/51)vs.72.55%(37/51)],差异具有统计学意义(P<0.05)。两组治疗后排尿指标、最大膀胱容量、最大尿流率、最大尿道闭合压、单次尿量、最大尿量、运动评分、感觉评分、生活质量评分较治疗前明显改善,且观察组较对照组改善幅度大,差异具有统计学意义(P<0.05)。结论:补阳还五汤与盆底肌电刺激共同作用于脊损后膀胱,可有效改善患尿功能、神经功能及生活质量,效果显著。

关键词：膀胱,神经源性电刺激补阳还五汤尿流动力学

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A Convection-Allowing Ensemble Forecast Based on the.Breeding Growth Mode and Associated Optimization of Precipitation Forecast

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Journal of Meteorological Research 2017年第5期31卷 955-964页

作者： xiang li hongrang he.chaohui che. ziqing miao shigang bai college of meteorology and oceanography pla university of science and technologyNanjing 211101 nanjing joint center of atmosphe.ic research Nanjing 210009 pla troop 96219 Kunming 650200 pla troop 96319 Puning 515347

A convection-allowing ensemble forecast experiment on a squall line was conducted based on the.breeding growth mode （BGM）. Meanwhile, the.probability matche. mean （PMM） and neighborhood ensemble probability （NEP） methods were used to optimize the.associated precipitation forecast. The.ensemble forecast predicted the.precipita- tion tendency accurately, which was closer to the.observation than in the.control forecast. For he.vy rainfall, the.pre- cipitation center produced by the.ensemble forecast was also better. The.Fractions Skill Score （FSS） results indicated that the.ensemble mean was skillful in light rainfall, while the.PMM produced better probability distribution of pre- cipitation for he.vy rainfall. Preliminary results demonstrated that convection-allowing ensemble forecast could im- prove precipitation forecast skill through providing valuable probability forecasts. It is necessary to employ new methods, such as the.PMM and NEP, to generate precipitation probability forecasts. Nonethe.ess, the.lack of spread and the.overprediction of precipitation by the.ensemble members are still problems that need to be solved.

关键词： convection-allowing ensemble forecast breeding growth mode (BGM) precipitation optimization prob-ability matche. mean (PMM) neighborhood ensemble probability (NEP) Fractions Skill Score (FSS)

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重复经颅磁刺激技术对精神分裂症患者症状及认知功能的影响

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中外医疗 2024年第15期43卷 40-43页

作者：陆东曦陈峰何时琰福建省宁德市康复医院福建宁德352100

目的分析精神分裂症患者行重复经颅磁刺激技术治疗对精神症状、认知功能的作用。方法方便选取2021年3月—2024年1月福建省宁德市康复医院治疗的82例精神分裂症患者为研究对象,并按照随机数表法分为对照组和观察组,每组41例。对照组给予... 详细信息

目的分析精神分裂症患者行重复经颅磁刺激技术治疗对精神症状、认知功能的作用。方法方便选取2021年3月—2024年1月福建省宁德市康复医院治疗的82例精神分裂症患者为研究对象,并按照随机数表法分为对照组和观察组,每组41例。对照组给予基础用药,观察组在对照组的基础上行重复经颅磁刺激技术,比较两组不同治疗时间的精神症状、认知功能以及社会功能。结果治疗后,观察组精神症状得分低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组认知功能得分高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组社会功能量表总得分为(40.12±4.78)分,高于对照组的(35.93±6.27)分,差异有统计学意义(t=3.402,P=0.001)。结论重复经颅磁刺激技术能够提高对精神分裂症患者精神症状的控制效果,并且对患者认知功能以及社会功能的改善有利。

关键词：精神分裂症重复经颅磁刺激技术精神症状认知功能

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High-performance phosphate supported on HZSM-5 catalyst for dehydration of glycerol to acrolein

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Chinese Journal of Che.ical Engineering 2018年第5期26卷 1031-1040页

作者： Feng Zhang Xin Ren he.Huang Jun Huang Medak Sudhakar Liche.g Liu Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences

The.purpose of this study is to increase acrolein yield and capability of coking resistance in the.reaction of glycerol dehydration to acrolein by assembling metal phosphate supported on HZSM-5 catalyst. The.as-prepared catalysts were characterized by XRD, SEM, EDS, BET, NH_3-TPD, CO_2-TPD and Py-IR techniques. It was found that metal phosphate species were incorporated into the.porous structure of HZSM-5 zeolites, thus influencing the.surface and textural physico-che.ical properties of the.supporters. The.alkaline-treated HZSM-5 catalyst promoted the.dispersion of phosphate species on the.carriers. Moreover, the.amount of strong acidity was tremendously improved by adding the.different metal hydrophosphates and the.catalysts show high catalytic activity. In this present work, the.Sn1/4 H_2PO_4/HZSM-5 catalyst exhibited good performance in the.catalytic activity and coking resistant ability, which resulted in a high acrolein yield of 83% initially and acrolein yield of 68% after 30 h. The.acidity, especially the.ratio of strong to weak acid, plays an important role in promoting acrolein yield and stability simultaneously.

关键词： JHZSM-5 Metal hydrophosphate Glycerol dehydration Coking resistance

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Effective and robust approach for fluorescence molecular tomography based on CoSaMP and SP_(3)model

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Journal of Innovative Optical he.lth Sciences 2016年第6期9卷 66-76页

作者： Xiaowei he.Hongbo Guo Jingjing Yu Xu Zhang Yuqing Hou Northwest University School of Information Sciences and Technology Xi'an P.R.China 710069 Shaanxi Normal University School of Physics and Information Technology Xi'an P.R.China 710062

Fluorescence molecular tomography(FMT)allows the.detection and quantification of various biological processes in small animals in vrivo,which expands the.horizons of pre clinical rescarch and drug *** three dimensional(3D)reconstruction algorithm is the.key to accurate localization and quant ification of fAuorescent target in *** this paper,3D recon-struction of FMT is regarded as a sparse signal recovery problem and the.compressive sampling matching pursuit(CoSaMP)algorithm is adopted to obtain greedy recovery of fuorescent ***,to reduce the.modeling error,the.simplified sphe.ical harmonics approximation to the.radiative transfer equation(RTE),more specifically SP_(3),is utilized to describe light prop-agation in biological *** performance of the.proposed reconstruction method is thor-oughly evaluated by simulations on a 3D digital mouse model by comparing it with three representative greedy methods including orthogonal matching pursuit(OMP),stagewise OMP(StOMP),and regularized OMP(ROMP).The.CoSaMP combined with SP_(3)shows an im-provement in reconstruction accuracy and exhibits distinct advantages over the.comparative algorithms in multiple targets *** analysis suggests that CoSaMP is robust to noise and performs stably with reduction of *** feasibility and reoonstruction accuracy of the.proposed method are furthe. validated by phantom experimental data.

关键词： Tomography image reconstruction techniques medical and biological imaging inverse problems

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Nrf2/HO-1信号通路在人脐带间充质干细胞来源的外泌体减轻小鼠肾缺血再灌注损伤中的作用

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中华麻醉学杂志 2024年第1期44卷 97-103页

作者：魏华锋李灵玉罗豪王浩贺佳辉姚雅韡吕兴华兰州大学第一临床医学院兰州730000 兰州大学第一医院日间手术中心兰州730000

目的评价核因子E2相关因子2(Nrf2)/血红素氧化酶-1(HO-1)在人脐带间充质干细胞来源的外泌体(hucMSCs-exo)减轻小鼠肾缺血再灌注损伤中的作用。方法培养人脐带间充质干细胞,提取外泌体,通过透射电子显微镜、纳米颗粒跟踪分析和Western b... 详细信息

目的评价核因子E2相关因子2(Nrf2)/血红素氧化酶-1(HO-1)在人脐带间充质干细胞来源的外泌体(hucMSCs-exo)减轻小鼠肾缺血再灌注损伤中的作用。方法培养人脐带间充质干细胞,提取外泌体,通过透射电子显微镜、纳米颗粒跟踪分析和Western blot法进行鉴定。雄性SPF级C57BL/6小鼠36只,体质量20~25 g,取30只小鼠,采用随机数字表法分为5组(n=6):假手术组(Sham组)、假手术+Nrf2抑制剂ML385组(Sham+ML385组)、肾缺血再灌注组(I/R组)、肾缺血再灌注+外泌体组(I/R+EXO组)、肾缺血再灌注+外泌体+Nrf2抑制剂ML385组(I/R+EXO+ML385组)。采用夹闭两侧肾蒂45 min后再灌注的方法制备肾缺血再灌注损伤模型。Sham+ML385组和I/R+EXO+ML385组于造模前45 min腹腔注射ML38530 mg/kg,I/R+EXO组和I/R+EXO+ML385组于再灌注前15 min尾静脉注射hucMSCs-exo 100μg。再灌注24 h时检测血清BUN和Cr浓度;取肾组织,观察病理学变化,检测IL-6、TNF-α和MDA含量、SOD活性和ROS水平,分别采用Western blot法和RT-qPCR法检测Nrf2、HO-1及其mRNA的表达。取6只小鼠采用随机数字表法分为2组(n=3):假手术组(Sham-im组)和肾缺血再灌注组(I/R-im组),进行VISQUE活体成像观察。结果透射电镜下观察外泌体具有典型的杯状形态,纳米颗粒跟踪分析外泌体平均直径96.7 nm,Western blot法检测其表面标志CD9、CD63、TSG101表达阳性。与Sham-im组比较,I/R-im组小鼠肾脏荧光强度值升高(P0.05)。与I/R组比较,I/R+EXO组血清BUN和Cr浓度降低,肾组织IL-6、TNF-α、MDA含量和ROS水平降低,SOD活性升高,Nrf2、HO-1及其mRNA表达上调(P<0.05),肾组织病理损伤减轻;与I/R+EXO组比较,I/R+EXO+ML385组血清BUN和Cr浓度升高,肾组织IL-6、TNF-α、MDA含量和ROS水平升高,SOD活性降低,Nrf2、HO-1及其mRNA表达下调(P<0.05),肾组织病理损伤加重。结论hucMSCs-exo减轻小鼠肾缺血再灌注损伤的机制可能与激活Nrf2/HO-1信号通路有关。

关键词：外泌体间充质干细胞肾再灌注损伤 NF-E2相关因子2 血红素加氧酶-1

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Regional Disparity and Convergence of China's Inbound Tourism Economy

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Chinese Geographical Science 2011年第6期21卷 715-722页

作者： WANG Shuxin he.Yuanqing WANG Xueding ZHU Guofeng CAO Weihong State Key Laboratory of Cryosphe.e Science Cold and Arid Regions Environmental and Engineering Research Institute ChineseAcademy of Sciences Lanzhou 730000 Chin1 Che.gdu Branch of Chinese Academy of Sciences Chengdu 610041 China

Comprehe.ding regional characteristics and influencing factors of China＇s inbound tourism economy is im- portant to make effective policies that will he.p inbound tourism develop harmoniously and shrink regional disparity. This paper studied the.regional disparity and convergence of China＇s inbound tourism economy during 1996-2008 with the.methods of a-convergence, club convergence and r-convergence. The.results indicate that 1） inbound tourism receipts per capita （ITRPC） of the.whole country, the.eastern, central and western regions presented the.rapid increasing trend; 2） ITRPC of the.whole country was characterized by convergence; 3） the.eastern region presented club con- vergence, but the.central and western regions did not show this trend; 4） the.star-hotel levels and investment in fixed assets for the.tourism industry per capita had a same trend to growth rates of ITRPC, promoting inbound tourism de- velopment, and the.e was no difference among the.31 provinces （municipalities） in the.mainland of China; 5） but the.proportion of employed persons in the.tourism industry accounting for total population and the.proportion of the.terti- ary industry accounting for GDP had a reversal trend to growth rates of ITRPC, shrinking the.provincial disparity in inbound tourism economy, and the.e were differences between the.developed provinces and the.developing provinces. Based on the.e analyses, we put forward some suggestions for the.developing provinces to speed up inbound tourism economy.

关键词： inbound tourism receipts regional disparity a-convergence club convergence fl-convergence China

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Ab initio Study of the.Potential Energy Surface and Product Branching Ratios for Reaction of O（^1D） with C2H5CI

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Chinese Journal of Che.ical Physics 2009年第1期22卷 87-96页

作者： Chong-fu Song Zhi-mei Tian Quan-xin Li Tian-jing he Department of Che.istry Fuyang Teacher's College Fuyang 236041 China Department of Che.ical Physics University of Science and Technology of China Hefei 230026 China

The.potential energy surface of O（^1D）＋C2H5Cl reaction was studied using QCISD（T）/6- 311＋＋G（d,p）//MP2/6-31G（d,p） method. The.calculations reveal an insertion-elimination mechanism. The.insertion reaction of O（^1D） and C2H5Cl produces two energy-rich intermediates, im1 and im2, which subsequently decompose into various products. The.calculations of the.branching ratios of various products formed through the.two intermediates were carried out using RRKM （Rice-Ramsperger-Kassel-Marcus） the.ry at the.collision energies of 0, 20.9, 41.8, 62.7, 83.6, 104.5, and 125.4 kJ/mol. HCl is the.main decomposition product for im1; CH2OH is the.main decomposition product for im2. Since im1 is more stable than im2, HCl is probably the.main product of the.O（^1D）＋C2H5Cl reaction.

关键词： C2H5Cl Branching ratio Rate constant

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广州地区成人网织红细胞相关参数参考区间的调查研究

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海南医学 2024年第2期35卷 249-251页

作者：何静熊铁何永建刘志伟冯丽梅邱凯孙德华南方医科大学南方医院检验科广东广州510515

目的调查广州地区成人网织红细胞相关参数的参考区间。方法选择2022年12月1日至2023年5月25日在南方医科大学南方医院体检的1 064名健康者进行网织红细胞检测,参数为网织红细胞计数(RET#)、网织红细胞百分比(RET%)、未成熟网织红细胞... 详细信息

目的调查广州地区成人网织红细胞相关参数的参考区间。方法选择2022年12月1日至2023年5月25日在南方医科大学南方医院体检的1 064名健康者进行网织红细胞检测,参数为网织红细胞计数(RET#)、网织红细胞百分比(RET%)、未成熟网织红细胞比率(IRF%)、低荧光网织红细胞百分比(LFR%)、中荧光网织红细胞百分比(MFR%)、高荧光网织红细胞百分比(HFR%)、网织红细胞血红蛋白量(RET-he.,健康志愿者按性别分组。另外,收集男女健康者各20份静脉血,进行参考区间验证。结果网织红细胞相关参数呈偏态分布(Phe.参考区间分别为0.93%~2.95%、(47.1~147.4)×10^(9)/L、5.60%~20.20%、79.86%~94.40%、5.00%~14.76%、0.30%~6.28%、32.60~37.88 pg,女性组以上参数参考区间分别为0.92%~2.64%、(41.57~118.56)×10^(9)/L、4.47%~18.53%、81.47%~95.53%、4.20%~13.47%、0.20%~5.67%、31.40~37.10 pg。男女组均通过参考区间验证。结论初步调查了广州地区成人网织红细胞相关参数参考区间。

关键词：广州地区网织红细胞网织红细胞血红蛋白量参考区间

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